Abstract：
:The metabolic disposition and elimination process of the anhydride co-polymer poly[1,3-bis(p-carboxy-phenoxypropane):sebacic acid] 20:80 [P(CPP:Sa)20:80] implanted in the rat brain was studied. Two polymers were prepared, one with [14C]SA and unlabelled CPP, and the other co-polymer with [14C]CPP and unlabelled SA. With these two polymers we were able to study the metabolic disposition of each monomer after polymer degradation. Polymer wafers loaded with N,N-bis(2-chloroethyl)-N-nitrosourea or without the drug were implanted in the rat brain. For the rats implanted with the [14C]SA-labelled polymer, approximately 40% of the radioactivity was found in the expired CO2, 10% in the urine, about 2% in the faeces and about 10% remained in the device 7 d after implantation. On the other hand, only 4% of the [14C]CPP monomer was eliminated by urine and faeces during this period. The drug-loaded polymer degraded faster than the blank polymer. This study supports the theory that the polymer is a biodegradable material that can be used for the direct and specific delivery of drugs into a targeted organ and can provide continued release of drugs over a period of time.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Domb AJ,Rock M,Schwartz J,Perkin C,Yipchuk G,Broxup B,Villemure JGdoi
10.1016/0142-9612(94)90166-xsubject
Has Abstractpub_date
1994-07-01 00:00:00pages
681-8issue
9eissn
0142-9612issn
1878-5905pii
0142-9612(94)90166-Xjournal_volume
15pub_type
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