听力与言语-语言病理学

行为科学

医学伦理学

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  • Phagocytosis of chemically modified carbon materials.

    abstract::An oxidizing treatment of carbon fibres in boiling nitric acid leads to significant changes in the chemical state of their surface. As a result of the chemical treatment on a hydrophobic carbon surface, hydrophilic domains are formed and phenolic, carbonyl and carboxyl groups appear. In this work the intensity of phag...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/s0142-9612(96)00103-2

    authors: Czajkowska B,Błazewicz M

    更新日期:1997-01-01 00:00:00

  • Histological evaluation of the biocompatibility of a glass-ionomer cement in rat alveolus.

    abstract::A type III glass-ionomer cement (Vidrion F), currently used as fast-setting lining material and fissure sealant, was implanted into rat dental alveolus immediately after tooth extraction and its biocompatibility was analysed in terms of incorporation into alveolar bone in the wound healing process. Histological and hi...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/s0142-9612(96)00110-x

    authors: Brentegani LG,Bombonato KF,Carvalho TL

    更新日期:1997-01-01 00:00:00

  • Light initiation of dental resins: dynamics of the polymerization.

    abstract::Literature has shown that slowing down the curing rate of light-initiated resin composites by lowering the light intensity of the light source improved the integrity of the adhesive composite-cavity interface as a result of a more gradual contraction stress development. This study investigated how the curing rate coul...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/s0142-9612(96)00074-9

    authors: Venhoven BA,de Gee AJ,Davidson CL

    更新日期:1996-12-01 00:00:00

  • Production of interleukin 1 from macrophages incubated with poly (DL-lactic acid) granules containing ovalbumin.

    abstract::The production profile of interleukin 1 (IL-1) from mouse peritoneal macrophages (M phi) was determined following their incubation with poly(DL-lactic acid) (PDLLA) granules containing ovalbumin (OVA). Upon incubation, M phi produced IL-1 at a significantly high rate compared with those incubated with OVA in the free ...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/0142-9612(96)00034-8

    authors: Nakaoka R,Tabata Y,Ikada Y

    更新日期:1996-12-01 00:00:00

  • Cytokine production and adhesive protein expression by endothelial cells after contact with polyethylene terephthalate.

    abstract::The authors have evaluated adhesive protein expression and cytokine production by human umbilical vein endothelial cells cultured in contact with polyethylene terephthalate (PET). ELAM-1, ICAM-1 and VCAM-1 expression was determined by flow cytometry; the concentration of interleukin-1 alpha (IL-1 alpha), interleukin-6...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/0142-9612(96)00037-3

    authors: Cenni E,Granchi D,Ciapetti G,Verri E,Cavedagna D,Gamberini S,Di Leo A,Pizzoferrato A

    更新日期:1996-11-01 00:00:00

  • Culture of human vascular endothelial cells on an RGD-containing synthetic peptide attached to a starch-coated polystyrene surface: comparison with fibronectin-coated tissue grade polystyrene.

    abstract::A synthetic peptide, Gly-Arg-Gly-Asp-Ser-Pro-Lys (GRGDSPK), which includes the cell-adhesive region of fibronectin, Arg-Gly-Asp (RGD), was covalently bound to a dialdehyde starch (DAS) coating on a polymer surface by reductive amination. The GRGDSPK/DAS-coated surface was characterized by atomic force microscopy (AFM)...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/0142-9612(96)00028-2

    authors: Holland J,Hersh L,Bryhan M,Onyiriuka E,Ziegler L

    更新日期:1996-11-01 00:00:00

  • Resin-modified glass ionomer cements: a comparison of water sorption characteristics.

    abstract::The purpose of this study was to quantify and compare the amount of water absorbed by six commercially available resin-modified glass ionomer cements and to investigate the possible influence of time and resin content on water sorption. The materials evaluated included Variglass used as a restoration, base and liner; ...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/0142-9612(95)00344-4

    authors: Yap AU

    更新日期:1996-10-01 00:00:00

  • Secretory function of adrenal chromaffin cells cultured on polypyrrole films.

    abstract::Polypyrrole (PPy) is a conducting polymer and is obtained electrochemically on an electrode such as indium-tin oxide (ITO). In this study, in order to develop a novel cell-culture system which makes it possible to communicate with cultured mammalian cells, bovine adrenal chromaffin cells were cultured on PPy-coated IT...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/0142-9612(96)00015-4

    authors: Aoki T,Tanino M,Sanui K,Ogata N,Kumakura K

    更新日期:1996-10-01 00:00:00

  • Studies on radio-opaque polymeric biomaterials with potential applications to endovascular prostheses.

