Role of material surfaces in regulating bone and cartilage cell response.


:Tissue engineering in vitro and in vivo involves the interaction of cells with a material surface. The nature of the surface can directly influence cellular response, ultimately affecting the rate and quality of new tissue formation. Initial events at the surface include the orientated adsorption of molecules from the surrounding fluid, creating a conditioned interface to which the cell responds. The gross morphology, as well as the microtopography and chemistry of the surface, determine which molecules can adsorb and how cells will attach and align themselves. The focal attachments made by the cells with their substrate determine cell shape which, when transduced via the cytoskeleton to the nucleus, result in expression of specific phenotypes. Osteoblasts and chondrocytes are sensitive to subtle differences in surface roughness and surface chemistry. Studies comparing chondrocyte response to TiO2 of differing crystallinities show that cells can discriminate between surfaces at this level as well. Cellular response also depends on the local environmental and state of maturation of the responding cells. Optimizing surface structure for site-specific tissue engineering is one option; modifying surfaces with biologicals is another.






Boyan BD,Hummert TW,Dean DD,Schwartz Z




Has Abstract


1996-01-01 00:00:00














  • Poly(glycerol-dodecanoate), a biodegradable polyester for medical devices and tissue engineering scaffolds.

    abstract::In this paper we describe the mechanical and biological features of a thermosetting polyester synthesized from glycerol and dodecanedioic acid named Poly-Glycerol-Dodecanoate (PGD). This polymer shows a glass transition temperature (T(g)) around 32 degrees C, and this accounts for its mechanical properties. At room te...


    pub_type: 杂志文章


    authors: Migneco F,Huang YC,Birla RK,Hollister SJ

    更新日期:2009-11-01 00:00:00

  • Promotion of osteoblast differentiation in 3D biomaterial micro-chip arrays comprising fibronectin-coated poly(methyl methacrylate) polycarbonate.

    abstract::Due to the architecture of solid body tissues including bone, three-dimensional (3D) in vitro microenvironments appear favorable, since herein cell growth proceeds under more physiological conditions compared to conventional 2D systems. In the present study we show that a 3D microenvironment comprising a fibronectin-c...


    pub_type: 杂志文章


    authors: Altmann B,Steinberg T,Giselbrecht S,Gottwald E,Tomakidi P,Bächle-Haas M,Kohal RJ

    更新日期:2011-12-01 00:00:00

  • Temperature sensitive contact lenses for triggered ophthalmic drug delivery.

    abstract::Ophthalmic drug delivery through eye drops is inefficient because of low corneal bioavailability and short residence time in tears. Contact lenses are ideally suited for extended and targeted drug delivery to cornea, but commercial contact lenses release ophthalmic drugs for only 1-2 h. This study focuses on dispersin...


    pub_type: 杂志文章


    authors: Jung HJ,Chauhan A

    更新日期:2012-03-01 00:00:00

  • Improving arterial prosthesis neo-endothelialization: application of a proactive VEGF construct onto PTFE surfaces.

    abstract::The formation of a confluent endothelium on expanded polytetrafluoroethylene (PTFE) vascular prostheses has never been observed. This lack of endothelialization is known to be one of the main reasons leading to the development of thromboses and/or intimal hyperplasia. In this context, several efforts were put forward ...


    pub_type: 杂志文章


    authors: Crombez M,Chevallier P,-Gaudreault RC,Petitclerc E,Mantovani D,Laroche G

    更新日期:2005-12-01 00:00:00

  • A combined hiPSC-derived endothelial cell and in vitro microfluidic platform for assessing biomaterial-based angiogenesis.

    abstract::Human induced pluripotent stem cell (hiPSC) derived angiogenesis models present a unique opportunity for patient-specific platforms to study the complex process of angiogenesis and the endothelial cell response to biomaterial and biophysical changes in a defined microenvironment. We present a refined method for differ...


    pub_type: 杂志文章


    authors: Natividad-Diaz SL,Browne S,Jha AK,Ma Z,Hossainy S,Kurokawa YK,George SC,Healy KE

    更新日期:2019-02-01 00:00:00

  • Designing hydrogel adhesives for corneal wound repair.

    abstract::Today, corneal wounds are repaired using nylon sutures. Yet there are a number of complications associated with suturing the cornea, and thus there is interest in an adhesive to replace or supplement sutures in the repair of corneal wounds. We are designing and evaluating corneal adhesives prepared from dendrimers--si...


    pub_type: 杂志文章,评审


    authors: Grinstaff MW

    更新日期:2007-12-01 00:00:00

  • Dynamic tissue engineering scaffolds with stimuli-responsive macroporosity formation.

