Less is more: Silver-AIE core@shell nanoparticles for multimodality cancer imaging and synergistic therapy.


:Nanomaterials with integrated multiple imaging and therapeutic modalities possess great potentials in accurate cancer diagnostics and enhanced therapeutic efficacy. Traditional strategies for achieving multimodality nanoplatform through one by one combination of different modalities are challenged by the complicated structural design and fabrication as well as inherent incompatibility between different modalities. Herein, a novel strategy is presented to realize multimodal imaging and synergistic therapy using a class of simple silver core/AIE (aggregation-induced emission) shell nanoparticles. In addition to the intrinsic AIE fluorescence (FL) and metal-based computed tomography (CT) and radiation therapy (RT) properties, an extra functionality at the core/shell interface was identified to enable excellent photothermal (PT) and photoacoustic (PA) performance. As a result, five imaging and therapy modalities (FL, CT, PA, photothermal therapy (PTT), and RT) were achieved with a single structural unit for sensitive tumor imaging and effective therapy.






He X,Peng C,Qiang S,Xiong LH,Zhao Z,Wang Z,Kwok RTK,Lam JWY,Ma N,Tang BZ




Has Abstract


2020-04-01 00:00:00












  • Cell surface characteristics of microbiological isolates from human percutaneous titanium implants in the head and neck.

    abstract::Percutaneous implants are commonly associated with several problems, and different failure modes have been described. Infections constitute one serious complication which may lead to the removal of the implant. In contrast to infections around polymer implants, infections around skin-penetrating titanium implants anch...


    pub_type: 杂志文章


    authors: Holgers KM,Ljungh A

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  • Tissue engineered bone mimetics to study bone disorders ex vivo: Role of bioinspired materials.

    abstract::Recent advances in materials development and tissue engineering has resulted in a substantial number of bioinspired materials that recapitulate cardinal features of bone extracellular matrix (ECM) such as dynamic inorganic and organic environment(s), hierarchical organization, and topographical features. Bone mimickin...


    pub_type: 杂志文章,评审


    authors: Shih YV,Varghese S

    更新日期:2019-04-01 00:00:00

  • Degradation of poly[bis(glycine ethyl ester)phosphazene] in aqueous media.

    abstract::The degradation of poly[bis(glycine ethyl ester)phosphazene] in aqueous media was studied by following the appearance of some of its expected by-products in solution. Disc-shaped polymer slabs of 12 mm diameter and 1.2 mm thickness were prepared by compression moulding, followed by incubation in aqueous media under ca...


    pub_type: 杂志文章


    authors: Ruiz EM,Ramírez CA,Aponte MA,Barbosa-Cánovas GV

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    abstract::The non-specific interaction between nanoparticles (NPs) and plasma proteins occurs immediately after NPs enter the blood, resulting in the formation of the protein corona that thereafter replaces the original NPs and becomes what the organs and cells really see. Consequently, the in vivo fate of NPs and the biologica...


    pub_type: 杂志文章


    authors: Peng Q,Zhang S,Yang Q,Zhang T,Wei XQ,Jiang L,Zhang CL,Chen QM,Zhang ZR,Lin YF

    更新日期:2013-11-01 00:00:00

  • Differential alkaline phosphatase responses of rat and human bone marrow derived mesenchymal stem cells to 45S5 bioactive glass.

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    pub_type: 杂志文章


    authors: Reilly GC,Radin S,Chen AT,Ducheyne P

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  • Composite core-and-skirt collagen hydrogels with differential degradation for corneal therapeutic applications.

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    pub_type: 杂志文章


    authors: Rafat M,Xeroudaki M,Koulikovska M,Sherrell P,Groth F,Fagerholm P,Lagali N

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  • A recombinant slow-release PACAP-derived peptide alleviates diabetes by promoting both insulin secretion and actions.

    abstract::Pituitary adenylate cyclase activating polypeptide (PACAP) is a neuroendocrine factor that activates both the receptor VPAC1 and VPAC2. Although PACAP possesses insulinotropic activity, its therapeutic application is limited by the extremely short acting half-life and the stimulatory effects on glucagon production via...


    pub_type: 杂志文章


    authors: Ma Y,Fang S,Zhao S,Wang X,Wang D,Ma M,Luo T,Hong A

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  • Light initiation of dental resins: dynamics of the polymerization.

    abstract::Literature has shown that slowing down the curing rate of light-initiated resin composites by lowering the light intensity of the light source improved the integrity of the adhesive composite-cavity interface as a result of a more gradual contraction stress development. This study investigated how the curing rate coul...


    pub_type: 杂志文章


    authors: Venhoven BA,de Gee AJ,Davidson CL

    更新日期:1996-12-01 00:00:00

  • Exosomes as biomimetic tools for stem cell differentiation: Applications in dental pulp tissue regeneration.