    abstract::A new polymeric biomaterial, which uniquely combines radio-opacity (X-ray visibility) and low thrombogenicity, is described. First, preparation, purification, and identification of the essential monomeric building block, 2-[2'-iodobenzoyl]-ethyl methacrylate (3), are outlined. Second, [Figure: See text] the synthesis ...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/0142-9612(95)00339-8

    authors: Kruft MA,Benzina A,Blezer R,Koole LH

    更新日期:1996-09-01 00:00:00

  • Meniscal repair by fibrocartilage in the dog: characterization of the repair tissue and the role of vascularity.

    abstract::Lesions in the avascular part of 20 canine menisci were repaired by implantation of a porous polyurethane. Seven menisci were not repaired and served as controls. The repair tissue was characterized by biochemical and immunological analysis. The role of vascularity in healing was studied by perfusion of menisci with I...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/0142-9612(96)87648-4

    authors: Klompmaker J,Veth RP,Jansen HW,Nielsen HK,de Groot JH,Pennings AJ,Kuijer R

    更新日期:1996-09-01 00:00:00

  • Histological and biochemical evaluation of osteogenic response in porous hydroxyapatite coated alumina ceramics.

    abstract::We compared the osteogenic response in porous alumni (Al) and hydroxyapatite coated porous alumni ceramic (HA/Al) by grafting rat bone marrow cells with these implants subcutaneously in the back of syngeneic rats. The ceramics did not show any bone formation without marrow, but did when combined with marrow cells. The...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/0142-9612(96)89774-2

    authors: Takaoka T,Okumura M,Ohgushi H,Inoue K,Takakura Y,Tamai S

    更新日期:1996-08-01 00:00:00

  • Morphological features of bone healing under the effect of collagen-graft-glycosaminoglycan copolymer supplemented with the tripeptide Gly-His-Lys.

    abstract::The authors prepared 7.5% and 12.5% collagen gel, and supplemented it with the tripeptide Gly-His-Lys (GHK), perfloxacine and hypersulphated glycosaminoglycan (HSGAG). By means of 125l marking, its absorption was followed from small polyurethane sponges placed under the skin of rats. The absorption of gel without HSGA...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/0142-9612(95)00310-x

    authors: Pohunková H,Stehlík J,Váchal J,Cech O,Adam M

    更新日期:1996-08-01 00:00:00

  • Application of benzyl hyaluronate membranes as potential wound dressings: evaluation of water vapour and gas permeabilities.

    abstract::Membranes of 75% and 100% benzyl hyaluronate esters (percentage of total carboxylate groups esterified) were prepared and their water vapour, oxygen and carbon dioxide transmission rates determined. The values of these properties were compared with the values obtained for several commercial wound dressings under the s...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/0142-9612(95)00324-x

    authors: Ruiz-Cardona L,Sanzgiri YD,Benedetti LM,Stella VJ,Topp EM

    更新日期:1996-08-01 00:00:00

  • Structure of dental gallium alloys.

    abstract::The interest in gallium alloys as a replacement for amalgam has increased in recent years due to the risk of environmental pollution from amalgam. Alloy powders with compositions close to those for alloys of amalgam are mixed with a liquid gallium alloy. The mix is condensed into a prepared cavity in much the same way...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:

    authors: Herø H,Simensen CJ,Jørgensen RB

    更新日期:1996-07-01 00:00:00

  • Biomaterial-induced alterations of human neutrophils under fluid shear stress: scanning electron microscopical study in vitro.

    abstract::Morphological changes of human polymorphonuclear neutrophils (PMN) adhering to hydrophilic (glass) and hydrophobic (FEP-Teflon, polyethylene, polypropylene) surfaces were studied in a parallel-plate flow chamber at the light and scanning electron microscopical levels. The PMN were exposed to a shear stress of 0.19 Pa ...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/0142-9612(96)87275-9

    authors: Tomczok J,Sliwa-Tomczok W,Klein CL,van Kooten TG,Kirkpatrick CJ

    更新日期:1996-07-01 00:00:00

  • Effect of chromium salts on invertase immobilization onto carboxymethyl-cellulose-gelatine carrier system.

    abstract::The carboxymethylcellulose-gelatine carrier system was investigated for invertase immobilization. Chromium (III) acetate, chromium (III) sulphate and potassium chromium (III) sulphate were used as cross-linking agents. Effect of carboxymethylcellulose-gelatine ratio and cross-linker concentration on immobilized enzyme...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/0142-9612(96)87285-1

    authors: Emregül E,Sungur S,Akbulut U

    更新日期:1996-07-01 00:00:00

  • The artificial disc: theory, design and materials.

