听力与言语-语言病理学

行为科学

医学伦理学

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  • Cryopreservation and CO2-independent culture of 3D cardiac progenitors for spaceflight experiments.

    abstract::Space experimentation of cardiomyocyte differentiation from human induced pluripotent stem cells offers an exciting opportunity to explore the potential of these cells for disease modeling, drug discovery and regenerative medicine. Previous studies on the International Space Station were done with 2D non-cryopreserved...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2021.120673

    authors: Rampoldi A,Jha R,Fite J,Boland G,Xu C

    更新日期:2021-01-11 00:00:00

  • Bioinspired membrane provides periosteum-mimetic microenvironment for accelerating vascularized bone regeneration.

    abstract::Periosteum plays a pivotal role in vascularization, ossification and remodeling during the healing process of bone injury. However, there are few studies focused on the construction of artificial implants with periosteum-mimetic effect. To emulate the primary role of natural periosteum or endosteal tissues in bone reg...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2020.120561

    authors: Yang G,Liu H,Cui Y,Li J,Zhou X,Wang N,Wu F,Li Y,Liu Y,Jiang X,Zhang S

    更新日期:2021-01-01 00:00:00

  • The regulation of cartilage extracellular matrix homeostasis in joint cartilage degeneration and regeneration.

    abstract::Osteoarthritis (OA) is a major cause of disability and socioeconomic loss worldwide. However, the current pharmacological approaches used to treat OA are largely palliative. Being the hallmark of OA, the cartilage extracellular matrix (ECM) destruction and abnormal homeostasis is gaining more attention as a therapeuti...

    journal_title:Biomaterials

    pub_type: 杂志文章,评审

    doi:10.1016/j.biomaterials.2020.120555

    authors: Peng Z,Sun H,Bunpetch V,Koh Y,Wen Y,Wu D,Ouyang H

    更新日期:2021-01-01 00:00:00

  • Rapid bioprinting of conjunctival stem cell micro-constructs for subconjunctival ocular injection.

    abstract::Ocular surface diseases including conjunctival disorders are multifactorial progressive conditions that can severely affect vision and quality of life. In recent years, stem cell therapies based on conjunctival stem cells (CjSCs) have become a potential solution for treating ocular surface diseases. However, neither a...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2020.120462

    authors: Zhong Z,Deng X,Wang P,Yu C,Kiratitanaporn W,Wu X,Schimelman J,Tang M,Balayan A,Yao E,Tian J,Chen L,Zhang K,Chen S

    更新日期:2021-01-01 00:00:00

  • Corn-like Au/Ag nanorod-mediated NIR-II photothermal/photodynamic therapy potentiates immune checkpoint antibody efficacy by reprogramming the cold tumor microenvironment.

    abstract::Immune checkpoint blocking (ICB) antibodies have shown great success in the clinic, but their low response rate in patients with immunosuppressive cold tumors remains a huge challenge. Inspired by the capability of immunogenic cell death (ICD) to convert tumors from cold to hot, we developed a corn-like Au/Ag nanorod ...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2020.120582

    authors: Jin L,Shen S,Huang Y,Li D,Yang X

    更新日期:2021-01-01 00:00:00

  • 3D cell-printing of biocompatible and functional meniscus constructs using meniscus-derived bioink.

    abstract::Meniscus injuries are prevalent in orthopedic diagnosis. The reconstruction of the structural inhomogeneity and anisotropy of the meniscus is a major challenge in clinical practice. Meniscal tissue engineering has emerged as a potential alternative for the treatment of various meniscal diseases and injuries. In this s...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2020.120466

    authors: Chae S,Lee SS,Choi YJ,Hong DH,Gao G,Wang JH,Cho DW

    更新日期:2021-01-01 00:00:00

  • Adjuvant-pulsed mRNA vaccine nanoparticle for immunoprophylactic and therapeutic tumor suppression in mice.

    abstract::Synthetic mRNA represents an exciting cancer vaccine technology for the implementation of effective cancer immunotherapy. However, inefficient in vivo mRNA delivery along with a requirement for immune co-stimulation present major hurdles to achieving anti-tumor therapeutic efficacy. Here, we demonstrate a proof-of-con...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2020.120431

    authors: Islam MA,Rice J,Reesor E,Zope H,Tao W,Lim M,Ding J,Chen Y,Aduluso D,Zetter BR,Farokhzad OC,Shi J