    abstract::Macropores in tissue engineering scaffolds provide space for vascularization, cell-proliferation and cellular interactions, and is crucial for successful tissue regeneration. Modulating the size and density of macropores may promote desirable cellular processes at different stages of tissue development. Most current t...


    pub_type: 杂志文章


    authors: Han LH,Lai JH,Yu S,Yang F

    更新日期:2013-06-01 00:00:00

  • Optimized phospholipid-based nanoparticles for inner ear drug delivery and therapy.

    abstract::To develop efficient carriers for inner ear drug delivery, we prepared four kinds of phospholipid-based nanoparticles: neutral, anionic, cationic, and cationic-PEG (polyethyleneglycol) particles. PEG was used to maintain long-term particle circulation in the perilymph, avoiding non-specific binding of particles to pro...


    pub_type: 杂志文章


    authors: Yang KJ,Son J,Jung SY,Yi G,Yoo J,Kim DK,Koo H

    更新日期:2018-07-01 00:00:00

  • Microstructure and mechanical properties of hydroxyapatite ceramics with zirconia dispersion prepared by post-sintering.

    abstract::Hydroxyapatite ceramics with zirconia dispersion from fine powders synthesized hydrothermally were post-sintered at 1000-1300 degrees C under 200 MPa of argon for 1 h without capsules, after normal sintering in air at 1200 degrees C for 3 h. Densification was most significant with post-sintering at 1200 degrees C. Fra...


    pub_type: 杂志文章


    authors: Ioku K,Yoshimura M,Somiya S

    更新日期:1990-01-01 00:00:00

  • Synthetic neoglycopolymer-recombinant human collagen hybrids as biomimetic crosslinking agents in corneal tissue engineering.

    abstract::Saturated neoglycopolymers, prepared via tandem ROMP-hydrogenation (ROMP=ring-opening metathesis polymerization) of carbohydrate-functionalized norbornenes, are investigated as novel collagen crosslinking agents in corneal tissue engineering. The neoglycopolymers were incorporated into recombinant human collagen type ...


    pub_type: 杂志文章


    authors: Merrett K,Liu W,Mitra D,Camm KD,McLaughlin CR,Liu Y,Watsky MA,Li F,Griffith M,Fogg DE

    更新日期:2009-10-01 00:00:00

  • A technique for preparing protein gradients on polymeric surfaces: effects on PC12 pheochromocytoma cells.

    abstract::A technique for preparing micropatterns and gradients of proteins on polymeric substrates has been developed in this work. Peroxides were generated on the substrate surface by UV preirradiation and they initiated graft polymerization of acrylic acid (AA) onto the surface upon a second UV irradiation. Micropatterns and...


    pub_type: 杂志文章


    authors: Li B,Ma Y,Wang S,Moran PM

    更新日期:2005-05-01 00:00:00

  • Dental cell sheet biomimetic tooth bud model.

    abstract::Tissue engineering and regenerative medicine technologies offer promising therapies for both medicine and dentistry. Our long-term goal is to create functional biomimetic tooth buds for eventual tooth replacement in humans. Here, our objective was to create a biomimetic 3D tooth bud model consisting of dental epitheli...


    pub_type: 杂志文章


    authors: Monteiro N,Smith EE,Angstadt S,Zhang W,Khademhosseini A,Yelick PC

    更新日期:2016-11-01 00:00:00

  • Enhanced immunostimulatory effects of DNA-encapsulated peptide hydrogels.

    abstract::DNA that encodes tumor-specific antigens represents potential immunostimulatory agents. However, rapid enzymatic degradation and fragmentation of DNA during administration can result in limited vector expression and, consequently, poor efficacy. These challenges have necessitated the use of novel strategies for DNA de...


    pub_type: 杂志文章


    authors: Medina SH,Li S,Howard OM,Dunlap M,Trivett A,Schneider JP,Oppenheim JJ

    更新日期:2015-01-01 00:00:00

  • Lactose mediated liver-targeting effect observed by ex vivo imaging technology.

    abstract::Two kinds of micelles containing Rhodamine B were prepared by a solvent evaporation method. One (Lac-f-micelles: lactose-free micelles) was from a Rhodamine-containing copolymer, poly(ethylene glycol)-b-poly(l-lactide-co-2,2-dihydroxylmethyl-propylene carbonate/Rhodamine) [PEG(5000)-b-P(LA(4000)-co-DHP(600)/Rhodamine)...


    pub_type: 杂志文章


    authors: Ma P,Liu S,Huang Y,Chen X,Zhang L,Jing X

    更新日期:2010-03-01 00:00:00

  • Interactions between meniscal cells and a self assembled biomimetic surface composed of hyaluronic acid, chitosan and meniscal extracellular matrix molecules.

