Biodegradable poly(polyol sebacate) polymers.

Abstract:

:We have developed a family of synthetic biodegradable polymers that are composed of structural units endogenous to the human metabolism, designated poly(polyol sebacate) (PPS) polymers. Material properties of PPS polymers can be tuned by altering the polyol monomer and reacting stiochiometric ratio of sebacic acid. These thermoset networks exhibited tensile Young's moduli ranging from 0.37+/-0.08 to 378+/-33 MPa with maximum elongations at break from 10.90+/-1.37% to 205.16+/-55.76%, and glass transition temperatures ranging from approximately 7-46 degrees C. In vitro degradation under physiological conditions was slower than in vivo degradation rates observed for some PPS polymers. PPS polymers demonstrated similar in vitro and in vivo biocompatibility compared to poly(L-lactic-co-glycolic acid) (PLGA).

journal_name

Biomaterials

journal_title

Biomaterials

authors

Bruggeman JP,de Bruin BJ,Bettinger CJ,Langer R

doi

10.1016/j.biomaterials.2008.08.037

subject

Has Abstract

pub_date

2008-12-01 00:00:00

pages

4726-35

issue

36

eissn

0142-9612

issn

1878-5905

pii

S0142-9612(08)00604-2

journal_volume

29

pub_type

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