Abstract:
:The microbial transformation of androst-4-ene-3,17-dione (4-AD; I) by three fungal species, involved Fusarium solani BH1031, Aspergillus awamori MH18 and Mucor circinelloides W12, has been studied. The latter two fungi were studied for the first time on biotransformation of 4-AD. The main product obtained by Fusarium solani BH1031 was 17α-oxa-D-homo-androst-1,4-diene-3,17-dione (testolactone; IV), which can be used as an anticancer agent. The main derivative yielded by Aspergillus awamori MH18 was 11α-hydroxyandrost-4-ene-3,17-dione (11α-OH-4-AD; VI), which was an important intermediate to produce Eplerenone. Meanwhile, the microbial transformation of 4-AD by Mucor circinelloides W12 produced three derivatives. Possible metabolic pathway of 4-AD via Fusarium solani BH1031 was proposed. Furthermore, the optimization for the production of 11α-OH-4-AD was carried out and the conversion rate reached to 84.0%. In this process, the dextrin and corn flour showed significant effects by response surface analysis.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
An X,Gao P,Zhao S,Zhu L,You X,Li C,Zhang Q,Shan Ldoi
10.1080/14786419.2019.1636238subject
Has Abstractpub_date
2021-02-01 00:00:00pages
428-435issue
3eissn
1478-6419issn
1478-6427journal_volume
35pub_type
杂志文章abstract::A new triterpenic glucoside, lup-1,5,20(29)-trien-3-O-beta-D-glucopyranoside (4), along with three known phytoconstituents: n-octacosane, friedelin and beta-amyrin, has been isolated from the leaves of Clerodendrum inerme (L.) Gaertn. (Verbenaceae). Structure elucidation was carried out on the basis of chemical and ph...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410902975566
更新日期:2010-01-01 00:00:00
abstract::This study reports for the first time in the chemical composition of acetone, ether, ethyl acetate and dichloromethane extracts of Hypogymnia tubulosa determined by HPLC-UV, GC-FID and GC-MS as well as effect of H. tubulosa acetone extract on micronucleus distribution on human lymphocytes and on cholinesterase activit...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1375926
更新日期:2018-11-01 00:00:00
abstract::This work aimed to evaluate the content of selected phenolic natural products in the wine samples made of three new Serbian Cabernet Franc clones (Nos. 02, 010 and 012, respectively) and mother vine (used as the relevant standard) during the period 2008-2012. Compared with all other wine samples, the Cabernet Franc wi...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2015.1135148
更新日期:2016-08-01 00:00:00
abstract::Ocimum is a genus of aromatic herbs, undershurbs or shrubs distributed in the tropical and warm temperate regions of the world. Larvicidal activity of essential oils and different extracts of O. sanctum, O. basilicum and O. gratissimum were compared on laboratory reared and field collected larvae of Culex quinquefasci...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2010.551755
更新日期:2011-12-01 00:00:00
abstract::Methylphophorbide a (MPa) has been isolated from the ethanol extract of the wheat grass plant. Its antioxidative efficacy is evaluated by hydroxyl radical scavenging activities and reducing capacity which are significantly up regulated in comparison with aqueous extract of the plant. The compound shows iron-binding ca...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2015.1022775
更新日期:2016-01-01 00:00:00
abstract::Two alkaloids of the furoquinoline-type were isolated from Ammi majus L.; a new one and was identified as 4-hydro-7-hydroxy-8-methoxyfuroquinoline (1), and the other was isolated for the second time from nature and was identified as 4-hydro-7-hydroxy-8-prenyloxyfuroquinoline (2). The structures of the isolated compoun...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2016.1217858
更新日期:2017-03-01 00:00:00
abstract::In Brazilian folk medicine, Protium heptaphyllum is used to treat inflammatory conditions and to hasten wound repair. This paper aims to investigate the chemical composition and the in vitro antibacterial effects of the essential oils (EOs) obtained from P. heptaphyllum leaves and ripe and unripe fruits against a repr...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2018.1536659
更新日期:2020-08-01 00:00:00
abstract::The chemical composition of the volatile concentrate prepared by supercritical CO(2) extraction of the needles of Pinus nigra Arnold ssp. laricio Poiret from Corsica was investigated using GC (RI), GC-MS and (13)C NMR spectroscopy. The major component was by far manoyl oxide (63%), a compound of potential interest for...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410701427280
