Abstract:
:To obtain more accessible oxidative stress inhibitors, a series of novel spin-labelled derivatives of 3-hydroxybutanolide (2a-d, 3a-d) with the natural active compound (kinsenoside) as the lead compound were designed, synthesised from the nitroxide free radical piperidine (pyrroline) and the main structural unit of kinsenoside: 3-hydroxybutanolide. Antioxidant activity screening of these derivatives was performed using MTT method on rat pheochromocytoma PC12 cells. The antioxidative stress effect was further investigated on the changes of the important antioxidant enzyme activities and intracellular reactive oxygen species production. Among the derivatives, 2b-d, 3a and 3c showed comparable or superior antioxidative stress activity to kinsenoside. Also, most of the tested derivatives displayed obvious antioxidative ability in concentrations. Cytotoxic assay simultaneously indicated that all compounds had very low toxicity to normal cells. Based on the observed results, the structure-activity relationship of these derivatives was discussed.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Liu Q,Liu ZL,Tian J,Shi W,Liu YQdoi
10.1080/14786419.2014.903477subject
Has Abstractpub_date
2014-01-01 00:00:00pages
1037-44issue
14eissn
1478-6419issn
1478-6427journal_volume
28pub_type
杂志文章abstract::This work aimed to evaluate the content of selected phenolic natural products in the wine samples made of three new Serbian Cabernet Franc clones (Nos. 02, 010 and 012, respectively) and mother vine (used as the relevant standard) during the period 2008-2012. Compared with all other wine samples, the Cabernet Franc wi...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2015.1135148
更新日期:2016-08-01 00:00:00
abstract::Three new sesquiterpenes: 4-acrylic-6-methyl-α-tetralone (1), ainsliaea acid A (2) and ainsliaea acid B (3), together with 8 known compounds (4-11) were isolated from the whole herb of Ainsliaea glabra and their structures were established by means of 1D and 2D NMR spectroscopy and HR-ESIMS. Compounds 1-6 were tested ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2018.1446134
更新日期:2019-01-01 00:00:00
abstract::The essential oil of Cyclospermum leptophyllum (Pers.) Sprague ex Britton and P. Wilson syn. Apium leptophyllum (Pers.) F. Muell. Ex Benth., family Apiaceae (Umbellifereae), was analysed by GC and GC-MS. The essential oil showed the presence of thymohydroquinone dimethyl ether (50.7%), thymol methyl ether (11.2%), γ-t...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2010.487190
更新日期:2011-03-01 00:00:00
abstract::Azadirachtin-A (Aza-A, figure 1) was subjected to a variety of synthetic transformations and the antifeedant activity and toxicity of the azadirachtin derivatives were assessed against second instar larvae Spodoptera litura on castor leaves in comparison with the crude material containing 9.14% Aza-A, as well as relat...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410512331330558
更新日期:2005-07-01 00:00:00
abstract::New sesquiterpene glycoside, cyclodipeptide and piperidine derivative were isolated from Streptomyces sp. YIM 63342. On the basis of spectral data, their structures were determined as 3R, 5R, 6S, 7E, 9R-megastigman-7-en-3,5,6,9-tetrol-9-O-β-D-apiofuranosyl-(1→ 2)-β-D-glucopyranoside (1), cyclo (L-Pro-L-OMet) (2) and (...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2012.718776
更新日期:2013-01-01 00:00:00
abstract::The first chemotaxonomic study based on volatile components of Porella viridissima (Mitt.) Grolle is reported. The GC-MS analysis of ether extract was performed; ten santalane and five pinguisane-type sesquiterpenes were identified together with perrottetianal A as major diterpene. Most of detected santalane-type sesq...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2019.1655022
更新日期:2019-08-23 00:00:00
abstract::In this work, we report a rapid and convenient HPLC-UV-DAD method for the isolation of δ-T3 on semi-preparative scale from two different vitamin E rich processed, commercially available products obtained from the fruits of Elaeis guineensis Jacq. (oil palm) and from the seeds of Bixa orellana L. (achiote tree). Chroma...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1320793
更新日期:2018-05-01 00:00:00
abstract::One new 14-membered ring cyclopeptide alkaloid, plenane A (1), along with six known compounds (2-7), was isolated from the roots of Clematis florida. Their structures were elucidated by means of NMR spectroscopic analysis and mass spectrometry. In addition, their anti- inflammatory effects on lipopolysaccharide-induce...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2020.1809399