    更新日期:2021-01-01 00:00:00

  • Breast cancer cells and macrophages in a paracrine-juxtacrine loop.

    abstract::Breast cancer cells (BCC) and macrophages are known to interact via epidermal growth factor (EGF) produced by macrophages and colony stimulating factor-1 (CSF-1) produced by BCC. Despite contradictory findings, this interaction is perceived as a paracrine loop. Further, the underlying mechanism of interaction remains ...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2020.120412

    authors: Onal S,Turker-Burhan M,Bati-Ayaz G,Yanik H,Pesen-Okvur D

    更新日期:2021-01-01 00:00:00

  • Matrix metalloproteinase (MMP)-degradable tissue engineered periosteum coordinates allograft healing via early stage recruitment and support of host neurovasculature.

    abstract::Despite serving as the clinical "gold standard" treatment for critical size bone defects, decellularized allografts suffer from long-term failure rates of ~60% due to the absence of the periosteum. Stem and osteoprogenitor cells within the periosteum orchestrate autograft healing through host cell recruitment, which i...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2020.120535

    authors: Li Y,Hoffman MD,Benoit DSW

    更新日期:2021-01-01 00:00:00

  • Knowledge gaps in immune response and immunotherapy involving nanomaterials: Databases and artificial intelligence for material design.

    abstract::Exploring the interactions between the immune system and nanomaterials (NMs) is critical for designing effective and safe NMs, but large knowledge gaps remain to be filled prior to clinical applications (e.g., immunotherapy). The lack of databases on interactions between the immune system and NMs affects the discovery...

    journal_title:Biomaterials

    pub_type: 杂志文章,评审

    doi:10.1016/j.biomaterials.2020.120469

    authors: Feng R,Yu F,Xu J,Hu X

    更新日期:2021-01-01 00:00:00

  • Understanding the role of tissue-specific decellularized spinal cord matrix hydrogel for neural stem/progenitor cell microenvironment reconstruction and spinal cord injury.

    abstract::The repair of spinal cord injury (SCI) highly relies on microenvironment remodeling and facilitating the recruitment and neuronal differentiation of endogenous stem/progenitor cells. Decellularized tissue matrices (DTMs) have shown their unique and beneficial characteristics in promoting neural tissue regeneration, es...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2020.120596

    authors: Xu Y,Zhou J,Liu C,Zhang S,Gao F,Guo W,Sun X,Zhang C,Li H,Rao Z,Qiu S,Zhu Q,Liu X,Guo X,Shao Z,Bai Y,Zhang X,Quan D

    更新日期:2021-01-01 00:00:00

  • Photothermally triggered nitric oxide nanogenerator targeting type IV pili for precise therapy of bacterial infections.

    abstract::Nitric oxide (NO) is an important biological messenger involved in the treatment of bacterial infections, but its controlled and targeted release in bacterial infections remains a major challenge. Herein, an intelligent NO nanogenerator triggered by near-infrared (NIR) light is constructed for targeted treatment of P....

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2020.120588

    authors: Wu Y,Deng G,Jiang K,Wang H,Song Z,Han H

    更新日期:2021-01-01 00:00:00

  • Microgel encapsulated nanoparticles for glucose-responsive insulin delivery.

    abstract::An insulin delivery system that self-regulates blood glucose levels has the potential to limit hypoglycemic events and improve glycemic control. Glucose-responsive insulin delivery systems have been developed by coupling glucose oxidase with a stimuli-responsive biomaterial. However, the challenge of achieving desirab...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2020.120458

    authors: Volpatti LR,Facklam AL,Cortinas AB,Lu YC,Matranga MA,MacIsaac C,Hill MC,Langer R,Anderson DG

    更新日期:2021-01-01 00:00:00

  • The complement cascade at the Utah microelectrode-tissue interface.

