Antimicrobial and anti-biofilm activity of tannic acid against Staphylococcus aureus.

Abstract:

:Tannic acid, a rich of natural and process-derived phenolic compound, has been shown to be an effective antagonist against viruses and bacteria. In this study, we determined the antimicrobial activity and mechanisms of tannic acid against Staphylococcus aureus with emphasis on inhibiting effect on biofilm formation. Based on the results of time-kill assay, binding ability assay, lysozyme susceptibility assay and the transmission electron microscope, we tentatively speculated that peptidoglycan might be the target of the process that tannic acid destroy the integrity of cell wall, moreover, tannic acid could reduce the biofilm formation at sub-MIC concentrations. These results manifested that natural product tannic acid could serve as a potentially effective candidate for development of novel strategies to treat methicillin-resistant S. aureus infections.

journal_name

Nat Prod Res

journal_title

Natural product research

authors

Dong G,Liu H,Yu X,Zhang X,Lu H,Zhou T,Cao J

doi

10.1080/14786419.2017.1366485

subject

Has Abstract

pub_date

2018-09-01 00:00:00

pages

2225-2228

issue

18

eissn

1478-6419

issn

1478-6427

journal_volume

32

pub_type

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