A scanning electron microscopy study of the interface between ceramics and bone.

abstract：:Although folate exhibits many advantages over other targeting ligands, it has one major defect: poor water solubility. Once it was conjugated to hydrophilic drug carrier such as N-(2-hydroxypropyl) methacrylamide (HPMA) copolymer, the hydrophobic folate may be buried inside the random polymer coil and not exposed to b...

journal_title：Biomaterials

authors： Li L,Yang Q,Zhou Z,Zhong J,Huang Y

更新日期：2014-06-01 00:00:00

abstract：:The use of a composite graft of bovine trabecular demineralized bone matrix (DBM) and perichondrium has been found a reliable method for in vivo generation of cartilage. In the present study, the mechanism whereby this commercially available matrix increases cartilage formation was investigated. First, the time course...

journal_title：Biomaterials

authors： van Osch GJ,ten Koppel PG,van der Veen SW,Poppe P,Burger EH,Verwoerd-Verhoef HL

更新日期：1999-02-01 00:00:00

abstract：:In vitro tissue engineered models are poised to have significant impact on disease modeling and preclinical drug development. Reliable methods to induce microvascular networks in such microphysiological systems are needed to improve the size and physiological function of these models. By systematically engineering sev...

journal_title：Biomaterials

authors： Brown A,He H,Trumper E,Valdez J,Hammond P,Griffith LG

更新日期：2020-06-01 00:00:00

abstract：:In this work, analytical transmission electron microscopy (TEM) was used to study the nanostructure of mineralised ivory dentine, in order to gain a clearer understanding of the relationship between the organic (collagen fibrils) and inorganic (calcium phosphate apatite crystals) components. Thin sections prepared by ...

journal_title：Biomaterials

authors： Jantou-Morris V,Horton MA,McComb DW

更新日期：2010-07-01 00:00:00

abstract：:The effect of inclusion of an immobilization matrix and the capsule membrane permeability on the viability, metabolic activity, and proliferation of encapsulated HEK cells was investigated in vitro. In the absence of a matrix, a particular transfected HEK cell line formed a single aggregate in the core of the poly(hyd...

journal_title：Biomaterials

authors： Lahooti S,Sefton MV

更新日期：2000-05-01 00:00:00

abstract：:Structural properties of several cross-linked hyaluronan derivatives, obtained by scanning electron microscopy, monodimensional NMR microscopy and small angle X-ray scattering of synchrotron radiation, are presented and compared with those observed for non-modified hyaluronic acid, used as a reference material. The ex...

journal_title：Biomaterials

authors： Gamini A,Paoletti S,Toffanin R,Micali F,Michielin L,Bevilacqua C

更新日期：2002-02-01 00:00:00

abstract：:Traditional therapeutic interventions against abnormal gene expression in disease states at the level of expressed proteins are becoming increasingly difficult due to poor selectivity, off-target effects and associated toxicity. Upstream catalytic targeting of specific RNA sequences offers an alternative platform for ...

journal_title：Biomaterials

authors： Staroseletz Y,Williams A,Burusco KK,Alibay I,Vlassov VV,Zenkova MA,Bichenkova EV

更新日期：2017-01-01 00:00:00

abstract：:The metabolic disposition and elimination process of the anhydride co-polymer poly[1,3-bis(p-carboxy-phenoxypropane):sebacic acid] 20:80 [P(CPP:Sa)20:80] implanted in the rat brain was studied. Two polymers were prepared, one with [14C]SA and unlabelled CPP, and the other co-polymer with [14C]CPP and unlabelled SA. Wi...

journal_title：Biomaterials

authors： Domb AJ,Rock M,Schwartz J,Perkin C,Yipchuk G,Broxup B,Villemure JG

更新日期：1994-07-01 00:00:00

abstract：:The pathogenesis of osteoarthritis is mediated in part by inflammatory cytokines including interleukin-1 (IL-1), which promote degradation of articular cartilage and prevent human mesenchymal stem cell (MSC) chondrogenesis. In this study, we combined gene therapy and functional tissue engineering to develop engineered...

journal_title：Biomaterials

authors： Glass KA,Link JM,Brunger JM,Moutos FT,Gersbach CA,Guilak F

更新日期：2014-07-01 00:00:00

abstract：:The long-term patency rates of vascular grafts and stents are limited by the lack of surface endothelialisation of the implanted materials. We have previously reported that GRGDS and WQPPRARI peptide micropatterns increase the endothelialisation of prosthetic materials in vitro. To investigate the mechanisms by which ...

