Role of material surfaces in regulating bone and cartilage cell response.


:Tissue engineering in vitro and in vivo involves the interaction of cells with a material surface. The nature of the surface can directly influence cellular response, ultimately affecting the rate and quality of new tissue formation. Initial events at the surface include the orientated adsorption of molecules from the surrounding fluid, creating a conditioned interface to which the cell responds. The gross morphology, as well as the microtopography and chemistry of the surface, determine which molecules can adsorb and how cells will attach and align themselves. The focal attachments made by the cells with their substrate determine cell shape which, when transduced via the cytoskeleton to the nucleus, result in expression of specific phenotypes. Osteoblasts and chondrocytes are sensitive to subtle differences in surface roughness and surface chemistry. Studies comparing chondrocyte response to TiO2 of differing crystallinities show that cells can discriminate between surfaces at this level as well. Cellular response also depends on the local environmental and state of maturation of the responding cells. Optimizing surface structure for site-specific tissue engineering is one option; modifying surfaces with biologicals is another.






Boyan BD,Hummert TW,Dean DD,Schwartz Z




Has Abstract


1996-01-01 00:00:00














  • pH-triggered release of manganese from MnAu nanoparticles that enables cellular neuronal differentiation without cellular toxicity.

    abstract::At high concentrations, manganese (Mn) promotes cellular neurodevelopment but causes toxicity. Here, we report that Mn ion at high concentrations can be delivered to pheochromocytoma 12 (PC12) cells using gold nanoparticles (AuNPs) to enhance cellular neurodevelopment without toxicity. Mn(2+) release from AuNPs was de...


    pub_type: 杂志文章


    authors: Bhang SH,Han J,Jang HK,Noh MK,La WG,Yi M,Kim WS,Kwon YK,Yu T,Kim BS

    更新日期:2015-07-01 00:00:00

  • Biocompatibility evaluation of sol-gel coatings for subcutaneously implantable glucose sensors.

    abstract::The objective of the current investigation is to determine the soft-tissue biocompatibility of sol-gel matrices which can be used to optimize the properties of implantable glucose sensors. The biocompatibility of sol-gel matrices with heparin, dextran sulphate, Nafion, polyethylene glycol, and polystyrene sulphonate w...


    pub_type: 杂志文章


    authors: Gerritsen M,Kros A,Sprakel V,Lutterman JA,Nolte RJ,Jansen JA

    更新日期:2000-01-01 00:00:00

  • Tissue plasminogen activator followed by antioxidant-loaded nanoparticle delivery promotes activation/mobilization of progenitor cells in infarcted rat brain.

    abstract::Inherent neuronal and circulating progenitor cells play important roles in facilitating neuronal and functional recovery post stroke. However, this endogenous repair process is rather limited, primarily due to unfavorable conditions in the infarcted brain involving reactive oxygen species (ROS)-mediated oxidative stre...


    pub_type: 杂志文章


    authors: Petro M,Jaffer H,Yang J,Kabu S,Morris VB,Labhasetwar V

    更新日期:2016-03-01 00:00:00

  • Therapeutic potential of nanoparticulate systems for macrophage targeting.

    abstract::The use of non-viral nanoparticulate systems for the delivery of therapeutic agents is receiving considerable attention for medical and pharmaceutical applications. This increasing interest results from the fact that these systems can be designed to meet specific physicochemical requirements, and they display low toxi...


    pub_type: 杂志文章,评审


    authors: Chellat F,Merhi Y,Moreau A,Yahia L

    更新日期:2005-12-01 00:00:00

  • Glycidyl acrylate plasma glow discharged polymers.

    abstract::A homogeneous glycidyl acrylate polymer (GAP) has been grafted on to polytetrafluoroethylene (PTFE) and polyethylene (PE) using a modified plasma glow discharge technique with glycidyl acrylate. The polymeric layer appears to be extremely stable to acidic media and to common organic solvents. The modified surface can ...


    pub_type: 杂志文章


    authors: Tanfani F,Durrani AA,Kojima M,Chapman D

    更新日期:1990-10-01 00:00:00

  • The formation of poly(ester-urea) networks in the absence of isocyanate monomers.

    abstract::The polymerization of N,N' carbonylbis (caprolactam) (CBC) and polyol in the presence of alcoholate as catalyst produced cross-linked poly(ester-urea)s via ring opening addition reaction. In contrast to conventional synthetic routes, the use of non-toxic CBC eliminates the need for toxic isocyanate-based monomers. The...


    pub_type: 杂志文章


    authors: Zimmermann J,Loontjens T,Scholtens BJ,Mülhaupt RR

    更新日期:2004-06-01 00:00:00

  • Formation of surface reaction products on bioactive glass and their effects on the expression of the osteoblastic phenotype and the deposition of mineralized extracellular matrix.