更新日期:2007-07-20 00:00:00
abstract::Essential oils from aerial parts of Senecio nutans, Senecio viridis, Tagetes terniflora and Aloysia gratissima were analysed by GC-MS and their antifungal activities were assayed on toxigenic Fusarium and Aspergillus species. Sabinene (27.6 ± 0.1%), α-phellandrene (15.7 ± 0.3%), o-cymene (9.6 ± 0.2%) and β-pinene (6.1...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2018.1511555
更新日期:2020-05-01 00:00:00
abstract::The compositions of phenolic compounds in 10 cultivars of two mulberry species (Morus atropurpurea Roxb. and Morus alba Linn.) grown in four regions of China were analysed using HPLC-TOF-MS. Results showed that a total of 27 phenolic compounds were identified in these mulberry cultivars. The Taiwan cultivar from the J...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2016.1274895
更新日期:2017-05-01 00:00:00
abstract::Mangrove plants are endowed with various biologically active compounds which have potent antibacterial and antioxidant properties. In present study, a bioactivity-guided fractionation for antibacterial and antioxidant active metabolites from the twigs of Avicennia officinalis collected from Kuala Selangor Nature Park,...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2018.1538220
更新日期:2020-08-01 00:00:00
abstract::Investigation on the leaves of Melicope bonwickii (F.Muell.) T.Hartley (Rutaceae) afforded a new 7-(2'-hydroxy-3'-chloroprenyloxy)-4-methoxyfuroquinoline (1) together with the known 7-(2',3'-epoxyprenyloxy)-4-methoxyfuroquinoline (2), evellerine (3) kokusaginine (4) and an amide aurantiamide acetate (5). Compounds 1 a...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410500462983
更新日期:2006-04-01 00:00:00
abstract::In a previous study, we evaluated the maternal and fetal safety of antimalarial herb Artemisia annua with artemisinin yield of 1.09%. Here, we attempted to ascertain the contraceptive claim of A. annua. Sexually matured female Wistar rats (180-220 g) were allotted into four study groups of six rats each. The control g...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2014.936016
更新日期:2014-01-01 00:00:00
abstract::A new triterpene saponin (1) was isolated from a methanol extract of Swartzia apetala Raddi var. glabra, together with the flavonoids mauritianin (2), kaempferol (3) and the triterpene saponin β-D-glucopyranosyl 3β-hydroxy-olean-12-en-28-oate (4). These compounds were characterised on the basis of their spectral data,...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2013.782493
更新日期:2013-10-01 00:00:00
abstract::Six chemical constituents were isolated from Enicosanthum cupulare (King) Airy-Shaw. The structures of the isolated compounds were determined using 1D, 2D-NMR and were found to be identical to those previously reported for these compounds. Three aporphine alkaloids, O-methylmoschatoline, liriodenine and oxostephanine ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786411003774338
更新日期:2010-10-01 00:00:00
abstract::Nerium oleander (NO), a member of the Apocynaceae family, is an ornamental plant. In this study, we evaluated the antiviral activity of hot and cold extract of NO against six different viruses such as herpes simplex virus type 1 (HSV-1), polio virus type 1 (Sb-1), vesicular stomatitis virus (VSV), reovirus type-1 (Reo...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2019.1582046
更新日期:2019-03-25 00:00:00
abstract::Phytochemical investigation of the stem and root barks of Friesodielsia obovata Benth (Annonaceae) afforded new 3',5'-diformyl-2',4',6'-trihydroxychalcone and N-formyl-7-hydroxyglaucine together with five known compounds, 3',5'-dimethyl-2',4',6'-trihydroxychalcone, (-)-crotepoxide, demethoxymatteucinol, lawinal, and b...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410701194310
更新日期:2007-09-01 00:00:00
abstract::A new xanthone, calothorexanthone, together with five known compounds, garbogiol, 1,4,8-trihydroxyxanthone, δ-tocotrienol, 1,7-dihydroxyxanthone and globuxanthone, was isolated from a petroleum ether extract of the bark of Calophyllum thorelii. Their structures were established on the basis of spectroscopic methods, m...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2012.682992
更新日期:2013-01-01 00:00:00
abstract::From the deep-sea-derived fungus Aspergillus candidus, one novel (1) and three known (2-4) p-terphenyl derivates were isolated. The structure of the new compound was established mainly on the basis of extensive analysis of 1D and 2D NMR data. All four isolates were tested for in vitro anti-food allergic and antitumor ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2019.1633651
更新日期:2019-06-24 00:00:00
