Efficiency of high molecular weight backbone degradable HPMA copolymer-prostaglandin E1 conjugate in promotion of bone formation in ovariectomized rats.

abstract：:Control of the precise location and extent of cellular attachment and proliferation, and of tissue outgrowth is important in a number of biomedical applications, including biomaterials and tissue engineered medical devices. Here we describe a method to control and direct the location and define boundaries of tissue gr...

journal_title：Biomaterials

authors： Thissen H,Johnson G,Hartley PG,Kingshott P,Griesser HJ

更新日期：2006-01-01 00:00:00

abstract：:Three-dimensional gelatin-chondroitin 6 sulphate-hyanuronic acid (gelatin-C6S-HA) biomatrices were used as the scaffold to investigate the phenotypic and molecular expression of basement membrane (BM) and extracellular matrix (ECM) proteins in vitro. The cells were cultured in three different culture conditions: kerat...

journal_title：Biomaterials

authors： Wang TW,Sun JS,Huang YC,Wu HC,Chen LT,Lin FH

更新日期：2006-10-01 00:00:00

abstract：:Anti-angiogenic therapeutics has been investigated extensively for the treatment of retinal and choroidal vascular diseases, and diabetic retinopathy. Anti-Flt1 peptide of GNQWFI is an antagonistic peptide for vascular endothelial growth factor receptor 1 (VEGFR1 or Flt1) inhibiting VEGFR1-mediated endothelial cell mi...

journal_title：Biomaterials

authors： Oh EJ,Choi JS,Kim H,Joo CK,Hahn SK

更新日期：2011-04-01 00:00:00

abstract：:Nanoparticles formulated from biodegradable polymers such as poly(lactic acid) (PLA) and poly(lactide-co-glycolide) (PLGA) are being extensively investigated as non-viral gene delivery systems due to their controlled release characteristics and biocompatibility. PLGA nanoparticles for DNA delivery are mainly formulate...

journal_title：Biomaterials

authors： Ravi Kumar MN,Bakowsky U,Lehr CM

更新日期：2004-05-01 00:00:00

abstract：:Polymethyl methacrylate (PMMA) films were treated by oxygen plasma discharge followed by acrylic acid (AA) grafting. The amount of carboxyl groups introduced by the grafting of AA on to the film surfaces was in the range 0.47-9.48 mumol/cm2, depending on the pressure of the plasma chamber during the discharge treatmen...

journal_title：Biomaterials

authors： Kang IK,Kwon BK,Lee JH,Lee HB

更新日期：1993-08-01 00:00:00

abstract：:An increased demand for soft-tissue substitutes has impelled the development of an in vitro adipose tissue. Ideally, such a tissue should contain a vascular network that can deliver blood throughout the construct following its engraftment. This study describes the in vitro fabrication of a pre-vascularized adipose tis...

journal_title：Biomaterials

authors： Sorrell JM,Baber MA,Traktuev DO,March KL,Caplan AI

更新日期：2011-12-01 00:00:00

abstract：:Cell-extracellular cell matrix (ECM) interactions play a vital role in development including cytoskeletal structure, growth and differentiation. A 15 amino acid, non-RGD containing, peptide that is derived from type I collagen was tested for its ability to confer cell survival. Two routinely utilized bone graft materi...

journal_title：Biomaterials

authors： Hanks T,Atkinson BL

更新日期：2004-08-01 00:00:00

abstract：:Oxidative stress is commonly existed in bone degenerative disease (osteoarthritis, osteoporosis etc.) and some antioxidants had great potential to enhance osteogenesis. In this study, we aim to investigate the anti-oxidative properties of various TiO2 nanotubes (TNTs) so to screen the desirable size for improved osteo...

journal_title：Biomaterials

authors： Yu Y,Shen X,Luo Z,Hu Y,Li M,Ma P,Ran Q,Dai L,He Y,Cai K

更新日期：2018-06-01 00:00:00

abstract：:In this work, isothermal microcalorimetry (IMC) was utilized to measure the exothermic heat flow from specimens of ultra-high-molecular-weight polyethylene (UHMWPE), that had been sterilized by various standard methods, under simulated shelf storage (air at 25 degrees C, 30% r.h.) and simulated implantation (phosphate...

journal_title：Biomaterials

authors： Charlebois SJ,Daniels AU,Lewis G

更新日期：2003-01-01 00:00:00

abstract：:Islet transplantation is a method for the treatment of type 1 diabetes mellitus (DM) and has been widely performed around the world. The long-term cryopreservation of islets shows many advantages in the field of islet transplantation. Previous studies have described the development of sheet-type polyvinyl alcohol (PVA...

