Abstract:
:Two new eremophilenolides, ligushicins A (1) and B (2), and two known compounds including β-sitosterol and ursolic acid were isolated from Ligulariopsis shichuana. The structures of new compounds were established on the basis of 1D and 2D NMR data and HRESIMS data interpretation. The absolute configuration of new compounds was assigned by ECD spectroscopy, and that of ligushicins A (1) was confirmed by X-ray diffraction analysis. The antifungal and antifeedant activities of new compounds were evaluated against four plant pathogenic fungi and third-instar larvae of Plutella xylostella, respectively. Ligushicins A (1) and B (2) exhibited potent antifungal activity against Botrytis cinerea and Fusarium oxysporum with minimum inhibitory concentration (MIC) values ranging from 50 to 100 mg/L, while they also exhibited weak antifeedant activities.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Wu H,Liu T,Lian Y,Wang Wdoi
10.1080/14786419.2017.1419240subject
Has Abstractpub_date
2019-05-01 00:00:00pages
1442-1448issue
10eissn
1478-6419issn
1478-6427journal_volume
33pub_type
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