Antibacterial activity of bactericide-immobilized filler for resin-based restoratives.

Abstract:

:This study examined the antibacterial activity of prepolymerized resin filler, in which the bactericide quaternary ammonium was immobilized. The experimental filler was prepared by grinding prepolymerized resin blocks of methacrylate monomers, silica particles, and the antibacterial monomer methacryloyloxydodecylpyridinium bromide (MDPB). The number of Streptococcus mutans after incubation for 18h in contact with the experimental filler with or without protein adsorption by saliva treatment was determined, and adherence of bacteria to the filler surface was evaluated by scanning electron microscopy. Elution of unpolymerized MDPB from the filler and its influence on bacterial growth were also investigated. The growth of S. mutans was completely inhibited by contact with the experimental filler without saliva treatment. Although the effects were attenuated, the saliva-treated filler still exhibited growth inhibition at >99.9%. Less bacteria attached to the experimental filler than the control filler without MDPB, indicating that the reduction in bacterial number after contact with the experimental filler was not due to bacterial adherence to the particles. Unpolymerized MDPB at 1 microg/ml was eluted from the filler particles but was confirmed to have little effect on bacterial growth. The results indicate that the bactericide-immobilized filler containing MDPB shows significant bacteriostatic effects without releasing antibacterial components, and is useful for incorporation into various resin-based restoratives.

journal_name

Biomaterials

journal_title

Biomaterials

authors

Imazato S,Ebi N,Takahashi Y,Kaneko T,Ebisu S,Russell RR

doi

10.1016/s0142-9612(03)00217-5

keywords:

subject

Has Abstract

pub_date

2003-09-01 00:00:00

pages

3605-9

issue

20

eissn

0142-9612

issn

1878-5905

pii

S0142961203002175

journal_volume

24

pub_type

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