Antioxidative and anticarcinogenic activities of methylpheophorbide a, isolated from wheat grass (Triticum aestivum Linn.).

abstract：:Alternanthera brasiliana is popularly known as 'penicillin' and used as an anti-inflammatory and for wound healing. The objective of this work was the phytochemical study of the species by analytical techniques such as LC-MS/MS and GC-MS. Twenty-seven compounds were identified, five by LC-MS and 22 by GC-MS analysis. ...

journal_title：Natural product research

authors： Alencar Filho JMT,Teixeira HAP,Sampaio PA,Pereira ECV,Amariz IAE,Rolim Neto PJ,Rolim LA,Araújo ECDC

更新日期：2020-02-01 00:00:00

abstract：:A novel monoterpenoid indole alkaloid, melognine (1) possessing an unprecedented skeleton with a 6/6/5/5/6/6 hexatomic rearranged ring system was isolated from the stems of Melodinus fusiformis. The structure with absolute configuration of 1 was established by extensive spectroscopic analyses and quantum ECD calculati...

journal_title：Natural product research

authors： Zhou J,Du SY,Fang ZY,Feng JH

更新日期：2019-11-01 00:00:00

abstract：:A new natural diketopiperazine (1) was obtained from the culture broth of Microbispora aerata strain imbas-11A, isolated from penguin excrements collected on the Antarctic Livingston Island. Compound 1 was purified consecutively by solvent extraction, silica gel column chromatography and preparative HPLC. The structur...

journal_title：Natural product research

authors： Ivanova V,Laatsch H,Kolarova M,Aleksieva K

更新日期：2013-01-01 00:00:00

abstract：:This article presents the very first phytochemical investigation on new species Tripleurospermum insularum Inceer & Hayırlıoglu-Ayaz. The volatile profile of odorous parts of the plant was analysed by GC/MS, and compounds were identified in headspace and essential oil obtained from aerial parts, representing 70.81% an...

journal_title：Natural product research

authors： Ćavar Zeljković S,Ayaz FA,Inceer H,Hayirlioglu-Ayaz S,Colak N

更新日期：2015-02-01 00:00:00

abstract：:Here is reported the anti Leishmania infantum activity of 48 hexane, CH2Cl2 and MeOH extracts from 16 macroalgae collected on the Iberian Coast. Seven hexane and CH2Cl2Cystoseira baccata, Cystoseira barbata, Cystoseira tamariscifolia, Cystoseira usneoides, Dictyota spiralis and Plocamium cartilagineum extracts were ac...

journal_title：Natural product research

authors： Bruno de Sousa C,Lago JHG,Macridachis J,Oliveira M,Brito L,Vizetto-Duarte C,Florindo C,Hendrickx S,Maes L,Morais T,Uemi M,Neto L,Dionísio L,Cortes S,Barreira L,Custódio L,Alberício F,Campino L,Varela J

更新日期：2019-06-01 00:00:00

abstract：:A new isocoumarin, along with 10 known compounds, was isolated from the aerial parts of Aconitum gymnandrum. Their structures were elucidated by spectroscopic methods including extensive 1D and 2D NMR techniques. Among the known compounds, compound 11 was obtained as a natural product for the first time, which was pre...

journal_title：Natural product research

authors： Zhao JQ,Wang YM,Wang S,Dang J,Shi YP,Mei LJ,Tao YD

更新日期：2016-08-01 00:00:00

abstract：:The CDC25 phosphatases regulate the cell division cycle by controlling the activity of cyclin-dependent kinases. While screening for inhibitors of phosphatases among natural products we repeatedly found that some polyprenyl-hydroquinones and polyprenyl-furans (furanoterpenoids) (furospongins, furospinosulins) were pot...

journal_title：Natural product research

authors： Erdogan-Orhan I,Sener B,de Rosa S,Perez-Baz J,Lozach O,Leost M,Rakhilin S,Meijer L

