Abstract：
:Albumin is a promising surface modifier of nanoparticulate drug delivery systems. Serving as a dysopsonin, albumin can protect circulating nanoparticles (NPs) from the recognition and clearance by the mononuclear phagocytic system (MPS). Albumin may also help transport the NPs to solid tumors based on the increased consumption by cancer cells and interactions with the tumor microenvironment. Several studies have explored the benefits of surface-bound albumin to enhance NP delivery to tumors. However, it remains unknown how the surface modification process affects the conformation of albumin and the performance of the albumin-modified NPs. We use three different surface modification methods including two prevalent approaches (physisorption and interfacial embedding) and a new method based on dopamine polymerization to modify the surface of poly(lactic-co-glycolic acid) NPs with albumin and compare the extent of albumin binding, conformation of the surface-bound albumin, and biological performances of the albumin-coated NPs. We find that the dopamine polymerization method preserves the albumin structure, forming a surface layer that facilitates NP transport and drug delivery into tumors via the interaction with albumin-binding proteins. In contrast, the interfacial embedding method creates NPs with denatured albumin that offers no particular benefit to the interaction with cancer cells but rather promotes the MPS uptake via direct and indirect interactions with scavenger receptor A. This study demonstrates that the surface-bound albumin can bring distinct effects according to the way they interact with NP surface and thus needs to be controlled in order to achieve favorable therapeutic outcomes.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Hyun H,Park J,Willis K,Park JE,Lyle LT,Lee W,Yeo Ydoi
10.1016/j.biomaterials.2018.07.024subject
Has Abstractpub_date
2018-10-01 00:00:00pages
206-224eissn
0142-9612issn
1878-5905pii
S0142-9612(18)30508-8journal_volume
180pub_type
杂志文章相关文献
BIOMATERIALS文献大全abstract：:Tissue engineering strategies for repairing and regenerating articular cartilage face critical challenges to recapitulate the dynamic and complex biochemical microenvironment of native tissues. One approach to mimic the biochemical complexity of articular cartilage is through the use of recombinant bacterial collagens...
journal_title：Biomaterials
pub_type： 杂志文章
doi：10.1016/j.biomaterials.2016.05.011
更新日期：2016-08-01 00:00:00
abstract：:Elimination of leukemia stem cells (LSCs) is necessary for the destruction of malignant cell populations. Owing to the very small number of LSCs in leukemia cells, xenotransplantation studies are difficult in terms of functionally and pathophysiologically replicating clinical conditions of cell culture experiments. Th...
journal_title：Biomaterials
pub_type： 杂志文章
doi：10.1016/j.biomaterials.2015.02.009
更新日期：2015-06-01 00:00:00
abstract：:We have created a porous bioresorbable nanocomposite bone scaffold that chemically, structurally and mechanically matched natural bone so that it could be recognized and remodeled by natural bone. Containing collagen fibers and synthetic apatite nanocrystals, our scaffold has high strength for supporting the surroundi...
journal_title：Biomaterials
pub_type： 杂志文章
doi：10.1016/j.biomaterials.2008.07.030
更新日期：2008-11-01 00:00:00
abstract：:Morphological changes of human polymorphonuclear neutrophils (PMN) adhering to hydrophilic (glass) and hydrophobic (FEP-Teflon, polyethylene, polypropylene) surfaces were studied in a parallel-plate flow chamber at the light and scanning electron microscopical levels. The PMN were exposed to a shear stress of 0.19 Pa ...
journal_title：Biomaterials
pub_type： 杂志文章
doi：10.1016/0142-9612(96)87275-9
更新日期：1996-07-01 00:00:00
abstract：:Recent advances in 3D bioprinting have transformed the tissue engineering landscape by enabling the controlled placement of cells, biomaterials, and bioactive agents for the biofabrication of living tissues and organs. However, the application of 3D bioprinting is limited by the availability of cytocompatible and prin...
journal_title：Biomaterials
pub_type： 杂志文章
doi：10.1016/j.biomaterials.2020.120294
更新日期：2020-11-01 00:00:00
abstract：:The interactions between alginate and polycations have been studied by using different labelling techniques. Binding of poly-L-lysine (PLL) to alginate in the gel state is mainly governed by the amount of dissociable negative charges on the bead surface. PLL was found to bind more rapidly to gel beads made from algina...
journal_title：Biomaterials
pub_type： 杂志文章
doi：10.1016/0142-9612(96)84680-1
更新日期：1996-05-01 00:00:00
abstract：:The removal of tenacious dental plaque is of paramount importance; however, early diagnosis can be a challenging task in dental clinics due to the limitations of current approaches, specifically X-ray-based techniques. We have approached this problem by integrating antibacterial properties and X-ray contrast enhanceme...
journal_title：Biomaterials
pub_type： 杂志文章
doi：10.1016/j.biomaterials.2018.07.053
更新日期：2018-10-01 00:00:00
abstract：:This paper presents for the first time a mathematical model for a mechanism of controlled drug release involving both ion exchange and transient counter diffusion of a drug and counterions. Numerical analysis was conducted to study the effect of different factors on drug release kinetics including environmental condit...
