Ectopic osteoinduction and early degradation of recombinant human bone morphogenetic protein-2-loaded porous beta-tricalcium phosphate in mice.

abstract：:A rapid and simple in vitro method is described which measures the extent of unrecoiled solids compression when a complex biopolymer is subjected to a centrifugal force. This method, termed the compaction assay, was used to assess the response of purulent cystic fibrosis (CF) sputum samples to the addition of recombin...

journal_title：Biomaterials

authors： Daugherty AL,Patapoff TW,Clark RC,Sinicropi DV,Mrsny RJ

更新日期：1995-05-01 00:00:00

abstract：:Duchenne Muscular Dystrophy (DMD) is a fatal genetic disorder currently having no cure. Here we report that culture substrates patterned with nanogrooves and functionalized with Matrigel (or laminin) present an engineered cell microenvironment to allow myotubes derived from non-diseased, less-affected DMD, and severel...

journal_title：Biomaterials

authors： Xu B,Magli A,Anugrah Y,Koester SJ,Perlingeiro RCR,Shen W

更新日期：2018-11-01 00:00:00

abstract：:Procoagulant (activated) platelets provide a site for assembly of the prothrombinase complex which can rapidly convert prothrombin into thrombin (a potent inducer of clot formation). Previously, we reported that adhesion of platelets to surfaces preadsorbed with blood plasma caused them to become procoagulant. In the ...

journal_title：Biomaterials

authors： Grunkemeier JM,Tsai WB,McFarland CD,Horbett TA

更新日期：2000-11-01 00:00:00

abstract：:Poly(ortho esters) with a low glass transition temperature are semi-solid materials so that therapeutic agents can be incorporated at room temperature, without the use of solvents, by a simple mixing procedure. When molecular weights are limited to < 5 kDa, such materials are directly injectable using a needle size no...

journal_title：Biomaterials

authors： Helle J,Barr J,Ng SY,Shen HR,Schwach-Abdellaoui K,Gurny R,Vivien-Castioni N,Loup PJ,Baehni P,Mombelli A

更新日期：2002-11-01 00:00:00

abstract：:Remarkable water-stimulated shape memory effect was revealed in a natural biopolymer of peacock's tail covert feathers of which the innate shape can almost be fully recovered after severe deformation by a short hydration step. The shape memory effect manifests a good stability of high recovery rate and ratio during cy...

journal_title：Biomaterials

authors： Liu ZQ,Jiao D,Zhang ZF

更新日期：2015-10-01 00:00:00

abstract：:Focal infections that are caused by antibiotic-resistant bacteria are becoming an ever-growing challenge to human health. To address this challenge, a pH-responsive amphiphilic polymer of polyaniline-conjugated glycol chitosan (PANI-GCS) that can self-assemble into nanoparticles (NPs) in situ is developed. The PANI-GC...

journal_title：Biomaterials

authors： Korupalli C,Huang CC,Lin WC,Pan WY,Lin PY,Wan WL,Li MJ,Chang Y,Sung HW

更新日期：2017-02-01 00:00:00

abstract：:Biomedical alloys may release nickel ions during corrosion phenomena and, in addition to their interaction with oral tissues, these ions may also influence characteristic properties of the immune system cells. The aim of this study was to evaluate the effect of nickel chloride on the expression of functionally distinc...

journal_title：Biomaterials

authors： D'Antò V,Eckhardt A,Hiller KA,Spagnuolo G,Valletta R,Ambrosio L,Schmalz G,Schweikl H

更新日期：2009-03-01 00:00:00

abstract：:Cancer cell metabolism is quite different from normal cells. Targeting cancer metabolism and untuning the tumor metabolic machine has emerged as a promising strategy for cancer therapy. We have developed a multi-functional Re-dca conjugate (Re-dca 2) by conjugating the metabolic modulator dichloroacetate (DCA) to mito...

journal_title：Biomaterials

authors： Yang J,Cao Q,Zhang H,Hao L,Zhou D,Gan Z,Li Z,Tong YX,Ji LN,Mao ZW

更新日期：2018-09-01 00:00:00

abstract：:The aim of this study was to develop a new diagnostic and therapeutic approach for the treatment of osteoporosis. Previously, we demonstrated that intraosseous transplantation of platelet-rich plasma (PRP) treated-osteoblast-like cells into ovariectomized senescence-accelerated mice (OVX-SAMP8) prevented the developme...

journal_title：Biomaterials

authors： Liu HY,Wu AT,Tsai CY,Chou KR,Zeng R,Wang MF,Chang WC,Hwang SM,Su CH,Deng WP

更新日期：2011-10-01 00:00:00

abstract：:After surgery, the bone and soft tissues around integrated biomaterials can be adversely affected by implant-related factors acting over a period of years. However, few studies have directly addressed the effects upon the adjacent soft tissue. The present study was designed to test the biological effects of various si...

