In vitro anti-enteroviral activity of stilbenoids isolated from the leaves of Macaranga barteri.

Abstract:

:The anti-enteroviral activity of three stilbenoids isolated from the leaves of Macaranga barteri was investigated using the cytopathic effect reduction assay. The stilbenes were inactive against echovirus E13 but showed activity against echoviruses E7 and E19. In particular, vedelianin (2), schweinfurthin G (3) and mappain (1) elicited antiviral activity on E19 with IC50 values of 0.0036 nM, 0.018 nM and 0.24 µM, respectively. Vedelianin (2) showed the best selectivity profile amongst the isolated compounds with selectivity index values of 31 and 216 against E7 and E19, respectively. It is possible these compounds may be responsible for the traditional use of Macaranga barteri in the treatment of viral infections.

journal_name

Nat Prod Res

journal_title

Natural product research

authors

Segun PA,Ogbole OO,Akinleye TE,Faleye TOC,Adeniji AJ

doi

10.1080/14786419.2019.1644505

subject

Has Abstract

pub_date

2019-07-25 00:00:00

pages

1-5

eissn

1478-6419

issn

1478-6427

pub_type

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