abstract::From the fruiting body of ectomycorrhizal fungi Cortinarius xiphidipus, sterols were identified from the crude extract and the cytotoxic effect of ergosta-4, 6, 8(14), 22-tetraen-3-one (ergone) was evaluated. Ten sterols including ergosta-3,5,7,9(11),22-pentaene, (22E)-ergosta-5,7,9(11),22-tetraen-3b-ol, (3β,22E)-ergo...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2016.1185717
更新日期:2017-02-01 00:00:00
abstract::Two new lupene-type triterpenoids, 3β,6β-dihydroxylup-20(29)-en-28-oic acid β-glucopyranosyl ester (1) and 2α-acetoxyl-3β,6β-dihydroxylup-20(29)-en-28-oic acid β-glucopyranosyl ester (2), along with 18 known compounds, were isolated from Liquidambar formosana. The structures were elucidated on the basis of spectroscop...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2010.539569
更新日期:2012-01-01 00:00:00
abstract::This study was performed to investigate the effect of ethanol extract from Saururus chinensis (Lour.) Baill on liver function, plasma lipid composition and antioxidant system with high-fat diet for 4 weeks. Rats were divided into the following five groups; untreated control group (normal), treated with 0.5% SE (normal...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410701590657
更新日期:2008-02-15 00:00:00
abstract::Artemisia herba-alba is widely used in traditional medicines for the treatment of several diseases. From the aerial parts organic extract of A. herba-alba, two new compounds, 1,3,8-trihydroxyeudesm-4-en-7α,11βH-12,6α-olide (1) and 5-β-D-glucopyranosyloxy-7-methoxy-6H-benzopyran-2-one (2), respectively, togethe...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2019.1647430
更新日期:2019-07-31 00:00:00
abstract::This paper aims to investigate, for the first time, physicochemical characteristics and antioxidant capacity of Psidium myrtoides ripe and unripe fruit. In addition, essential oil was extracted from fresh leaves (PM-EO) collected in dry and rainy seasons to investigate the influence of seasonality and, after that, to ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2020.1844689
更新日期:2020-11-09 00:00:00
abstract::Two new and one known compounds were isolated from the methanol extract of Sesamum indicum leaves. By means of spectroscopic methods, their structures were elucidated and identified to be 3-epibartogenic acid (1), kaempferol 3-O-[2-O-(trans-p-coumaroyl)-3-O-α-L-rhamnopyranosyl]-β-D-glucopyranoside (2) and epigallocate...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2015.1057730
更新日期:2016-01-01 00:00:00
abstract::Studies were made to increase the yield of piperine extraction using Naviglio Extractor® solid-liquid dynamic extractor (SLDE) from fruits of Piper longum. The effects of ratio w/v were investigated and optimised for the best method. The maximum yield of piperine (317.7 mg/g) from P. longum fruits was obtained in SLDE...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2016.1217209
更新日期:2017-01-01 00:00:00
abstract::Natural estrogens have demonstrated a wide variety of biological activities, which makes them a good candidate for the treatment of diabetes. In vitro, this study evidenced that isoflavones enhanced insulin secretion and inhibited α-amylase activity. In vivo, the findings indicated that soy isoflavones stimulated insu...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786411003683117
更新日期:2011-02-01 00:00:00
abstract::Essential oils from the leaves, twigs and barks of Bocageopsis pleiosperma Maas were obtained by using hydrodistillation and analysed by using gas chromatography coupled to mass spectrometry. Several compounds (51) were detected and identified, being β-bisabolene the main component in all aerial parts of the plant, wi...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2014.996148
更新日期:2015-01-01 00:00:00
abstract::Two new ent-atisanes ent-1β,3β,16β,17-tetrahydroxyatisane (1), ent-1β,3α,16β,17-tetrahydroxyatisane (2) together with 11 known diterpenes were isolated from the anti-tumour activity fraction of Euphorbia fischeriana Steud. The compounds were identified by detailed spectroscopic analysis, including extensive 2D-NMR exp...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2015.1045904
更新日期:2016-01-01 00:00:00
abstract::A novel aromatic compound, grandiuvarone B (5-acetoxy-3-benzoyloxymethyl-5H-oxepin-4-one), along with a known compound grandiuvarone A (5-acetoxy-6-benzoyloxymethyl-5H-oxepin-4-one) were isolated from methanol extracts of Desmos chinensis leaves. Their structures were determined by various spectroscopic techniques inc...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2018.1550762
更新日期:2020-04-01 00:00:00