Less is more: Silver-AIE core@shell nanoparticles for multimodality cancer imaging and synergistic therapy.

Abstract:

:Nanomaterials with integrated multiple imaging and therapeutic modalities possess great potentials in accurate cancer diagnostics and enhanced therapeutic efficacy. Traditional strategies for achieving multimodality nanoplatform through one by one combination of different modalities are challenged by the complicated structural design and fabrication as well as inherent incompatibility between different modalities. Herein, a novel strategy is presented to realize multimodal imaging and synergistic therapy using a class of simple silver core/AIE (aggregation-induced emission) shell nanoparticles. In addition to the intrinsic AIE fluorescence (FL) and metal-based computed tomography (CT) and radiation therapy (RT) properties, an extra functionality at the core/shell interface was identified to enable excellent photothermal (PT) and photoacoustic (PA) performance. As a result, five imaging and therapy modalities (FL, CT, PA, photothermal therapy (PTT), and RT) were achieved with a single structural unit for sensitive tumor imaging and effective therapy.

journal_name

Biomaterials

journal_title

Biomaterials

authors

He X,Peng C,Qiang S,Xiong LH,Zhao Z,Wang Z,Kwok RTK,Lam JWY,Ma N,Tang BZ

doi

10.1016/j.biomaterials.2020.119834

subject

Has Abstract

pub_date

2020-04-01 00:00:00

pages

119834

eissn

0142-9612

issn

1878-5905

pii

S0142-9612(20)30080-6

journal_volume

238

pub_type

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