Elaboration and evaluation of an intraoral controlled release delivering system.

abstract：:Checkpoint blocking antibodies that interfere in the PD-1/PD-L1 axis provide effective cancer immunotherapy for tumors that are immune inflamed or induced to become "hot". It has also been demonstrated that a small molecule inhibitor of the signaling hub kinase GSK3 can interfere in the PD-1/PD-L1 axis in T-cells by s...

journal_title：Biomaterials

authors： Allen SD,Liu X,Jiang J,Liao YP,Chang CH,Nel AE,Meng H

更新日期：2020-12-28 00:00:00

abstract：:High-throughput screening techniques for cellular response are often unable to account for several factors present in the in vivo environment, many of which have been shown to modulate cellular response to the screened parameter. Culture in three-dimensional biomaterials and active mechanical stimulation are two such ...

journal_title：Biomaterials

authors： Moraes C,Wang G,Sun Y,Simmons CA

更新日期：2010-01-01 00:00:00

abstract：:Immobilization of biomolecules on surfaces enables both localization and retention of molecules at the cell-biomaterial interface. Since metallic biomaterials used for orthopedic and dental implants possess a paucity of reactive functional groups, biomolecular modification of these materials is challenging. In the pre...

journal_title：Biomaterials

authors： Puleo DA,Kissling RA,Sheu MS

更新日期：2002-05-01 00:00:00

abstract：:Poly(epsilon-caprolactone) (PCL)/continuous bioglass fibre composite was prepared using the monomer transfer moulding technique coupled with a surface initiated polymerisation. The bioglass fibres were surface treated with an amine ended silane in order to initiate polymerisation of epsilon-caprolactone from the fibre...

journal_title：Biomaterials

authors： Jiang G,Evans ME,Jones IA,Rudd CD,Scotchford CA,Walker GS

更新日期：2005-05-01 00:00:00

abstract：:To prevent bone metastasis, we developed polyethylene glycol (PEG)-conjugated aspartic acid (Asp)-modified liposomes (PEG-Asp-Lipo) as a bone-targeting carrier of paclitaxel (PTX) by using Asp-modified 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine (DPPE-Asp). The affinity of Asp-modified liposomes to hydroxyapatite...

journal_title：Biomaterials

authors： Yamashita S,Katsumi H,Hibino N,Isobe Y,Yagi Y,Tanaka Y,Yamada S,Naito C,Yamamoto A

更新日期：2018-02-01 00:00:00

abstract：:Biocompatibility and tissue regenerating capacity are essential characteristics in the design of collagenous biomaterials for tissue engineering. Attachment of glycosaminoglycans (GAGs) to collagen may add to these characteristics by creating an appropriate micro-environment. In this study, porous type I collagen matr...

journal_title：Biomaterials

authors： Pieper JS,van Wachem PB,van Luyn MJA,Brouwer LA,Hafmans T,Veerkamp JH,van Kuppevelt TH

更新日期：2000-08-01 00:00:00

abstract：:Porous silica gels with high surface areas were prepared from tetraethylothosilicate and polyacrylic acid (PAA) of high molecular weight in acidic media by a sol-gel method. PAA content and ageing temperatures were varied in order to obtain different microstructures. Samples were sintered at temperatures up to 400 deg...

journal_title：Biomaterials

authors： Gallardo J,Galliano PG,Porto López JM

更新日期：2002-11-01 00:00:00

abstract：:The emergence of combinatorial chemistries and the increased discovery of natural compounds have led to the production of expansive libraries of drug candidates and vast numbers of compounds with potentially interesting biological activities. Despite broad interest in high throughput screening (HTS) across varied fiel...

journal_title：Biomaterials

authors： Wu J,Wheeldon I,Guo Y,Lu T,Du Y,Wang B,He J,Hu Y,Khademhosseini A

更新日期：2011-01-01 00:00:00

abstract：:The interest in gallium alloys as a replacement for amalgam has increased in recent years due to the risk of environmental pollution from amalgam. Alloy powders with compositions close to those for alloys of amalgam are mixed with a liquid gallium alloy. The mix is condensed into a prepared cavity in much the same way...

journal_title：Biomaterials

authors： Herø H,Simensen CJ,Jørgensen RB

更新日期：1996-07-01 00:00:00

abstract：:Arterial catheterization is one of the most frequently performed inpatient diagnostic and therapeutic procedures in the development countries. Complications may occur after any catheterization from inadequate hemostasis, particularly in the setting of aggressive anticoagulation. This study suggests that microcrystalli...

