Abstract:
:We have developed a family of synthetic biodegradable polymers that are composed of structural units endogenous to the human metabolism, designated poly(polyol sebacate) (PPS) polymers. Material properties of PPS polymers can be tuned by altering the polyol monomer and reacting stiochiometric ratio of sebacic acid. These thermoset networks exhibited tensile Young's moduli ranging from 0.37+/-0.08 to 378+/-33 MPa with maximum elongations at break from 10.90+/-1.37% to 205.16+/-55.76%, and glass transition temperatures ranging from approximately 7-46 degrees C. In vitro degradation under physiological conditions was slower than in vivo degradation rates observed for some PPS polymers. PPS polymers demonstrated similar in vitro and in vivo biocompatibility compared to poly(L-lactic-co-glycolic acid) (PLGA).
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Bruggeman JP,de Bruin BJ,Bettinger CJ,Langer Rdoi
10.1016/j.biomaterials.2008.08.037subject
Has Abstractpub_date
2008-12-01 00:00:00pages
4726-35issue
36eissn
0142-9612issn
1878-5905pii
S0142-9612(08)00604-2journal_volume
29pub_type
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