当前位置： SCI文献检索 > BIOMATERIALS期刊下所有文献 > Relationship between osseointegration and superelastic biomechanics in porous NiTi scaffolds.

Relationship between osseointegration and superelastic biomechanics in porous NiTi scaffolds.

Abstract：

:The superelastic nature of bones requires matching biomechanical properties from the ideal artificial biomedical implants in order to provide smooth load transfer and foster the growth of new bone tissues. In this work, we determine the biomechanical characteristics of porous NiTi implants and investigate bone ingrowth under actual load-bearing conditions in vivo. In this systematic and comparative study, porous NiTi, porous Ti, dense NiTi, and dense Ti are implanted into 5 mm diameter holes in the distal part of the femur/tibia of rabbits for 15 weeks. The bone ingrowth and interfacial bonding strength are evaluated by histological analysis and push-out test. The porous NiTi materials bond very well to newly formed bone tissues and the highest average strength of 357 N and best ductility are achieved from the porous NiTi materials. The bonding curve obtained from the NiTi scaffold shows similar superelasticity as natural bones with a deflection of 0.30-0.85 mm thus shielding new bone tissues from large load stress. This is believed to be the reason why new bone tissues can penetrate deeply into the porous NiTi scaffold compared to the one made of porous Ti. Histological analysis reveals that new bone tissues adhere and grow well on the external surfaces as well as exposed areas on the inner pores of the NiTi scaffold. The in vitro study indicates that the surface chemical composition and topography of the porous structure leads to good cytocompatibility. Consequently, osteoblasts proliferate smoothly on the entire implant including the flat surface, embossed region, exposed area of the pores, and interconnected channels. In conjunction with the good cytocompatibility, the superelastic biomechanical properties of the porous NiTi scaffold bodes well for fast formation and ingrowth of new bones, and porous NiTi scaffolds are thus suitable for clinical applications under load-bearing conditions.

journal_name

Biomaterials

journal_title

Biomaterials

authors

Liu X,Wu S,Yeung KW,Chan YL,Hu T,Xu Z,Liu X,Chung JC,Cheung KM,Chu PK

doi

10.1016/j.biomaterials.2010.08.102

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

330-8

issue

2

eissn

0142-9612

issn

1878-5905

pii

S0142-9612(10)01140-3

journal_volume

32

pub_type

杂志文章

相关文献

BIOMATERIALS文献大全
  • Cytotoxicity and MMP-9 activation induced in human mononuclear cells by UHMWPE oxidation.

    abstract：:Ultra high molecular weight polyethylene (UHMWPE) used in orthopedic prosthesis can be oxidized during sterilization processes such as gamma-ray irradiation. Oxidation alters UHMWPE structure and mechanical properties and it has been suggested that this alteration is the first step in the loosening process. Direct eff...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/s0142-9612(02)00097-2

    authors： Renò F,Bracco P,Costa L,Cannas M

    更新日期：2002-09-01 00:00:00

  • Corrosion behavior of copper/LDPE nanocomposites in simulated uterine solution.

    abstract：:We prepared copper/low-density polyethylene (LDPE) nanocomposites with various mass fractions of copper nanoparticles and investigated the Cu(2+) release rate of them for 220 days in a simulated uterine solution .The influences of copper nanoparticle mass fraction on Cu(2+) release and volume resistivity confirm that ...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2004.08.003

    authors： Cai S,Xia X,Xie C

    更新日期：2005-05-01 00:00:00

  • Nanofibrous spongy microspheres to deliver rabbit mesenchymal stem cells and anti-miR-199a to regenerate nucleus pulposus and prevent calcification.

    abstract：:Lower back pain is mainly caused by intervertebral disc degeneration, in which calcification is frequently involved. Here novel nanofibrous spongy microspheres (NF-SMS) are used to carry rabbit bone marrow mesenchymal stromal cells (MSCs) to regenerate nucleus pulposus tissues. NF-SMS are shown to significantly enhanc...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2020.120213

    authors： Feng G,Zhang Z,Dang M,Rambhia KJ,Ma PX

    更新日期：2020-10-01 00:00:00

  • Bioreactor based engineering of large-scale human cartilage grafts for joint resurfacing.

