In vivo mineralization and osteogenesis of nanocomposite scaffold of poly(lactide-co-glycolide) and hydroxyapatite surface-grafted with poly(L-lactide).

abstract：:This study investigated the in vitro effects of akermanite, a new kind of Ca-, Mg-, Si-containing bioceramic, on the attachment, proliferation and osteogenic differentiation of human adipose-derived stem cells (hASCs). Parallel comparison of the cellular behaviors of hASCs on the akermanite was made with those on beta...

journal_title：Biomaterials

authors： Liu Q,Cen L,Yin S,Chen L,Liu G,Chang J,Cui L

更新日期：2008-12-01 00:00:00

abstract：:As double stranded, single stranded siRNA (ss-siRNA) has demonstrated gene silencing activity but still requires efficient carriers to reach its cytoplasmic target. To better understand the fundamental aspect driving the complexation of ss-siRNA with nanocarriers, the interactions between surfaces of various compositi...

journal_title：Biomaterials

authors： Giraud L,Viricel W,Leblond J,Giasson S

更新日期：2017-01-01 00:00:00

abstract：:Nanovectors hold substantial promise in abating the off-target effects of therapeutics by providing a means to selectively accumulate payloads at the target lesion, resulting in an increase in the therapeutic index. A sophisticated understanding of the factors that govern the degradation and release dynamics of these ...

journal_title：Biomaterials

authors： Martinez JO,Chiappini C,Ziemys A,Faust AM,Kojic M,Liu X,Ferrari M,Tasciotti E

更新日期：2013-11-01 00:00:00

abstract：:Osteonecrosis of the femoral head (ONFH) is a debilitating disease that may progress to femoral head collapse and subsequently, degenerative arthritis. Although injection of bone marrow-derived mononuclear cells (BMMCs) is often performed with core decompression (CD) in the early stage of ONFH, these treatments are no...

journal_title：Biomaterials

authors： Maruyama M,Nabeshima A,Pan CC,Behn AW,Thio T,Lin T,Pajarinen J,Kawai T,Takagi M,Goodman SB,Yang YP

更新日期：2018-12-01 00:00:00

abstract：:There is currently no effective treatment for the retinal disorders caused by retinal pigment epithelium (RPE) degeneration. Transplantation of allografts is the main strategy towards correction of this malady. Tissue engineering could offer hope and involve the use of biodegradable polymeric templates to replace dise...

journal_title：Biomaterials

authors： Tezcaner A,Bugra K,Hasirci V

更新日期：2003-11-01 00:00:00

abstract：:Surface sensitive spectroscopies, Auger electron and X-ray photoelectron (XPS), were used to determine changes in titanium oxide composition, oxide stoichiometry, and adsorbed surface species as a function of exposure to human serum in a balanced electrolyte (serum/SIE) and 8.0 mM ethylenediaminetetraacetic acid in a ...

journal_title：Biomaterials

authors： Healy KE,Ducheyne P

更新日期：1992-01-01 00:00:00

abstract：:Effect of poly(epsilon-caprolactone) (PCL) content on the bioactivity and mechanical properties of PCL/silica hybrid was investigated. The PCL/silica hybrids with different PCL contents were prepared through co-condensation reaction with triethoxysilane end capped PCL and tetraethyl orthosilicate. The higher the PCL c...

journal_title：Biomaterials

authors： Rhee SH

更新日期：2004-03-01 00:00:00

abstract：:Adipose tissue engineering offers a promising alternative to the current breast reconstruction options. Here we investigated patient-specific breast scaffolds fabricated from poly(d,l)-lactide polymer with pore sizes>1 mm for their potential in long-term sustained regeneration of high volume adipose tissue. An optimis...

journal_title：Biomaterials

authors： Chhaya MP,Melchels FP,Holzapfel BM,Baldwin JG,Hutmacher DW

更新日期：2015-06-01 00:00:00

abstract：:Semisynthetic network alginate polymer (SNAP), synthesized by acetalization of linear alginate with di-aldehyde, is a pH-responsive tetrafunctionally linked 3D gel network, and has potential application in oral delivery of protein therapeutics and active biologicals, and as tissue bioscaffold for regenerative medicine...

journal_title：Biomaterials

authors： Chan AW,Neufeld RJ

更新日期：2009-10-01 00:00:00

abstract：:Surface properties of implanted biomaterials can cause fibrotic tissue reactions by stimulating differentiation of host fibroblasts into contractile myofibroblasts. Silk fibroin (SF) protein has been used as biomaterial in pure and blended form. however, its effect on myofibroblast differentiation remains elusive. We ...

