Meniscal repair by fibrocartilage in the dog: characterization of the repair tissue and the role of vascularity.

abstract：:Semisynthetic network alginate polymer (SNAP), synthesized by acetalization of linear alginate with di-aldehyde, is a pH-responsive tetrafunctionally linked 3D gel network, and has potential application in oral delivery of protein therapeutics and active biologicals, and as tissue bioscaffold for regenerative medicine...

journal_title：Biomaterials

authors： Chan AW,Neufeld RJ

更新日期：2009-10-01 00:00:00

abstract：:Programmed cell death-ligand 1 (PD-L1)-based immune checkpoint blockade therapy using the anti-PD-L1 antibody is effective for a subset of patients with advanced metastatic melanoma but about half of the patients do not respond to the therapy because of the tumor immunosuppressive microenvironment. Immunogenic cell de...

journal_title：Biomaterials

authors： Qiu N,Liu Y,Liu Q,Chen Y,Shen L,Hu M,Zhou X,Shen Y,Gao J,Huang L

更新日期：2020-12-17 00:00:00

abstract：:Bioabsorbable internal fixation devices were introduced clinically in the treatment of fractures and osteotomies of the extremities at the Department of Orthopaedics and Traumatology, Helsinki University, in 1984. Since November 5, 1984, a total of 3200 patients were managed using bone or ligament fixation devices mad...

journal_title：Biomaterials

authors： Rokkanen PU,Böstman O,Hirvensalo E,Mäkelä EA,Partio EK,Pätiälä H,Vainionpää SI,Vihtonen K,Törmälä P

更新日期：2000-12-01 00:00:00

abstract：:The non-specific interaction between nanoparticles (NPs) and plasma proteins occurs immediately after NPs enter the blood, resulting in the formation of the protein corona that thereafter replaces the original NPs and becomes what the organs and cells really see. Consequently, the in vivo fate of NPs and the biologica...

journal_title：Biomaterials

authors： Peng Q,Zhang S,Yang Q,Zhang T,Wei XQ,Jiang L,Zhang CL,Chen QM,Zhang ZR,Lin YF

更新日期：2013-11-01 00:00:00

abstract：:One of the most common non-viral methods for the introduction of foreign deoxyribonucleic acid (DNA) into cultured cells is calcium phosphate co-precipitate transfection. This technique involves the encapsulation of DNA within a calcium phosphate co-precipitate, particulate addition to in vitro cell culture, endocytos...

journal_title：Biomaterials

authors： Kofron MD,Laurencin CT

更新日期：2004-06-01 00:00:00

abstract：:We report the fabrication of a one-pot antigen system that delivers antigen to dendritic cells (DCs) and tracks their in vivo migration after injection. Multifunctional polymer nanoparticles containing ovalbumin protein, magnetic resonance imaging contrast agents (iron oxide nanoparticles), and near-infrared fluoropho...

journal_title：Biomaterials

authors： Noh YW,Jang YS,Ahn KJ,Lim YT,Chung BH

更新日期：2011-09-01 00:00:00

abstract：:We have shown that nanoparticles (NPs) conjugated to trans-activating transcriptor (TAT) peptide bypass the efflux action of P-glycoprotein and increase the transport of the encapsulated ritonavir, a protease inhibitor (PI), across the blood-brain-barrier (BBB) to the central nervous system (CNS). A steady increase in...

journal_title：Biomaterials

authors： Rao KS,Reddy MK,Horning JL,Labhasetwar V

更新日期：2008-11-01 00:00:00

abstract：:The efficient delivery of short interfering RNA (siRNA) is an enormous challenge in the field of gene therapy. Herein, we report a delivery nanosystem based on programmed DNA self-assembly mammalian target of rapamycin (mTOR) siRNA-loaded DNA nanotubes (DNA-NTs). We demonstrate that these siRNA-DNA-NTs can be effectiv...

journal_title：Biomaterials

authors： You Z,Qian H,Wang C,He B,Yan J,Mao C,Wang G

更新日期：2015-10-01 00:00:00

abstract：:Long-term elution of fluoride ions has been studied for one silicate and six glass-ionomer cements over a period of some two and-a-half years. Because equilibrium was not reached, classical diffusion theory could not be applied to the process. It was postulated that two elution processes were taking place, one short-t...

journal_title：Biomaterials

authors： Tay WM,Braden M

更新日期：1988-09-01 00:00:00

abstract：:Patient-derived tumor organoids offer potentially useful models of cancer tissue physiology. Yet, conventional organoid cultures utilize generic matrices that are difficult to tailor for various unique tumor microenvironments. Here, we employ synthetic, enzymatically crosslinked hydrogels to define mechanical and bioc...

journal_title：Biomaterials

authors： Ng S,Tan WJ,Pek MMX,Tan MH,Kurisawa M

更新日期：2019-10-01 00:00:00

abstract：:In previous papers, we have described the preparation and heparin-like properties of insoluble modified polystyrene resins. We now report results obtained with amino acid sulphamide resins that are virtually devoid of sulphonate groups and with resins bearing both sulphonate groups as well as amino acid sulphamides wi...

