Abstract:
:In the present investigation, the anti-inflammatory activity of a polyphenolic enriched extract of Schima wallichii bark was evaluated in vitro using human peripheral blood mononuclear cells (PBMCs) and in vivo by carrageenan-induced paw oedema assay (acute study) and cotton pallet granuloma assay (chronic study). The extract exhibited significant inhibition of the production of tumour necrotic factor-α and interleukin-6 by PBMCs stimulated with lipopolysaccharide (LPS) in a concentration-dependent manner. The extract at the selected doses of 150 and 300 mg kg(-1) body weight p.o. exhibited significant dose-dependent anti-inflammatory responses, with 44.32 and 38.65% inhibition of inflammation in carrageenan-induced paw oedema and cotton pallet granuloma, respectively.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Dewanjee S,Mandal V,Sahu R,Dua TK,Manna A,Mandal SCdoi
10.1080/14786410802560732subject
Has Abstractpub_date
2011-04-01 00:00:00pages
696-703issue
7eissn
1478-6419issn
1478-6427pii
913547210journal_volume
25pub_type
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