Anti-inflammatory activity of a polyphenolic enriched extract of Schima wallichii bark.

Abstract:

:In the present investigation, the anti-inflammatory activity of a polyphenolic enriched extract of Schima wallichii bark was evaluated in vitro using human peripheral blood mononuclear cells (PBMCs) and in vivo by carrageenan-induced paw oedema assay (acute study) and cotton pallet granuloma assay (chronic study). The extract exhibited significant inhibition of the production of tumour necrotic factor-α and interleukin-6 by PBMCs stimulated with lipopolysaccharide (LPS) in a concentration-dependent manner. The extract at the selected doses of 150 and 300 mg kg(-1) body weight p.o. exhibited significant dose-dependent anti-inflammatory responses, with 44.32 and 38.65% inhibition of inflammation in carrageenan-induced paw oedema and cotton pallet granuloma, respectively.

journal_name

Nat Prod Res

journal_title

Natural product research

authors

Dewanjee S,Mandal V,Sahu R,Dua TK,Manna A,Mandal SC

doi

10.1080/14786410802560732

subject

Has Abstract

pub_date

2011-04-01 00:00:00

pages

696-703

issue

7

eissn

1478-6419

issn

1478-6427

pii

913547210

journal_volume

25

pub_type

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