journal_title：Biomaterials

authors： Acharya C,Hinz B,Kundu SC

更新日期：2008-12-01 00:00:00

abstract：:The design of peptide-based subunit vaccine formulations for the direct delivery of tumor antigen peptides (Aps) to dendritic cells (DCs) localized within draining lymph nodes (DLNs) is challenging. Mature DCs (mDCs) are abundantly distributed within DLNs but have dramatically reduced endocytic uptake and antigen-proc...

journal_title：Biomaterials

authors： Qian Y,Jin H,Qiao S,Dai Y,Huang C,Lu L,Luo Q,Zhang Z

更新日期：2016-08-01 00:00:00

abstract：:Podophyllotoxin (PPT) exhibited significant activity against P-glycoprotein mediated multidrug resistant (MDR) tumor cell lines; however, due to its poor solubility and high toxicity, PPT cannot be dosed systemically, preventing its clinical use for MDR cancer. We developed a nanoparticle dosage form of PPT by covalen...

journal_title：Biomaterials

authors： Roy A,Ernsting MJ,Undzys E,Li SD

更新日期：2015-06-01 00:00:00

abstract：:It is well known that biomaterials play an important role in the regulation of adhesion and growth of a variety of cultured cell types. However, whether biomaterials are associated with the senescence of cultured cells is not known. The present work shows that the decrease of the hydrophobic property of poly (ethylene...

journal_title：Biomaterials

authors： Lou PJ,Chiu MY,Chou CC,Liao BW,Young TH

更新日期：2010-03-01 00:00:00

abstract：:A two-layer hydroxyapatite (HA)/HA+TiO(2) bond coat composite coating (HTH coating) on titanium was fabricated by plasma spraying. The HA+TiO(2) bond coat (HTBC) consists of 50 vol% HA and 50 vol% TiO(2) (HT). The microstructural characterization of the HTH coatings before and after heat treatment was conducted by usi...

journal_title：Biomaterials

authors： Lu YP,Li MS,Li ST,Wang ZG,Zhu RF

更新日期：2004-08-01 00:00:00

abstract：:Realizing the potential of human pluripotent stem cell (hPSC)-based therapy requires the development of defined scalable culture systems with efficient expansion, differentiation and isolation protocols. We report an engineered 3D microfiber system that efficiently supports long-term hPSCs self-renewal under chemicall...

journal_title：Biomaterials

authors： Lu HF,Narayanan K,Lim SX,Gao S,Leong MF,Wan AC

更新日期：2012-03-01 00:00:00

abstract：:Compression, tension and torsion tests were designed and completed successfully on a brushite and a precipitated hydroxyapatite cement in moist condition. Elastic and strength properties were measured for these three loading cases. For each cement, the full set of strength data was fitted to an isotropic Tsai-Wu crite...

journal_title：Biomaterials

authors： Charrière E,Terrazzoni S,Pittet C,Mordasini PH,Dutoit M,Lemaître J,Zysset PH

更新日期：2001-11-01 00:00:00

abstract：:Understanding mechanisms that govern cell fate determination of human induced pluripotent stem cells (hiPSCs) could assist in maintenance of the undifferentiated state during cell expansion. We used polyamidoamine dendrimer surfaces with first-generation (G1), third-generation (G3) and fifth-generation (G5) of dendron...

journal_title：Biomaterials

authors： Kim MH,Kino-oka M

更新日期：2014-07-01 00:00:00

abstract：:Cell attachment, proliferation and differentiation on different materials depend largely on the surface properties of the materials. This study sheds light on the mechanism by which the modulation of the chemical composition of calcium silicate cements with different Si/Ca molar ratios could produce different cell res...

journal_title：Biomaterials

authors： Shie MY,Ding SJ

更新日期：2013-09-01 00:00:00

abstract：:Acute and chronic wounds affect millions and are associated with billions of dollars in healthcare costs. The use of healing markers, biochemical cues from biocompatible matrices and materials, and their correlation with wound healing has the potential to generate valuable diagnostic, prognostic, and therapeutic infor...

journal_title：Biomaterials

authors： Roussakis E,Ortines RV,Pinsker BL,Mooers CT,Evans CL,Miller LS,Calderón-Colón X

更新日期：2019-08-01 00:00:00

abstract：:This paper presents some results concerning the size-controlled hydroxyapatite nanoparticles obtained in aqueous media in a biopolymer matrix from soluble precursors salts. Taking the inspiration from nature, where composite materials made of a polymer matrix and inorganic fillers are often found, e.g. bone, shell of ...

journal_title：Biomaterials

authors： Rusu VM,Ng CH,Wilke M,Tiersch B,Fratzl P,Peter MG

更新日期：2005-09-01 00:00:00

abstract：:Recapitulation of the cellular microenvironment of the heart, which promotes cell contraction, remains a key challenge in cardiac tissue engineering. We report here on our work, where for the first time, a 3-dimensional (3D) spring-like fiber scaffold was fabricated, successfully mimicking the coiled perimysial fibers...