journal_title：Biomaterials

authors： Hoekstra A,Struszczyk H,Kivekäs O

更新日期：1998-08-01 00:00:00

abstract：:A novel class of multiblock poly(epsilon-caprolactone)-based polymers containing hydrophilic trioxyethylene segments and potentially relevant to the delivery of drugs is described in this work. L-phenylalanine residues may also be inserted into the hydrophilic blocks to generate peptide bonds susceptible to enzymatic ...

journal_title：Biomaterials

authors： Barbato F,La Rotonda MI,Maglio G,Palumbo R,Quaglia F

更新日期：2001-06-01 00:00:00

abstract：:The kinetics of thrombin inhibition by antithrombin (AT) and heparin cofactor II (HC II) were analysed as a function of the heparin concentration, from 10(-9) to 10(-4) M. The initial concentrations of inhibitor (l) and thrombin (E) were set at equimolar levels (CI = CE = 10(-8) M). The experimental data indicate that...

journal_title：Biomaterials

authors： Maaroufi RM,Jozefowicz M,Tapon-Bretaudière J,Fischer AM

更新日期：1997-02-01 00:00:00

abstract：:Acute and chronic wounds affect millions and are associated with billions of dollars in healthcare costs. The use of healing markers, biochemical cues from biocompatible matrices and materials, and their correlation with wound healing has the potential to generate valuable diagnostic, prognostic, and therapeutic infor...

journal_title：Biomaterials

authors： Roussakis E,Ortines RV,Pinsker BL,Mooers CT,Evans CL,Miller LS,Calderón-Colón X

更新日期：2019-08-01 00:00:00

abstract：:Frequent outbreaks and the rapid global spread of infectious diseases have increased the urgent need for massive vaccination especially in countries with limited resources. Intranasal vaccination facilitates the mass vaccination via needle-free delivery of vaccine through nasal mucosal surfaces. Inspired by the strong...

journal_title：Biomaterials

authors： Wang X,Yang D,Li S,Xu X,Qin CF,Tang R

更新日期：2016-11-01 00:00:00

abstract：:A three layer (trilayer) polymeric micelle system based on the self-association of the triblock polymer poly(ethylene glycol)-b-poly{N-[N-(2-aminoethyl)-2-aminoethyl] aspartamide}-b-poly(ε-caprolactone) (PEG-b-PAsp(DET)-b-PCL) has been synthesized and investigated for combination delivery of rapamycin (RAP) and siRNA ...

journal_title：Biomaterials

authors： Zeng S,Xiong MP

更新日期：2013-09-01 00:00:00

abstract：:Following intravenous injection of anti-cancer nanomedicines, many barriers need to be overcome en route to the tumor. Cell-mediated delivery of nanoparticles (NPs) is promising in terms of overcoming several of these barriers based on the tumoritropic migratory properties of particular cell types. This guided transpo...

journal_title：Biomaterials

authors： Wayteck L,Dewitte H,De Backer L,Breckpot K,Demeester J,De Smedt SC,Raemdonck K

更新日期：2016-01-01 00:00:00

abstract：:Bioceramic coatings, created by the high velocity oxy-fuel combustion spraying of hydroxyapatite (HA) powders onto commercially pure titanium, were characterized in order to determine whether this relatively new coating process can be successfully applied to bioceramic coatings of orthopaedic and dental implants. Four...

journal_title：Biomaterials

authors： Haman JD,Lucas LC,Crawmer D

更新日期：1995-02-01 00:00:00

abstract：:Carbon nanotubes have shown great potential in various areas of biomedicine. Herein, we synthesize a series of amphiphilic polymers by anchoring polyethylene glycol (PEG) of different lengths at various densities on poly(maleic anhydride-alt-1-octadecene) (PMHC(18)). The blood circulation and biodistribution of those ...

journal_title：Biomaterials

authors： Liu X,Tao H,Yang K,Zhang S,Lee ST,Liu Z

更新日期：2011-01-01 00:00:00

abstract：:Long-term (8 and 24 month) reactions of the (hypo) dermis of the guinea pig to solid and porous (50 vol%) acrylic implants and four human biopsies from porous subcutaneous acrylic implants were studied light microscopically. The solid implants were encapsulated by dense connective tissue. Mobility was evidenced by the...

journal_title：Biomaterials

authors： van Mullem PJ,Vaandrager JM,Nicolai JP,de Wijn JR

更新日期：1990-07-01 00:00:00

abstract：:This study was undertaken to investigate the relative importance of a hydroxyapatite (HA) coating and the macrotexture of titanium implants to the quality of bony ingrowth and fixation. Various types of titanium cylinders were implanted into the cancellous bone of the intercondylar region of the distal femur of the do...

