Abstract：
:Dense, reconstituted collagen membranes, using an optimized cross-linking protocol, were implanted subcutaneously into rats. After implantation, only a mild inflammatory response in the surrounding tissues was observed. The morphology of the fibroblasts around the membranes was seen to go through characteristic stages of proliferation and synthesis. In the 7 week follow-up it was found that these membranes did not allow any fibroblast ingrowth into their substance and remained completely intact and supple without signs of calcification, whereas the non-cross-linked controls proved to be completely degraded. The cross-linked reconstituted collagen may thus be considered for use in situations where neither incorporation nor dissolution of the biomaterial is desired.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Boon ME,Ruijgrok JM,Vardaxis MJdoi
10.1016/0142-9612(95)98905-tsubject
Has Abstractpub_date
1995-09-01 00:00:00pages
1089-93issue
14eissn
0142-9612issn
1878-5905pii
014296129598905Tjournal_volume
16pub_type
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