更新日期:2020-08-18 00:00:00
abstract::A series of new thiazolyl chalcones, 1-[2-amino-4-methyl-1,3-thiazol-5-yl]-3-aryl-prop-2-en-1-one were prepared by piperidine mediated Claisen-Schmidt condensation of thiazolyl ketone with aromatic aldehyde. These chalcones on cyclisation gave 2-amino-6-(2-amino-4-methyl-1,3-thiazol-5-yl)-4-aryl-4H-pyridine-3-carbonit...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2010.536161
更新日期:2012-01-01 00:00:00
abstract::Alzheimer's disease (AD) is a multifactorial health problem widespread over the world. Regarding the historical importance of the alkaloids in the central nervous system pharmacology they remain as promising drug candidates against AD. Seven alkaloids from Amaryllidaceae and Fabaceae were evaluated in vivo, in vitro a...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2020.1727471
更新日期:2020-02-18 00:00:00
abstract::Two new monoterpene esters illigerates F and G (1 and 2) together with 5 know compounds illigerate A (3), illigerate C (4), actinodaphnine (5), N-methylactinodaphnine(6) and N-methyllaurotetanine(7) were isolated from Illigera aromatica S. Z. Huang et S. L. Mo. Their structures were identified by extensive NMR data an...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2019.1614574
更新日期:2019-05-28 00:00:00
abstract::Botryodiplodia theobromae Pat. belongs to the endophytic fungi that live within the tissues of medicinal plants and produce bioactive natural products. The endophyte was isolated from the leaves of Dracaena draco L. The LC-MS-based metabolite fingerprinting of the ethyl acetate extract of B. theobromae with antibacter...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2015.1012715
更新日期:2015-01-01 00:00:00
abstract::Proximate composition of the seeds and chemical analysis of the oils of Lonchocarpus sericeus and Lonchocarpus cyanescens were determined. The oil content of the seed of L. cyanescens is 29.71 ± 0.20% while that of L. sericeus is 28.00 ± 0.50%. The seeds as well as the oils of L. cyanescens and L. sericeus were found ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2011.643311
更新日期:2012-01-01 00:00:00
abstract::A new chalcone named as balanochalcone (1) together with eight known compounds, methyl caffeate (2), β-hydroxydihydrochalcone (3), methyl gallate (4), dimethyl-6,9,10-trihydroxybenzo[kl]xanthene-1,2-dicarboxylate (5), p-coumaric acid (6), quercetin (7), scopoletin (8) and pinoresinol (9) have been isolated from the et...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1359172
更新日期:2018-04-01 00:00:00
abstract::Sahandinone (1), 12-deoxysalvipisone (2), miltirone (3), 7α-acetoxyroyleanone (4), and labda-7,14-dien-13-ol (5) were isolated from the roots of Salvia rhytidea Benth. (Lamiaceae). Their structures were elucidated by a combination of spectroscopic analyses including EIMS and NMR. The 13C NMR spectroscopic data were re...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2016.1188096
更新日期:2017-02-01 00:00:00
abstract::Five flavonol glycosides characterised as kaempferide 3-O-(2'',3''-diacetylglucoside), kaempferide 3-O-(2''-O-galloylrhamnoside), kaempferide 3-O-(2''-O-galloylrutinoside)-7-O-alpha-rhamnoside, kaempferol 3-O-[beta-glucosyl-(1 --> 2)]-[alpha-rhamnosyl-(1 --> 6)]-beta-glucoside-7-O-alpha-rhamnoside and kaempferol 3-O-[...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410601035811
更新日期:2007-01-01 00:00:00
abstract::Two new briarane-type diterpenoids, dollfusilin A (1) and dollfusilin B (2), along with five known briarane-type diterpenoids (3-7), were isolated from the gorgonian Ellisella dollfusi collected from the South China Sea. The structures of the two new compounds (1 and 2) were elucidated through a comprehensive analysis...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2013.827191
更新日期:2014-01-01 00:00:00
abstract::Three new aconitine-type C19-diterpenoid alkaloids, taipeinines A-C (1-3), were isolated from the roots of Aconitum taipaicum. The chemical structures of these three compounds were established as (1α,6α,8α,14α,16α)-20-ethyl-8,14-dihydroxy-1,6,16-trimethoxy-4-(methoxymethyl)-aconitane (1), (1α,6α,8α,14α,16β)-20-ethyl-8...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2013.861832
更新日期:2014-01-01 00:00:00
abstract::The dichloromethane extracts of the leaves, stem bark, bark and the roots of the three species of the primitive endemic genus Hortonia, H. angustifolia, H. floribunda and H. ovalifolia, collected from nine geographical locations ranging from lower elevations (84-420 m) to higher (2000 m) showed comparable HPLC profile...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410701722433
