Anti-inflammatory ergosterol derivatives from the endophytic fungus Fusarium chlamydosporum.

Abstract:

:Two new ergosterol derivatives namely, chlamydosterols A [(22E,24R)-ergosta-7,22-diene-3β,5α,6β-triol 6-decanoate] (1) and B [5α,6β,25-trihydroxy-(22E,24R)-ergosta-7,22-dien-3-one] (5) and three known ergosterols: ergosta-7,22-dien-3β-ol (2), ergosta-5,7,22-triene-3β-ol (3), and ergosta-7,22-diene-3β,5α,6β-triol (4) were separated from the EtOAc extract of the endophytic fungus Fusarium chlamydosporum isolated from Anvillea garcinii (Asteraceae) leaves growing in Saudi Arabia. Their structural assignment was accomplished by various spectroscopic analyses, as well as comparing with the published data. The 5-lipoxygenase (5-LOX) inhibitory potential of the isolated metabolites was assessed. Compounds 1 and 3 displayed moderate 5-LOX inhibitory potential with IC50s 3.06 and 3.57 µM, respectively compared to indomethacin (IC50 1.13 µM).

journal_name

Nat Prod Res

journal_title

Natural product research

authors

Al-Rabia MW,Mohamed GA,Ibrahim SRM,Asfour HZ

doi

10.1080/14786419.2020.1762185

subject

Has Abstract

pub_date

2020-05-06 00:00:00

pages

1-10

eissn

1478-6419

issn

1478-6427

pub_type

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