Abstract：
:Nanovectors hold substantial promise in abating the off-target effects of therapeutics by providing a means to selectively accumulate payloads at the target lesion, resulting in an increase in the therapeutic index. A sophisticated understanding of the factors that govern the degradation and release dynamics of these nanovectors is imperative to achieve these ambitious goals. In this work, we elucidate the relationship that exists between variations in pore size and the impact on the degradation, loading, and release of multistage nanovectors. Larger pored vectors displayed faster degradation and higher loading of nanoparticles, while exhibiting the slowest release rate. The degradation of these particles was characterized to occur in a multi-step progression where they initially decreased in size leaving the porous core isolated, while the pores gradually increased in size. Empirical loading and release studies of nanoparticles along with diffusion modeling revealed that this prolonged release was modulated by the penetration within the porous core of the vectors regulated by their pore size.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Martinez JO,Chiappini C,Ziemys A,Faust AM,Kojic M,Liu X,Ferrari M,Tasciotti Edoi
10.1016/j.biomaterials.2013.07.049subject
Has Abstractpub_date
2013-11-01 00:00:00pages
8469-77issue
33eissn
0142-9612issn
1878-5905pii
S0142-9612(13)00847-8journal_volume
34pub_type
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