更新日期：2004-02-01 00:00:00

abstract：:New analogues of a long-chain secondary alcohol (1) and laserine (2) were isolated from the flowers of Tamarix hampeana L. The isolated compounds were identified using 1D and 2D NMR, LCMS/APCI, and chemical methods. Laserine was isolated for the first time from T. hampeana L. ...

journal_title：Natural product research

authors： Aykac A,Akgül Y

更新日期：2010-01-01 00:00:00

abstract：:Three new aconitine-type C19-diterpenoid alkaloids, taipeinines A-C (1-3), were isolated from the roots of Aconitum taipaicum. The chemical structures of these three compounds were established as (1α,6α,8α,14α,16α)-20-ethyl-8,14-dihydroxy-1,6,16-trimethoxy-4-(methoxymethyl)-aconitane (1), (1α,6α,8α,14α,16β)-20-ethyl-8...

journal_title：Natural product research

authors： Guo ZJ,Xu Y,Zhang H,Li MY,Xi K

更新日期：2014-01-01 00:00:00

abstract：:Chronic neuroinflammation is a key component of many neurodegenerative disorders. Chronic activation of this process produces pro-inflammatory cytokines, prostaglandins and reactive oxygen species that induce brain injury and neuronal dysfunction. Agave species contain saponins, compounds with anti-inflammatory activi...

journal_title：Natural product research

authors： Herrera-Ruiz M,Jiménez-Ferrer E,Tortoriello J,Zamilpa A,Alegría-Herrera E,Jiménez-Aparicio AR,Arenas-Ocampo ML,Martínez-Duncker I,Monterrosas-Brisson N

更新日期：2019-05-14 00:00:00

abstract：:Four new and seven known diterpenes have been isolated from the dichloromethane extract of the aerial parts of Calceolaria polifolia. The structures of the new compounds were established by spectroscopic evidence. ...

journal_title：Natural product research

authors： Garbarino JA,Piovano M,Chamy MC,Espinoza L

更新日期：2007-02-01 00:00:00

abstract：:A new prenylated xanthone, mangostanaxanthone VIII (7) and six known metabolites: gartanin (1), 1,3,8-trihydroxy-2-(3-methyl-2-butenyl)-4-(3-hydroxy-3-methylbutanoyl)-xanthone (2), rubraxanthone (3), 1,3,6,7-tetrahydroxy-8-prenylxanthone (4), garcinone C (5), and xanthone I (9-hydroxycalabaxanthone) (6) were separated...

journal_title：Natural product research

authors： Ibrahim SRM,Abdallah HM,El-Halawany AM,Nafady AM,Mohamed GA

更新日期：2019-01-01 00:00:00

abstract：:The essential oil of Cyclospermum leptophyllum (Pers.) Sprague ex Britton and P. Wilson syn. Apium leptophyllum (Pers.) F. Muell. Ex Benth., family Apiaceae (Umbellifereae), was analysed by GC and GC-MS. The essential oil showed the presence of thymohydroquinone dimethyl ether (50.7%), thymol methyl ether (11.2%), γ-t...

journal_title：Natural product research

authors： Pande C,Tewari G,Singh C,Singh S

更新日期：2011-03-01 00:00:00

abstract：:Three anthraquinones, Cdc25B phosphatase inhibitors, were isolated from the methanolic extract of the roots of Polygonum multiflorum Thunb. (Polygonaceae). Anthraquinones, physcion (1), emodin (2), and questin (3), inhibited the enzymatic activity of Cdc25B phosphatase with IC(50) values of 62.5, 30, and 34 microg mL(...

journal_title：Natural product research

authors： Choi SG,Kim J,Sung ND,Son KH,Cheon HG,Kim KR,Kwon BM

更新日期：2007-05-20 00:00:00

abstract：:In the present investigation, the anti-inflammatory activity of a polyphenolic enriched extract of Schima wallichii bark was evaluated in vitro using human peripheral blood mononuclear cells (PBMCs) and in vivo by carrageenan-induced paw oedema assay (acute study) and cotton pallet granuloma assay (chronic study). The...