    abstract::Low back pain is one of the most common medical conditions in the Western world. Disc degeneration, an inevitable process of aging, of variable rate and degree, is one of the major causes of low back pain. Currently, there are two major surgical interventions for treating conditions related to the degenerative disc: d...

    journal_title:Biomaterials

    pub_type: 杂志文章,评审

    doi:10.1016/0142-9612(96)84936-2

    authors: Bao QB,McCullen GM,Higham PA,Dumbleton JH,Yuan HA

    更新日期:1996-06-01 00:00:00

  • Tissue reaction to Dacron velour and titanium fibre mesh used for anchorage of percutaneous devices.

    abstract::Dacron velour is often used to anchor a percutaneous device, like the catheter used in peritoneal dialysis. However, exit-site infections complicate this method of dialysis and are supposed to be related to the design of the catheter. In animal experiments, a percutaneous device provided with a titanium fibre mesh to ...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/0142-9612(96)84946-5

    authors: Paquay YC,de Ruijter JE,van der Waerden JP,Jansen JA

    更新日期:1996-06-01 00:00:00

  • Characterization of a hyaluronic acid-Arg-Gly-Asp peptide cell attachment matrix.

    abstract::We have developed a method to modify cross-linked hyaluronic acid with peptides containing the Arg-Gly-Asp sequence. The material created by this process is a three-dimensional porous matrix capable of supporting integrin receptor-mediated cell attachment. Peptide density can be controlled by varying the reaction cond...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/0142-9612(96)85911-4

    authors: Glass JR,Dickerson KT,Stecker K,Polarek JW

    更新日期:1996-06-01 00:00:00

  • Quantitative assessment of the tissue response to films of hyaluronan derivatives.

    abstract::The aim of this study was to evaluate the in vivo response following implantation into a rat model of three innovative hyaluronan derivatives for clinical use: HYAFF 7, HYAFF 11 and HYAFF 11p75 (respectively, the 100% ethyl ester, 100% and 75% benzyl esters). The tissue reaction evoked by films of these new biomateria...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/0142-9612(96)84670-9

    authors: Campoccia D,Hunt JA,Doherty PJ,Zhong SP,O'Regan M,Benedetti L,Williams DF

    更新日期:1996-05-01 00:00:00

  • Alginate polycation microcapsules. I. Interaction between alginate and polycation.

    abstract::The interactions between alginate and polycations have been studied by using different labelling techniques. Binding of poly-L-lysine (PLL) to alginate in the gel state is mainly governed by the amount of dissociable negative charges on the bead surface. PLL was found to bind more rapidly to gel beads made from algina...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/0142-9612(96)84680-1

    authors: Thu B,Bruheim P,Espevik T,Smidsrød O,Soon-Shiong P,Skjåk-Braek G

    更新日期:1996-05-01 00:00:00

  • Adsorption of bovine serum albumin on to titanium powder.

    abstract::The adsorption of bovine serum albumin (BSA) on to titanium powder has been studied as a function of protein concentration and pH, and in the presence of calcium and phosphate ions. Isotherm data have shown that the adsorption process does not follow the Langmuir model (inflection points). The maximum adsorption (Adma...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/0142-9612(96)83280-7

    authors: Wassell DT,Embery G

    更新日期:1996-05-01 00:00:00

  • 5-FU loaded pHEMA drainage implants for glaucoma-filtering surgery: device design and in vitro release kinetics.

    abstract::Implantable monolithic and reservoir-like water-swellable drainage devices were developed for the subconjunctival sustained release of 5-fluorouracil (5-FU) in glaucoma-filtering surgery. A water-swellable matrix was formed of a copolymer of 2-hydroxyethyl methacrylate (HEMA) with different amounts of ethylene glycol ...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/0142-9612(96)83290-x

    authors: Gökce M,Akata RF,Kiremitçi-Gümüşderelioğlu M

    更新日期:1996-05-01 00:00:00

  • Role of polymers in improving the results of stenting in coronary arteries.

    abstract::This article is a review of recent developments of polymer-related stents mainly employed in the coronary arteries, including polymer-coated stents, biostable stents and biodegradable stents. Polymer paving is covered as well. The problems with the stents currently investigated and the development of new stents are di...

    journal_title:Biomaterials

    pub_type: 杂志文章,评审

    doi:10.1016/0142-9612(96)86738-x

    authors: Peng T,Gibula P,Yao KD,Goosen MF

    更新日期:1996-04-01 00:00:00

  • Cross-linking of dermal sheep collagen using a water-soluble carbodiimide.