    abstract：:Apart from partial or total joint replacement, no surgical procedure is currently available to treat large and deep cartilage defects associated with advanced diseases such as osteoarthritis. In this work, we developed a perfusion bioreactor system to engineer human cartilage grafts in a size with clinical relevance f...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2010.08.009

    authors： Santoro R,Olivares AL,Brans G,Wirz D,Longinotti C,Lacroix D,Martin I,Wendt D

    更新日期：2010-12-01 00:00:00

  • Characterization of calcium phosphate coatings deposited by Nd:YAG laser ablation at 355 nm: influence of thickness.

    abstract：:Calcium phosphate coatings were deposited by pulsed laser ablation with a radiation of 355 nm from a Nd:YAG laser. All the coatings were obtained at the same conditions, but deposition was stopped after different number of pulses to get coatings with different thickness. The influence of thickness in the structural an...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/s0142-9612(01)00327-1

    authors： Fernández-Pradas JM,Clèries L,Sardin G,Morenza JL

    更新日期：2002-05-01 00:00:00

  • Diaminododecane-based cationic bolaamphiphile as a non-viral gene delivery carrier.

    abstract：:The advancement in gene therapy relies upon the discovery of safe and efficient delivery agents and methods. In this study, we report the design and synthesis of a cationic bolaamphiphile as a non-viral gene delivery agent. The bolaamphiphile is composed of 1,12-diaminododecane as the central hydrophobic unit linked t...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2012.02.067

    authors： Khan M,Ang CY,Wiradharma N,Yong LK,Liu S,Liu L,Gao S,Yang YY

    更新日期：2012-06-01 00:00:00

  • Dexamethasone-releasing biodegradable polymer scaffolds fabricated by a gas-foaming/salt-leaching method.

    abstract：:Dexamethasone, a steroidal anti-inflammatory drug, was incorporated into porous biodegradable polymer scaffolds for sustained release. The slowly released dexamethasone from the degrading scaffolds was hypothesized to locally modulate the proliferation and differentiation of various cells. Dexamethasone containing por...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/s0142-9612(03)00024-3

    authors： Yoon JJ,Kim JH,Park TG

    更新日期：2003-06-01 00:00:00

  • Combination strategy of multi-layered surface camouflage using hyperbranched polyethylene glycol and immunosuppressive drugs for the prevention of immune reactions against transplanted porcine islets.

    abstract：:This study suggests a novel method of stabilizing fragile porcine islets to prevent the dissociation after isolation and reducing immune cell invasion in a combination therapy of 'surface camouflaging' and immunosuppressive drugs (FK506, Rapamycin, MR-1, anti-CD19 mAb, and Clodrosome(®)) to effectively alleviate overa...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2016.01.039

    authors： Haque MR,Jeong JH,Byun Y

    更新日期：2016-04-01 00:00:00

  • Electrical conduction in some nucleic acid base complexes with acridine orange dye: study of localized levels.

    abstract：:Semiconduction activation energies of adenine, guanine, thymine and uracil complexes with acridine orange dye at various dye concentrations were measured in both Ohmic and space charge limited (SCL) current regimes. The behaviour of the complexes is non-extrinsic at high dye concentrations but extrinsic at low dye con...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/0142-9612(89)90025-2

    authors： Sarkar D,Misra TN

    更新日期：1989-04-01 00:00:00

  • The protective role of arjunolic acid against doxorubicin induced intracellular ROS dependent JNK-p38 and p53-mediated cardiac apoptosis.

    abstract：:In spite of tremendous demand for the development and implementation of effective therapeutic strategies, limitations are still associated with doxorubicin-induced cardiotoxicity. Arjunolic acid (AA) has been shown to possess a multitude of biological functions. The purpose of the present study was to explore whether ...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2011.03.048

    authors： Ghosh J,Das J,Manna P,Sil PC

    更新日期：2011-07-01 00:00:00

  • Prion inhibition with multivalent PrPSc binding compounds.