journal_title：Natural product research

authors： Dewanjee S,Mandal V,Sahu R,Dua TK,Manna A,Mandal SC

更新日期：2011-04-01 00:00:00

abstract：:Ginsenoside Re (G-Re) is a major ingredient of the ginseng bud. A novel and rapid method to isolate and purify G-Re from ginseng buds was established. The procedure involves solvent extraction of ginseng bud powder, then pre-purification with an active carbon column and purification by preparative HPLC (prep-HPLC). Ac...

journal_title：Natural product research

authors： Kuang P,Wang G,Yuan Q,Liang H

更新日期：2012-01-01 00:00:00

abstract：:Ocimum is a genus of aromatic herbs, undershurbs or shrubs distributed in the tropical and warm temperate regions of the world. Larvicidal activity of essential oils and different extracts of O. sanctum, O. basilicum and O. gratissimum were compared on laboratory reared and field collected larvae of Culex quinquefasci...

journal_title：Natural product research

authors： Rajamma AJ,Dubey S,Sateesha SB,Tiwari SN,Ghosh SK

更新日期：2011-12-01 00:00:00

abstract：:Four C-13, C-14 side chain modified 9(R)-hydroxy-1-deoxy-taxane analogues 15, 16, 19 and 22 were semi-synthesized from 1-deoxybaccatin VI. The in vitro antitumor activity of these compounds was evaluated against A549 and A2780 cell lines. The preliminary SAR analysis showed that introduction of oxygen-containing group...

journal_title：Natural product research

authors： Tang P,Lin HX,Yuan TH,Cui YM

更新日期：2019-12-01 00:00:00

abstract：:Two new neoclerodane diterpenoids, barbatin F (1), barbatin G (2) together with four known compounds, scutebata A (3), scutebata B (4), scutebata C (5) and scutebata P (6) were isolated from the whole plant of Scutellaria barbata D.Don. Their structures were elucidated on the basis of spectroscopic studies. In vitro c...

journal_title：Natural product research

authors： Wang M,Chen Y,Hu P,Ji J,Li X,Chen J

更新日期：2020-05-01 00:00:00

abstract：:A short total synthesis of natural isocarbostyril ruprechstyril (3-n-pentyl-6-methoxy-8-hydroxy-1(2H)-isoquinolinone) isolated from Ruprechtia tangarana is reported. 6,8-Dimethoxy-3-pentylisocoumarin obtained by condensation of 3,5-dimethoxyhomophthalic anhydride with hexanoyl chloride was smoothly converted to O-meth...

journal_title：Natural product research

authors： Saeed A

更新日期：2013-01-01 00:00:00

abstract：:A new alkynol, platycodynol (1), identified as 2, 3, 9, 13, 14-pentahydroxy-4, 6-tetradecadiyne, along with six known compounds (2-7) were obtained from Platycodins folium for the first time. Their structures were elucidated with infrared (IR), ultraviolet (UV), 1D and 2D nuclear magnetic resonance (NMR) spectroscopic...

journal_title：Natural product research

authors： Wang C,Dong Q,Wu F,Li Z,Li P,Liu J,Wang F

更新日期：2020-01-17 00:00:00

abstract：:A facile, atom-economic synthesis of isoxazilidino withaferin, a novel hybrid of withaferin A, has been accomplished via two-step reaction of nitrone synthesis followed by nitrone 1,3-dipolar cycloaddition. The reaction is highly chemoselective (preferential reaction only on one of the two double bonds present on with...

journal_title：Natural product research

authors： Mandal R,Singh M,Krishnan AAV,Dahat YH,Bharitkar YP,Ravichandiran V,Hazra A

更新日期：2020-08-01 00:00:00

abstract：:A new carotenoid glycoside, namely neo-rehmannioside (1), together with five known compounds, 6-O-seco-hydroxyaeginetoyl ajugol (2), oxyrehmaionoside B (3), ajugol (4), geniposidic acid (5) and geniposide (6) was isolated from the 95% ethanol extract of dry roots of Rehmannia glutinosa. The structure of the new compou...

