Neuroprotective triterpene saponins from the leaves of Panax notoginseng.

Abstract:

:Two new triterpene saponins, namely notoginsenoside Ng5 (1) and notoginsenoside Ng6 (2) were isolated from the leaves of Panax notoginseng, along with five known ones. Their structures were determined by chemical methods, NMR and X-ray experiments. The absolute configuration of compound 3 with four sugar units was confirmed by single crystal X-ray analysis. Compounds 2-4 and 6 inhibited PC12 cell damage induced by serum deprivation, and increased cell viability from 58.7 ± 6.7% to 66.7 ± 4.5%, 76.1 ± 6.1%, 64.7 ± 5.2% and 67.2 ± 5.0% at 10 μM, respectively.

journal_name

Nat Prod Res

journal_title

Natural product research

authors

Huang JW,Du YQ,Li CJ,Yang JZ,Ma J,Zang YD,Chen NH,Zhang DM

doi

10.1080/14786419.2019.1677657

subject

Has Abstract

pub_date

2019-10-22 00:00:00

pages

1-7

eissn

1478-6419

issn

1478-6427

pub_type

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