Abstract:
:The Aedes aegypti mosquito is one of the major vectors of arboviruses. These diseases have re-emerged and the insecticides used nowadays are toxic to mammals and environment and have only been effective in the short-term. In this context, natural products are an alternative. The genus Piper has many active compounds against arthropods, including neolignans. The present study evaluated the larvicidal potential of the n-hexanic extract of Piper solmsianum and eupomatenoid-6, identified by GC-MS and NMR techniques, from this extract against Ae. aegypti. The crude extract (100 μg/mL) killed 80% and 98.3% of larvae in the first and third day, respectively. Eupomatenoid-6 exhibited LD50 of 19.33 μM and LD90 of 28.68 μM and was then assayed in human fibroblast cells (MRC5), showing an IC50 of 39.30 μM with estimated LD50 of 42.26 mmol/kg. Our results indicate eupomatenoid-6 as a potent insecticide with relatively low toxicity for mammals.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Macedo AL,Duprat RC,Moreira DL,Kaplan MAC,Vasconcelos TRA,Pinto LC,Montenegro RC,Ratcliffe NA,Mello CB,Valverde ALdoi
10.1080/14786419.2017.1374265subject
Has Abstractpub_date
2018-11-01 00:00:00pages
2701-2704issue
22eissn
1478-6419issn
1478-6427journal_volume
32pub_type
杂志文章abstract::The aim of this study was to explore the extract/fractions and compounds of Diospyros lotus against various Gram-positive and Gram-negative bacteria strain. The results showed marked susceptibility of extract and its fractions against test pathogens. Among them, chloroform fraction was most dominant and effective agai...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2015.1013957
更新日期:2016-01-01 00:00:00
abstract::The aerial parts of Baccharis dracunculifolia (BdE) is used in the Brazilian folk medicine to treat inflammatory conditions. Here we examined the ability of free and liposomal BdE to modulate reactive oxygen species generation in human neutrophils in vitro and zymosan-induced acute joint inflammation in Wistar rats. W...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2018.1448809
更新日期:2019-09-01 00:00:00
abstract::One new triterpenoid olean-18-ene-1β, 2α, 3β-triol (1) along with four known compounds were isolated from the chloroform extract of the aerial part of Salvia atropatana Bunge. The known compounds were two flavonoids, 5-hydroxy-7,4'-dimethoxyflavone (2) and 5-hydroxy-6,7,4'-trimethoxyflavone (3), an abietane-type diter...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2011.628668
更新日期:2012-01-01 00:00:00
abstract::The oral squamous cell carcinoma (OSCC) is the eighth more common cancer in men. The development of new and more efficient drugs is needed. Plants of the genus Piper are popularly used in the treatment of many diseases. This study evaluated the antitumor effect of extract, fraction and isolated compounds from leaves o...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2020.1831494
更新日期:2020-10-14 00:00:00
abstract::Cyanamide (NH(2)CN) has recently been isolated as a plant growth inhibitor from Vicia villosa, which is the first discovery of cyanamide from natural sources. To reveal the presence of the biosynthesized cyanamide in plants, 3.4 mM potassium ((15)N)nitrate was administered to 15- to 35-day-old plants of V. villosa, fr...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410500143583
更新日期:2006-05-10 00:00:00
abstract::Eight known abietane diterpenes (1-8) were isolated for the first time from Abies numidica cones (Pinaceae). The structures of all compounds were established by means of 1D and 2D NMR, and UV spectral analyses. The hydromethanolic extract of A. numidica cones was tested for its antimicrobial activity against 17 gram-p...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2016.1190723
更新日期:2017-03-01 00:00:00
abstract::The chemical composition of the essential oil of Kurzamra pulchella (Lamiaceae) was determined. Twelve compounds were identified, with isomenthone (60.6%) and pulegone (37.1%) predominating. Chemotaxonomical considerations were discussed. ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2016.1214828