    abstract：:Quinacrine and related heterocyclic compounds have antiprion activity. Since the infectious pathogen of prion diseases is composed of multimeric PrP(Sc) assemblies, we hypothesized that this antiprion property could be enhanced by attaching multiple quinacrine-derived chloroquinoline or acridine moieties to a scaffold...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2012.06.004

    authors： Mays CE,Joy S,Li L,Yu L,Genovesi S,West FG,Westaway D

    更新日期：2012-10-01 00:00:00

  • The performance of gadolinium diethylene triamine pentaacetate-pullulan hepatocyte-specific T1 contrast agent for MRI.

    abstract：:The magnetic resonance (MR) functionalities of pullulan-conjugated gadolinium diethylene triamine pentaacetate (Gd-DTPA-Pullulan) as a new hepatocyte-specific contrast agent were evaluated. Pullulan, which specifically accumulates on hepatocytes via asialoglycoprotein receptors, was chemically linked with Gd-DTPA. Gd-...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2011.03.069

    authors： Yim H,Yang SG,Jeon YS,Park IS,Kim M,Lee DH,Bae YH,Na K

    更新日期：2011-08-01 00:00:00

  • Miscibility and in vitro osteocompatibility of biodegradable blends of poly[(ethyl alanato) (p-phenyl phenoxy) phosphazene] and poly(lactic acid-glycolic acid).

    abstract：:Previously we demonstrated the ability of ethyl glycinato substituted polyphosphazenes to neutralize the acidic degradation products and control the degradation rate of poly(lactic acid-glycolic acid) (PLAGA) by blending. In this study, blends of high strength poly[(50% ethyl alanato) (50% p-phenyl phenoxy) phosphazen...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2007.09.029

    authors： Deng M,Nair LS,Nukavarapu SP,Kumbar SG,Jiang T,Krogman NR,Singh A,Allcock HR,Laurencin CT

    更新日期：2008-01-01 00:00:00

  • A 3D microfibrous scaffold for long-term human pluripotent stem cell self-renewal under chemically defined conditions.

    abstract：:Realizing the potential of human pluripotent stem cell (hPSC)-based therapy requires the development of defined scalable culture systems with efficient expansion, differentiation and isolation protocols. We report an engineered 3D microfiber system that efficiently supports long-term hPSCs self-renewal under chemicall...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2011.11.077

    authors： Lu HF,Narayanan K,Lim SX,Gao S,Leong MF,Wan AC

    更新日期：2012-03-01 00:00:00

  • Cell adhesion to silicon substrata: characterization by means of optical and acoustic cytometric techniques.

    abstract：:The adhesion and growth of cells on silicon dioxide substrata are analysed. The adhesion of human red blood cells to silicon dioxide layers of different depth and doping compares well with that to glass. Rat pheochromocytoma cells also grow on the same substrata. The adhesion of these two biological systems is charact...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/0142-9612(88)90079-8

    authors： Grattarola M,Tedesco M,Cambiaso A,Perlo G,Giannetti G,Sanguineti A

    更新日期：1988-01-01 00:00:00

  • Development of membranes for the cultivation of kidney epithelial cells.

    abstract：:The development of biohybrid organs (BHO) will benefit from improved membranes regarding transport and cell contacting properties. Here we describe in a first study the development and testing of membranes made of polyacrylonitrile (PAN) and polysulfone (PSU) for the immobilisation of kidney epithelial cells. Comparat...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/s0142-9612(99)00147-7

    authors： Fey-Lamprecht F,Groth T,Albrecht W,Paul D,Gross U

    更新日期：2000-01-01 00:00:00

  • Tailoring the pore architecture in 3-D alginate scaffolds by controlling the freezing regime during fabrication.