    abstract::The objective of the study was to examine the effect of alkali ion release, pH control and buffer capacity on the expression of the osteoblastic phenotype. In addition we determined the importance of modifications of the surface of porous bioactive glass (BG) on the activity of rat calvaria osteoblasts in vitro. We fo...


    pub_type: 杂志文章


    authors: el-Ghannam A,Ducheyne P,Shapiro IM

    更新日期:1997-02-01 00:00:00

  • Nanodiamonds coupled with plant bioactive metabolites: a nanotech approach for cancer therapy.

    abstract::Nanodiamond application in biotechnological and medical fields is nowadays in continuous progress. In fact, biocompatibility, reduced dimensions and high surface chemical interaction are specific features that make nanodiamonds perfect intracellular carriers of bioactive compounds. By confocal microscopy, we confirmed...


    pub_type: 杂志文章


    authors: Gismondi A,Reina G,Orlanducci S,Mizzoni F,Gay S,Terranova ML,Canini A

    更新日期:2015-01-01 00:00:00

  • BMP-2 plasmid loaded PLGA/HAp composite scaffolds for treatment of bone defects in nude mice.

    abstract::We studied three different types of scaffolds, encapsulating bone morphogenetic protein-2 (BMP-2) plasmid, in terms of their performances in bone regeneration in nude mice. The plasmid was loaded into fibrous matrices in three different ways: coating of naked DNA (Group A) or DNA/chitosan nanoparticles (Group B) onto ...


    pub_type: 杂志文章


    authors: Nie H,Ho ML,Wang CK,Wang CH,Fu YC

    更新日期:2009-02-01 00:00:00

  • Bone-like apatite-forming ability and mechanical properties of poly(epsilon-caprolactone)/silica hybrid as a function of poly(epsilon-caprolactone) content.

    abstract::Effect of poly(epsilon-caprolactone) (PCL) content on the bioactivity and mechanical properties of PCL/silica hybrid was investigated. The PCL/silica hybrids with different PCL contents were prepared through co-condensation reaction with triethoxysilane end capped PCL and tetraethyl orthosilicate. The higher the PCL c...


    pub_type: 杂志文章


    authors: Rhee SH

    更新日期:2004-03-01 00:00:00

  • Rare-earth-incorporated polymeric vector for enhanced gene delivery.

    abstract::Cationic polymer PEI-CyD is doped with Nd by plasma technology to produce the gene vector: Nd@PEI-CyD. Luciferase expression and EGFP transfection experiments performed in vitro reveal that Nd@PEI-CyD has significantly higher transfection efficiency than lipofectamine 2000 and PEI-CyD and the mechanism is studied and ...


    pub_type: 杂志文章


    authors: Wang Q,Jin W,Wu G,Zhao Y,Jin X,Hu X,Zhou J,Tang G,Chu PK

    更新日期:2014-01-01 00:00:00

  • Synthesis of polylactides with different molecular weights.

    abstract::The synthesis of poly(lactic acid) through polycondensation of the lactic acid monomer gave weight average molecular weights (Mw) lower than 1.6 x 10(4), whereas ring-opening polymerization of lactides in bulk at 130 degrees C for 72 h using stannous octoate as catalyst in the concentration range from 0.003 to 0.8 wt%...


    pub_type: 杂志文章


    authors: Hyon SH,Jamshidi K,Ikada Y

    更新日期:1997-11-01 00:00:00

  • Toward carbon nanotube-based imaging agents for the clinic.

    abstract::Among the many applications for carbon nanotubes (CNTs), their use in medicine has drawn special attention due to their potential for a variety of therapeutic and diagnostic applications. As progress toward clinical applications continues, monitoring CNTs in vivo will be essential to evaluate their biodistribution, po...


    pub_type: 杂志文章,评审


    authors: Hernández-Rivera M,Zaibaq NG,Wilson LJ

    更新日期:2016-09-01 00:00:00

  • Design and evaluation of polypseudorotaxanes of pegylated insulin with cyclodextrins as sustained release system.

    abstract::Supramolecular assemblies have attracted a great attention, due to their intriguing topologies and their application in various fields such as nanodevices, sensors, molecular switches, and drug delivery systems. In this study, we prepared the monosubstituted insulin with poly(ethylene glycol) (PEG, MW about 2200) and ...


    pub_type: 杂志文章


    authors: Higashi T,Hirayama F,Misumi S,Arima H,Uekama K

    更新日期:2008-10-01 00:00:00

  • Parameters influencing the stealthiness of colloidal drug delivery systems.

