Abstract:
:The development of biohybrid organs (BHO) will benefit from improved membranes regarding transport and cell contacting properties. Here we describe in a first study the development and testing of membranes made of polyacrylonitrile (PAN) and polysulfone (PSU) for the immobilisation of kidney epithelial cells. Comparative investigations on overall polymer toxicity tested with 3T3 fibroblasts, and morphology and proliferation of Madin-Darby canine kidney (MDCK) cells cultured on the membranes could show that these materials have comparable cell contacting properties like Millicell membranes. Since PAN and PSU have superior membrane forming properties with regard to membrane geometry, i.e. for the preparation of hollow fibres, and porosity, i.e. for immuno isolation, both materials or modifications thereof seem to be suitable for the application in BHO such as biohybrid kidney.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Fey-Lamprecht F,Groth T,Albrecht W,Paul D,Gross Udoi
10.1016/s0142-9612(99)00147-7keywords:
subject
Has Abstractpub_date
2000-01-01 00:00:00pages
183-92issue
2eissn
0142-9612issn
1878-5905pii
S0142-9612(99)00147-7journal_volume
21pub_type
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