Abstract:
:The authors have evaluated adhesive protein expression and cytokine production by human umbilical vein endothelial cells cultured in contact with polyethylene terephthalate (PET). ELAM-1, ICAM-1 and VCAM-1 expression was determined by flow cytometry; the concentration of interleukin-1 alpha (IL-1 alpha), interleukin-6 (IL-6), granulocyte colony stimulating factor (G-CSF) and granulocyte-macrophage colony stimulating factor (GM-CSF) in the supernatant was determined by enzyme immunoassay. The contact with PET determined a significant increase in ELAM-1 expression and insignificant increase in cytokine production, demonstrating that PET had a limited capability to stimulate endothelial cells in a pro-inflammatory sense.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Cenni E,Granchi D,Ciapetti G,Verri E,Cavedagna D,Gamberini S,Di Leo A,Pizzoferrato Adoi
10.1016/0142-9612(96)00037-3subject
Has Abstractpub_date
1996-11-01 00:00:00pages
2071-6issue
21eissn
0142-9612issn
1878-5905pii
0142961296000373journal_volume
17pub_type
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