Cytokine production and adhesive protein expression by endothelial cells after contact with polyethylene terephthalate.

Abstract:

:The authors have evaluated adhesive protein expression and cytokine production by human umbilical vein endothelial cells cultured in contact with polyethylene terephthalate (PET). ELAM-1, ICAM-1 and VCAM-1 expression was determined by flow cytometry; the concentration of interleukin-1 alpha (IL-1 alpha), interleukin-6 (IL-6), granulocyte colony stimulating factor (G-CSF) and granulocyte-macrophage colony stimulating factor (GM-CSF) in the supernatant was determined by enzyme immunoassay. The contact with PET determined a significant increase in ELAM-1 expression and insignificant increase in cytokine production, demonstrating that PET had a limited capability to stimulate endothelial cells in a pro-inflammatory sense.

journal_name

Biomaterials

journal_title

Biomaterials

authors

Cenni E,Granchi D,Ciapetti G,Verri E,Cavedagna D,Gamberini S,Di Leo A,Pizzoferrato A

doi

10.1016/0142-9612(96)00037-3

subject

Has Abstract

pub_date

1996-11-01 00:00:00

pages

2071-6

issue

21

eissn

0142-9612

issn

1878-5905

pii

0142961296000373

journal_volume

17

pub_type

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