    abstract::Menisci are one of the most commonly injured parts of the knee with a limited healing potential. This study focuses on fabrication and characterization of biomimetic surfaces for meniscal tissue engineering. To achieve this, a combination of hyaluronic acid/chitosan (HA/CH) mutilayers with covalently immobilized major...


    pub_type: 杂志文章


    authors: Tan GK,Dinnes DL,Butler LN,Cooper-White JJ

    更新日期:2010-08-01 00:00:00

  • Morphological features of bone healing under the effect of collagen-graft-glycosaminoglycan copolymer supplemented with the tripeptide Gly-His-Lys.

    abstract::The authors prepared 7.5% and 12.5% collagen gel, and supplemented it with the tripeptide Gly-His-Lys (GHK), perfloxacine and hypersulphated glycosaminoglycan (HSGAG). By means of 125l marking, its absorption was followed from small polyurethane sponges placed under the skin of rats. The absorption of gel without HSGA...


    pub_type: 杂志文章


    authors: Pohunková H,Stehlík J,Váchal J,Cech O,Adam M

    更新日期:1996-08-01 00:00:00

  • HEMA/MMMA microcapsule implants in hemiparkinsonian rat brain: biocompatibility assessment using [3H]PK11195 as a marker for gliosis.

    abstract::Microencapsulation of dopamine-secreting cells in biocompatible, semi-permeable polymer membranes has been proposed as an alternative strategy for dopamine replacement for Parkinson's disease. In order to assess the viability of this proposal, dopamine-secreting PC12 cells were immunoisolated via microencapsulation in...


    pub_type: 杂志文章


    authors: Campioni EG,Nobrega JN,Sefton MV

    更新日期:1998-04-01 00:00:00

  • Mass transfer and metabolic reactions in hepatocyte spheroids cultured in rotating wall gas-permeable membrane system.

    abstract::Isolated hepatocytes in spheroid configuration exhibit a high degree of cell-cell contacts, which are important in the maintenance of viability and liver specific functions. In the absence of a vascular network, the cells in a large spheroid size experience mass transfer limitations of metabolites and oxygen in the co...


    pub_type: 杂志文章


    authors: Curcio E,Salerno S,Barbieri G,De Bartolo L,Drioli E,Bader A

    更新日期:2007-12-01 00:00:00

  • Recombinant spider silk matrices for neural stem cell cultures.

    abstract::Neural stem cells (NSCs) have the capacity to differentiate into neurons, astrocytes, and oligodendrocytes. Accordingly, NSCs hold great promise in drug screening and treatment of several common diseases. However, a major obstacle in applied stem cell research is the limitation of synthetic matrices for culturing stem...


    pub_type: 杂志文章


    authors: Lewicka M,Hermanson O,Rising AU

    更新日期:2012-11-01 00:00:00

  • In vitro and in vivo changes to PLGA/sirolimus coating on drug eluting stents.

    abstract::The degradation behavior of the absorbable coating may have significant impacts to the short and long-term safety of the drug eluting stent (DES). A poly(lactide-co-glycolide) (PLGA) polymer coating containing sirolimus on stent surface was studied when stents were expanded to 3.0 mm. In vitro and in vivo degradation ...


    pub_type: 杂志文章


    authors: Xi T,Gao R,Xu B,Chen L,Luo T,Liu J,Wei Y,Zhong S

    更新日期:2010-07-01 00:00:00

  • Dragon fruit-like biocage as an iron trapping nanoplatform for high efficiency targeted cancer multimodality imaging.

    abstract::Natural biopolymer based multifunctional nanomaterials are perfect candidates for multimodality imaging and therapeutic applications. Conventional methods of building multimodal imaging probe require either cross-linking manners to increase its in vivo stability or attach a target module to realize targeted imaging. I...


    pub_type: 杂志文章


    authors: Yang M,Fan Q,Zhang R,Cheng K,Yan J,Pan D,Ma X,Lu A,Cheng Z

    更新日期:2015-11-01 00:00:00

  • Transplantable retinal pigment epithelial cell sheets for tissue engineering.

    abstract::The native retinal pigment epithelium (RPE) exists as a monolayer structure and is critically involved in the maintenance of photoreceptors. Damage or destruction of the RPE due to a variety of diseases therefore often results in loss of vision. With regenerative purposes in mind, we have examined various culture cond...


    pub_type: 杂志文章


    authors: Kubota A,Nishida K,Yamato M,Yang J,Kikuchi A,Okano T,Tano Y

    更新日期:2006-07-01 00:00:00

  • Transdermal immunization with low-pressure-gene-gun mediated chitosan-based DNA vaccines against Japanese encephalitis virus.