journal_title：Natural product research

authors： Fu GM,Shi SP,Ip FC,Pang HH,Ip NY

更新日期：2011-08-01 00:00:00

abstract：:Inhibitory activity of the biocontrol bacterial strain Lysobacter capsici AZ78 is related to the production of cyclo(l-Pro-l-Tyr), a 2,5-diketopiperazine with in vitro and in vivo toxic activity against Phytophthora infestans and Plasmopara viticola. Further investigation of culture filtrate organic extracts showed it...

journal_title：Natural product research

authors： Cimmino A,Bejarano A,Masi M,Puopolo G,Evidente A

更新日期：2020-04-30 00:00:00

abstract：:Toxicity of the pesticide carbofuran (CF) can be alleviated by curcumin, if not for its poor bioavailability. Hence, we investigated the effect of a bioavailable curcumin-galactomannan complex (CGM) on CF-induced neurotoxicity in rats in comparison to that of unformulated standard curcumin (CS). The CF (5 mg/kg b.wt/d...

journal_title：Natural product research

authors： E R S,P P B,Nair SS,Maliakel B,Kuttan R,I M K

更新日期：2020-05-01 00:00:00

abstract：:The comet assay-guided fractionation of the twigs of Manglietia hookeri resulted in the isolation of three sesquiterpene-neolignans, including a new one 5-allyl-2-(4-allyl-phenoxy)-3-[7-(1-hydroxy-1-methyl-ethyl)-1, 4a-dimethyl-decahydro-naphthalen-1-yloxy]-phenol (1), and eudesobovatol A (2) and eudesobovatol B (3), ...

journal_title：Natural product research

authors： Hu X,Sui X,Wang Y,Wang W,Wu H,Zhang F,Tan Y,Zhang F

更新日期：2016-07-01 00:00:00

abstract：:Plants mentioned in this study have numerous records in traditional Peruvian medicine being used in treatment of cancer and other diseases likely to be associated with oxidative stress. Amongst the eight plant species tested, only Dysphania ambrosioides exhibited combinatory antioxidant and anti-proliferative effect o...

journal_title：Natural product research

authors： Tauchen J,Huml L,Bortl L,Doskocil I,Jarosova V,Marsik P,Frankova A,Clavo Peralta ZM,Chuspe Zans ME,Havlik J,Lapcik O,Kokoska L

更新日期：2019-09-01 00:00:00

abstract：:To date, despite extensive investigations, full understanding of the endocannabinoid system remains elusive; in particular, anandamide cellular uptake is a current controversial topic. An iodo-arylazido probe was synthesized from commercially available azelaic acid monomethyl ester, in order to shed light on the anand...

journal_title：Natural product research

authors： Balas L,Hellal M,Rossi JC,Durand T

更新日期：2005-06-01 00:00:00

abstract：:The stem-derived essential oil of Aglaia odorata Lour. was obtained by hydrodistillation using a Clevenger-type system. Gas chromatography-mass spectrometry analysis of the oil revealed the identification of 39 compounds, representing 76.4% of the oil; germacrene D (20.3%), α-humulene (17.1%), α-himachalene (12.7%) an...

journal_title：Natural product research

authors： Joycharat N,Thammavong S,Voravuthikunchai SP,Plodpai P,Mitsuwan W,Limsuwan S,Subhadhirasakul S

更新日期：2014-01-01 00:00:00

abstract：:We report the first analysis in absolute, and in particular, concerning the phytochemical pattern, about an endemic Italian species, Ajuga tenorei C. Presl. The analysis, performed by means of techniques such as Column Chromatography and NMR spectroscopy and Mass spectrometry, led to the isolation and the identificati...

journal_title：Natural product research

authors： Frezza C,Venditti A,Di Cecco M,Ciaschetti G,Serafini M,Bianco A

更新日期：2017-01-01 00:00:00