    abstract::Over the last few decades, colloidal drug delivery systems (CDDS) such as nano-structures have been developed in order to improve the efficiency and the specificity of drug action. Their small size permits them to be injected intravenously in order to reach target tissues. However, it is known that they can be rapidly...


    pub_type: 杂志文章,评审


    authors: Vonarbourg A,Passirani C,Saulnier P,Benoit JP

    更新日期:2006-08-01 00:00:00

  • Developing mechanically robust, triazole-zwitterionic hydrogels to mitigate foreign body response (FBR) for islet encapsulation.

    abstract::Zwitterionic hydrogels such as those based on polycarboxybetaine (PCB) or polysulfobetaine (PSB) have potential for various biomedical applications, due to their biocompatibility and low biofouling properties. However, the poor mechanical properties of zwitterionic hydrogels developed to date remain a challenge, sever...


    pub_type: 杂志文章


    authors: Liu Q,Chiu A,Wang L,An D,Li W,Chen EY,Zhang Y,Pardo Y,McDonough SP,Liu L,Liu WF,Chen J,Ma M

    更新日期:2020-02-01 00:00:00

  • Effect of water-soluble phospholipid polymers conjugated with papain on the enzymatic stability.

    abstract::To maintain enzymatic activity during long-term storage by conjugation with water-soluble 2-methacryloyloxyethyl phosphorylcholine (MPC) polymers (PMPC-COOH) having various molecular weights with a carboxylic group on the terminal, such compounds were synthesized as a polymer modifier using a photoinduced living radic...


    pub_type: 杂志文章


    authors: Miyamoto D,Watanabe J,Ishihara K

    更新日期:2004-01-01 00:00:00

  • Failure of Aβ(1-40) amyloid fibrils under tensile loading.

    abstract::Amyloid fibrils and plaques are detected in the brain tissue of patients affected by Alzheimer's disease, but have also been found as part of normal physiological processes such as bacterial adhesion. Due to their highly organized structures, amyloid proteins have also been used for the development of nanomaterials, f...


    pub_type: 杂志文章


    authors: Paparcone R,Buehler MJ

    更新日期:2011-05-01 00:00:00

  • Doxorubicin-loaded glycyrrhetinic acid-modified alginate nanoparticles for liver tumor chemotherapy.

    abstract::Doxorubicin (DOX)-loaded glycyrrhetinic acid (GA)-modified alginate (ALG) nanoparticles (DOX/GA-ALG NPs) were prepared for targeting therapy of liver cancer. This study focused on the biodistribution of DOX/GA-ALG NPs in Kunming mice as well as their antitumor activity against liver tumors in situ and side effects. Th...


    pub_type: 杂志文章


    authors: Zhang C,Wang W,Liu T,Wu Y,Guo H,Wang P,Tian Q,Wang Y,Yuan Z

    更新日期:2012-03-01 00:00:00

  • Calcium phosphate coating of nickel-titanium shape-memory alloys. Coating procedure and adherence of leukocytes and platelets.

    abstract::Nickel-titanium shape-memory alloys (NiTi-SMA) were coated with calcium phosphate by dipping in oversaturated calcium phosphate solution. The layer thickness (typically 5-20 micrometer) can be varied by choice of the immersion time. The porous nature of the layer of microcrystals makes it mechanically stable enough to...


    pub_type: 杂志文章


    authors: Choi J,Bogdanski D,Köller M,Esenwein SA,Müller D,Muhr G,Epple M

    更新日期:2003-09-01 00:00:00

  • Interaction of polystyrene/poly(gamma-benzyl L-glutamate) and poly(methyl methacrylate)/poly(gamma-benzyl L-glutamate) block copolymers with plasma proteins and platelets.

    abstract::A-B-type block copolymers, consisting of polystyrene (PST) or poly(methyl methacrylate) (PMMA) forming segment (A) and poly(gamma-benzyl L-glutamate) (P[Glu(OBzl)]) segment (B), were synthesized and the thrombus formation on these block copolymer films was investigated in relation to the adsorption of plasma proteins ...


    pub_type: 杂志文章


    authors: Mori A,Ito Y,Sisido M,Imanishi Y

    更新日期:1986-09-01 00:00:00

  • The inhibition effects of insulin on BMP2-induced muscle heterotopic ossification.

    abstract::Bone morphogenetic proteins (BMPs) play an important role in regulating osteoblastic differentiation and bone formation. But the diffuse of BMPs into muscle tissues around bone injury sites often leads to heterotopic ossification, which has been regarded as one of major side-effects of BMP implementation in bone defec...


    pub_type: 杂志文章


    authors: Zhang J,Zhao Y,Hou X,Chen B,Xiao Z,Han J,Shi C,Liu J,Miao Q,Dai J

    更新日期:2014-11-01 00:00:00

  • Gene delivery to differentiated neurotypic cells with RGD and HIV Tat peptide functionalized polymeric nanoparticles.