journal_title：Biomaterials

authors： Fougnot C,Dupillier MP,Jozefowicz M

更新日期：1983-04-01 00:00:00

abstract：:There is a need for new therapeutic strategies to treat bone defects caused by trauma, disease or tissue loss. Injectable systems for cell transplantation have the advantage of allowing the use of minimally invasive surgical procedures, and thus for less discomfort to patients. In the present study, it is hypothesized...

journal_title：Biomaterials

authors： Evangelista MB,Hsiong SX,Fernandes R,Sampaio P,Kong HJ,Barrias CC,Salema R,Barbosa MA,Mooney DJ,Granja PL

更新日期：2007-09-01 00:00:00

abstract：OBJECT:Allogenic human fascia lata used in neurosurgery, as dura mater substitute, can be associated with a risk of viral and bacterial transmission. Chemical and physical procedures, developed to inactivate virus and bacteria, have been applied to fascia lata. The aim of this study consists in the evaluation of the bi...

journal_title：Biomaterials

authors： Dufrane D,Cornu O,Delloye C,Schneider YJ

更新日期：2002-07-01 00:00:00

abstract：:This study examined the effects of copolymer hydrophilicity and temperature on water sorption and solubility characteristics of five copolymer blends of increasing degree of hydrophilicity using gravimetric measurements. Six resin disks (15 mm in diameter x 1 mm in thickness) were prepared from each copolymer blend an...

journal_title：Biomaterials

authors： Yiu CK,King NM,Carrilho MR,Sauro S,Rueggeberg FA,Prati C,Carvalho RM,Pashley DH,Tay FR

更新日期：2006-03-01 00:00:00

abstract：:Osteoarthritis (OA) is a progressively degenerative disease that is accompanied by articular cartilage deterioration, sclerosis of the underlying bone and ultimately joint destruction. Although therapeutic medicine and surgical treatment are done to alleviate the symptoms of OA, it is difficult to restore normal carti...

journal_title：Biomaterials

authors： Kim SJ,Kim JE,Kim SH,Kim SJ,Jeon SJ,Kim SH,Jung Y

更新日期：2016-01-01 00:00:00

abstract：:Three-dimensional gelatin-chondroitin 6 sulphate-hyanuronic acid (gelatin-C6S-HA) biomatrices were used as the scaffold to investigate the phenotypic and molecular expression of basement membrane (BM) and extracellular matrix (ECM) proteins in vitro. The cells were cultured in three different culture conditions: kerat...

journal_title：Biomaterials

authors： Wang TW,Sun JS,Huang YC,Wu HC,Chen LT,Lin FH

更新日期：2006-10-01 00:00:00

abstract：:AuCu and AuAg alloys (30 at. % Au) have been immersed in aqueous solutions of chloride and sulphide with additions of protein (mucin). The surfaces of the alloys were subsequently analysed by means of ESCA and compared with previous and similar tests without addition of mucin. No noticeable effect of the mucin additio...

journal_title：Biomaterials

authors： Herø H,Hultquist G,Odén A

更新日期：1985-11-01 00:00:00

abstract：:It is estimated that 4 to 5 million people are currently co-infected with Human Immunodeficiency Virus (HIV) and Hepatitis C Virus (HCV). HIV/HCV co-infection is associated with unique health risks including increased hepatotoxicity of antiretrovirals, accelerated progression of HCV and liver diseases. The standard in...

journal_title：Biomaterials

authors： Zhang J,Mulvenon A,Makarov E,Wagoner J,Knibbe J,Kim JO,Osna N,Bronich TK,Poluektova LY

更新日期：2013-05-01 00:00:00

abstract：:Polyphosphazenes have been synthesized with tris(hydroxymethyl)amino methane (THAM) side groups and with co-substituents glycine ethyl ester and alanine ethyl ester. The THAM side group was linked to the polyphosphazene backbone via the amino function. The three pendent hydroxyl functions on each THAM side group were ...

journal_title：Biomaterials

authors： Krogman NR,Weikel AL,Kristhart KA,Nukavarapu SP,Deng M,Nair LS,Laurencin CT,Allcock HR

更新日期：2009-06-01 00:00:00

abstract：:Despite its long history and some preliminary work in tissue engineering nearly 30 years ago, electrospinning has not gained widespread interest as a potential polymer processing technique for applications in tissue engineering and drug delivery until the last 5-10 years. This renewed interest can be attributed to ele...

journal_title：Biomaterials

authors： Sill TJ,von Recum HA

更新日期：2008-05-01 00:00:00

abstract：:Adipose-derived stem cells (ASCs) hold promise for bone regeneration but possess inferior osteogenesis potential. Allotransplantation of ASCs engineered with the BMP2/VEGF-expressing baculoviruses into rabbits healed critical-size segmental bone defects. To translate the technology to clinical applications, we aimed t...

