Abstract:
:Two new flavonoids, 3, 3', 4' -Trihydroxy- 6, 7, 8 -trimethoxy flavone (1) and 3-Hydroxy-6, 7, 8, 3', 4'-pentamethoxy flavone (2) have been isolated from the methanol extract of Blumea eriantha DC. The structures of these compounds were determined on the basis of spectroscopic techniques such as IR, MS, 1 D, and 2 D NMR spectroscopy. The compounds (1) and (2) were tested for their anti-proliferative activity on NCI-H23 cell line. A standard drug Paclitaxel showed potent anti-proliferative effect (56%) at 100 nM concentration after 24 h treatment whereas compound (2) did not show any anti-proliferative effect. Only compound (1) showed significant reduction in cell viability at concentration 25773 nM (89%) and 257731 nM (68%) after 24 h when compared with 0.1% DMSO. The compound (1) showed significant but much lower reduction in cell viability as compared to the standard drug Paclitaxel.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Tambewagh UU,Javir GR,Joshi KS,Rojatkar SRdoi
10.1080/14786419.2019.1672063subject
Has Abstractpub_date
2019-10-03 00:00:00pages
1-8eissn
1478-6419issn
1478-6427pub_type
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