journal_title：Biomaterials

authors： Hoesli CA,Garnier A,Juneau PM,Chevallier P,Duchesne C,Laroche G

更新日期：2014-01-01 00:00:00

abstract：:Focal infections that are caused by antibiotic-resistant bacteria are becoming an ever-growing challenge to human health. To address this challenge, a pH-responsive amphiphilic polymer of polyaniline-conjugated glycol chitosan (PANI-GCS) that can self-assemble into nanoparticles (NPs) in situ is developed. The PANI-GC...

journal_title：Biomaterials

authors： Korupalli C,Huang CC,Lin WC,Pan WY,Lin PY,Wan WL,Li MJ,Chang Y,Sung HW

更新日期：2017-02-01 00:00:00

abstract：:One of the major limitations of studying cancer-bone metastasis has been the lack of an appropriate ex-vivo model which can be used under defined conditions that simulates closely the in vivo live bone microenvironment in response to cancer-bone interactions. We have developed and utilized a three-dimensional (3D) can...

journal_title：Biomaterials

authors： Curtin P,Youm H,Salih E

更新日期：2012-02-01 00:00:00

abstract：:Seven nominally identical samples of Na-free carbonate apatite (CO(3)Ap) were prepared by reaction of CaHPO(4) with ammonium carbonate solution at 70 degrees C over 3 days. They were studied by chemical analysis, Rietveld analysis of powder X-ray diffraction (XRD) data, Ca/P ratio determinations (quantitative phase an...

journal_title：Biomaterials

authors： Wilson RM,Dowker SE,Elliott JC

更新日期：2006-09-01 00:00:00

abstract：:Induced pluripotent stem cells (iPSCs) hold great promise as a cell source for regenerative medicine yet its culture, maintenance of pluripotency and induction of differentiation remain challenging. Conversely, graphene (G) and graphene oxide (GO) have captured tremendous interests in the fields of materials science, ...

journal_title：Biomaterials

authors： Chen GY,Pang DW,Hwang SM,Tuan HY,Hu YC

更新日期：2012-01-01 00:00:00

abstract：:In this study, we report the systematic comparison of different poly(ethylene glycol) (PEG) self-assembled monolayers on glass with respect to their protein adsorption and cell adhesion resistance. Combining PEGylation with micellar nanolithography allowed the formation of gold nanoparticle arrays on glass and selecti...

journal_title：Biomaterials

authors： Blümmel J,Perschmann N,Aydin D,Drinjakovic J,Surrey T,Lopez-Garcia M,Kessler H,Spatz JP

更新日期：2007-11-01 00:00:00

abstract：:The ultra-short pulse microwave could excite to the strong thermoacoustic (TA) shock wave and deeply penetrate in the biological tissues. Based on this, we developed a novel deep-seated tumor therapy modality with mitochondria-targeting single wall carbon nanotubes (SWNTs) as microwave absorbing agents, which act effi...

journal_title：Biomaterials

authors： Wen L,Ding W,Yang S,Xing D

更新日期：2016-01-01 00:00:00

abstract：:Anti-angiogenic therapeutics has been investigated extensively for the treatment of retinal and choroidal vascular diseases, and diabetic retinopathy. Anti-Flt1 peptide of GNQWFI is an antagonistic peptide for vascular endothelial growth factor receptor 1 (VEGFR1 or Flt1) inhibiting VEGFR1-mediated endothelial cell mi...

journal_title：Biomaterials

authors： Oh EJ,Choi JS,Kim H,Joo CK,Hahn SK

更新日期：2011-04-01 00:00:00

abstract：:Heparin-conjugated electrospun poly(ε-caprolactone) (PCL)/gelatin scaffolds were developed to provide controlled release of platelet-derived growth factor-BB (PDGF-BB) and allow prolonged bioactivity of this molecule. A mixture of PCL and gelatin was electrospun into three different morphologies. Next, heparin molecul...

journal_title：Biomaterials

authors： Lee J,Yoo JJ,Atala A,Lee SJ

更新日期：2012-10-01 00:00:00

abstract：:Polyethylene terephthalate (PET), ethylene-vinyl alcohol copolymer (EVOH) and Nylon 6 in plate form were treated with silane-coupling agents, a titanium alkoxide-alcohol solution and a hot HCl solution to form a thin crystalline titanium oxide layer. When placed in a simulated body fluid with ion concentrations nearly...

journal_title：Biomaterials

authors： Balas F,Kawashita M,Nakamura T,Kokubo T

更新日期：2006-03-01 00:00:00

abstract：:A simple route for synthesizing nano-sized beta-tricalcium phosphate (beta-TCP) at room temperature has been developed in methanol solvent. The phase evolution from CaHPO4, intermediate amorphous calcium phosphate (ACP) phases (including ACP1 and ACP2 with different structures) to final beta-TCP with increasing aging ...