journal_title：Biomaterials

authors： Lin CY,Wang YH,Li KC,Sung LY,Yeh CL,Lin KJ,Yen TC,Chang YH,Hu YC

更新日期：2015-05-01 00:00:00

abstract：:The long-term behaviour of cellulose sponge implants, 10 x 10 x 5 mm in size, and tissue reactions in and around them were examined in the subcutaneous tissue of the rat from 1 to 60 weeks after implantation. The cellulose sponge used was filled up with connective tissue 4 to 8 weeks after implantation. Histologically...

journal_title：Biomaterials

authors： Märtson M,Viljanto J,Hurme T,Laippala P,Saukko P

更新日期：1999-11-01 00:00:00

abstract：:Despite being increasingly used as artificial enzymes, little has been known for the origin of the pH-switchable peroxidase-like and catalase-like activities of metals. Using calculations and experiments, we report the mechanisms for both activities and their pH-switchability for metals Au, Ag, Pd and Pt. The calculat...

journal_title：Biomaterials

authors： Li J,Liu W,Wu X,Gao X

更新日期：2015-04-01 00:00:00

abstract：:Gold nanoparticles have been conceived as a radiosensitizer in cancer radiation therapy, but one of the important questions for primary drug screening is what size of gold nanoparticles can optimally enhance radiation effects. Herein, we perform in vitro and in vivo radiosensitization studies of 4.8, 12.1, 27.3, and 4...

journal_title：Biomaterials

authors： Zhang XD,Wu D,Shen X,Chen J,Sun YM,Liu PX,Liang XJ

更新日期：2012-09-01 00:00:00

abstract：:Optimal nano-sized drug carrier requires long blood circulation, selective extravasation, and efficient cell uptake. Here we develop a charge-convertible nanoplatform based on Pt(IV) prodrug loaded NaYF4:Yb,Tm upconversion nanoparticles (UCNs), followed by coating a layer of PEG-PAH-DMMA polymer (UCNs-Pt(IV)@PEG-PAH-D...

journal_title：Biomaterials

authors： Xu J,Kuang Y,Lv R,Yang P,Li C,Bi H,Liu B,Yang D,Dai Y,Gai S,He F,Xing B,Lin J

更新日期：2017-06-01 00:00:00

abstract：:Cyclic RGD peptide-decorated polymeric micellar-like nanoparticles (MNP) based on PEGylated poly (trimethylene carbonate) (PEG-PTMC) were prepared for active targeting to integrin-rich cancer cells. An amphiphilic diblock copolymer, α-carboxyl poly (ethylene glycol)-poly (trimethylene carbonate) (HOOC-PEG-PTMC), was s...

journal_title：Biomaterials

authors： Jiang X,Sha X,Xin H,Chen L,Gao X,Wang X,Law K,Gu J,Chen Y,Jiang Y,Ren X,Ren Q,Fang X

更新日期：2011-12-01 00:00:00

abstract：:Retinal degenerations cause permanent visual loss and affect millions world-wide. Presently, a novel treatment highlights the potential of using biodegradable polymer scaffolds to induce differentiation and deliver retinal progenitor cells for cell replacement therapy. In this study, we engineered and analyzed a micro...

journal_title：Biomaterials

authors： Redenti S,Neeley WL,Rompani S,Saigal S,Yang J,Klassen H,Langer R,Young MJ

更新日期：2009-07-01 00:00:00

abstract：:Modified high shear homogenization and ultrasound techniques were employed to produce solid lipid nanoparticles (SLNs). Model drug mifepristone had been incorporated in SLNs. The mean particle size measured by laser diffractometry (LD) was found to be 106 nm with a narrow particle distribution of polydispersity index,...

journal_title：Biomaterials

authors： Hou D,Xie C,Huang K,Zhu C

更新日期：2003-05-01 00:00:00

abstract：:We report here the development of a chitosan/beta-glycerophosphate(Ch/beta-GP) thermo-sensitive gel to deliver ellagic acid (EA) for cancer treatment. The properties of the Ch/beta-GP gels were characterized regarding chemical structure, surface morphology, and viscoelasticity. In vitro EA release rate from the EA loa...

journal_title：Biomaterials

authors： Kim S,Nishimoto SK,Bumgardner JD,Haggard WO,Gaber MW,Yang Y

更新日期：2010-05-01 00:00:00

abstract：:After spinal cord injury (SCI), loss of cells and damage to ascending and descending tracts can result in paralysis. Current treatments for SCI are based on patient stabilization, and much-needed regenerative therapies are still under development. To activate and instruct stem and progenitor cells or injured tissue to...

journal_title：Biomaterials

authors： Lowry N,Goderie SK,Lederman P,Charniga C,Gooch MR,Gracey KD,Banerjee A,Punyani S,Silver J,Kane RS,Stern JH,Temple S

更新日期：2012-04-01 00:00:00