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    pub_type: 杂志文章


    authors: Huang CC,Narayanan R,Alapati S,Ravindran S

    更新日期:2016-12-01 00:00:00

  • In vivo bone tissue response to a canasite glass-ceramic.

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    pub_type: 杂志文章


    authors: da Rocha Barros VM,Salata LA,Sverzut CE,Xavier SP,van Noort R,Johnson A,Hatton PV

    更新日期:2002-07-01 00:00:00

  • The effect of hydrophilic chain length and iRGD on drug delivery from poly(ε-caprolactone)-poly(N-vinylpyrrolidone) nanoparticles.

    abstract::Poly(ε-caprolactone)-b-Poly(N-vinylpyrrolidone) (PCL-b-PVP) copolymers with different PVP block length were synthesized by xanthate-mediated reverse addition fragment transfer polymerization (RAFT) and the xanthate chain transfer agent on chain end was readily translated to hydroxy or aldehyde for conjugating various ...


    pub_type: 杂志文章


    authors: Zhu Z,Xie C,Liu Q,Zhen X,Zheng X,Wu W,Li R,Ding Y,Jiang X,Liu B

    更新日期:2011-12-01 00:00:00

  • Comparing predictive drug nephrotoxicity biomarkers in kidney 3-D primary organoid culture and immortalized cell lines.

    abstract::The cellular microenvironment is recognized to play a key role in stabilizing cell differentiation states and phenotypes in culture. This study addresses the hypothesis that preservation of in vivo-like tissue architecture in vitro produces a cell culture more capable of responding to environmental stimuli with clinic...


    pub_type: 杂志文章


    authors: Astashkina AI,Mann BK,Prestwich GD,Grainger DW

    更新日期:2012-06-01 00:00:00

  • Toward carbon nanotube-based imaging agents for the clinic.

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    pub_type: 杂志文章,评审


    authors: Hernández-Rivera M,Zaibaq NG,Wilson LJ

    更新日期:2016-09-01 00:00:00

  • Osteoblast response to PLGA tissue engineering scaffolds with PEO modified surface chemistries and demonstration of patterned cell response.

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    pub_type: 杂志文章


    authors: Koegler WS,Griffith LG

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    pub_type: 杂志文章


    authors: Healy KE,Ducheyne P

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    pub_type: 杂志文章


    authors: Skajaa T,Cormode DP,Jarzyna PA,Delshad A,Blachford C,Barazza A,Fisher EA,Gordon RE,Fayad ZA,Mulder WJ

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    pub_type: 杂志文章


    authors: Kaur G,Valarmathi MT,Potts JD,Wang Q

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  • Folic acid conjugated nanoparticles of mixed lipid monolayer shell and biodegradable polymer core for targeted delivery of Docetaxel.

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    pub_type: 杂志文章


    authors: Liu Y,Li K,Pan J,Liu B,Feng SS

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  • 3D cell entrapment in crosslinked thiolated gelatin-poly(ethylene glycol) diacrylate hydrogels.

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    pub_type: 杂志文章


    authors: Fu Y,Xu K,Zheng X,Giacomin AJ,Mix AW,Kao WJ

    更新日期:2012-01-01 00:00:00

  • The balance between adipogenesis and osteogenesis in bone regeneration by platelet-rich plasma for age-related osteoporosis.

    abstract::The aim of this study was to develop a new diagnostic and therapeutic approach for the treatment of osteoporosis. Previously, we demonstrated that intraosseous transplantation of platelet-rich plasma (PRP) treated-osteoblast-like cells into ovariectomized senescence-accelerated mice (OVX-SAMP8) prevented the developme...


    pub_type: 杂志文章


    authors: Liu HY,Wu AT,Tsai CY,Chou KR,Zeng R,Wang MF,Chang WC,Hwang SM,Su CH,Deng WP

    更新日期:2011-10-01 00:00:00

  • Skin basement membrane and extracellular matrix proteins characterization and quantification by real time RT-PCR.

    abstract::Three-dimensional gelatin-chondroitin 6 sulphate-hyanuronic acid (gelatin-C6S-HA) biomatrices were used as the scaffold to investigate the phenotypic and molecular expression of basement membrane (BM) and extracellular matrix (ECM) proteins in vitro. The cells were cultured in three different culture conditions: kerat...


    pub_type: 杂志文章


    authors: Wang TW,Sun JS,Huang YC,Wu HC,Chen LT,Lin FH

    更新日期:2006-10-01 00:00:00

  • Tumor microenvironment sensitive doxorubicin delivery and release to glioma using angiopep-2 decorated gold nanoparticles.

