Abstract:
:Camptothecin (CPT), the derivatives of which are used clinically for the treatment of metastatic colon cancer, is isolated from intact plants that can be subjected to environmental fluctuations. In vitro cultures may be an alternate and continuous source for year-round production of CPT. Since CPT production by undifferentiated cell cultures is low, differentiated tissues such as root cultures may be a viable alternate source for CPT production. Hairy roots were induced in Ophiorriza rugosa, a source of CPT, using Agrobacterium rhizogenes strain LBA9402. The hairy roots, when cultured in light, showed spontaneous regeneration of shoots. Analysis of CPT levels in the hairy roots and in vitro-grown transformed shoots revealed 0.009% d.w. and 0.012% d.w., respectively.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Kamble S,Gopalakrishnan R,Eapen Sdoi
10.1080/14786419.2011.559469subject
Has Abstractpub_date
2011-10-01 00:00:00pages
1762-5issue
18eissn
1478-6419issn
1478-6427journal_volume
25pub_type
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