    abstract：:The pore architecture in 3-D polymeric scaffoldings plays a critical role in tissue engineering as it provides the framework for the seeded cells to organize into a functioning tissue. In the present paper, we investigate the effect of freezing regime on the pore microstructure in 3-D alginate scaffolds, fabricated by...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/s0142-9612(02)00146-1

    authors： Zmora S,Glicklis R,Cohen S

    更新日期：2002-10-01 00:00:00

  • Polyethyleneimine-mediated synthesis of folic acid-targeted iron oxide nanoparticles for in vivo tumor MR imaging.

    abstract：:We report a facile polyethyleneimine (PEI)-mediated approach to synthesizing folic acid (FA)-targeted magnetic iron oxide nanoparticles (Fe3O4 NPs) for in vivo magnetic resonance (MR) imaging of tumors. In this study, stable PEI-coated Fe3O4 NPs were prepared by a one-pot hydrothermal route. The aminated Fe3O4 NPs wit...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2013.07.070

    authors： Li J,Zheng L,Cai H,Sun W,Shen M,Zhang G,Shi X

    更新日期：2013-11-01 00:00:00

  • Ectopic osteoinduction and early degradation of recombinant human bone morphogenetic protein-2-loaded porous beta-tricalcium phosphate in mice.

    abstract：:The present study investigated the ectopic osteoinduction and early degradation of recombinant human bone morphogenetic protein-2 (rhBMP-2)-loaded porous beta-tricalcium phosphate (beta-TCP) in mice. The porous beta-TCP with 50 microg of rhBMP-2 (n = 25) and porous beta-TCP (control group, n = 25) were implanted into ...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2004.10.035

    authors： Liang G,Yang Y,Oh S,Ong JL,Zheng C,Ran J,Yin G,Zhou D

    更新日期：2005-07-01 00:00:00

  • Carbon nanotube-based substrates for modulation of human pluripotent stem cell fate.

    abstract：:We investigated the biological response of human pluripotent stem cells (hPSCs) cultured on a carbon nanotube (CNT) array-based substrate with the long term goal to direct hPSC germ layer specification for a wide variety of tissue engineering applications. CNT arrays were fabricated using a chemical vapor deposition s...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2014.03.011

    authors： Pryzhkova MV,Aria I,Cheng Q,Harris GM,Zan X,Gharib M,Jabbarzadeh E

    更新日期：2014-06-01 00:00:00

  • Surface modification of polymer nanoparticles with native albumin for enhancing drug delivery to solid tumors.

    abstract：:Albumin is a promising surface modifier of nanoparticulate drug delivery systems. Serving as a dysopsonin, albumin can protect circulating nanoparticles (NPs) from the recognition and clearance by the mononuclear phagocytic system (MPS). Albumin may also help transport the NPs to solid tumors based on the increased co...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2018.07.024

    authors： Hyun H,Park J,Willis K,Park JE,Lyle LT,Lee W,Yeo Y

    更新日期：2018-10-01 00:00:00

  • A scanning electron microscopy study of the interface between ceramics and bone.

    abstract：:By use of scanning electron microscopy (SEM), together with energy dispersive chemical analysis, a study has been made of the comparison of an in vitro method of assessing interface reactions between bone and ceramic implants with the naturally occurring changes seen in the rat ear model. Interface reactions between b...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/0142-9612(85)90024-9

    authors： Williams KR,Blayney AW,Frootko NJ,Ashton BA

    更新日期：1985-07-01 00:00:00

  • Nanotopography-responsive myotube alignment and orientation as a sensitive phenotypic biomarker for Duchenne Muscular Dystrophy.

    abstract：:Duchenne Muscular Dystrophy (DMD) is a fatal genetic disorder currently having no cure. Here we report that culture substrates patterned with nanogrooves and functionalized with Matrigel (or laminin) present an engineered cell microenvironment to allow myotubes derived from non-diseased, less-affected DMD, and severel...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2018.08.047

    authors： Xu B,Magli A,Anugrah Y,Koester SJ,Perlingeiro RCR,Shen W

    更新日期：2018-11-01 00:00:00

  • Surfactant functionalization induces robust, differential adhesion of tumor cells and blood cells to charged nanotube-coated biomaterials under flow.