更新日期:2008-01-01 00:00:00
abstract::Seven pentacyclic triterpenoids including 3beta-O-(E)-coumaroyl-15alpha-hydroxy-beta-amyrin (1), 15alpha-hydroxy-beta-amyrin (2), 3beta-taraxerol (3), 3beta-taraxerol formate (4), 3beta-taraxerol acetate (5), 3beta-O-(E)-coumaroyl-taraxerol (6), and 3beta-O-(Z)-coumaroyl-taraxerol (7) were isolated and identified from...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410701640452
更新日期:2008-06-15 00:00:00
abstract::A new indole diterpene, named penicindopene A (1), together with seven known compounds (2 - 8), was isolated from the deep-sea fungus Penicillium sp. YPCMAC1. The structure of penicindopene A was elucidated by extensive spectroscopic analyses (1 D and 2 D NMR, and HRESIMS data), in addition to the ECD calculations for...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2018.1514402
更新日期:2019-10-01 00:00:00
abstract::Nerium oleander (NO), a member of the Apocynaceae family, is an ornamental plant. In this study, we evaluated the antiviral activity of hot and cold extract of NO against six different viruses such as herpes simplex virus type 1 (HSV-1), polio virus type 1 (Sb-1), vesicular stomatitis virus (VSV), reovirus type-1 (Reo...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2019.1582046
更新日期:2019-03-25 00:00:00
abstract::Sasa coreana Nakai (SCN) is a medicinal plant commonly used against inflammation. However, the underlined mechanisms against skin inflammation is poorly understood. The present study investigated the effects of SCN leave extract on ear inflammation. To this aim, six-week-old male ICR mice was subjected to 12-O-tetrade...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2020.1753053
更新日期:2020-04-14 00:00:00
abstract::Phytochemical investigation of Eucommia ulmoides Oliver staminate flowers provided twenty-seven compounds, including 11 triterpenes (1-11), 4 fatty acids (12-15), 1 coumarin (16), 1 chromone (17), 7 flavonoids (18-24) and 3 cyclopeptide alkaloids (25-27). Compounds 4-6, 8-9, 11-15, 17 and 25-27 were reported for the f...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2020.1858411
更新日期:2020-12-12 00:00:00
abstract::Essential oil composition of the leaves of Viola odorata L. growing wild in Kashan, central Iran, was extracted by hydro distillation-solvent extraction method and analysed using GC-MS technique. The analysis revealed the presence of 25 identified compounds, representing 92.77% of the oil with butyl-2-ethylhexylphthal...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2011.558013
更新日期:2012-01-01 00:00:00
abstract::Six compounds, benzyl 3-O-β-D-glucopyranosyl-7-hydroxybenzoate (1), spathulenol (2), 1,7,8-trihydroxy-2-naphtaldehyde (3), quercetin (4), astragalin (5) and 2-methoxy-4-(2-propenyl)phenyl β-D-glucoside (6), were isolated from the leaves of Melia azedarach L. The structure elucidation of compound 1 was discussed in det...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2018.1501690
更新日期:2019-10-01 00:00:00
abstract::Juniperus chinensis cv. Kaizuca has extensive pharmacological activities. The cone oils exhibited protein tyrosine phosphatase 1B inhibitory activity in vitro. The IC50 value was 4.49 ± 0.04 μg/mL. A total of 17 compounds were characterised from the cone oils by GC-MS. In order to explain the activity against protein ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1374267
更新日期:2018-11-01 00:00:00
abstract::Three new neolignan derivatives (1-3), together with three known isolariciresinol derivatives (4-6) were isolated from Selaginella picta. Their structures were elucidated by spectroscopic methods (1D/2D NMR, HRESIMS and CD). All isolated compounds were assayed on the neuroprotective activity against the injury of HT-2...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2018.1560284
更新日期:2020-05-01 00:00:00
abstract::A new 5-O-beta-D-glucopyranosyl-4-(4-hydroxyphenyl)-7-methoxy-2H-chromen-2-one (1), together with four known compounds, one coumarin, 5-O-beta-D-galactopyranosyl-4-(4-hydroxyphenyl)-7-methoxy-2H-chromen-2-one (2) and three cucurbitacins, 23,24-dihydrocucurbitacin F (3), 23,24-dihydro-25-acetylcucurbitacin F (4) and 2-...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410701371116
更新日期:2007-06-01 00:00:00
abstract::Globe artichoke has been long considered a nutraceutical food for its valuable content of bioactive compounds. However, beside a well-known polyphenol profile, poor information is available about its metabolite and mineral composition. The aim of this study was to investigate edible parts of Sicilian artichokes, 'Spin...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2016.1258563
更新日期:2017-05-01 00:00:00