journal_title：Biomaterials

authors： Sun JS,Tsuang YH,Chang WH,Li J,Liu HC,Lin FH

更新日期：1997-05-01 00:00:00

abstract：:Elimination of leukemia stem cells (LSCs) is necessary for the destruction of malignant cell populations. Owing to the very small number of LSCs in leukemia cells, xenotransplantation studies are difficult in terms of functionally and pathophysiologically replicating clinical conditions of cell culture experiments. Th...

journal_title：Biomaterials

authors： Zhang B,Shimada Y,Kuroyanagi J,Ariyoshi M,Nomoto T,Shintou T,Umemoto N,Nishimura Y,Miyazaki T,Tanaka T

更新日期：2015-06-01 00:00:00

abstract：:The infection of an implanted prosthetic material can have serious consequences on the tissue integration of the implant and the scarring process in the host, and may even necessitate replacement of the prosthesis. This study was designed to explore the in vitro effects of Staphylococcus aureus (Sa) and Staphylococcus...

journal_title：Biomaterials

authors： Bellón JM,G-Honduvilla N,Jurado F,Carranza A,Buján J

更新日期：2001-07-01 00:00:00

abstract：:Protein therapeutics targeting inflammatory mediators have shown great promise for the treatment of autoimmunities such as rheumatoid arthritis (RA). However, a significant challenge in this area has been their low in vivo stability and consequently their severely compromised therapeutic efficacy. One such therapeutic...

journal_title：Biomaterials

authors： Pasi S,Kant R,Gupta S,Surolia A

更新日期：2015-02-01 00:00:00

abstract：:Reduced expression of autophagy regulators has been observed in pathological cartilage in humans and mice. The present study aimed to investigate the synergistic therapeutic effect of promotion of chondrocyte autophagy via exposure to sinomenium (SIN) encapsulated by chitosan microspheres (CM-SIN) and photo-crosslinke...

journal_title：Biomaterials

authors： Chen P,Xia C,Mei S,Wang J,Shan Z,Lin X,Fan S

更新日期：2016-03-01 00:00:00

abstract：:Biological surface engineering using synthetic biological materials has a great potential for advances in our understanding of complex biological phenomena. We developed a simple system to engineer biologically relevant surfaces using a combination of self-assembling oligopeptide monolayers and microcontact printing (...

journal_title：Biomaterials

authors： Zhang S,Yan L,Altman M,Lässle M,Nugent H,Frankel F,Lauffenburger DA,Whitesides GM,Rich A

更新日期：1999-07-01 00:00:00

abstract：:The major problem in skin grafting is that tissue-engineered skin grafts after their transplantation are initially entirely dependent on diffusion. Since this process is slow and inefficient, nutrients, growth factors, and oxygen will insufficiently be supplied and the regenerating graft will undergo a physiological c...

journal_title：Biomaterials

authors： Klar AS,Güven S,Biedermann T,Luginbühl J,Böttcher-Haberzeth S,Meuli-Simmen C,Meuli M,Martin I,Scherberich A,Reichmann E

更新日期：2014-06-01 00:00:00

abstract：:The release of the anti-inflammatory agent dexamethasone (DEX) from nanoparticles of poly(lactic-co-glycolic acid) (PLGA) embedded in alginate hydrogel (HG) matrices was investigated. DEX-loaded PLGA nanoparticles were prepared using a solvent evaporation technique and were characterized for size, drug loading, and in...

journal_title：Biomaterials

authors： Kim DH,Martin DC

更新日期：2006-05-01 00:00:00

abstract：:Cartilage engineering is one of the most challenging issue in regenerative medicine, due to its limited self-ability to repair. Here, we assessed engineering of cartilage tissue starting from human bone marrow (hBM) stem cells under hypoxic environment and delineated the mechanism whereby chondrogenesis could be condu...

journal_title：Biomaterials

authors： Duval E,Baugé C,Andriamanalijaona R,Bénateau H,Leclercq S,Dutoit S,Poulain L,Galéra P,Boumédiene K

更新日期：2012-09-01 00:00:00

abstract：:An ideal approach for bone tissue engineering allows for osteoconductivity, osteoinductivity, and cell transplantation. In this study, we examined coprecipitation and surface adsorption schemes with respect to their abilities to control the spatial quantity and localization of a model protein, bovine serum albumin (BS...

journal_title：Biomaterials

authors： Luong LN,Hong SI,Patel RJ,Outslay ME,Kohn DH

更新日期：2006-03-01 00:00:00

abstract：:Topographic features can modulate cell behaviours such as proliferation, migration, differentiation and apoptosis. Biochemical mechanotransduction implies the conversion of mechanical forces (e.g. changes in cell spreading and morphology from changing surface topography) into biochemical signal via biomolecules. Still...

journal_title：Biomaterials

authors： Kantawong F,Burgess KE,Jayawardena K,Hart A,Burchmore RJ,Gadegaard N,Oreffo RO,Dalby MJ

