Abstract：
:Thrombomodulin (TM) is a newly described endothelial cell-associated protein that functions as a potent natural anticoagulant by converting thrombin from a procoagulant protease to an anticoagulant. In this study, focussing on the application of TM for biomedical materials, recombinant human TM (hTM) was immobilized onto the polymers for medical use, and the evaluation of their antithrombogenicity and the interaction with platelets were investigated. As the base polymer for immobilization reaction, poly(ether urethane urea) (PEUU), which was reported to have good blood compatibility, was used. hTM-immobilized PEUU showed superior antithrombogenic activity, such as the prolongation of plasma recalcification time and the inhibition of thrombin-induced platelet aggregation, though the amount of immobilized hTM was very small (i.e. less than 1 microgram/cm2). Platelet adhesions onto hTM-immobilized PEUU were not observed. These results show that the immobilization of hTM does not change the native good blood compatibility of PEUU, but provides excellent anticoagulant activity.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Kishida A,Ueno Y,Fukudome N,Yashima E,Maruyama I,Akashi Mdoi
10.1016/0142-9612(94)90041-8subject
Has Abstractpub_date
1994-08-01 00:00:00pages
848-52issue
10eissn
0142-9612issn
1878-5905pii
0142-9612(94)90041-8journal_volume
15pub_type
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