The mechanical properties of the skin epidermis in relation to targeted gene and drug delivery.

abstract：:Polymerized high internal phase emulsion (polyHIPE) foams are extremely versatile materials for investigating cell-substrate interactions in vitro. Foam morphologies can be controlled by polymerization conditions to result in either open or closed pore structures with different levels of connectivity, consequently ena...

journal_title：Biomaterials

authors： Viswanathan P,Ondeck MG,Chirasatitsin S,Ngamkham K,Reilly GC,Engler AJ,Battaglia G

更新日期：2015-06-01 00:00:00

abstract：:The necessity of information about the inner microscopical features of low absorbing materials is one of the most important goals in the structural research field. So far, non destructive analysis have been performed using contact radiography giving the scope for great advances in the production and application of new...

journal_title：Biomaterials

authors： Baruchel J,Lodini A,Romanzetti S,Rustichelli F,Scrivani A

更新日期：2001-06-01 00:00:00

abstract：:In this study, modifications of glass ionomer cements (GICs) were made by adding bioactive glass (BAG) to GIC to obtain bioactive restorative materials. This study used SEM, EDS and visual analysis to examine the bioactivity and the ability of the study materials to mineralize dentin. Conventional cure and resin-modif...

journal_title：Biomaterials

authors： Yli-Urpo H,Närhi M,Närhi T

更新日期：2005-10-01 00:00:00

abstract：:High-throughput screening techniques for cellular response are often unable to account for several factors present in the in vivo environment, many of which have been shown to modulate cellular response to the screened parameter. Culture in three-dimensional biomaterials and active mechanical stimulation are two such ...

journal_title：Biomaterials

authors： Moraes C,Wang G,Sun Y,Simmons CA

更新日期：2010-01-01 00:00:00

abstract：:Antigen-specific treatments are highly desirable for autoimmune diseases in contrast to treatments which induce systemic immunosuppression. A novel antigen-specific therapy has been developed which, when administered semi-therapeutically, is highly efficacious in the treatment of the mouse model for multiple sclerosis...

journal_title：Biomaterials

authors： Cho JJ,Stewart JM,Drashansky TT,Brusko MA,Zuniga AN,Lorentsen KJ,Keselowsky BG,Avram D

更新日期：2017-10-01 00:00:00

abstract：:Lung fibrosis is a poor prognostic factor for pulmonary adenocarcinoma, and the effect of a rigid microenvironment on cancer behavior is unclear. We cultured A549 cells on matrices of 0.2, 2, and 25 kPa to mimic the rigidities of normal lung parenchyma, progressive fibrotic change, and lung fibrosis, respectively. Lun...

journal_title：Biomaterials

authors： Chang CC,Hsieh TL,Tiong TY,Hsiao CH,Ji AT,Hsu WT,Lee OK,Ho JH

更新日期：2015-08-01 00:00:00

abstract：:The interactions between alginate and polycations have been studied by using different labelling techniques. Binding of poly-L-lysine (PLL) to alginate in the gel state is mainly governed by the amount of dissociable negative charges on the bead surface. PLL was found to bind more rapidly to gel beads made from algina...

journal_title：Biomaterials

authors： Thu B,Bruheim P,Espevik T,Smidsrød O,Soon-Shiong P,Skjåk-Braek G

更新日期：1996-05-01 00:00:00

abstract：:The magnetic resonance (MR) functionalities of pullulan-conjugated gadolinium diethylene triamine pentaacetate (Gd-DTPA-Pullulan) as a new hepatocyte-specific contrast agent were evaluated. Pullulan, which specifically accumulates on hepatocytes via asialoglycoprotein receptors, was chemically linked with Gd-DTPA. Gd-...

journal_title：Biomaterials

authors： Yim H,Yang SG,Jeon YS,Park IS,Kim M,Lee DH,Bae YH,Na K

更新日期：2011-08-01 00:00:00

abstract：:In vitro protein adsorption, platelet adhesion and activation on new hydrogel surfaces, composed of poly(ethylene oxide) (PEO) and poly(tetramethylene oxide) (PTMO) or poly(dimethyl siloxane) (PDMS), were investigated. By varying PEO length (MW = 2000 or 3400), hydrophobic components (PTMO or PDMS) or polymer topology...

journal_title：Biomaterials

authors： Park JH,Bae YH

更新日期：2002-04-01 00:00:00

abstract：:The ability to manipulate and control the surface properties, without altering the substrate properties, is of crucial importance in the designing of biomedical materials. In this work, surface-initiated atom transfer radical polymerization (ATRP) is employed to tailor the functionality of polycaprolactone (PCL) film ...