更新日期：2009-09-01 00:00:00

abstract：:In contractile tissues such as myocardium, functional properties are directly related to the cellular orientation and elongation. Thus, tissue engineering of functional cardiac patches critically depends on our understanding of the interaction between multiple guidance cues such as topographical, adhesive or electrica...

journal_title：Biomaterials

authors： Au HT,Cheng I,Chowdhury MF,Radisic M

更新日期：2007-10-01 00:00:00

abstract：:This study investigated a strategy by which antibodies are displayed to engage T cells. A peptide composite containing binding sites was characterized in vitro and explored as an injectable system in vivo. The composite consists of two amphiphilic peptides, AEAEAKAKAEAEAKAK (referred to as "EAK") and EAK appended with...

journal_title：Biomaterials

authors： Zheng Y,Wen Y,George AM,Steinbach AM,Phillips BE,Giannoukakis N,Gawalt ES,Meng WS

更新日期：2011-01-01 00:00:00

abstract：:A glass of nominal composition (wt%) 17.25 MgO-52.75 3CaO.P2O5-30 SiO2 and a glass-ceramic obtained from it showed surface modifications when immersed in an acellular medium having a composition similar to that of human blood plasma. A (Ca, P)-rich layer, with an approximate Ca/P atomic ratio of 1.7, identified as hyd...

journal_title：Biomaterials

authors： Oliveira JM,Correia RN,Fernandes MH

更新日期：1995-07-01 00:00:00

abstract：:Photodynamic therapy (PDT) is a new therapeutic approach for the palliative treatment of malignant bile duct obstruction. In this study, we designed photosensitizer-embedded self-expanding nonvascular metal stent (PDT-stent) which allows repeatable photodynamic treatment of cholangiocarcinoma without systemic injectio...

journal_title：Biomaterials

authors： Bae BC,Yang SG,Jeong S,Lee DH,Na K,Kim JM,Costamagna G,Kozarek RA,Isayama H,Deviere J,Seo DW,Nageshwar Reddy D

更新日期：2014-10-01 00:00:00

abstract：:Tropoelastin, the polypeptide monomer precursor of elastin, is covalently cross-linked to give stable elastic structures. We show here that elastic biomaterials can be generated from tropoelastin in the absence of the classically accepted cross-linking pathway. Under alkaline conditions tropoelastin proceeds through a...

journal_title：Biomaterials

authors： Mithieux SM,Tu Y,Korkmaz E,Braet F,Weiss AS

更新日期：2009-02-01 00:00:00

abstract：:In order to evaluate degradation kinetics and biocompatibility of a resorbable poly(D,L-lactic acid) (PDLLA) plug for total cemented hip prostheses, an experimental in vitro and in vivo study was carried out. Degradation rate studies were performed in Ringer solution and after in vivo plug implantation in the femoral ...

journal_title：Biomaterials

authors： Giardino R,Fini M,Aldini NN,Giavaresi G,Rocca M,Orienti L,de Lollis A,Fambri L

更新日期：1997-07-01 00:00:00

abstract：:Bacterial infection has been a threat to human health, and so early diagnosis and treatment of bacterial infection is an urgent problem that needs to be solved. In this work, a multifunctional theranostic selenium nanoplatform (Se@PEP-Ru NPs) with early imaging diagnosis and efficient treatment of bacterial infections...

journal_title：Biomaterials

authors： Huang N,Chen X,Zhu X,Xu M,Liu J

更新日期：2017-10-01 00:00:00

abstract：:In this in vitro study, the biocompatibility of acrylamide-based hydrogels such as acrylamide/crotonic and acrylamide/itaconic acid, prepared by using gamma-rays, has been investigated against some biochemical parameters of human serum. The swelling kinetics of acrylamide/crotonic and acrylamide/itaconic acid hydrogel...

journal_title：Biomaterials

authors： Karadağ E,Saraydin D,Cetinkaya S,Güven O

更新日期：1996-01-01 00:00:00

abstract：:A challenge in combating many major diseases is breaching the skin's tough outer layer (the stratum corneum (SC)) and delivering drugs and genes into the underlying abundant immunologically sensitive viable epidermal cells with safe, practical physical technologies. To achieve this effectively and accurately, design i...

journal_title：Biomaterials

authors： Kendall MA,Chong YF,Cock A

更新日期：2007-11-01 00:00:00

abstract：:Injectable scaffolds made of biodegradable biomaterials can stabilize a myocardial infarct and promote cardiac repair. Here, we describe the synthesis of a new, temperature-sensitive, aliphatic polyester hydrogel (HG) conjugated with vascular endothelial growth factor (VEGF) and evaluate its effects on cardiac recover...

journal_title：Biomaterials

authors： Wu J,Zeng F,Huang XP,Chung JC,Konecny F,Weisel RD,Li RK

更新日期：2011-01-01 00:00:00