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Bioinspired membrane provides periosteum-mimetic microenvironment for accelerating vascularized bone regeneration.

Abstract：

:Periosteum plays a pivotal role in vascularization, ossification and remodeling during the healing process of bone injury. However, there are few studies focused on the construction of artificial implants with periosteum-mimetic effect. To emulate the primary role of natural periosteum or endosteal tissues in bone regeneration, here we provide a functional biomimetic membrane with micropatterns of site-specific biomineralization. The micropattern is generated by using printed hydroxyapatite nanoparticles (HANPs), combined with selective growth of biomineralized apatite and in situ coprecipitation with growth factors. The biomimetic membrane can sustainably provide a periosteum-mimetic microenvironment, such as long-term topographical guidance for cell recruitment and induced cell differentiation, by releasing calcium phosphate and growth factors. We demonstrated that rat mesenchymal stem cells (rMSCs) on such biomimetic membrane exhibited highly aligned organization, leading to enhanced angiogenesis and osteogenesis. In the rat calvarial defect model, our biomimetic membranes with biomineralized micropatterns could significantly enhance vascularized ossification and accelerate new bone formation. The current work suggests that the functionally biomimetic membranes with specific biomineralized micropatterns can be a promising alternative to periosteal autografts, with great potential for bench-to-bedside translation in orthopedics.

journal_name

Biomaterials

journal_title

Biomaterials

authors

Yang G,Liu H,Cui Y,Li J,Zhou X,Wang N,Wu F,Li Y,Liu Y,Jiang X,Zhang S

doi

10.1016/j.biomaterials.2020.120561

subject

Has Abstract

pub_date

2021-01-01 00:00:00

pages

120561

eissn

0142-9612

issn

1878-5905

pii

S0142-9612(20)30807-3

journal_volume

268

pub_type

杂志文章

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