Abstract:
:Two novel benzoquinones, uvarmicranones A (1) and B (2), along with 15 known compounds (3 - 17) were isolated from the stems of Uvaria micrantha (Annonaceae). Their structures were elucidated by analyses of NMR and high-resolution mass data. A plausible biosynthetic pathway of uvarmicranone A (1) via Diels-Alder cycloaddition reaction was also proposed. Some isolated compounds were evaluated for their cytotoxic activities. Compounds 1, 14, and 15 showed moderate cytotoxic effects against T-cell acute lymphoblastic cells (MOLT-3), with IC50 values of 7.83 ± 0.83, 6.53 ± 1.01, and 4.20 ± 0.29 μM, respectively. Additionally, compound 15 exhibited moderate cytotoxicity against cervical carcinoma cells (HeLa) with an IC50 value of 7.00 ± 3.15 μM.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Boonsombat J,Thongnest S,Kheawchaum S,Mahidol C,Ruchirawat S,Prawat Hdoi
10.1080/14786419.2020.1824221subject
Has Abstractpub_date
2020-09-22 00:00:00pages
1-10eissn
1478-6419issn
1478-6427pub_type
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