    abstract::Devices implanted within the central nervous system (CNS) are subjected to tissue reactivity due to the lack of biocompatibility between implanted material and the cells' microenvironment. Studies have attributed blood-brain barrier disruption, inflammation, and oxidative stress as main contributing factors that lead ...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2020.120583

    authors: Bennett C,Álvarez-Ciara A,Franklin M,Dietrich WD,Prasad A

    更新日期:2021-01-01 00:00:00

  • Lymph-directed nitric oxide increases immune cell access to lymph-borne nanoscale solutes.

    abstract::Lymph nodes (LNs) are immune organs housing high concentrations of lymphocytes, making them critical targets for therapeutic immunomodulation in a wide variety of diseases. While there is great interest in targeted drug delivery to LNs, many nanoscale drug delivery carriers have limited access to parenchymal resident ...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2020.120411

    authors: Sestito LF,Thomas SN

    更新日期:2021-01-01 00:00:00

  • Immune checkpoint inhibition in syngeneic mouse cancer models by a silicasome nanocarrier delivering a GSK3 inhibitor.

    abstract::Checkpoint blocking antibodies that interfere in the PD-1/PD-L1 axis provide effective cancer immunotherapy for tumors that are immune inflamed or induced to become "hot". It has also been demonstrated that a small molecule inhibitor of the signaling hub kinase GSK3 can interfere in the PD-1/PD-L1 axis in T-cells by s...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2020.120635

    authors: Allen SD,Liu X,Jiang J,Liao YP,Chang CH,Nel AE,Meng H

    更新日期:2020-12-28 00:00:00

  • In vitro bone metastasis dwelling in a 3D bioengineered niche.

    abstract::Bone is the most frequent metastasis site for breast cancer. As well as dramatically increasing disease burden, bone metastases are also an indicator of poor prognosis. One of the main challenges in investigating bone metastasis in breast cancer is engineering in vitro models that replicate the features of in vivo bon...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2020.120624

    authors: Han W,El Botty R,Montaudon E,Malaquin L,Deschaseaux F,Espagnolle N,Marangoni E,Cottu P,Zalcman G,Parrini MC,Assayag F,Sensebe L,Silberzan P,Vincent-Salomon A,Dutertre G,Roman-Roman S,Descroix S,Camonis J

    更新日期:2020-12-24 00:00:00

  • A dual-modal PET/near infrared fluorescent nanotag for long-term immune cell tracking.

    abstract::Adoptive cell transfer of targeted chimeric antigen receptor (CAR) T cells has emerged as a highly promising cancer therapy. The pharmacodynamic action or CAR T cells is closely related to their pharmacokinetic profile; because of this as well as the risk of non-specific action, it is important to monitor their biodis...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2020.120630

    authors: Harmsen S,Medine EI,Moroz M,Nurili F,Lobo J,Dong Y,Turkekul M,Pillarsetty NVK,Ting R,Ponomarev V,Akin O,Aras O

    更新日期:2020-12-23 00:00:00

  • Disease-induced immunomodulation at biomaterial scaffolds detects early pancreatic cancer in a spontaneous model.

    abstract::Pancreatic cancer has the worst prognosis of all cancers due to disease aggressiveness and paucity of early detection platforms. We developed biomaterial scaffolds that recruit metastatic tumor cells and reflect the immune dysregulation of native metastatic sites. While this platform has shown promise in orthotopic br...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2020.120632

    authors: Bushnell GG,Orbach SM,Ma JA,Crawford HC,Wicha MS,Jeruss JS,Shea LD

    更新日期:2020-12-23 00:00:00

  • Celastrol nanoemulsion induces immunogenicity and downregulates PD-L1 to boost abscopal effect in melanoma therapy.

    abstract::Programmed cell death-ligand 1 (PD-L1)-based immune checkpoint blockade therapy using the anti-PD-L1 antibody is effective for a subset of patients with advanced metastatic melanoma but about half of the patients do not respond to the therapy because of the tumor immunosuppressive microenvironment. Immunogenic cell de...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2020.120604

    authors: Qiu N,Liu Y,Liu Q,Chen Y,Shen L,Hu M,Zhou X,Shen Y,Gao J,Huang L

    更新日期:2020-12-17 00:00:00

  • Cryogel/hydrogel biomaterials and acupuncture combined to promote diabetic skin wound healing through immunomodulation.