    abstract::A number of neurodegenerative disorders may potentially be treated by the delivery of therapeutic genes to neurons. Nonviral gene delivery systems, however, typically provide low transfection efficiency in post-mitotic differentiated neurons. To uncover mechanistic reasons for this observation, we compared gene transf...


    pub_type: 杂志文章


    authors: Suk JS,Suh J,Choy K,Lai SK,Fu J,Hanes J

    更新日期:2006-10-01 00:00:00

  • Cryopreservation and CO2-independent culture of 3D cardiac progenitors for spaceflight experiments.

    abstract::Space experimentation of cardiomyocyte differentiation from human induced pluripotent stem cells offers an exciting opportunity to explore the potential of these cells for disease modeling, drug discovery and regenerative medicine. Previous studies on the International Space Station were done with 2D non-cryopreserved...


    pub_type: 杂志文章


    authors: Rampoldi A,Jha R,Fite J,Boland G,Xu C

    更新日期:2021-01-11 00:00:00

  • Preparation of poly(epsilon-caprolactone)/continuous bioglass fibre composite using monomer transfer moulding for bone implant.

    abstract::Poly(epsilon-caprolactone) (PCL)/continuous bioglass fibre composite was prepared using the monomer transfer moulding technique coupled with a surface initiated polymerisation. The bioglass fibres were surface treated with an amine ended silane in order to initiate polymerisation of epsilon-caprolactone from the fibre...


    pub_type: 杂志文章


    authors: Jiang G,Evans ME,Jones IA,Rudd CD,Scotchford CA,Walker GS

    更新日期:2005-05-01 00:00:00

  • Creating polymer hydrogel microfibres with internal alignment via electrical and mechanical stretching.

    abstract::Hydrogels have been widely used for 3-dimensional (3D) cell culture and tissue regeneration due to their tunable biochemical and physicochemical properties as well as their high water content, which resembles the aqueous microenvironment of the natural extracellular matrix. While many properties of natural hydrogel ma...


    pub_type: 杂志文章


    authors: Zhang S,Liu X,Barreto-Ortiz SF,Yu Y,Ginn BP,DeSantis NA,Hutton DL,Grayson WL,Cui FZ,Korgel BA,Gerecht S,Mao HQ

    更新日期:2014-03-01 00:00:00

  • On the mechanisms of biocompatibility.

    abstract::The manner in which a mutually acceptable co-existence of biomaterials and tissues is developed and sustained has been the focus of attention in biomaterials science for many years, and forms the foundation of the subject of biocompatibility. There are many ways in which materials and tissues can be brought into conta...


    pub_type: 杂志文章,评审


    authors: Williams DF

    更新日期:2008-07-01 00:00:00

  • Arginine-rich self-assembling peptides as potent antibacterial gels.

    abstract::Hydrogel materials that display inherent activity against bacteria can be used to directly treat accessible wounds to prevent or kill existing infection. Hydrogels composed of self-assembling β-hairpin peptides, having a high content of arginine, were found to be extremely effective at killing both gram-positive and g...


    pub_type: 杂志文章


    authors: Veiga AS,Sinthuvanich C,Gaspar D,Franquelim HG,Castanho MA,Schneider JP

    更新日期:2012-12-01 00:00:00

  • Tumor necrosis factor-inducible gene 6 reprograms hepatic stellate cells into stem-like cells, which ameliorates liver damage in mouse.

    abstract::Liver fibrosis is a major characteristic of liver disease. When the liver is damaged, quiescent hepatic stellate cells (HSCs) transdifferentiate into proliferative myofibroblastic/activated HSCs, which are the main contributors to liver fibrosis. Hence, a strategy for regulating HSC activation is important in the trea...


    pub_type: 杂志文章


    authors: Wang S,Kim J,Lee C,Oh D,Han J,Kim TJ,Kim SW,Seo YS,Oh SH,Jung Y

    更新日期:2019-10-01 00:00:00

  • Morphological features of bone healing under the effect of collagen-graft-glycosaminoglycan copolymer supplemented with the tripeptide Gly-His-Lys.

    abstract::The authors prepared 7.5% and 12.5% collagen gel, and supplemented it with the tripeptide Gly-His-Lys (GHK), perfloxacine and hypersulphated glycosaminoglycan (HSGAG). By means of 125l marking, its absorption was followed from small polyurethane sponges placed under the skin of rats. The absorption of gel without HSGA...


    pub_type: 杂志文章


    authors: Pohunková H,Stehlík J,Váchal J,Cech O,Adam M

    更新日期:1996-08-01 00:00:00