    abstract::A cross-linking method for collagen-based biomaterials was developed using the water-soluble carbodiimide 1-ethyl-3-(3-dimethyl aminopropyl)carbodiimide hydrochloride (EDC). Cross-linking using EDC involves the activation of carboxylic acid groups to give O-acylisourea groups, which form cross-links after reaction wit...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/0142-9612(96)81413-x

    authors: Olde Damink LH,Dijkstra PJ,van Luyn MJ,van Wachem PB,Nieuwenhuis P,Feijen J

    更新日期:1996-04-01 00:00:00

  • Mineral evolution of bone.

    abstract::A study on the evolution with age of the mineral composition of bones was performed on samples belonging to human and other common mammalian species (cattle, sheep, dog). The study was carried out on the ashes obtained by calcination of the bone samples (1 h at 900 degrees C). The calcined powders were carefully exami...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/0142-9612(96)88712-6

    authors: Ravaglioli A,Krajewski A,Celotti GC,Piancastelli A,Bacchini B,Montanari L,Zama G,Piombi L

    更新日期:1996-03-01 00:00:00

  • Evaluation of the effect of three surface treatments on the biocompatibility of 316L stainless steel using human differentiated cells.

    abstract::AISI 316L stainless steel (SS) is widely used in orthopaedic implantology, although biological complications may result from its insufficient mechanical and tribological properties. In order to improve the wear and corrosion resistance as well as the hardness of 316L SS, three surface treatments, derived from those ap...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/0142-9612(96)82723-2

    authors: Bordji K,Jouzeau JY,Mainard D,Payan E,Delagoutte JP,Netter P

    更新日期:1996-03-01 00:00:00

  • Microbial adhesion to ionogenic PHEMA, PU and PP implants.

    abstract::This study concentrates on adhesion of microorganisms to polymeric biomaterials implanted in the urinary tract. A number of extensively used polymeric biomaterials (i.e., poly(hydroxyethyl-methacrylate) and its copolymers with a series of acrylic monomers--acrylic acid and dimethylaminoethyl methacrylate--polyetherure...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/0142-9612(96)89662-1

    authors: Kiremitci-Gumusderelioglu M,Pesmen A

    更新日期:1996-02-01 00:00:00

  • Tissue engineering and autologous transplant formation: practical approaches with resorbable biomaterials and new cell culture techniques.

    abstract::The engineering of living tissues in vivo requires new concepts in cell culture technology. In contrast to conventional cell cultures, the development of tissues depends on a three-dimensional arrangement of cells and the formation or synthesis of an appropriate extracellular matrix. Special emphasis is given to the m...

    journal_title:Biomaterials

    pub_type: 杂志文章,评审

    doi:10.1016/0142-9612(96)85561-x

    authors: Sittinger M,Bujia J,Rotter N,Reitzel D,Minuth WW,Burmester GR

    更新日期:1996-02-01 00:00:00

  • Biointeractive polymers and tissue engineered blood vessels.

    abstract::The regulation of endothelial cell (EC) and smooth muscle cell (SMC) proliferation following vascular interventions is critical to clinical efficacy. Our laboratory has developed a method of impregnating biomaterials with suspensions containing bioactive proteins resulting in the capability of differentially modulatin...

    journal_title:Biomaterials

    pub_type: 杂志文章,评审

    doi:10.1016/0142-9612(96)85571-2

    authors: Greisler HP,Gosselin C,Ren D,Kang SS,Kim DU

    更新日期:1996-02-01 00:00:00

  • In vitro swelling studies and preliminary biocompatibility evaluation of acrylamide-based hydrogels.

    abstract::In this in vitro study, the biocompatibility of acrylamide-based hydrogels such as acrylamide/crotonic and acrylamide/itaconic acid, prepared by using gamma-rays, has been investigated against some biochemical parameters of human serum. The swelling kinetics of acrylamide/crotonic and acrylamide/itaconic acid hydrogel...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/0142-9612(96)80757-5

    authors: Karadağ E,Saraydin D,Cetinkaya S,Güven O

    更新日期:1996-01-01 00:00:00

  • Role of material surfaces in regulating bone and cartilage cell response.

    abstract::Tissue engineering in vitro and in vivo involves the interaction of cells with a material surface. The nature of the surface can directly influence cellular response, ultimately affecting the rate and quality of new tissue formation. Initial events at the surface include the orientated adsorption of molecules from the...