    abstract::DNA vaccine is a milestone in contemporary vaccine development. It has considerably offset many shortcomings in conventional vaccines. Although DNA vaccines applied through 'traditional' high-pressure gene guns generally elicit high titers of protective immunity, such a practice however requires enormous investment in...


    pub_type: 杂志文章


    authors: Huang HN,Li TL,Chan YL,Chen CL,Wu CJ

    更新日期:2009-10-01 00:00:00

  • The use of biotinylated-EGF-modified gelatin nanoparticle carrier to enhance cisplatin accumulation in cancerous lungs via inhalation.

    abstract::To develop a polymer-anticancer drug conjugate, we employed gelatin nanoparticles (GPs) as carriers of cisplatin (CDDP) with anticipated improved therapeutic effect and reduced side effects. The anticancer activities of CDDP-incorporated in GPs (GP-Pt) with biotinylated-EGF (bEGF) modification (GP-Pt-bEGF) were studie...


    pub_type: 杂志文章


    authors: Tseng CL,Su WY,Yen KC,Yang KC,Lin FH

    更新日期:2009-07-01 00:00:00

  • Histological reaction to titanium alloy and hydroxyapatite particles in the rabbit tibia.

    abstract::The interfacial membrane harvested from failed joint replacements contains particulate debris from the materials used for the implant. To define the tissue response to particulate titanium alloy and hydroxyapatite (HA) alone, 16 mature New Zealand white rabbits were divided into 2 groups of 8 rabbits. Using sterile te...


    pub_type: 杂志文章


    authors: Goodman SB,Davidson JA,Fornasier VL

    更新日期:1993-08-01 00:00:00

  • Compound changes and tooth mineralization effects of glass ionomer cements containing bioactive glass (S53P4), an in vivo study.

    abstract::In this study, modifications of glass ionomer cements (GICs) were made by adding bioactive glass (BAG) to GIC to obtain bioactive restorative materials. This study used SEM, EDS and visual analysis to examine the bioactivity and the ability of the study materials to mineralize dentin. Conventional cure and resin-modif...


    pub_type: 杂志文章


    authors: Yli-Urpo H,Närhi M,Närhi T

    更新日期:2005-10-01 00:00:00

  • Potent anti-viral vaccine adjuvant based on pH-degradable nanogels with covalently linked small molecule imidazoquinoline TLR7/8 agonist.

    abstract::Improving the immunogenicity of subunit vaccines, in particular skewing of the immune response towards Th1 type immunity, is crucial for the development of effective vaccines against intracellular infections and for the development of anti-cancer vaccines. Small molecule TLR7/8 agonist hold high potential for this pur...


    pub_type: 杂志文章


    authors: Nuhn L,Van Hoecke L,Deswarte K,Schepens B,Li Y,Lambrecht BN,De Koker S,David SA,Saelens X,De Geest BG

    更新日期:2018-09-01 00:00:00

  • Lack of OH in nanocrystalline apatite as a function of degree of atomic order: implications for bone and biomaterials.

    abstract::Using laser Raman microprobe spectroscopy, we have characterized the degree of hydroxylation and the state of atomic order of several natural and synthetic calcium phosphate phases, including apatite of biological (human bone, heated human bone, mouse bone, human and boar dentin, and human and boar enamel), geological...


    pub_type: 杂志文章


    authors: Pasteris JD,Wopenka B,Freeman JJ,Rogers K,Valsami-Jones E,van der Houwen JA,Silva MJ

    更新日期:2004-01-01 00:00:00

  • Engineered phage-based therapeutic materials inhibit Chlamydia trachomatis intracellular infection.

    abstract::Developing materials that are effective against sexually transmitted pathogens such as Chlamydia trachomatis (Ct) and HIV-1 is challenging both in terms of material selection and improving bio-membrane and cellular permeability at desired mucosal sites. Here, we engineered the prokaryotic bacterial virus (M13 phage) c...


    pub_type: 杂志文章


    authors: Bhattarai SR,Yoo SY,Lee SW,Dean D

    更新日期:2012-07-01 00:00:00

  • A robust strategy for preparation of sequential stimuli-responsive block copolymer prodrugs via thiolactone chemistry to overcome multiple anticancer drug delivery barriers.

    abstract::Block copolymer prodrugs (BCPs) have attracted considerable attentions in clinical translation of nanomedicine owing to their self-assembly into well-defined core-shell nanoparticles for improved pharmacokinetics, stability in blood circulation without drug leakage, and optimized biodistribution. However, a cascade of...


    pub_type: 杂志文章


    authors: Ke W,Yin W,Zha Z,Mukerabigwi JF,Chen W,Wang Y,He C,Ge Z

    更新日期:2018-02-01 00:00:00