Isolation of amylase regulators from the leaves of Ixeridium dentatum.

Abstract:

:Two new compounds, one sesquiterpene lactone (1) and one phenylethanoid tautomer (2), together with eleven known compounds (3-13) were isolated from the leaves of Ixeridium dentatum. Their structures were determined by extensive spectroscopic methods, including 1D-, 2D-NMR, and mass spectrometry. All compounds were evaluated for their amylase secretion activity in human salivary gland cells after treatment in 40 mM of high glucose. All compounds showed increased amylase secretion activity. Moreover, previously undescribed compounds (1-2), luteolin 7-O-β-D-glucopyranoside (10), quercimeritrin (11), and quercetin 3-O-β-D-xylopyranoside (13) exhibited significant amylase activity, which is comparable to the positive control.

journal_name

Nat Prod Res

journal_title

Natural product research

authors

Park S,Nhiem NX,Park JH,Bhattarai KR,Chae HJ,Kim HR,Kim SH

doi

10.1080/14786419.2019.1599885

subject

Has Abstract

pub_date

2019-04-10 00:00:00

pages

1-6

eissn

1478-6419

issn

1478-6427

pub_type

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