journal_title：Biomaterials

authors： Xu FJ,Wang ZH,Yang WT

更新日期：2010-04-01 00:00:00

abstract：:Nanomaterials conjugated with biomacromolecules, including viruses, have great potential for in vivo applications. Therefore, it is important to evaluate the safety of nanoparticle-conjugated macromolecule biomaterials (Nano-mbio). Although a number of studies have assessed the risks of nanoparticles and macromolecule...

journal_title：Biomaterials

authors： Wang M,Zheng Z,Meng J,Wang H,He M,Zhang F,Liu Y,Hu B,He Z,Hu Q,Wang H

更新日期：2015-09-01 00:00:00

abstract：:Liver diseases can be caused by viral infection, metabolic disorder, alcohol consumption, carcinoma or injury, chronically progressing to end-stage liver disease or rapidly resulting in acute liver failure. In either situation, liver transplantation is most often sought for life saving, which is, however, significantl...

journal_title：Biomaterials

authors： Zhang J,Zhao X,Liang L,Li J,Demirci U,Wang S

更新日期：2018-03-01 00:00:00

abstract：:A biodegradable microvessel scaffold comprised of distinct parenchymal and vascular compartments separated by a permeable membrane interface was conceptualized, fabricated, cellularized, and implanted. The device was designed with perfusable microfluidic channels on the order of 100 μm to mimic small blood vessels, an...

journal_title：Biomaterials

authors： Ye X,Lu L,Kolewe ME,Park H,Larson BL,Kim ES,Freed LE

更新日期：2013-12-01 00:00:00

abstract：:A UV-hardening lacquer material based on polyurethane, used in Philips compact disc lens systems, was tested as suitable material for low-cost intraocular lenses (IOLs). A slightly changed composition (code number I-0.5A) came out as the best and was subsequently tested, with reference to poly(methyl methacrylate) (PM...

journal_title：Biomaterials

authors： Jongebloed WL,van der Veen G,Kalicharan D,van Andel MV,Bartman G,Worst JG

更新日期：1994-08-01 00:00:00

abstract：:Cell movement on adhesive surfaces is a complicated process based on myriad cell-surface interactions. Although both micron and nanoscale surface topography have been known to be important in understanding cell-materials interactions, typically only simple patterns (e.g., parallel lines or aligned posts) have been use...

journal_title：Biomaterials

authors： Jeon H,Hidai H,Hwang DJ,Healy KE,Grigoropoulos CP

更新日期：2010-05-01 00:00:00

abstract：:Nanocomposite of hydroxyapatite (HAP) surface-grafted with poly(l-lactide) (PLLA) (g-HAP) shows a wide application for bone fixation materials due to its improved interface compatibility, mechanical property and biocompatibility in our previous study. In this paper, a 3-D porous scaffold of g-HAP/poly(lactide-co-glyco...

journal_title：Biomaterials

authors： Zhang P,Hong Z,Yu T,Chen X,Jing X

更新日期：2009-01-01 00:00:00

abstract：:Procoagulant (activated) platelets provide a site for assembly of the prothrombinase complex which can rapidly convert prothrombin into thrombin (a potent inducer of clot formation). Previously, we reported that adhesion of platelets to surfaces preadsorbed with blood plasma caused them to become procoagulant. In the ...

journal_title：Biomaterials

authors： Grunkemeier JM,Tsai WB,McFarland CD,Horbett TA

更新日期：2000-11-01 00:00:00

abstract：:Liposome is one of the most commonly used drug delivery systems in the world, due to its excellent biocompatibility, satisfactory ability in controlling drug release, and passive targeting capability. However, some drawbacks limit the application of liposomes in clinical, such as problems in transporting, storing, and...

journal_title：Biomaterials

authors： Cheng R,Liu L,Xiang Y,Lu Y,Deng L,Zhang H,Santos HA,Cui W

更新日期：2020-02-01 00:00:00

abstract：:Films of polyoxyethylene network were prepared from two types of triethoxysilane-terminated prepolymers. In this way, films of polyoxyethylene network with possible applications in the biomedical field could be made easier. To test their biocompatibility, these networks were added to organ cultures of adult human skin...

journal_title：Biomaterials

authors： Beele H,Thierens H,Deveux R,Goethals E,de Ridder L

更新日期：1992-01-01 00:00:00

abstract：:Achieving remote and reversible control of bacterial cell-cell interactions associated with interference with pathological processes in living systems remains a challenge owing to the complexity of the in vivo microenvironment and the lack of regulation systems. We present, for the first time, the development of a ver...

