Abstract:
:Two new neoclerodane diterpenoids, barbatin F (1), barbatin G (2) together with four known compounds, scutebata A (3), scutebata B (4), scutebata C (5) and scutebata P (6) were isolated from the whole plant of Scutellaria barbata D.Don. Their structures were elucidated on the basis of spectroscopic studies. In vitro cytotoxicity of selected compounds against cancer cell lines LoVo, SMMC-7721, HCT-116, and MCF-7 were evaluated, compound 1 and 2 showed weak cytotoxic activities against HCT-116 colon cancer cell lines with IC50 value of 44.3, 32.3 μM, respectively, while compound 3 and 4 exhibited moderate cytotoxic activities against four tested human cancer cell lines with IC50 values of 5.31~28.5 μM.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Wang M,Chen Y,Hu P,Ji J,Li X,Chen Jdoi
10.1080/14786419.2018.1514399subject
Has Abstractpub_date
2020-05-01 00:00:00pages
1345-1351issue
10eissn
1478-6419issn
1478-6427journal_volume
34pub_type
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