Abstract:
:The search for bioactive natural products from the rhizomes of Paris polyphylla (Trilliaceae) has resulted in the isolation of four known constituents, 1,5-dihydroxy-7-methoxy-3-methylanthraquinone (1), diosgenin-3-O-[alpha-L-rhamnopyranosyl-(1 --> 3)-beta-D-glucopyranoside] (2), diosgenin-3-O-[alpha-L-rhamnopyranosyl-(1(Rha) --> 2(Glu))-alpha-L-arabinofuranosyl-(1(Ara) --> 4(Glu))]-beta-D-glucopyranoside (3), and diosgenin-3-O-[alpha-L-rhamnopyranosyl-(1(Rha) --> 2(Glu))-alpha-L-rhamnopyranosyl-(1(Ara) --> 4(Glu))]-beta-D-glucopyranoside (4). Their structures were identified by spectral comparison with the reported data. Compound 1 was isolated for the first time from this genus. The chloroform, ethyl acetate, and butanol extracts of the plant were found to have mild to moderate inhibitory potentials against the enzyme tyrosinase. Compound 1 showed strong (IC(50) = 0.23 microM), while compounds 2-4 and hydrolyzed product 4a showed mild to moderate (IC(50) = 0.93-36.87 microM) activities against the tyrosinase. Similarly, compounds 2-4 and 4a showed mild to moderate (IC(50) = 1.59-83.72 microg mL(-1)) antileishmanial activities.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Devkota KP,Khan MT,Ranjit R,Lannang AM,Samreen,Choudhary MIdoi
10.1080/14786410701192777subject
Has Abstractpub_date
2007-04-01 00:00:00pages
321-7issue
4eissn
1478-6419issn
1478-6427pii
778116022journal_volume
21pub_type
杂志文章abstract::The ethanol extract of roots of Solidago canadensis yielded eight labdane-type diterpenes. Five of those were new natural compounds (9,13,15,16-bisepoxy-labdane-7-ene-6,15-dione (3a), 13-epi-9,13,15,16-bisepoxy-labdane-7-ene-6,15-dione (3b), 15,16-epoxy-labdane-7,13-diene-6,16-dione (5), 15-ethoxy-9,13,15,16-bisepoxy-...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2011.565005
更新日期:2012-01-01 00:00:00
abstract::A new chromone glycoside, 8-O-β-D-Glucopyranosyl-2-methylchromone (1), together with eight known compounds (2-9) were isolated from the Tibetan medicine plant of Swertia punicea. All compounds of this plant were reported for the first time. The structures of these metabolites were elucidated by analysis of their HR-ES...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2020.1777123
更新日期:2020-06-11 00:00:00
abstract::Alkylglycerols (AKGs) are bioactive natural compounds that vary by alkyl chain length and degree of unsaturation, and their absolute configuration is 2S. Three AKGs (5l-5n) were synthesised in enantiomerically pure form, and were characterised for the first time together with 12 other known and naturally occurring AKG...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2019.1686370
更新日期:2019-11-04 00:00:00
abstract::One new anthraquinone, 1,8-dihydroxy-2-ethyl-3-methylanthraquinone (1), together with two known compounds octadecanoic acid (2) and cholest-4-en-3-one (3) was isolated from marine actinomycete Streptomyces sp. FX-58. The structure of 1 was elucidated on the basis of spectroscopic methods, especially, the 2D-NMR spectr...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410600899142
更新日期:2006-11-01 00:00:00
abstract::A new isoflavone glycoside, named 3'-hydroxytectorigenin-7-O-β-D-xylosyl-(1→6)-β-D-glucopyranoside (1) was isolated from the flowers of Pueraria montana var. lobata (Willd.) Sanjappa & Pradeep. The structure of compound 1 was characterised by HR-ESI-MS and NMR spectroscopic methods. In radical scavenging activity test...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2019.1655021
更新日期:2019-08-21 00:00:00
abstract::The antiplasmodial active extract of Xanthium cavanillesii contains 3,4-dicaffeoyl quinic acid (3,4-DCQA), 3,5-dicaffeoyl quinic acid (3,5-DCQA) and 1,3,5-tricaffeoyl quinic acid (1,3,5-TCQA). These results inspired us to investigate the interaction of these molecules with a promising validated target of Plasmodium, P...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2016.1219856
更新日期:2017-03-01 00:00:00
abstract::Natural products represent a rich source of bioactive compounds that have been historically used to obtain substances with great medicinal potential. The skin of anuran amphibians is a rich source of compounds with a wide range of biological activity. Alzheimer's disease (AD) is a complex disease associated with all k...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2019.1591396
更新日期:2019-03-31 00:00:00
abstract::A new isoflavonoid, excelsanone (2), was isolated from the ethyl acetate extract of Erythrina excelsa stem bark, together with three known compounds namely 6,8-diprenylgenistein (3), β-sitosterol (1) and sitosteryl-β-D-glucopyranoside (4). Their structures were elucidated using spectroscopic methods (HR-ESI-MS, NMR an...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2018.1495639