journal_title：Biomaterials

authors： Qi Z,Shen Y,Yanai G,Yang K,Shirouzu Y,Hiura A,Sumi S

更新日期：2010-05-01 00:00:00

abstract：:The reaction of calcium ions and organic phosphate ester monomer at varying pHs was examined. Above pH 10, poorly crystallized hydroxyapatite was formed, which had lower crystallinity than that synthesized with inorganic phosphate as a source of P under the same conditions. On the other hand, the results of X-ray diff...

journal_title：Biomaterials

authors： Okazaki M,Hattori M

更新日期：1989-03-01 00:00:00

abstract：:To develop artificial materials for prolonged use in the vascular system, the complicated process of surface-induced thrombosis needs to be better understood. Steroidal hormones have a profound role in thrombosis and haemostasis, although adequate studies are not available to demonstrate their part in the thromboembol...

journal_title：Biomaterials

authors： Sharma CP,Chandy T

更新日期：1989-11-01 00:00:00

abstract：:Permanent male sterilization has been recognized as useful tools for the development of neuter experimental animals and fattening livestock, as well as efficient control of pet overpopulation. Traditional routes such as surgical ways, chemical injections, and anti-fertility vaccines have addressed these crucial proble...

journal_title：Biomaterials

authors： Liu Z,Liu X,Ran X,Ju E,Ren J,Qu X

更新日期：2015-11-01 00:00:00

abstract：:Breast cancer is associated with high mortality due to tumor metastasis. The anti-metastasis efficacy of photochemotherapy is strictly limited by poor targeting capability with respect to circulating tumor cells (CTCs) in blood and lymph. Herein, we decorate the platelet membrane (PM) on a surface of nanoparticles (NP...

journal_title：Biomaterials

authors： Ye H,Wang K,Wang M,Liu R,Song H,Li N,Lu Q,Zhang W,Du Y,Yang W,Zhong L,Wang Y,Yu B,Wang H,Kan Q,Zhang H,Wang Y,He Z,Sun J

更新日期：2019-06-01 00:00:00

abstract：:Measurements were made of the extremes in temperature which occur at different sites in the oral cavity during fluid intake. The results indicate that temperatures noted at the tooth surface, within the mouth, during fluid intake were less than the temperatures of the fluid imbibed. Variations in temperature were note...

journal_title：Biomaterials

authors： Longman CM,Pearson GJ

更新日期：1987-09-01 00:00:00

abstract：:Colloidal nanoparticle drug delivery systems have attracted much interest for their ability to enable effective formulation and delivery of therapeutic agents. The selective delivery of these nanoparticles to the disease site can be enhanced by coating the surface of the nanoparticles with targeting moieties, such as ...

journal_title：Biomaterials

authors： Fay F,McLaughlin KM,Small DM,Fennell DA,Johnston PG,Longley DB,Scott CJ

更新日期：2011-11-01 00:00:00

abstract：:In mammalian embryos, cortical interneurons travel long distances among complex three-dimensional tissues before integrating into cortical circuits. Several molecular guiding cues involved in this migration process have been identified, but the influence of physical parameters remains poorly understood. In the present...

journal_title：Biomaterials

authors： Leclech C,Renner M,Villard C,Métin C

更新日期：2019-09-01 00:00:00

abstract：:In the present study we compare LPEI and BPEI characteristics related to DNA condensation and their role as free polycation chains in gene transfection. Using radioactive (32)P labeled DNA, we investigated the effect of free PEI chains on the cellular uptake of polyplexes. Our investigations show different properties ...

journal_title：Biomaterials

authors： Dai Z,Gjetting T,Mattebjerg MA,Wu C,Andresen TL

更新日期：2011-11-01 00:00:00

abstract：:The development of biohybrid organs (BHO) will benefit from improved membranes regarding transport and cell contacting properties. Here we describe in a first study the development and testing of membranes made of polyacrylonitrile (PAN) and polysulfone (PSU) for the immobilisation of kidney epithelial cells. Comparat...

journal_title：Biomaterials

authors： Fey-Lamprecht F,Groth T,Albrecht W,Paul D,Gross U

更新日期：2000-01-01 00:00:00

abstract：:Bone tissue engineering strategies are fundamentally based upon porous scaffold materials that serve as a support for ingrowth of host cells and/or provide a substrate for exogenously delivered cells. Here we report the application of a surface calcium phosphate (CaP) mineral layer to a macroporous polymeric/CaP compo...

journal_title：Biomaterials

authors： Lickorish D,Guan L,Davies JE

更新日期：2007-03-01 00:00:00

abstract：:Brain tumors and brain metastases are among the deadliest malignancies of all human cancers, largely due to the cellular blood-brain and blood-tumor barriers that limit the delivery of imaging and therapeutic agents from the systemic circulation to tumors. Thus, improved strategies for brain tumor visualization and ta...

