Abstract:
:Two new ent-atisanes ent-1β,3β,16β,17-tetrahydroxyatisane (1), ent-1β,3α,16β,17-tetrahydroxyatisane (2) together with 11 known diterpenes were isolated from the anti-tumour activity fraction of Euphorbia fischeriana Steud. The compounds were identified by detailed spectroscopic analysis, including extensive 2D-NMR experiments. X-ray analysis was applied to determine the structure of compound 2. All 13 compounds were screened for cytotoxicity in vitro against human tumour MCF-7, HepG-2 and SGC-7901 cell lines. Compounds 1 and 2 showed the inhibitory effects against MCF-7 with IC50 levels of 23.21 and 15.42 μM; simultaneously, compounds 4, 6, 8 and 11 also had definite inhibitory effect against different cell lines.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Wang M,Wang Q,Wei Q,Li J,Guo C,Yang B,Kuang Hdoi
10.1080/14786419.2015.1045904subject
Has Abstractpub_date
2016-01-01 00:00:00pages
144-9issue
2eissn
1478-6419issn
1478-6427journal_volume
30pub_type
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