Abstract:
:A series of isoquinoline alkaloids including tetrahydroprotoberberines, N-methyl tetrahydroprotoberberines and protoberberines were facile synthesised with protopines as the starting material. All compounds were evaluated for their antibacterial activities against four pathogenic bacteria Escherichia coli, Staphyloccocus aureus, Staphylococcus gallinarum and Salmonella choleraesuis. Experimental results indicated that protoberberines were the most active compounds to the target bacteria among the tested alkaloids. It was suggested that planar molecule with high aromatisation level (e.g. coptisine 5 and berberine 6) or a positive charge of the molecules (e.g. N-methyl tetrahydroprotoberberines 11 and 12) had a positive influence on the antibacterial effects.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Cheng P,Wang B,Liu X,Liu W,Kang W,Zhou J,Zeng Jdoi
10.1080/14786419.2013.867344subject
Has Abstractpub_date
2014-01-01 00:00:00pages
413-9issue
7eissn
1478-6419issn
1478-6427journal_volume
28pub_type
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