    abstract：:The metastatic spread of cancer cells from the primary tumor to distant sites leads to a poor prognosis in cancers originating from multiple organs. Increasing evidence has linked selectin-based adhesion between circulating tumor cells (CTCs) and endothelial cells of the microvasculature to metastatic dissemination, i...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2015.03.045

    authors： Mitchell MJ,Castellanos CA,King MR

    更新日期：2015-07-01 00:00:00

  • Antiviral peptide nanocomplexes as a potential therapeutic modality for HIV/HCV co-infection.

    abstract：:It is estimated that 4 to 5 million people are currently co-infected with Human Immunodeficiency Virus (HIV) and Hepatitis C Virus (HCV). HIV/HCV co-infection is associated with unique health risks including increased hepatotoxicity of antiretrovirals, accelerated progression of HCV and liver diseases. The standard in...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2013.01.026

    authors： Zhang J,Mulvenon A,Makarov E,Wagoner J,Knibbe J,Kim JO,Osna N,Bronich TK,Poluektova LY

    更新日期：2013-05-01 00:00:00

  • Novel bilayer wound dressing composed of silicone rubber with particular micropores enhanced wound re-epithelialization and contraction.

    abstract：:Wound dressing is critical important for cutaneous wound healing. However, the application of current products is limited due to poor mechanical property, unsuitable water vapor transmission rate (WVTR), poor anti-infective property or poor biocompatibility, etc. In the present study, a microporous silicone rubber mem...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2014.10.077

    authors： Xu R,Luo G,Xia H,He W,Zhao J,Liu B,Tan J,Zhou J,Liu D,Wang Y,Yao Z,Zhan R,Yang S,Wu J

    更新日期：2015-02-01 00:00:00

  • A recombinant slow-release PACAP-derived peptide alleviates diabetes by promoting both insulin secretion and actions.

    abstract：:Pituitary adenylate cyclase activating polypeptide (PACAP) is a neuroendocrine factor that activates both the receptor VPAC1 and VPAC2. Although PACAP possesses insulinotropic activity, its therapeutic application is limited by the extremely short acting half-life and the stimulatory effects on glucagon production via...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2015.01.064

    authors： Ma Y,Fang S,Zhao S,Wang X,Wang D,Ma M,Luo T,Hong A

    更新日期：2015-05-01 00:00:00

  • Preparation, characterization, and performance of magnetic iron-carbon composite microparticles for chemotherapy.

    abstract：:Magnetic microcarrier particles useful for delivering chemotherapeutic drug molecules are described. The particles are formed by joint deformation of iron and carbon in a ball mill. Physical, chemical, and functional characterization has been carried out on the particles. Physical characteristics include microscopy, p...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/s0142-9612(00)00006-5

    authors： Rudge SR,Kurtz TL,Vessely CR,Catterall LG,Williamson DL

    更新日期：2000-07-01 00:00:00

  • Mechanical properties, drug eluting characteristics and in vivo performance of a genipin-crosslinked chitosan polymeric stent.

    abstract：:A limitation with the use of polymers as stent matrices is their inherent mechanical weakness. In this study, a polymeric stent, made from chitosan-based films fixed by genipin which has a cyclic molecular structure, was developed (the genipin stent). The mechanical properties of the genipin stent were investigated; i...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2009.06.039

    authors： Chen MC,Liu CT,Tsai HW,Lai WY,Chang Y,Sung HW

    更新日期：2009-10-01 00:00:00

  • Smooth muscle-like tissues engineered with bone marrow stromal cells.

    abstract：:Bone marrow-derived cells have demonstrated the ability to differentiate into multiple mesenchymal cell lineages. Here we tested whether smooth muscle (SM)-like tissues can be created in vivo with bone marrow stromal cells (BMSCs). Cultured canine BMSCs, which expressed SM cell-specific markers including SM alpha-acti...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2003.09.068

    authors： Cho SW,Kim IK,Lim SH,Kim DI,Kang SW,Kim SH,Kim YH,Lee EY,Choi CY,Kim BS

    更新日期：2004-07-01 00:00:00