Abstract:
:Chemical investigation of the root bark of Morus alba led to the isolation of a new flavone, dioxycudraflavone A (1) and a new 2-arylbenzofuran, 5-hydroxyethyl moracin M (2), together with seven known compounds namely sanggenon V (3), morusin (4), morusignin L (5), licoflavone C (6), moracin C (7), alfafuran (8) and mulberrofuran G (9). The structure elucidation of these compounds was based on analyses of spectroscopic data including 1D, 2D NMR and HR-ESI-MS. All compounds were evaluated for the α-glucosidase inhibitory and cytotoxic activities. Compounds 2-4, 8 and 9 exhibited strong α-glucosidase inhibitory activities with IC50 less than 10 μM, while only 4 and 9 showed moderate cytotoxic effects against lung cancer cells.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Li M,Wu X,Wang X,Shen T,Ren Ddoi
10.1080/14786419.2017.1327862subject
Has Abstractpub_date
2018-01-01 00:00:00pages
36-42issue
1eissn
1478-6419issn
1478-6427journal_volume
32pub_type
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