    abstract::Unhealed chronic wounds often deteriorate into multiple infection with several kinds of bacteria and excessive proteolytic wound exudate and remains one of the common healthcare issues. Here, the functional and antimicrobial hydrogel and cryogel biomaterials were prepared from glycol chitosan and a novel biodegradable...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2020.120608

    authors: Chen TY,Wen TK,Dai NT,Hsu SH

    更新日期:2020-12-16 00:00:00

  • Injectable biodegradation-visual self-healing citrate hydrogel with high tissue penetration for microenvironment-responsive degradation and local tumor therapy.

    abstract::Local tumor therapy through injectable biodegradable hydrogels with controlled drug release has attracted much attention recently, due to their easy operation, low side effect and efficiency. However, most of the reported therapeutic hydrogel system showed a lack of biodegradation tracking and tumor environment-respon...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2020.120301

    authors: Wang M,Chen M,Niu W,Winston DD,Cheng W,Lei B

    更新日期:2020-12-01 00:00:00

  • Photocrosslinkable nanocomposite ink for printing strong, biodegradable and bioactive bone graft.

    abstract::3D printing is known as a cost-effective technique that shows huge potential in fabrication of graft substitutes for bone tissue regeneration. However, the tradeoff between 3D printability, mechanical strength and bioactivity of the printed materials (i.e., inks) remains a challenge. In this work, we present a novel p...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2020.120378

    authors: Yang Y,Zhang Q,Xu T,Zhang H,Zhang M,Lu L,Hao Y,Fuh JH,Zhao X

    更新日期:2020-12-01 00:00:00

  • The fibrotic response of primary liver spheroids recapitulates in vivo hepatic stellate cell activation.

    abstract::A major obstacle in the development of efficient therapies for progressive liver fibrosis is the lack of representative in vitro models of liver fibrosis to aid in understanding the mechanisms of the disease and to promote the development of pharmaceuticals. Our aim was to develop a relevant in vitro mouse liver fibro...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2020.120335

    authors: Mannaerts I,Eysackers N,Anne van Os E,Verhulst S,Roosens T,Smout A,Hierlemann A,Frey O,Leite SB,van Grunsven LA

    更新日期:2020-12-01 00:00:00

  • Localized inhibition of platelets and platelet derived growth factor by a matrix targeted glycan mimetic significantly attenuates liver fibrosis.

    abstract::New therapeutic strategies are needed for the growing unmet clinical needs in liver disease and fibrosis. Platelet activation and PDGF activity are recognized as important therapeutic targets; however, no therapeutic approach has yet addressed these two upstream drivers of liver fibrosis. We therefore designed a matri...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2020.120538

    authors: Kabra H,Walimbe T,Stuart K,Indey C,Jalgaonkar S,Ikwa E,Skurnac T,Chen J,Woolley A,Snead NM,Bachtell N,Leeming DJ,Karsdal M,Prestwich G,Panitch A,Paderi J

    更新日期:2020-11-17 00:00:00

  • Receptor tyrosine kinases-instructed release of its inhibitor from hydrogel to delay ovarian aging.

    abstract::Premature ovarian failure (POF) is the most frequently occurred disease in ovary. Direct inhibition of mammalian target of rapamycin (mTOR) activity can treat woman POF but brings adverse effects to women. Herein, by rational design of a hydrogelator Nap-Phe-Phe-Asp-Arg-Leu-Tyr-OH (Y) and co-assembling Y with an inhib...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2020.120536

    authors: Shi Z,Li X,Wei M,Chen P,Zhang T,Ling X,Zhang J,Zhao C,Wang F,Liang G

    更新日期:2020-11-16 00:00:00

  • A sequential 3D bioprinting and orthogonal bioconjugation approach for precision tissue engineering.

    abstract::Recent advances in 3D bioprinting have transformed the tissue engineering landscape by enabling the controlled placement of cells, biomaterials, and bioactive agents for the biofabrication of living tissues and organs. However, the application of 3D bioprinting is limited by the availability of cytocompatible and prin...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2020.120294

    authors: Yu C,Miller KL,Schimelman J,Wang P,Zhu W,Ma X,Tang M,You S,Lakshmipathy D,He F,Chen S