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    pub_type: 杂志文章


    authors: Ruan S,Yuan M,Zhang L,Hu G,Chen J,Cun X,Zhang Q,Yang Y,He Q,Gao H

    更新日期:2015-01-01 00:00:00

  • Designing hydrogel adhesives for corneal wound repair.

    abstract::Today, corneal wounds are repaired using nylon sutures. Yet there are a number of complications associated with suturing the cornea, and thus there is interest in an adhesive to replace or supplement sutures in the repair of corneal wounds. We are designing and evaluating corneal adhesives prepared from dendrimers--si...


    pub_type: 杂志文章,评审


    authors: Grinstaff MW

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  • Effect of surface-functionalized nanoparticles on the elongation phase of beta-amyloid (1-40) fibrillogenesis.

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    pub_type: 杂志文章


    authors: Chan HM,Xiao L,Yeung KM,Ho SL,Zhao D,Chan WH,Li HW

    更新日期:2012-06-01 00:00:00

  • A biodegradable microvessel scaffold as a framework to enable vascular support of engineered tissues.

    abstract::A biodegradable microvessel scaffold comprised of distinct parenchymal and vascular compartments separated by a permeable membrane interface was conceptualized, fabricated, cellularized, and implanted. The device was designed with perfusable microfluidic channels on the order of 100 μm to mimic small blood vessels, an...


    pub_type: 杂志文章


    authors: Ye X,Lu L,Kolewe ME,Park H,Larson BL,Kim ES,Freed LE

    更新日期:2013-12-01 00:00:00

  • The response of normal human osteoblasts to anionic polysaccharide polyelectrolyte complexes.

    abstract::Polyelectrolyte complexes (PEC) were prepared from chitosan as the polycation and several synthesized functional anion polysaccharides, and their effects on cell attachment, morphology, proliferation and differentiation were estimated using normal human osteoblasts (NHOst). After a 1-week incubation, PEC made from pol...


    pub_type: 杂志文章


    authors: Nagahata M,Nakaoka R,Teramoto A,Abe K,Tsuchiya T

    更新日期:2005-09-01 00:00:00

  • Separation of non-collagenous proteins of bone formed in titanium implants: experimental study in the rabbit tibia, using a bone harvest chamber.

    abstract::The non-collagenous proteins of mature cortical rabbit bone and 3 wk old bone specimens formed in titanium implant bone harvest chambers, were separated by means of fine pressure liquid chromatography. It was found that a sufficient amount of bone could be obtained from five bone harvest chambers in five rabbits durin...


    pub_type: 杂志文章


    authors: Lundgren T,Sennerby L

    更新日期:1990-04-01 00:00:00

  • Cell behavior on protein matrices containing laminin α1 peptide AG73.

    abstract::Collagen has been widely used for tissue engineering. Here, we applied bioactive laminin-derived peptides as an additive for collagen, laminin-111, and fibronectin matrices resulting in peptide/collagen, peptide/laminin-111, and peptide/fibronectin matrices. Several syndecan-binding peptides, including AG73 (RKRLQVQLS...


    pub_type: 杂志文章


    authors: Yamada Y,Katagiri F,Hozumi K,Kikkawa Y,Nomizu M

    更新日期:2011-07-01 00:00:00

  • The effect of lactose-conjugated silk biomaterials on the development of fibrogenic fibroblasts.

    abstract::Surface properties of implanted biomaterials can cause fibrotic tissue reactions by stimulating differentiation of host fibroblasts into contractile myofibroblasts. Silk fibroin (SF) protein has been used as biomaterial in pure and blended form. however, its effect on myofibroblast differentiation remains elusive. We ...


    pub_type: 杂志文章


    authors: Acharya C,Hinz B,Kundu SC

    更新日期:2008-12-01 00:00:00

  • Dual purpose hafnium oxide nanoparticles offer imaging Streptococcus mutans dental biofilm and fight it In vivo via a drug free approach.

    abstract::The removal of tenacious dental plaque is of paramount importance; however, early diagnosis can be a challenging task in dental clinics due to the limitations of current approaches, specifically X-ray-based techniques. We have approached this problem by integrating antibacterial properties and X-ray contrast enhanceme...


    pub_type: 杂志文章


    authors: Ostadhossein F,Misra SK,Tripathi I,Kravchuk V,Vulugundam G,LoBato D,Selmic LE,Pan D

    更新日期:2018-10-01 00:00:00