Isolation of a larvicidal compound from Piper solmsianum C.DC. (Piperaceae).

Abstract:

:The Aedes aegypti mosquito is one of the major vectors of arboviruses. These diseases have re-emerged and the insecticides used nowadays are toxic to mammals and environment and have only been effective in the short-term. In this context, natural products are an alternative. The genus Piper has many active compounds against arthropods, including neolignans. The present study evaluated the larvicidal potential of the n-hexanic extract of Piper solmsianum and eupomatenoid-6, identified by GC-MS and NMR techniques, from this extract against Ae. aegypti. The crude extract (100 μg/mL) killed 80% and 98.3% of larvae in the first and third day, respectively. Eupomatenoid-6 exhibited LD50 of 19.33 μM and LD90 of 28.68 μM and was then assayed in human fibroblast cells (MRC5), showing an IC50 of 39.30 μM with estimated LD50 of 42.26 mmol/kg. Our results indicate eupomatenoid-6 as a potent insecticide with relatively low toxicity for mammals.

journal_name

Nat Prod Res

journal_title

Natural product research

authors

Macedo AL,Duprat RC,Moreira DL,Kaplan MAC,Vasconcelos TRA,Pinto LC,Montenegro RC,Ratcliffe NA,Mello CB,Valverde AL

doi

10.1080/14786419.2017.1374265

subject

Has Abstract

pub_date

2018-11-01 00:00:00

pages

2701-2704

issue

22

eissn

1478-6419

issn

1478-6427

journal_volume

32

pub_type

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