Skin organ culture model to test the toxicity of polyoxyethylene networks.

Abstract:

:Films of polyoxyethylene network were prepared from two types of triethoxysilane-terminated prepolymers. In this way, films of polyoxyethylene network with possible applications in the biomedical field could be made easier. To test their biocompatibility, these networks were added to organ cultures of adult human skin and embryonic chicken skin. A rapid toxic effect was observed, especially with the urethane-linked network. Enzymatical degradation of the network by enzymes in the culture medium might be responsible for the formation of toxic metabolites. Testing of related chemical compounds in our in vitro assay suggested that the formation of a silane group with an amino terminal is most likely to be responsible for the toxic effects observed.

journal_name

Biomaterials

journal_title

Biomaterials

authors

Beele H,Thierens H,Deveux R,Goethals E,de Ridder L

doi

10.1016/0142-9612(92)90155-h

keywords:

subject

Has Abstract

pub_date

1992-01-01 00:00:00

pages

1031-7

issue

14

eissn

0142-9612

issn

1878-5905

pii

0142-9612(92)90155-H

journal_volume

13

pub_type

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