journal_title：Biomaterials

authors： Bow JS,Liou SC,Chen SY

更新日期：2004-07-01 00:00:00

abstract：:Polymerized high internal phase emulsion (polyHIPE) foams are extremely versatile materials for investigating cell-substrate interactions in vitro. Foam morphologies can be controlled by polymerization conditions to result in either open or closed pore structures with different levels of connectivity, consequently ena...

journal_title：Biomaterials

authors： Viswanathan P,Ondeck MG,Chirasatitsin S,Ngamkham K,Reilly GC,Engler AJ,Battaglia G

更新日期：2015-06-01 00:00:00

abstract：:Meniscus injuries are prevalent in orthopedic diagnosis. The reconstruction of the structural inhomogeneity and anisotropy of the meniscus is a major challenge in clinical practice. Meniscal tissue engineering has emerged as a potential alternative for the treatment of various meniscal diseases and injuries. In this s...

journal_title：Biomaterials

authors： Chae S,Lee SS,Choi YJ,Hong DH,Gao G,Wang JH,Cho DW

更新日期：2021-01-01 00:00:00

abstract：:Metal particles and ions from hip prostheses have the potential to induce the production of reactive oxygen species (ROS), making them prime suspects for disturbing the cellular balance of oxidants/antioxidants (redox state of the cell). To better understand the cellular effect of metal ions from metal-on-metal prosth...

journal_title：Biomaterials

authors： Petit A,Mwale F,Tkaczyk C,Antoniou J,Zukor DJ,Huk OL

更新日期：2005-07-01 00:00:00

abstract：:We have investigated the interface between bone and hydroxyapatite (HA) chronically implanted in man. By light microscopy, HA appeared to bind directly to bone without intervening fibrous tissue. By transmission electron microscopy, two patterns were noted: (1) HA either bound directly to bone; or (2) electron-dense m...

journal_title：Biomaterials

authors： Oguchi H,Ishikawa K,Mizoue K,Seto K,Eguchi G

更新日期：1995-01-01 00:00:00

abstract：:The metastatic spread of cancer cells from the primary tumor to distant sites leads to a poor prognosis in cancers originating from multiple organs. Increasing evidence has linked selectin-based adhesion between circulating tumor cells (CTCs) and endothelial cells of the microvasculature to metastatic dissemination, i...

journal_title：Biomaterials

authors： Mitchell MJ,Castellanos CA,King MR

更新日期：2015-07-01 00:00:00

abstract：:Menisci are one of the most commonly injured parts of the knee with a limited healing potential. This study focuses on fabrication and characterization of biomimetic surfaces for meniscal tissue engineering. To achieve this, a combination of hyaluronic acid/chitosan (HA/CH) mutilayers with covalently immobilized major...

journal_title：Biomaterials

authors： Tan GK,Dinnes DL,Butler LN,Cooper-White JJ

更新日期：2010-08-01 00:00:00

abstract：:Nanocomposite of hydroxyapatite (HAP) surface-grafted with poly(l-lactide) (PLLA) (g-HAP) shows a wide application for bone fixation materials due to its improved interface compatibility, mechanical property and biocompatibility in our previous study. In this paper, a 3-D porous scaffold of g-HAP/poly(lactide-co-glyco...

journal_title：Biomaterials

authors： Zhang P,Hong Z,Yu T,Chen X,Jing X

更新日期：2009-01-01 00:00:00

abstract：:A method to fabricate porous, biodegradable conduits using a combined injection molding, thermally induced phase transition technique was developed which produced conduits with dimensionally toleranced, longitudinally aligned channels. The geometry of the channels was designed to approximate the architecture of periph...

journal_title：Biomaterials

authors： Sundback C,Hadlock T,Cheney M,Vacanti J

更新日期：2003-02-01 00:00:00

abstract：:The search for a cell-supporting scaffold with controlled topography and surface chemistry is a constant topic within tissue engineering. Here we have employed M13 phages, which are genetically modifiable biological nanofibers (∼ 880 nm long and ∼ 6.6 nm wide) non-toxic to human beings, to form films for supporting th...

journal_title：Biomaterials

authors： Zhu H,Cao B,Zhen Z,Laxmi AA,Li D,Liu S,Mao C

更新日期：2011-07-01 00:00:00

abstract：:The magnetic resonance (MR) functionalities of pullulan-conjugated gadolinium diethylene triamine pentaacetate (Gd-DTPA-Pullulan) as a new hepatocyte-specific contrast agent were evaluated. Pullulan, which specifically accumulates on hepatocytes via asialoglycoprotein receptors, was chemically linked with Gd-DTPA. Gd-...

journal_title：Biomaterials

authors： Yim H,Yang SG,Jeon YS,Park IS,Kim M,Lee DH,Bae YH,Na K

更新日期：2011-08-01 00:00:00