journal_title：Biomaterials
pub_type： 杂志文章
doi：10.1016/j.biomaterials.2007.11.044
更新日期：2008-04-01 00:00:00
abstract：:Experimental and histological studies on the reaction of surrounding gingiva to permucosal implants of dense calcium hydroxyapatite were carried out in dogs. Epithelial attachment and connection of supra-alveolar collagen fibres to the implant surface seemed to form a biological seal around implants similar to that ar...
journal_title：Biomaterials
pub_type： 杂志文章
doi：10.1016/0142-9612(84)90018-8
更新日期：1984-07-01 00:00:00
abstract：:Biodegradable and non-biodegradable polymers represent promising materials for sustained protein delivery systems. However, structural protein instabilities due to interactions with the polymer surface are often observed. Aim of the present study was to analyze and predict these instabilities by determination of adsor...
journal_title：Biomaterials
pub_type： 杂志文章
doi：10.1016/j.biomaterials.2011.11.037
更新日期：2012-02-01 00:00:00
abstract：:When subjected to a monotonically increasing deformation state, the mechanical behavior of UHMWPE is characterized by a linear elastic response followed by distributed yielding and strain hardening at large deformations. During the unloading phases of an applied cyclic deformation process, the response is characterize...
journal_title：Biomaterials
pub_type： 杂志文章
doi：10.1016/s0142-9612(01)00367-2
更新日期：2002-06-01 00:00:00
abstract：:Osteogenic agents, such as bone morphogenetic protein-2 (BMP-2), can stimulate the degradation as well as the formation of bone. Hence, they could impair the osteoconductivity of functionalized implant surfaces. We assessed the effects of BMP-2 and its mode of delivery on the osteoconductivity of dental implants with ...
journal_title：Biomaterials
pub_type： 杂志文章
doi：10.1016/j.biomaterials.2007.02.003
更新日期：2007-06-01 00:00:00
abstract：:Human adipose tissue extracellular matrix, derived through decellularization processing, has been shown to provide a biomimetic microenvironment for adipose tissue regeneration. This study reports the use of human adipose tissue-derived extracellular matrix (hDAM) scaffolds as a three-dimensional cell culturing system...
journal_title：Biomaterials
pub_type： 杂志文章
doi：10.1016/j.biomaterials.2014.03.003
更新日期：2014-06-01 00:00:00
abstract：:Poly(ethylene glycol) diacrylate (PEGDA) hydrogel scaffolds were engineered to promote contractile smooth muscle cell (SMC) phenotype via controlled release of heparin. The scaffold design was evaluated by quantifying the effects of free heparin on SMC phenotype, engineering hydrogels to provide controlled release of ...
journal_title：Biomaterials
pub_type： 杂志文章
doi：10.1016/j.biomaterials.2009.08.004
更新日期：2009-10-01 00:00:00
abstract：:The torque-tension characteristics of standard, conical and flanged external fixator pins and a cortical screw were compared using a commercially available testing apparatus. The flanged pin and the screw were similar in behaviour, and converted torque into tension more efficiently than conical and standard external f...
journal_title：Biomaterials
pub_type： 杂志文章
doi：10.1016/0142-9612(95)98137-4
更新日期：1995-11-01 00:00:00
abstract：:There are many ways to influence cell activities, and biomaterials with functional groups attached is an attractive method that clearly has the ability to modulate cell behavior. The evidence is clear that biomaterials, with or without growth factors and cells, have resulted in numerous products for the regenerative m...
journal_title：Biomaterials
pub_type： 杂志文章
doi：10.1016/j.biomaterials.2011.02.028
更新日期：2011-06-01 00:00:00
abstract：:A major goal of bone tissue engineering is to design better scaffold configuration and materials to better control osteoblast behavior. Nanoporous architecture has been shown to significantly affect cellular response. In this work, nanoporous alumina membranes were fabricated by a two-step anodization method to invest...
journal_title：Biomaterials
pub_type： 杂志文章
doi：10.1016/j.biomaterials.2004.11.026
更新日期：2005-08-01 00:00:00
abstract：:Retinal ischemia is a major cause of vision loss and impairment and a common underlying mechanism associated with diseases such as glaucoma, diabetic retinopathy, and central retinal artery occlusion. The regenerative capacity of the diseased human retina is limited. Our previous studies have shown the neuroprotective...
journal_title：Biomaterials
pub_type： 杂志文章
doi：10.1016/j.biomaterials.2019.01.016
更新日期：2019-03-01 00:00:00
abstract：:Autologous melanocyte transplantation for vitiligo treatment by use of melanocyte suspension has drawbacks including cell damage in cell preparation and transportation, difficult manipulation and low engraftment rate in acral vitiligious lesions. We have proposed the concept of cellular patch as an alternative solutio...
