Abstract:
:Two new triterpene saponins, namely notoginsenoside Ng5 (1) and notoginsenoside Ng6 (2) were isolated from the leaves of Panax notoginseng, along with five known ones. Their structures were determined by chemical methods, NMR and X-ray experiments. The absolute configuration of compound 3 with four sugar units was confirmed by single crystal X-ray analysis. Compounds 2-4 and 6 inhibited PC12 cell damage induced by serum deprivation, and increased cell viability from 58.7 ± 6.7% to 66.7 ± 4.5%, 76.1 ± 6.1%, 64.7 ± 5.2% and 67.2 ± 5.0% at 10 μM, respectively.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Huang JW,Du YQ,Li CJ,Yang JZ,Ma J,Zang YD,Chen NH,Zhang DMdoi
10.1080/14786419.2019.1677657subject
Has Abstractpub_date
2019-10-22 00:00:00pages
1-7eissn
1478-6419issn
1478-6427pub_type
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