journal_title：Biomaterials

authors： Wu JB,Shi C,Chu GC,Xu Q,Zhang Y,Li Q,Yu JS,Zhau HE,Chung LW

更新日期：2015-10-01 00:00:00

abstract：:Efficacy of different chemical treatments on calcification of vascular graft in vitro and in vivo was studied. Culture medium-filled rat aortas were separately treated in 0.2% glutaraldehyde and epoxy compound, and photooxidized in 0.01% methylene blue for a shorter period (group 1). Another group of rat aortas were s...

journal_title：Biomaterials

authors： Chanda J,Kondoh K,Ijima K,Matsukawa M,Kuribayashi R

更新日期：1998-09-01 00:00:00

abstract：:Titanium and its alloys are widely used in load-bearing implants as a result of their excellent mechanical properties and corrosion resistance. In order to improve their performances with respect to osseointegration, the use of bioactive coatings has been suggested. Polypyrrole (PPy) has been chosen as coating polymer...

journal_title：Biomaterials

authors： De Giglio E,Guascito MR,Sabbatin L,Zambonin G

更新日期：2001-10-01 00:00:00

abstract：:As part of a study of elicited angiogenesis, hyaluronan (HA)-based hydrogels crosslinked by polyethylene glycol diacrylate (PEGDA) were loaded with combinations of the cytokine growth factors vascular endothelial growth factor (VEGF), angiopoietin-1 (Ang-1), keratinocyte growth factor (KGF) and platelet-derived growth...

journal_title：Biomaterials

authors： Elia R,Fuegy PW,VanDelden A,Firpo MA,Prestwich GD,Peattie RA

更新日期：2010-06-01 00:00:00

abstract：:This study is concerned with the effect of dual implantation of calcium and phosphorus upon the structure, corrosion resistance and biocompatibility of titanium. The ions were implanted in sequence, first Ca and then P, both at a dose of 10(17) ions/cm2 at a beam energy of 25 keV. Transmission electron microscopy was ...

journal_title：Biomaterials

authors： Krupa D,Baszkiewicz J,Kozubowski JA,Barcz A,Sobczak JW,Biliński A,Lewandowska-Szumieł M,Rajchel B

更新日期：2005-06-01 00:00:00

abstract：:Collagen has been widely used for tissue engineering. Here, we applied bioactive laminin-derived peptides as an additive for collagen, laminin-111, and fibronectin matrices resulting in peptide/collagen, peptide/laminin-111, and peptide/fibronectin matrices. Several syndecan-binding peptides, including AG73 (RKRLQVQLS...

journal_title：Biomaterials

authors： Yamada Y,Katagiri F,Hozumi K,Kikkawa Y,Nomizu M

更新日期：2011-07-01 00:00:00

abstract：:A newly developed bone equivalent hydroxyapatite was derived from veterinary bone (VHAP). Sections of 1 cm of six rabbit mandibles were equally replaced by this VHAP graft. Radiological studies by X-ray were performed pre-operatively, immediately, and 1, 2 and 3 months post-operatively. The graft host-bone interface w...

journal_title：Biomaterials

authors： Abdel-Fattah WI,Osiris WG,Mohamed SS,Khalil MR

更新日期：1994-06-01 00:00:00

abstract：:Polydimethacrylate resins were prepared by photopolymerization of Bis-GMA, TEGDMA, UDMA or Bis-EMA (4) monomer, initiated by camphoroquinone/N,N-dimethylaminoethyl methacrylate system. The study of physical properties of these resins showed that TEGDMA seems to create the most dense polymer network, which however is t...

journal_title：Biomaterials

authors： Sideridou I,Tserki V,Papanastasiou G

更新日期：2003-02-01 00:00:00

abstract：:Though reduced serum or myoblast co-culture alone can differentiate adipose-derived stem cells (ASCs) into mesenchymal lineages, efficiency is usually not sufficient to restore function in vivo. Often when injected into fibrotic muscle, their differentiation may be misdirected by the now stiffened tissue. Here ASCs ar...

journal_title：Biomaterials

authors： Choi YS,Vincent LG,Lee AR,Dobke MK,Engler AJ

更新日期：2012-03-01 00:00:00

abstract：:Silver nanoparticles (AgNPs) have anti-cancer effect. However, whether and how these particles could inhibit the growth of acute myeloid leukemia (AML) cells is unclear. In the present study, we prepared AgNPs with various sizes and investigated their cytotoxic effect on AML cells. We found that AgNPs could inhibit th...

journal_title：Biomaterials

authors： Guo D,Zhu L,Huang Z,Zhou H,Ge Y,Ma W,Wu J,Zhang X,Zhou X,Zhang Y,Zhao Y,Gu N

更新日期：2013-10-01 00:00:00