更新日期:2017-01-01 00:00:00
abstract::A wide range of proteinaceous inhibitors are present in plants to protect themselves from hydrolytic enzymes. In this study, turmerin, a water-soluble peptide in turmeric rhizomes, was evaluated for its inhibitory potential against glucosidase and its antioxidant (AO) capacity. Turmerin inhibited α-amylase and α-gluco...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2011.589386
更新日期:2012-01-01 00:00:00
abstract::Seven pentacyclic triterpenoids including 3beta-O-(E)-coumaroyl-15alpha-hydroxy-beta-amyrin (1), 15alpha-hydroxy-beta-amyrin (2), 3beta-taraxerol (3), 3beta-taraxerol formate (4), 3beta-taraxerol acetate (5), 3beta-O-(E)-coumaroyl-taraxerol (6), and 3beta-O-(Z)-coumaroyl-taraxerol (7) were isolated and identified from...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410701640452
更新日期:2008-06-15 00:00:00
abstract::The chemical composition of the essential oils isolated from the aerial parts of Anthemis arvensis L. subsp. arvensis, Anthemis cretica subsp. messanensis (Brullo) Giardina & Raimondo and from flowers and leaves of Anthemis cretica subsp. columnae (Ten.) Frezén were determinated by GC-FID and GC-MS analyses. Torreyol ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1297444
更新日期:2017-12-01 00:00:00
abstract::Euphorbia hirta (L.) plant is traditionally used in Malaysia for the treatment of gastrointestinal, bronchial and respiratory ailments caused by nosocomial infectious agents. Bioactivity-guided fractionation of the methanol extract of the aerial parts of E. hirta and analysis using high-performance liquid chromatograp...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2014.999242
更新日期:2015-01-01 00:00:00
abstract::Chemical investigation of the stems of Epigunum griffithianum led to the isolation and identification of a new triterpenoid saponin (1) and two known compounds (epigynosides A (2) and B (3)). These structures were elucidated by means of spectroscopic analysis (1D and 2D NMR, MS, UV, IR) as well as comparison with the ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2018.1512989
更新日期:2020-05-01 00:00:00
abstract::Plants, in their life cycle, are usually exposed to various kinds of non-biological stresses including heavy metals. One of these heavy metals is nickel which affects many physiological processes of plants. Studies have shown that the changes in planting conditions can affect the qualitative and quantitative features ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2014.913240
更新日期:2014-01-01 00:00:00
abstract::Acetylcholinesterase (AChE) inhibitors have been used for the symptomatic treatment of Alzheimer's disease. Eleven whole plants from Panama belonging to the Lycopodiaceae family have been screened for their anticholinesterase inhibitory and antioxidant activities by a thin-layer chromatography (TLC) bioautography meth...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2012.701217
更新日期:2013-03-01 00:00:00
abstract::The essential oils obtained by hydrodistillation from the leaves of Tabernaemontana catharinensis had their composition analysed by GC-MS. A total of 18 substances were identified, consisting of a complex mixture of sesquiterpenes (83.52%), monoterpenes (5.46%) and triterpenes (4.56%). The main components in the oil w...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2011.653971
更新日期:2013-01-01 00:00:00
abstract::Several factors affect the vegetative growth of fungi, such as temperature, pH, and culture medium. In addition to mycelial growth, these factors affect metabolite production. There are limited studies that have identified the metabolites produced by the fungus Bjerkandera adusta, which have potential biotechnological...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2020.1758092
更新日期:2020-05-06 00:00:00
abstract::Medicinal plants have been the main remedy to treat various ailments for a long time and nowadays, many drugs have been developed from traditional medicine. This paper reviews some medicinal plants and their main constituents which possess anti-inflammatory activities useful for curing joint inflammation, inflammatory...