journal_title：Biomaterials

authors： Hayashi K,Mashima T,Uenoyama K

更新日期：1999-01-01 00:00:00

abstract：:Self-assembly is a prominent phenomenon observed in nature. Inspired by this thermodynamically favorable approach, several natural and synthetic materials have been investigated to develop functional systems for various biomedical applications, including drug delivery. Furthermore, layered self-assembled systems provi...

journal_title：Biomaterials

authors： Sarode A,Annapragada A,Guo J,Mitragotri S

更新日期：2020-02-29 00:00:00

abstract：:Chemotherapy is a popular treatment approach against cancer but significant uptake of drugs by normal tissues is still a major limitation. Magnetic drug targeting (MDT) has been used to improve localized drug delivery to interstitial tumor targets. MDT is now being developed to improve drug delivery to tumor vessels. ...

journal_title：Biomaterials

authors： Dandamudi S,Campbell RB

更新日期：2007-11-01 00:00:00

abstract：:In this work, an N-varied dissipative particle dynamics (DPD) simulation technique is applied to investigate detailed endocytosis kinetics for ligand-coated nanoparticles with different shapes, including sphere-, rod- and disk-shaped nanoparticles. Our results indicate that the rotation of nanoparticles, which is one ...

journal_title：Biomaterials

authors： Li Y,Yue T,Yang K,Zhang X

更新日期：2012-06-01 00:00:00

abstract：:Cell processes, including growth cones, respond to biophysical cues in their microenvironment to establish functional tissue architecture and intercellular networks. The mechanisms by which cells sense and translate biophysical cues into directed growth are unknown. We used photopolymerization to fabricate methacrylat...

journal_title：Biomaterials

authors： Li S,Tuft BW,Xu L,Polacco MA,Clarke JC,Guymon CA,Hansen MR

更新日期：2015-06-01 00:00:00

abstract：:Arterial smooth muscle cell (SMC) phenotype and proliferation is regulated by their surrounding collagens, which transform from fibrillar to monomeric type in atherogenesis, and platelet-derived growth factor (PDGF)-BB/interleukin (IL)-1β. This study aims at elucidating the mechanisms by which physical (monomeric vs. ...

journal_title：Biomaterials

authors： Yeh YT,Lee CI,Lim SH,Chen LJ,Wang WL,Chuang YJ,Chiu JJ

更新日期：2012-10-01 00:00:00

abstract：:Biomimetic materials that target the immune system and generate an anti-tumor responses hold promise in augmenting cancer immunotherapy. These synthetic materials can be engineered and optimized for their biodegradability, physical parameters such as shape and size, and controlled release of immune-modulators. As thes...

journal_title：Biomaterials

authors： Kosmides AK,Meyer RA,Hickey JW,Aje K,Cheung KN,Green JJ,Schneck JP

更新日期：2017-02-01 00:00:00

abstract：:Immune checkpoint blocking (ICB) antibodies have shown great success in the clinic, but their low response rate in patients with immunosuppressive cold tumors remains a huge challenge. Inspired by the capability of immunogenic cell death (ICD) to convert tumors from cold to hot, we developed a corn-like Au/Ag nanorod ...

journal_title：Biomaterials

authors： Jin L,Shen S,Huang Y,Li D,Yang X

更新日期：2021-01-01 00:00:00

abstract：:Multiblock, high molecular weight, linear, backbone degradable HPMA copolymer-prostaglandin E1 (PGE1) conjugate has been synthesized by RAFT polymerization mediated by a new bifunctional chain transfer agent (CTA), which contains an enzymatically degradable oligopeptide sequence flanked by two dithiobenzoate groups, f...

journal_title：Biomaterials

authors： Pan H,Sima M,Miller SC,Kopečková P,Yang J,Kopeček J

更新日期：2013-09-01 00:00:00

abstract：:Artificial extracellular matrix proteins, genetically engineered from elastin- and fibronectin-derived repeating units, were crosslinked with hexamethylene diisocyanate in dimethylsulfoxide. The resulting hydrogel films were transparent, uniform, and highly extensible. Their tensile moduli depended on crosslinker conc...

journal_title：Biomaterials

authors： Nowatzki PJ,Tirrell DA

更新日期：2004-03-01 00:00:00

abstract：:Engineered nanomaterials are known to exhibit diverse and sometimes unexpected biological effects. Fullerene nanoparticles have been reported to specifically bind to and elicit persistent activation of hippocampal Ca(2+)/calmodulin-dependent protein kinase II (CaMKII), a multimeric intracellular serine/threonine kinas...

journal_title：Biomaterials

authors： Chen L,Miao Y,Chen L,Xu J,Wang X,Zhao H,Shen Y,Hu Y,Bian Y,Shen Y,Chen J,Zha Y,Wen LP,Wang M

更新日期：2014-11-01 00:00:00