Abstract：
:Nanomaterials with integrated multiple imaging and therapeutic modalities possess great potentials in accurate cancer diagnostics and enhanced therapeutic efficacy. Traditional strategies for achieving multimodality nanoplatform through one by one combination of different modalities are challenged by the complicated structural design and fabrication as well as inherent incompatibility between different modalities. Herein, a novel strategy is presented to realize multimodal imaging and synergistic therapy using a class of simple silver core/AIE (aggregation-induced emission) shell nanoparticles. In addition to the intrinsic AIE fluorescence (FL) and metal-based computed tomography (CT) and radiation therapy (RT) properties, an extra functionality at the core/shell interface was identified to enable excellent photothermal (PT) and photoacoustic (PA) performance. As a result, five imaging and therapy modalities (FL, CT, PA, photothermal therapy (PTT), and RT) were achieved with a single structural unit for sensitive tumor imaging and effective therapy.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
He X,Peng C,Qiang S,Xiong LH,Zhao Z,Wang Z,Kwok RTK,Lam JWY,Ma N,Tang BZdoi
10.1016/j.biomaterials.2020.119834subject
Has Abstractpub_date
2020-04-01 00:00:00pages
119834eissn
0142-9612issn
1878-5905pii
S0142-9612(20)30080-6journal_volume
238pub_type
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