更新日期:2020-03-01 00:00:00
abstract::A new 20-membered macrolide named as levantilide C was isolated from the Micromonospora strain FIM07-0019 recovered from shallow coastal waters near the island of Chiloe, Chile. The chemical structure of levantilide C was elucidated on the basis of one- and two-dimensional NMR analysis. Two known indole derivatives we...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2012.740038
更新日期:2013-08-01 00:00:00
abstract::Phytochemical investigation of the aerial parts of Eriope blanchetii and E. latifolia (Lamiaceae) yielded podophyllotoxin, as well as the aryltetralin lignans α- and β-peltatin and yatein. Oleanolic, ursolic and epikatonic acids were also isolated. This is the first occurrence of podophyllotoxin in the family. ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410902809500
更新日期:2011-09-01 00:00:00
abstract::Cedronella canariensis is a lemon-scented species of the family Lamiaceae endemic to the Canary Islands where it is used in the traditional medicine to prepare infusions or inhalations for anti-catarrhal, tonic, diuretic, hypoglycaemiant, hypotensive, anti-inflammatory and decongestant of the respiratory tract. In thi...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2014.994213
更新日期:2015-01-01 00:00:00
abstract::The phytochemical constituents in the aqueous methanolic leaf extract of Triclisia gilletii responsible for its nephroprotective potentials against ethane-1,2-diol induced nephrolithiasis as previously investigated in our laboratory were elucidated. The extract was prepared using 80% aqueous methanol in 72 h, Phytoche...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2020.1845672
更新日期:2020-11-12 00:00:00
abstract::This study was performed to investigate the effect of ethanol extract from Saururus chinensis (Lour.) Baill on liver function, plasma lipid composition and antioxidant system with high-fat diet for 4 weeks. Rats were divided into the following five groups; untreated control group (normal), treated with 0.5% SE (normal...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410701590657
更新日期:2008-02-15 00:00:00
abstract::From the fruit of Pandanus tectorius Parkinson ex Du Roi, one new dihydrofurocoumarin, named pandanusin A (1) and 15 known compounds, including one furanocoumarin (2), two coumarins (3, 4), four lignans (5-8), one neolignan (9), two flavonoids (10, 11), three phenolics (12-14), one monoglyceride (15) and one monosacch...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2016.1188095
更新日期:2016-11-01 00:00:00
abstract::Protein kinase C (PKC) plays a key role in neurotransmission in the central nervous system, and targeting PKC domain is considered as a strategy to modulate the anaesthetic effects. In this study, we described a synthetic pipeline to perform high-throughput virtual screening against a large library of 3D structural na...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2014.955491
更新日期:2015-01-01 00:00:00
abstract::Fermentation of (+)-androst-4-ene-3,17-dione (1) with Curvularia lunata for 10 days yielded five oxidative and reductive metabolites, androsta-1,4-diene-3,17-dione (2), 17beta-hydroxyandrosta-1,4-dien-3-one (3), 11alpha-hydroxyandrost-4-ene-3,17-dione (4), 11alpha,17beta-dihydroxyandrost-4-en-3-one (5) and 15alpha-hyd...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410310001620628
更新日期:2004-12-01 00:00:00
abstract::A series of isoquinoline alkaloids including tetrahydroprotoberberines, N-methyl tetrahydroprotoberberines and protoberberines were facile synthesised with protopines as the starting material. All compounds were evaluated for their antibacterial activities against four pathogenic bacteria Escherichia coli, Staphylocco...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2013.867344
更新日期:2014-01-01 00:00:00
abstract::A new triterpenoid saponin, silenoviscoside F (1), was isolated from the roots of Silene viscidula, together with three known saponins, dianchinenoside D (2), sinocrassuloside I (3) and sinocrassuloside II (4). The structure of compound 1 was elucidated by spectroscopic data, GC-MS and chemical methods. The structures...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2011.637216
更新日期:2012-11-01 00:00:00
abstract::Antioxidant, anticholinesterase and antidiabetic activities of three curcuminoids isolated from the Curcuma longa were simultaneously tested and compared in this study. The highest antioxidant power was detected for curcumin with the applied methods. The drug potentials of curcuminoids for Alzheimer's disease were con...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1299727
