Constitutive modeling of ultra-high molecular weight polyethylene under large-deformation and cyclic loading conditions.

abstract：:We have developed a family of synthetic biodegradable polymers that are composed of structural units endogenous to the human metabolism, designated poly(polyol sebacate) (PPS) polymers. Material properties of PPS polymers can be tuned by altering the polyol monomer and reacting stiochiometric ratio of sebacic acid. Th...

journal_title：Biomaterials

authors： Bruggeman JP,de Bruin BJ,Bettinger CJ,Langer R

更新日期：2008-12-01 00:00:00

abstract：:The integrin α5β1 plays a major role in corneal wound healing by promoting epithelial cell adhesion and migration over the fibronectin matrix secreted as a cellular response to corneal damage. Expression of α5 is induced when rabbit corneal epithelial cells (RCECs) are grown in the presence of fibronectin. Here, we ex...

journal_title：Biomaterials

authors： Lake J,Zaniolo K,Gaudreault M,Carrier P,Deschambault A,Bazin R,Germain L,Salesse C,Guérin SL

更新日期：2013-09-01 00:00:00

abstract：:Poly(ether-ether-ketone) (PEEK) has been used as a load bearing orthopaedic implant material with clinical success. All of the orthopaedic applications contain stress concentrations (notches) in their design; however, little work has been done to examine the fatigue behavior of PEEK in the presence of a notch. This wo...

journal_title：Biomaterials

authors： Sobieraj MC,Murphy JE,Brinkman JG,Kurtz SM,Rimnac CM

更新日期：2010-12-01 00:00:00

abstract：:Osteoinductive biomaterials are promising for bone repair. There is no direct proof that bone marrow mesenchymal stem cells (BMSCs) home to non-osseous sites and participate in ectopic bone formation induced by osteoinductive bioceramics. The objective of this study was to use a sex-mismatched beagle dog model to inve...

journal_title：Biomaterials

authors： Song G,Habibovic P,Bao C,Hu J,van Blitterswijk CA,Yuan H,Chen W,Xu HH

更新日期：2013-03-01 00:00:00

abstract：:Increasing knowledge about molecular mechanisms of endogenous RNA interference (RNAi) and small interfering RNAs (siRNAs) has been incorporated into innovative nucleic acid medicines for treatment of diseases such as cancers. Although RNAi and siRNA have the potential to become powerful therapeutic drugs, their delive...

journal_title：Biomaterials

authors： Kesharwani P,Gajbhiye V,Jain NK

更新日期：2012-10-01 00:00:00

abstract：:The iron-containing fluoridated hydroxyapatites Fe-FeFAp and FeF-FeAp were synthesized heterogeneously in the presence of ferrous ions at 80 degrees C and pH 7.4 in two different types of solution, i.e. fluoride-free solution during the initial half of the experimental period and fluoride-containing solution during th...

journal_title：Biomaterials

authors： Okazaki M,Takahashi J

更新日期：1997-01-01 00:00:00

abstract：:The role of albumin in the mineralisation process of commercial hydroxyapatite (HAp) and synthesised biphasic (HAp-tricalcium phosphate) ceramics in a bufferless simulated inorganic plasma (HBSS) was investigated by conventional in vitro tests and static and dynamic wettability measurements. Albumin was either pre-ads...

journal_title：Biomaterials

authors： Marques PA,Serro AP,Saramago BJ,Fernandes AC,Magalhães MC,Correia RN

更新日期：2003-02-01 00:00:00

abstract：:Scanning electron microscopy has been used to study the interface between implants of pure metals and the muscular tissue of rats. Several problems arise in the interpretation of the observations made, due to the potential for disruption to the tissue and the exacerbation of any corrosion that may have occurred in viv...

journal_title：Biomaterials

authors： McNamara A,Williams DF

更新日期：1982-07-01 00:00:00

abstract：:Chemotherapeutic agents often cause severe side effects because they produce a similar cytotoxicity in both cancerous and healthy cells. In this study, a rational strategy was implemented to take advantage of a combination of both tumor microenvironment-sensitive polypeptides (TMSP) and folate to create a more selecti...

journal_title：Biomaterials

authors： Gao W,Xiang B,Meng TT,Liu F,Qi XR

更新日期：2013-05-01 00:00:00

abstract：:In the cellular microenvironment, growth factor gradients are crucial in dictating cell fate. Towards developing materials that capture the native microenvironment we engineered biomimetic films that present gradients of matrix-bound bone morphogenetic proteins (BMP-2 and BMP-7). To this end layer-by-layer films compo...

journal_title：Biomaterials

authors： Almodóvar J,Guillot R,Monge C,Vollaire J,Selimović S,Coll JL,Khademhosseini A,Picart C