journal_title：Biomaterials

authors： Fleischer S,Feiner R,Shapira A,Ji J,Sui X,Daniel Wagner H,Dvir T

更新日期：2013-11-01 00:00:00

abstract：:Multifunctional nanoparticles integrated with imaging modalities (such as magnetic resonance and optical) and therapeutic drugs are promising candidates for future cancer diagnostics and therapy. While targeted drug delivery and imaging of tumor cells have been the major focus in engineering nanoparticle probes, no ex...

journal_title：Biomaterials

authors： Mitra RN,Doshi M,Zhang X,Tyus JC,Bengtsson N,Fletcher S,Page BD,Turkson J,Gesquiere AJ,Gunning PT,Walter GA,Santra S

更新日期：2012-02-01 00:00:00

abstract：:Following an original synthesis route, we have prepared a single-component calcium phosphate apatite-like powder which settles and hardens when mixed with deionized water in an approximative 1.2 g:1 ml ratio. This paper describes the first physico-chemical studies and characterizations of the material. Observations of...

journal_title：Biomaterials

authors： Zoulgami M,Lucas A,Briard P,Gaudé J

更新日期：2001-07-01 00:00:00

abstract：:A homogeneous glycidyl acrylate polymer (GAP) has been grafted on to polytetrafluoroethylene (PTFE) and polyethylene (PE) using a modified plasma glow discharge technique with glycidyl acrylate. The polymeric layer appears to be extremely stable to acidic media and to common organic solvents. The modified surface can ...

journal_title：Biomaterials

authors： Tanfani F,Durrani AA,Kojima M,Chapman D

更新日期：1990-10-01 00:00:00

abstract：:The electrospinning process was utilized successfully to fabricate the random oriented and aligned electrically conductive nanofibers of biodegradable poly-DL-lactide (PLA) in which multiwalled carbon nanotubes (MWCNTs) were embedded. The topographical features of the composite nanofibers were characterized by SEM. Th...

journal_title：Biomaterials

authors： Shao S,Zhou S,Li L,Li J,Luo C,Wang J,Li X,Weng J

更新日期：2011-04-01 00:00:00

abstract：:We describe the design of original nanocarriers that allows for ultrahigh chromophore loading while maintaining the photo-activity of each individual molecule. They consist in shells of charged biocompatible polymers grafted on gold nanospheres. The self-organization of extended polymer chains results from repulsive c...

journal_title：Biomaterials

authors： Navarro JR,Lerouge F,Cepraga C,Micouin G,Favier A,Chateau D,Charreyre MT,Lanoë PH,Monnereau C,Chaput F,Marotte S,Leverrier Y,Marvel J,Kamada K,Andraud C,Baldeck PL,Parola S

更新日期：2013-11-01 00:00:00

abstract：:The significant drawbacks and lack of success associated with current methods to treat critically sized nerve defects have led to increased interest in neural tissue engineering. Conducting polymers show great promise due to their electrical properties, and in the case of polypyrrole (PPY), its cell compatibility as w...

journal_title：Biomaterials

authors： Xu H,Holzwarth JM,Yan Y,Xu P,Zheng H,Yin Y,Li S,Ma PX

更新日期：2014-01-01 00:00:00

abstract：:Polydimethylsiloxanes exhibit hydrophobic behaviour and poor wettability. These features impose some problems with the clinical performance of the material when used for the construction of intraoral and extraoral facial prostheses. Surface active agents were added to modify the surface energy of the polydimethylsilox...

journal_title：Biomaterials

authors： Polyzois GL,Winter RW,Stafford GD

更新日期：1991-01-01 00:00:00

abstract：:In this work, five self-assembled monolayers (SAMs) and three polymeric brushes with very low fibrinogen adsorption were prepared. The five SAMs are oligo(ethylene glycol) (OEG), phosphorylcholine (PC), oligo(phosphorylcholine) (OPC), and two mixed positively and negatively charged SAMs of SO(3)(-)/N(+)(CH(3))(3) (SA/...

journal_title：Biomaterials

authors： Zhang Z,Zhang M,Chen S,Horbett TA,Ratner BD,Jiang S

更新日期：2008-11-01 00:00:00

abstract：:In this study, we quantified the adsorption of immunoglobulin G (IgG) protein onto several polyelectrolyte-modified sintered porous polyethylene (PPE) membranes. The polymer surfaces had both cationic and anionic charges obtained via the adsorption of polyethylenimine (PEI) and polyacrylic acid (PAA), respectively, on...

journal_title：Biomaterials

authors： Greene G,Radhakrishna H,Tannenbaum R

更新日期：2005-10-01 00:00:00