更新日期:2017-12-01 00:00:00
abstract::Supported by a growing increase of scientific research attesting the health properties of salvia species, we have decided to investigate nine Salvia namely Salvia sclarea, Salvia atropatana, Salvia sahendica, Salvia hydrangea, Salvia xanthocheila, Salvia macrosiphon, Salvia glutinosa, Salvia chloroleuca and Salvia cer...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2014.939086
更新日期:2014-01-01 00:00:00
abstract::A total of 205 bluefin and yellowfin tuna samples were examined for mercury detection in order to verify possible differences and have a detailed risk assessment of the two tuna species. The results showed significant higher mercury concentration in muscle tissue of bluefin tuna respect yellowfin tuna (p < 0.001) with...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1309538
更新日期:2018-02-01 00:00:00
abstract::Illicium lanceolatum is a popular aromatic and medicinal plant in China. Essential oil from the roots of I. lanceolatum, obtained by hydrodistillation, was analysed by GC-MS. The essential oil was dominated by phenylpropenes. The major components were myristicin (17.63%), α-asarone (17.23%), methyl isoeugenol (11.19%)...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2011.603318
更新日期:2012-01-01 00:00:00
abstract::A phytochemical investigation of Ajuga forrestii Diels led to the isolation of 14 compounds, including eight neo-clerodane diterpenes (1-8), two phytoecdysteroids (9, 11), one stigmastane sterol (10) and three iridoid glycosides (12-14). The structures of these compounds were identified by spectroscopic methods and a ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1371161
更新日期:2018-04-01 00:00:00
abstract::From the ethanolic extract of Lentinus edodes (Shiitake) eight known sterols were isolated and identified: ergosterol, ergosterol peroxide, (22E)-ergosta-5,7,9(11), 22-tetraen-3beta-ol, (22E)-ergosta-7,9(11),22-trien-3beta-ol, (22E)-ergosta-6,8,22-trien-3beta-ol, (22E)-norergosta-5,7,9,22-tetraen-3beta-ol, 3beta,5alph...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410802038671
更新日期:2009-01-01 00:00:00
abstract::A new β-tetralonyl glucoside, methylberchemiaside (1), along with five known compounds (2-6) were isolated from a fungus Colletotrichum sp . GDMU-1 derived from the leaves of Santalum album. Their structures were determined by detailed analysis of spectroscopic data. All compounds were tested for the inhibitory effect...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2018.1452003
更新日期:2019-02-01 00:00:00
abstract::Analgesic and anti-inflammatory activities of the aqueous and ethanol extracts of Thespesia populnea Soland. ex. Correa (Malvaceae) leaves were evaluated in animal models. Orally-administered aqueous and ethanol extracts (100, 200 and 400 mg kg⁻¹ bw) showed significant analgesic activity in chemical-, mechanical- and ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2011.574134
更新日期:2012-01-01 00:00:00
abstract::Three allylbenzenes from Asiasarum heterotropoides, methyleugenol (1), elemicin (2) and gamma-asaron (3) showed suppressive effects on umu gene expression of the SOS response in the Salmonella typhimurium OY1001/1A2 umu test against the mutagen 2-amino-3,4-dimethylimidazo[4,5-f ]quinoline (MeIQ). Gene expression was s...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410500462629
更新日期:2006-06-01 00:00:00
abstract::The antiradical activity of the freshwater bryozoan Hyalinella punctata water extracts (two samples, seasonal collection) was evaluated by using electron paramagnetic resonance spectroscopy against hydroxyl (√OH), superoxide anion (√O2(- )), methoxy (√CH2OH), carbon-dioxide anion (√CO2(- )), nitric-oxide (√NO) and 2,2...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2014.921788
更新日期:2014-01-01 00:00:00
abstract::This study is designed to examine the chemical composition of the essential oil obtained from Buddleja thyrsoides Lam leaves from south Brazil. Gas chromatography/mass spectrometry analysis resulted in the detection of 12 components, representing 91.4% of the total oil composition. Germacrene D (27.16%), 1,10-di-epi-C...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2012.740035
更新日期:2013-01-01 00:00:00
abstract::A wide range of proteinaceous inhibitors are present in plants to protect themselves from hydrolytic enzymes. In this study, turmerin, a water-soluble peptide in turmeric rhizomes, was evaluated for its inhibitory potential against glucosidase and its antioxidant (AO) capacity. Turmerin inhibited α-amylase and α-gluco...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2011.589386
更新日期:2012-01-01 00:00:00