journal_title:Natural product research
pub_type: 杂志文章,评审
doi:10.1080/14786419.2015.1062761
更新日期:2016-06-01 00:00:00
abstract::In this study, 12 compounds, which include a new flavanone 5-methoxy mundulin, were isolated from the leaves, stem bark and twigs of Mundulea sericea (Willd.) A. Chev. (Fabaceae; Papilionoideae). The structures of the compounds were identified based on spectral data analyses. The constituents of M. sericea also showed...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2011.616504
更新日期:2012-01-01 00:00:00
abstract::The aims of the present study were to determine the antibacterial activity of bark extract of Cryptomeria japonica D. Don and to isolate potential antibacterial constituents. The results showed that the ethanolic extract of C. japonica bark possessed a good antibacterial activity. Nine compounds including seven diterp...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410802267510
更新日期:2008-01-01 00:00:00
abstract::The methanolic extract of the aerial parts of Datura innoxia afforded a new withanolide, daturacin, the structure of which was elucidated as (20R, 22S)-21,24-epoxy-1,6-dioxo-14alpha-methoxy-5beta-witha-2,25(27)-dienolide (1) by an analysis of the spectroscopic data, including extensive NMR experiments. ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410512331330620
更新日期:2005-09-01 00:00:00
abstract::Studies were made to increase the yield of piperine extraction using Naviglio Extractor® solid-liquid dynamic extractor (SLDE) from fruits of Piper longum. The effects of ratio w/v were investigated and optimised for the best method. The maximum yield of piperine (317.7 mg/g) from P. longum fruits was obtained in SLDE...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2016.1217209
更新日期:2017-01-01 00:00:00
abstract::Juniperus chinensis cv. Kaizuca has extensive pharmacological activities. The cone oils exhibited protein tyrosine phosphatase 1B inhibitory activity in vitro. The IC50 value was 4.49 ± 0.04 μg/mL. A total of 17 compounds were characterised from the cone oils by GC-MS. In order to explain the activity against protein ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1374267
更新日期:2018-11-01 00:00:00
abstract::Epicatechin (EC) is the most effective compound in Euonymus alatus (Thunb.)Sieb, and possesses a series of benefits, including anti-inflammatory, antioxidant, antiobesity and anticancer effects. In this study, we investigated the protective effects of EC in Acetaminophen(N-acetyl-p-aminophenol, APAP)-induced acute liv...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2018.1503261
更新日期:2020-03-01 00:00:00
abstract::A new diterpenoid, 15-epi-(4E)-jatrogrossidentadione acetate, along with several known constituents has been isolated from the stem of Jatropha multifida. The structure of the new compound was settled by a detailed analysis of its 1D- and 2D-NMR spectra. ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786411003792207
更新日期:2010-10-01 00:00:00
abstract::A new triterpene, javablumine A (1) along with six known ones were isolated from the aerial parts of Sambucus javanica Blume. They were identified as 3β,23-dihydroxy-11α,12α-epoxy-urs-20(30)-en-28,13β-olide (1), ursolic acid (2), pomolic acid (3), oleanic acid (4), 2α-hydroxy-oleanolic acid (5), α-amyrin (6), and lupe...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2019.1596092
更新日期:2020-10-01 00:00:00
abstract::One new anthraquinone, 1,8-dihydroxy-2-ethyl-3-methylanthraquinone (1), together with two known compounds octadecanoic acid (2) and cholest-4-en-3-one (3) was isolated from marine actinomycete Streptomyces sp. FX-58. The structure of 1 was elucidated on the basis of spectroscopic methods, especially, the 2D-NMR spectr...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410600899142
更新日期:2006-11-01 00:00:00
abstract::The antiradical activity of the freshwater bryozoan Hyalinella punctata water extracts (two samples, seasonal collection) was evaluated by using electron paramagnetic resonance spectroscopy against hydroxyl (√OH), superoxide anion (√O2(- )), methoxy (√CH2OH), carbon-dioxide anion (√CO2(- )), nitric-oxide (√NO) and 2,2...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2014.921788
更新日期:2014-01-01 00:00:00
abstract::Natural products represent a rich source of bioactive compounds that have been historically used to obtain substances with great medicinal potential. The skin of anuran amphibians is a rich source of compounds with a wide range of biological activity. Alzheimer's disease (AD) is a complex disease associated with all k...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2019.1591396
更新日期:2019-03-31 00:00:00
abstract::Two new oleanane triterpenoid saponins, bodiniosides Q (1) and R (2), along with five known saponins, niga-ichigoside F1 (3), 3-O-[β-D-glucopyranosyl]-28-O-[α-L-rhamnopyranosyl -(1→2)-β-D-glucopyranosyl] arjunolic acid (4), asiaticoside E (5), sericoside (6), and bodinioside E (7), were isolated from the aerial parts ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2020.1721489
更新日期:2020-02-06 00:00:00
abstract::A minor new withanolide, named plantagiolide F, was isolated from the whole plant of Tacca plantaginea (Hance). The structure of plantagiolide F was elucidated on the basis of spectroscopic methods including extensive 1- and 2-D NMR experiments. ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786411003774304
更新日期:2011-01-01 00:00:00