更新日期：2014-04-01 00:00:00

abstract：:Integrins represent the primary mechanism of cell-extracellular matrix interactions and control cell morphology, proliferation, and differentiation. We have previously shown that substrate-dependent modulation of adsorbed fibronectin (Fn) conformation alters alpha5beta1 integrin binding to Fn and directs C2C12 myoblas...

journal_title：Biomaterials

authors： Stephansson SN,Byers BA,García AJ

更新日期：2002-06-01 00:00:00

abstract：:Platelet concentrates (PCs) constitute new biological mediators used in osseous reconstructive surgery. In this study, we assessed (i) the effects of various concentrations of calcium and thrombin on the kinetics of platelet-derived growth factor (PDGF-BB), transforming growth factor-beta1(TGF-beta 1), basic fibroblas...

journal_title：Biomaterials

authors： Martineau I,Lacoste E,Gagnon G

更新日期：2004-08-01 00:00:00

abstract：:To avoid the overheating effect of excitation light and improve the efficacy of photodynamic therapy (PDT) of upconversion nanoplatform, a novel nanoprobe based on 808 nm-excited upconversion nanocomposites (T-UCNPs@Ce6@mSiO2) with low heating effect and deep penetration has been successfully constructed for targeted ...

journal_title：Biomaterials

authors： Zeng L,Pan Y,Zou R,Zhang J,Tian Y,Teng Z,Wang S,Ren W,Xiao X,Zhang J,Zhang L,Li A,Lu G,Wu A

更新日期：2016-10-01 00:00:00

abstract：:Nowadays, two-dimensional (2D) nanomaterials with many fascinating physicochemical properties have drawn extensive attention as drug delivery platforms for cancer theranostics. Nevertheless, current existing 2D nanomaterial-based drug delivery systems normally undergo the bottlenecks of hash preparation process, low d...

journal_title：Biomaterials

authors： Liu F,Lin L,Zhang Y,Sheng S,Wang Y,Xu C,Tian H,Chen X

更新日期：2019-12-01 00:00:00

abstract：:Porous biomaterials designed to support cellular infiltration and tissue formation play a critical role in implant fixation and engineered tissue repair. The purpose of this Leading Opinion Paper is to advocate the use of high resolution 3D imaging techniques as a tool to quantify extracellular matrix formation and va...

journal_title：Biomaterials

authors： Guldberg RE,Duvall CL,Peister A,Oest ME,Lin AS,Palmer AW,Levenston ME

更新日期：2008-10-01 00:00:00

abstract：:In this study, we used deoxyribozyme (DNAzyme) functionalized gold nanoparticles (AuNPs) to catalytically silence tumor necrosis factor-α (TNF-α) in vivo as a potential therapeutic for myocardial infarction (MI). Using primary macrophages as a model, we demonstrated 50% knockdown of TNF-α, which was not attainable usi...

journal_title：Biomaterials

authors： Somasuntharam I,Yehl K,Carroll SL,Maxwell JT,Martinez MD,Che PL,Brown ME,Salaita K,Davis ME

更新日期：2016-03-01 00:00:00

abstract：:Thin and defect-free calcium phosphate films with a Ca/P ratio of 1.62 were formed by electron-beam evaporation. The as-deposited films had average bonding strengths to the metal implants of 64.8 MPa and the dissolution rates of 47.5 nm/h in isotonic saline solutions. The interface mechanical characteristics and histo...

journal_title：Biomaterials

authors： Le IS,Kim DH,Kim HE,Jung YC,Han CH

更新日期：2002-01-01 00:00:00

abstract：:Cerium oxide nanoparticles (nanoceria) are promising materials for intracellular oxygen free radical scavenging providing a potential therapy for reactive oxygen species (ROS)-mediated inflammatory processes. In this study rhombohedral-shaped nanoceria were synthesized by flame spray pyrolysis with tuneable particle d...

journal_title：Biomaterials

authors： Lord MS,Jung M,Teoh WY,Gunawan C,Vassie JA,Amal R,Whitelock JM

更新日期：2012-11-01 00:00:00

abstract：:Synthetic hydroxyapatite particles of two median sizes and different morphologies have been used to manufacture hydroxyapatite reinforced high density polyethylene composites (HAPEX) for medical applications. The effects of hydroxyapatite particle size on properties of the resultant composites were investigated using ...

journal_title：Biomaterials

authors： Wang M,Joseph R,Bonfield W

更新日期：1998-12-01 00:00:00

abstract：:Lingo-1 is selectively expressed on both oligodendrocytes and neurons in the central nervous system (CNS) and serves as a key negative regulator of nerve regeneration, implying a therapeutic target for spinal cord injury (SCI). Here we described a strategy to knock-down Lingo-1 expression in vivo using lentiviral vect...