journal_title：Biomaterials
pub_type： 杂志文章
doi：10.1016/j.biomaterials.2005.08.031
更新日期：2006-03-01 00:00:00
abstract：:Delivery of polynucleotide-based therapeutics into target cells involves interactions with glycosaminoglycan chains that are located on cell membrane milieu. Mechanisms governing glycosaminoglycan-mediated changes in the nanoparticulate structures of polymer-polynucleotide complexes are unknown, and cannot be fully el...
journal_title：Biomaterials
pub_type： 杂志文章
doi：10.1016/j.biomaterials.2017.11.037
更新日期：2018-02-01 00:00:00
abstract：:In addition to unidirectional laminates and short fiber reinforcements for compression bone plate developments in the literature, we have proposed using a textile structure, i.e. braid preform, for this purpose. In the present paper, the influence of braiding angles and plate thicknesses on the bending performance of ...
journal_title：Biomaterials
pub_type： 杂志文章
doi：10.1016/s0142-9612(03)00065-6
更新日期：2003-07-01 00:00:00
abstract：:The surface of soft contact lenses made of crosslinked poly(2-hydroxyethyl methacrylate). pHEMA, has been investigated with atomic force microscopy in contact mode. The friction force and adhesive force measurements were able to differentiate the non-crosslinked pHEMA chains from the surface of the crosslinked pHEMA n...
journal_title：Biomaterials
pub_type： 杂志文章
doi：10.1016/s0142-9612(01)00175-2
更新日期：2001-12-01 00:00:00
abstract：:Space experimentation of cardiomyocyte differentiation from human induced pluripotent stem cells offers an exciting opportunity to explore the potential of these cells for disease modeling, drug discovery and regenerative medicine. Previous studies on the International Space Station were done with 2D non-cryopreserved...
journal_title：Biomaterials
pub_type： 杂志文章
doi：10.1016/j.biomaterials.2021.120673
更新日期：2021-01-11 00:00:00
abstract：:Nano- to micro-structured biodegradable poly(L-lactide-co-epsilon-caprolactone) (PLCL) fabrics were prepared by electrospinning. Electrospun microfiber fabrics with different compositions of PLCL (mol% in feed; 70/30, 50/50, and 30/70), poly(L-lactide) (PLL) and poly(epsilon-caprolactone) (PCL) were obtained using met...
journal_title：Biomaterials
pub_type： 杂志文章
doi：10.1016/j.biomaterials.2004.10.007
更新日期：2005-06-01 00:00:00
abstract：:Culture of seeded osteoblastic cells in three-dimensional osteoconductive scaffolds in vitro is a promising approach to produce an osteoinductive material for repair of bone defects. However, culture of cells in scaffolds sufficiently large to bridge critical-sized defects is a challenge for tissue engineers. Diffusio...
journal_title：Biomaterials
pub_type： 杂志文章
doi：10.1016/s0142-9612(00)00280-5
更新日期：2001-06-01 00:00:00
abstract：:Controlled delivery of bioactive molecules to modulate or control biological processes has a number of clinical applications. The present study reports a delivery system which was designed to deliver growth factors locally to a fracture site. Ethylene vinyl acetate copolymer (EVAc), bovine serum albumin (BSA) and plat...
journal_title：Biomaterials
pub_type： 杂志文章
doi：10.1016/0142-9612(95)91047-3
更新日期：1995-11-01 00:00:00
abstract：:Microspheres comprised of particulate hydroxyapatites dispersed in fibrous collagen matrices were prepared. The procedure involved the droplet formation of hydroxyapatite/collagen mixture emulsified in olive oil, followed by the reconstitution of collagen in the presence of hydroxyapatite particles at 37 degrees C. Va...
journal_title：Biomaterials
pub_type： 杂志文章
doi：10.1016/s0142-9612(99)00095-2
更新日期：1999-10-01 00:00:00
abstract：:A Vroman-like exchange of different proteins adsorbing from a concentrated mixture to the same hydrophobic adsorbent surface is shown to arise naturally from the selective pressure imposed by a fixed interfacial-concentration capacity (w/v, mg/mL) for which protein molecules compete. A size (molecular weight, MW) disc...
journal_title：Biomaterials
pub_type： 杂志文章
doi：10.1016/j.biomaterials.2006.09.006
更新日期：2007-01-01 00:00:00
abstract：:The adsorption of chondroitin-4-sulphate (C4S) and heparin onto titanium has been studied in the absence and presence of bovine serum albumin (BSA). Isotherm data (0.02 M calcium acetate, pH 6.8) have shown that BSA in solution and BSA-coated titanium result in decreased adsorption for both C4S and heparin. For the BS...
journal_title：Biomaterials
pub_type： 杂志文章
doi：10.1016/s0142-9612(97)00044-6
更新日期：1997-08-01 00:00:00
abstract：:Chemotherapy is a popular treatment approach against cancer but significant uptake of drugs by normal tissues is still a major limitation. Magnetic drug targeting (MDT) has been used to improve localized drug delivery to interstitial tumor targets. MDT is now being developed to improve drug delivery to tumor vessels. ...
journal_title：Biomaterials
pub_type： 杂志文章
doi：10.1016/j.biomaterials.2007.07.024
更新日期：2007-11-01 00:00:00