    更新日期:2020-11-01 00:00:00

  • Development of a two-part biomaterial adhesive strategy for annulus fibrosus repair and ex vivo evaluation of implant herniation risk.

    abstract::Intervertebral disc (IVD) herniation causes pain and disability, but current discectomy procedures alleviate pain without repairing annulus fibrosus (AF) defects. Tissue engineering strategies seal AF defects by utilizing hydrogel systems to prevent recurrent herniation, however current biomaterials are limited by poo...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2020.120309

    authors: DiStefano TJ,Shmukler JO,Danias G,Di Pauli von Treuheim T,Hom WW,Goldberg DA,Laudier DM,Nasser PR,Hecht AC,Nicoll SB,Iatridis JC

    更新日期:2020-11-01 00:00:00

  • Electrical stimulation and piezoelectric biomaterials for bone tissue engineering applications.

    abstract::Bioelectrical phenomenon in natural bone has been well recognized for its role in bone development and fracture healing. For example, the piezoelectricity induced modulation in cellular functionality assists in the repair and regeneration of bone tissue. Against this backdrop, we review here the origin of dielectric a...

    journal_title:Biomaterials

    pub_type: 杂志文章,评审

    doi:10.1016/j.biomaterials.2020.120280

    authors: Khare D,Basu B,Dubey AK

    更新日期:2020-11-01 00:00:00

  • A multilayered epithelial mucosa model of head neck squamous cell carcinoma for analysis of tumor-microenvironment interactions and drug development.

    abstract::Pharmacotherapy of head and neck squamous cell carcinoma (HNSCC) often fails due to the development of chemoresistance and severe systemic side effects of current regimens limiting dose escalation. Preclinical models comprising all major elements of treatment resistance are urgently needed for the development of new s...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2020.120277

    authors: Gronbach L,Wolff C,Klinghammer K,Stellmacher J,Jurmeister P,Alexiev U,Schäfer-Korting M,Tinhofer I,Keilholz U,Zoschke C

    更新日期:2020-11-01 00:00:00

  • CaproGlu: Multifunctional tissue adhesive platform.

    abstract::Driven by the clinical need for a strong tissue adhesive with elastomeric material properties, a departure from legacy crosslinking chemistries was sought as a multipurpose platform for tissue mending. A fresh approach to bonding wet substrates has yielded a synthetic biomaterial that overcomes the drawbacks of free-r...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2020.120215

    authors: Djordjevic I,Pokholenko O,Shah AH,Wicaksono G,Blancafort L,Hanna JV,Page SJ,Nanda HS,Ong CB,Chung SR,Chin AYH,McGrouther D,Choudhury MM,Li F,Teo JS,Lee LS,Steele TWJ

    更新日期:2020-11-01 00:00:00

  • Tumor-activatable ultrasmall nanozyme generator for enhanced penetration and deep catalytic therapy.

    abstract::Tumor-activatable ultrasmall nanozyme generation is an unprecedented strategy to overcome intrinsically fatal defects of traditional reactive oxygen species (ROS)-based nanoagents for deep tumor penetration, including limited tissue-penetrating depth of external energy, heavy reliance on oxygen and nonspecific toxicit...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2020.120263

    authors: Liu X,Liu Z,Dong K,Wu S,Sang Y,Cui T,Zhou Y,Ren J,Qu X

    更新日期:2020-11-01 00:00:00

  • A free-standing multilayer film as a novel delivery carrier of platelet lysates for potential wound-dressing applications.

    abstract::Great efforts have been made to develop suitable bioactive constructs that release growth factors (GFs) in a controlled manner for tissue-regeneration applications. Platelet lysates (PLs) are an affordable source of multiple GFs and other proteins, and show great potential in the wound-healing process. Herein, poly-l-...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2020.120138

    authors: Tang Q,Lim T,Wei XJ,Wang QY,Xu JC,Shen LY,Zhu ZZ,Zhang CQ

    更新日期:2020-10-01 00:00:00

  • A multifunctional anti-inflammatory drug that can specifically target activated macrophages, massively deplete intracellular H2O2, and produce large amounts CO for a highly efficient treatment of osteoarthritis.

