Abstract:
:We have created a porous bioresorbable nanocomposite bone scaffold that chemically, structurally and mechanically matched natural bone so that it could be recognized and remodeled by natural bone. Containing collagen fibers and synthetic apatite nanocrystals, our scaffold has high strength for supporting the surrounding tissue. The foam-like scaffold has a similar microstructure as trabecular bone, with nanometer-sized and micron-sized pores. The apatitic phase of the scaffold exhibited similar chemical composition, crystalline phase and grain size as the trabecular bone apatite. The nanocomposite scaffold demonstrated excellent bioactivity for promoting cell attachment and proliferation. It was osteoconductive and successfully healed a non-union fracture in rat femur as well as a critical-sized defect in pig tibia.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Pek YS,Gao S,Arshad MS,Leck KJ,Ying JYdoi
10.1016/j.biomaterials.2008.07.030subject
Has Abstractpub_date
2008-11-01 00:00:00pages
4300-5issue
32eissn
0142-9612issn
1878-5905pii
S0142-9612(08)00490-0journal_volume
29pub_type
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