journal_title：Biomaterials

authors： Li W,Dong K,Wang H,Zhang P,Sang Y,Ren J,Qu X

更新日期：2019-10-01 00:00:00

abstract：:Tissue engineering in vitro and in vivo involves the interaction of cells with a material surface. The nature of the surface can directly influence cellular response, ultimately affecting the rate and quality of new tissue formation. Initial events at the surface include the orientated adsorption of molecules from the...

journal_title：Biomaterials

authors： Boyan BD,Hummert TW,Dean DD,Schwartz Z

更新日期：1996-01-01 00:00:00

abstract：:A surface functionalization strategy that produces substrates with well-controlled ligand density is critical to investigating the role of cell-substrate interactions in regulating cell adhesion, viability, migration, proliferation and differentiation. Towards this end, we have designed and synthesized a triblock prot...

journal_title：Biomaterials

authors： Fischer SE,Liu X,Mao HQ,Harden JL

更新日期：2007-08-01 00:00:00

abstract：:The first calcium phosphate cements (CPCs) were discovered in the 1980s. Two decades later, the interest for these materials is still rising. The goal of the present document is to review the most recent achievements in the field and to analyze future directions in research and development. ...

journal_title：Biomaterials

authors： Bohner M,Gbureck U,Barralet JE

更新日期：2005-11-01 00:00:00

abstract：:Magnesium (Mg), a potential biodegradable material, has recently received increasing attention due to its unique antibacterial property. However, rapid corrosion in the physiological environment and potential toxicity limit clinical applications. In order to improve the corrosion resistance meanwhile not compromise th...

journal_title：Biomaterials

authors： Qin H,Zhao Y,An Z,Cheng M,Wang Q,Cheng T,Wang Q,Wang J,Jiang Y,Zhang X,Yuan G

更新日期：2015-06-01 00:00:00

abstract：:Five Garren-Edwards Gastric Bubbles were characterized, following up to 4 months use in vivo, using size exclusion chromatography, differential scanning calorimetry and attenuated total reflectance infrared spectroscopy. These techniques show that the material used to construct the bubble is probably an aromatic polye...

journal_title：Biomaterials

authors： Dillon JG,Hughes MK

更新日期：1992-01-01 00:00:00

abstract：:Human (h) pluripotent stem cells (PSC) such as embryonic stem cells (ESC) can be directed into cardiomyocytes (CMs), representing a potential unlimited cell source for disease modeling, cardiotoxicity screening and myocardial repair. Although the electrophysiology of single hESC-CMs is now better defined, their multi-...

journal_title：Biomaterials

authors： Wang J,Chen A,Lieu DK,Karakikes I,Chen G,Keung W,Chan CW,Hajjar RJ,Costa KD,Khine M,Li RA

更新日期：2013-11-01 00:00:00

abstract：:Islet transplantation is a method for the treatment of type 1 diabetes mellitus (DM) and has been widely performed around the world. The long-term cryopreservation of islets shows many advantages in the field of islet transplantation. Previous studies have described the development of sheet-type polyvinyl alcohol (PVA...

journal_title：Biomaterials

authors： Qi Z,Shen Y,Yanai G,Yang K,Shirouzu Y,Hiura A,Sumi S

更新日期：2010-05-01 00:00:00

abstract：:Enterococcus faecalis is an opportunistic pathogen, which today represents one of the leading aetiologic agents of nosocomial infections and, increasingly, of implant infections. Here, in a collection of 43 E. faecalis isolated from implant orthopaedic infections, virulence-related phenotypes (biofilm and gelatinase p...

journal_title：Biomaterials

authors： Arciola CR,Baldassarri L,Campoccia D,Creti R,Pirini V,Huebner J,Montanaro L

更新日期：2008-02-01 00:00:00

abstract：:Ectopic transplantation of islets provides a beta cell-replacement approach that may allow the recovery of physiological regulation of the blood sugar level in patients with Type I diabetes (T1D). In development of new extrahepatic islet transplantation protocols in support of the islet engraftment, it is pivotal to d...

journal_title：Biomaterials

authors： Wang X,Wang K,Zhang W,Qiang M,Luo Y

更新日期：2017-09-01 00:00:00

abstract：:Hydroxylated and methylated surfaces were prepared by the self-assembled monolayer technique (SAM) of alkane thiols on gold. The surfaces were used to evaluate the influence of implant surface chemistry on protein deposition and inflammatory cell response. Implants were inserted subcutaneously in the rat for 3 and 24 ...

journal_title：Biomaterials

authors： Källtorp M,Oblogina S,Jacobsson S,Karlsson A,Tengvall P,Thomsen P

更新日期：1999-11-01 00:00:00