    abstract::Specifically inhibiting the proliferation of activated macrophages and clearing the high levels of reactive oxygen species (ROS) secreted by macrophages is crucial for osteoarthritis (OA) treatment. Moreover, if the clearance of these high levels of ROS can be simultaneously used to induce oxidation-responsive release...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2020.120155

    authors: Yang G,Fan M,Zhu J,Ling C,Wu L,Zhang X,Zhang M,Li J,Yao Q,Gu Z,Cai X

    更新日期:2020-10-01 00:00:00

  • Direct 3D bioprinting of cardiac micro-tissues mimicking native myocardium.

    abstract::The heart possesses a complex three-dimensional (3D) laminar myofiber organization; however, because engineering physiologically relevant 3D tissues remains a technical challenge, the effects of cardiomyocyte alignment on excitation-contraction coupling, shortening and force development have not been systematically st...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2020.120204

    authors: Liu J,Miller K,Ma X,Dewan S,Lawrence N,Whang G,Chung P,McCulloch AD,Chen S

    更新日期:2020-10-01 00:00:00

  • Nanofibrous spongy microspheres to deliver rabbit mesenchymal stem cells and anti-miR-199a to regenerate nucleus pulposus and prevent calcification.

    abstract::Lower back pain is mainly caused by intervertebral disc degeneration, in which calcification is frequently involved. Here novel nanofibrous spongy microspheres (NF-SMS) are used to carry rabbit bone marrow mesenchymal stromal cells (MSCs) to regenerate nucleus pulposus tissues. NF-SMS are shown to significantly enhanc...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2020.120213

    authors: Feng G,Zhang Z,Dang M,Rambhia KJ,Ma PX

    更新日期:2020-10-01 00:00:00

  • Pre- and post-irradiation mild hyperthermia enabled by NIR-II for sensitizing radiotherapy.

    abstract::The clinical application of cancer radiotherapy is critically impeded by hypoxia-induced radioresistance, insufficient DNA damage, and multiple DNA repair mechanisms. Herein we demonstrate a dual-hyperthermia strategy to potentiate radiotherapy by relieving tumor hypoxia and preventing irradiation-induced DNA damage r...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2020.120235

    authors: Li Q,Hang L,Jiang W,Dou J,Xiao L,Tang X,Yao Y,Wang Y

    更新日期:2020-10-01 00:00:00

  • Localized mandibular infection affects remote in vivo bioreactor bone generation.

    abstract::Mandibular reconstruction requires functional and aesthetic repair and is further complicated by contamination from oral and skin flora. Antibiotic-releasing porous space maintainers have been developed for the local release of vancomycin and to promote soft tissue attachment. In this study, mandibular defects in six ...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2020.120185

    authors: Watson E,Smith BT,Smoak MM,Tatara AM,Shah SR,Pearce HA,Hogan KJ,Shum J,Melville JC,Hanna IA,Demian N,Wenke JC,Bennett GN,van den Beucken JJJP,Jansen JA,Wong ME,Mikos AG

    更新日期:2020-10-01 00:00:00

  • Localized delivery of CRISPR/dCas9 via layer-by-layer self-assembling peptide coating on nanofibers for neural tissue engineering.

    abstract::The clustered regularly interspaced short palindromic repeat (CRISPR) systems have a wide variety of applications besides precise genome editing. In particular, the CRISPR/dCas9 system can be used to control specific gene expression by CRISPR activation (CRISPRa) or interference (CRISPRi). However, the safety concerns...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2020.120225

    authors: Zhang K,Chooi WH,Liu S,Chin JS,Murray A,Nizetic D,Cheng D,Chew SY

    更新日期:2020-10-01 00:00:00

  • Hierarchically constructed selenium-doped bone-mimetic nanoparticles promote ROS-mediated autophagy and apoptosis for bone tumor inhibition.

    abstract::Biomimetic materials are often capable of subtly affecting tissue development, regeneration and carcinogenesis due to their high similarity to natural tissues. Despite the benefit of using such materials in tissue engineering, their prospective use in cancer therapy has been neglected, particularly the functions and m...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2020.120253

    authors: Li X,Wang Y,Chen Y,Zhou P,Wei K,Wang H,Wang J,Fang H,Zhang S

    更新日期:2020-10-01 00:00:00

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