    journal_title:Biomaterials

    pub_type: 杂志文章,评审

    doi:10.1016/0142-9612(96)85758-9

    authors: Boyan BD,Hummert TW,Dean DD,Schwartz Z

    更新日期:1996-01-01 00:00:00

  • Tissue engineering scaffolds using superstructures.

    abstract::Here, scaffolds as cell and tissue carriers are approached from an engineering point of view, emphasizing material superstructuring in the design of supports. Superstructure engineering provides optimal spatial and nutritional conditions for cell maintenance by the arrangement of structural elements (e.g. pores or fib...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/0142-9612(96)85753-x

    authors: Wintermantel E,Mayer J,Blum J,Eckert KL,Lüscher P,Mathey M

    更新日期:1996-01-01 00:00:00

  • Synthesis and properties of novel block copolymers containing poly(lactic-glycolic acid) and poly(ethyleneglycol) segments.

    abstract::A synthetic process for obtaining high-molecular-weight block copolymers containing poly(lactic-glycolic acid) and poly(ethylene glycol) segments has been established. This process involves the reaction of poly(ethylene glycols) with phosgene, followed by polycondensation of the resulting alpha, omega-bis(chloroformat...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/0142-9612(95)96879-5

    authors: Ferruti P,Penco M,D'Addato P,Ranucci E,Deghenghi R

    更新日期:1995-12-01 00:00:00

  • Modification of layered atelocollagen: enzymatic degradation and cytotoxicity evaluation.

    abstract::Two kinds of layered atelocollagen materials cross-linked with hexamethylene diisocyanate (HMDIC), starch dialdehyde and glyoxal were enzymatically treated by bacterial collagenase. Evaluating collagenase digestion assay for these material showed progressive differences, particularly in the group of samples cross-link...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/0142-9612(95)98127-z

    authors: Vizárová K,Bakos D,Rehákova M,Petríkova M,Panáková E,Koller J

    更新日期:1995-11-01 00:00:00

  • Investigation of the torque-tension characteristics of a flanged external fixator pin.

    abstract::The torque-tension characteristics of standard, conical and flanged external fixator pins and a cortical screw were compared using a commercially available testing apparatus. The flanged pin and the screw were similar in behaviour, and converted torque into tension more efficiently than conical and standard external f...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/0142-9612(95)98137-4

    authors: Oni OO,Batchelor JS

    更新日期:1995-11-01 00:00:00

  • Controlled release of platelet-derived growth factor using ethylene vinyl acetate copolymer (EVAc) coated on stainless-steel wires.

    abstract::Controlled delivery of bioactive molecules to modulate or control biological processes has a number of clinical applications. The present study reports a delivery system which was designed to deliver growth factors locally to a fracture site. Ethylene vinyl acetate copolymer (EVAc), bovine serum albumin (BSA) and plat...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/0142-9612(95)91047-3

    authors: Walsh WR,Kim HD,Jong YS,Valentini RF

    更新日期:1995-11-01 00:00:00

  • Mapping of endogenous lectins in macrophages colonizing an implanted polymer surface--effect of polymer structure.

    abstract::The design of synthetic polymers may affect structural features of inflammatory cells, for example the expression of endogenous sugar receptor molecules like lectins in macrophages and foreign body giant multinucleate cells. This characteristic was studied histochemically by use of biotinylated (neo)glycoproteins. The...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/0142-9612(95)93578-2

    authors: Smetana K Jr,Gabius HJ,Vacík J,Jelínková M,Lukás J

    更新日期:1995-10-01 00:00:00

  • Collagen implants remain supple not allowing fibroblast ingrowth.

    abstract::Dense, reconstituted collagen membranes, using an optimized cross-linking protocol, were implanted subcutaneously into rats. After implantation, only a mild inflammatory response in the surrounding tissues was observed. The morphology of the fibroblasts around the membranes was seen to go through characteristic stages...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/0142-9612(95)98905-t

    authors: Boon ME,Ruijgrok JM,Vardaxis MJ

    更新日期:1995-09-01 00:00:00

  • Effect of temperature on electrochemical deposition of calcium phosphate coatings in a simulated body fluid.

    abstract::Calcium phosphate coatings were deposited on titanium plate by an electrochemical method in simulated body fluid at 5-62 degrees C. X-ray diffractometry and FTIR studies demonstrated that the deposits at 5, 22 and 37 degrees C were amorphous and those at 52 and 62 degrees C contained Mg(OH)2, CaCO3 and carbonate apati...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/0142-9612(95)94904-y

    authors: Ban S,Maruno S

    更新日期:1995-09-01 00:00:00

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