journal_title：Biomaterials

authors： Wu HF,Cen JS,Zhong Q,Chen L,Wang J,Deng DY,Wan Y

更新日期：2013-02-01 00:00:00

abstract：:Bioabsorbable internal fixation devices were introduced clinically in the treatment of fractures and osteotomies of the extremities at the Department of Orthopaedics and Traumatology, Helsinki University, in 1984. Since November 5, 1984, a total of 3200 patients were managed using bone or ligament fixation devices mad...

journal_title：Biomaterials

authors： Rokkanen PU,Böstman O,Hirvensalo E,Mäkelä EA,Partio EK,Pätiälä H,Vainionpää SI,Vihtonen K,Törmälä P

更新日期：2000-12-01 00:00:00

abstract：:The physiological role of cumulus cell surrounding oocytes is particularly important for normal cytoplasmic maturation of oocytes. Collagen-based demineralized bone matrix (DBM) is a valuable biomaterial for the three-dimensional (3-D) cell culture. The present study was designed to determine whether in vitro maturati...

journal_title：Biomaterials

authors： Ma S,Lin H,Miao Y,Liu X,Wang B,Dai J

更新日期：2007-07-01 00:00:00

abstract：:Low back pain is one of the most common medical conditions in the Western world. Disc degeneration, an inevitable process of aging, of variable rate and degree, is one of the major causes of low back pain. Currently, there are two major surgical interventions for treating conditions related to the degenerative disc: d...

journal_title：Biomaterials

authors： Bao QB,McCullen GM,Higham PA,Dumbleton JH,Yuan HA

更新日期：1996-06-01 00:00:00

abstract：:A major hindrance in islet transplantation as a feasible therapeutic approach for patients with type 1 diabetes is the insufficient oxygenation of the grafts, which results in cell death in portions of the implant. Here we address this limitation through the application of oxygen-generating microparticles (MP) and a f...

journal_title：Biomaterials

authors： Montazeri L,Hojjati-Emami S,Bonakdar S,Tahamtani Y,Hajizadeh-Saffar E,Noori-Keshtkar M,Najar-Asl M,Ashtiani MK,Baharvand H

更新日期：2016-05-01 00:00:00

abstract：:As double stranded, single stranded siRNA (ss-siRNA) has demonstrated gene silencing activity but still requires efficient carriers to reach its cytoplasmic target. To better understand the fundamental aspect driving the complexation of ss-siRNA with nanocarriers, the interactions between surfaces of various compositi...

journal_title：Biomaterials

authors： Giraud L,Viricel W,Leblond J,Giasson S

更新日期：2017-01-01 00:00:00

abstract：:Prosthetic heart valves epitomize both the triumphant advance of cardiac surgery in its early days and its stagnation into a retrospective, exclusive first world discipline of late. Fifty-two years after the first diseased heart valve was replaced in a patient, prostheses largely represent the concepts of the 1960s wi...

journal_title：Biomaterials

authors： Zilla P,Brink J,Human P,Bezuidenhout D

更新日期：2008-02-01 00:00:00

abstract：:Cytokines, chemokines, and growth factors were analyzed periodically over eight weeks from the wound exudate fluid surrounding biomaterials implanted subcutaneously within stainless steel mesh cages. TNF-alpha, MCP-1, MIP-1alpha, IL-2, IL-6, IL-1beta, VEGF, IL-4, and IL-10 were measured from exudate samples collected ...

journal_title：Biomaterials

authors： Schutte RJ,Xie L,Klitzman B,Reichert WM

更新日期：2009-01-01 00:00:00

abstract：:Adhesion of tissue cells is a prerequisite for their growth and differentiation but prevents also apoptosis. Here the layer-by-layer technique (LbL) was used to design multilayer structures of poly(ethylene imine) (PEI) and heparin (HEP) on glass as model biomaterial to control the adhesion of primary human dermal fib...

journal_title：Biomaterials

authors： Niepel MS,Peschel D,Sisquella X,Planell JA,Groth T

更新日期：2009-10-01 00:00:00

abstract：:Bioengineering of whole hearts using human embryonic stem cells (hESCs)-derived cardiovascular progenitor cells (CPCs) and natural matrices is a promising approach to overcome organ donor shortage threatening millions of patients awaiting for heart transplantation. Here, we developed a novel strategy for generation of...

journal_title：Biomaterials

authors： Rajabi S,Pahlavan S,Ashtiani MK,Ansari H,Abbasalizadeh S,Sayahpour FA,Varzideh F,Kostin S,Aghdami N,Braun T,Baharvand H

更新日期：2018-02-01 00:00:00

abstract：:Rare-earth upconversion nanoparticles (UCNP) which can absorb low-energy photons and emit high energy photons have attracted great interest not only because of their unique application in upconversion luminescence imaging, but also because they can be used as ideal building blocks for multimodal bioimaging probes. Imp...

journal_title：Biomaterials

authors： Liu Q,Chen M,Sun Y,Chen G,Yang T,Gao Y,Zhang X,Li F

更新日期：2011-11-01 00:00:00