A chemically defined surface for the co-culture of melanocytes and keratinocytes.

abstract：:Large-scale expansion of highly functional adult human mesenchymal stem cells (aMSCs) remains technologically challenging as aMSCs lose self renewal capacity and multipotency during traditional long-term culture and their quality/quantity declines with donor age and disease. Identification of culture conditions enabli...

journal_title：Biomaterials

authors： Ng CP,Sharif AR,Heath DE,Chow JW,Zhang CB,Chan-Park MB,Hammond PT,Chan JK,Griffith LG

更新日期：2014-04-01 00:00:00

abstract：:The present study has examined the efficacy of a polymer microarray platform to screen a library of polyurethanes for applications such as human skeletal progenitor cell isolation and surface modification of tissue engineering scaffolds to enhance skeletal cell growth and differentiation. Analysis of polyurethane micr...

journal_title：Biomaterials

authors： Tare RS,Khan F,Tourniaire G,Morgan SM,Bradley M,Oreffo RO

更新日期：2009-02-01 00:00:00

abstract：:The development of biocompatible photopolymerizing polymers for biomedical and tissue engineering applications has the potential to reduce the invasiveness and cost of biomaterial implants designed to repair or augment tissues. However, more information is needed about the cellular toxicity of the compounds and initia...

journal_title：Biomaterials

authors： Williams CG,Malik AN,Kim TK,Manson PN,Elisseeff JH

更新日期：2005-04-01 00:00:00

abstract：:Ex-vivo blood-brain barrier (BBB) model is of great value for studying brain function and drug development, but it is still challenging to engineer macroscale three-dimensional (3D) tissue constructs to recapitulate physiological and functional aspects of BBB. Here, we describe a delicate 3D vascularized neural constr...

journal_title：Biomaterials

authors： Yue H,Xie K,Ji X,Xu B,Wang C,Shi P

更新日期：2020-07-01 00:00:00

abstract：:In this study, we investigate the molecular mechanisms by which human osteoblasts (HOB) challenged with wear debris promote the differentiation of osteoclast precursors. HOB were obtained from trabecular bone and exposed to alumina (Al(2)O(3)) or 'ultra-high molecular weight polyethylene' (UHMWPE) particles for 24h. T...

journal_title：Biomaterials

authors： Granchi D,Amato I,Battistelli L,Ciapetti G,Pagani S,Avnet S,Baldini N,Giunti A

更新日期：2005-05-01 00:00:00

abstract：:We investigated the bioactivity of new chitosan-based multi-membrane hydrogel (MMH) architectures towards chondrocyte-like cells. The microstructure of the hydrogels constituting the membranes precludes any living cell penetration, whereas their lower scale architecture allows the protein diffusion. The biological beh...

journal_title：Biomaterials

authors： Ladet SG,Tahiri K,Montembault AS,Domard AJ,Corvol MT

更新日期：2011-08-01 00:00:00

abstract：:Improving the immunogenicity of subunit vaccines, in particular skewing of the immune response towards Th1 type immunity, is crucial for the development of effective vaccines against intracellular infections and for the development of anti-cancer vaccines. Small molecule TLR7/8 agonist hold high potential for this pur...

journal_title：Biomaterials

authors： Nuhn L,Van Hoecke L,Deswarte K,Schepens B,Li Y,Lambrecht BN,De Koker S,David SA,Saelens X,De Geest BG

更新日期：2018-09-01 00:00:00

abstract：:Hyaluronan (HL), a naturally occurring glycosaminoglycan, has been chemically modified through the esterification of its carboxylic groups with different types of alcohol. The physico-chemical properties of these new biopolymers allow the preparation of many biomaterials which may be used in several medical applicatio...

journal_title：Biomaterials

authors： Benedetti L,Cortivo R,Berti T,Berti A,Pea F,Mazzo M,Moras M,Abatangelo G

更新日期：1993-12-01 00:00:00

abstract：:The generation of effective tissue engineered bone grafts requires efficient exchange of nutrients and mechanical stimulus. Bioreactors provide a manner in which this can be achieved. We have recently developed a biaxial rotating bioreactor with efficient fluidics through in-silico modeling. Here we investigated its p...

journal_title：Biomaterials

authors： Zhang ZY,Teoh SH,Chong WS,Foo TT,Chng YC,Choolani M,Chan J

更新日期：2009-05-01 00:00:00

abstract：:Materials used for total knee arthroplasty (TKA), may elicit an immune response whose role in the outcome of the arthroplasty is still unclear. The aim of this study was to evaluate the frequency of sensitization in patients who had undergone TKA, and the clinical impact of this event on the outcome of the implant. Ni...

journal_title：Biomaterials

authors： Granchi D,Cenni E,Tigani D,Trisolino G,Baldini N,Giunti A

更新日期：2008-04-01 00:00:00

abstract：:Physicochemical features of a cell nanoenvironment exert important influence on stem cell behavior and include the influence of matrix elasticity and topography on differentiation processes. The presence of growth factors such as TGF-β and BMPs on these matrices provides chemical cues and thus plays vital role in dire...

journal_title：Biomaterials

authors： Das RK,Zouani OF

更新日期：2014-07-01 00:00:00

abstract：:Macrophages are multifunctional immune cells with diverse physiological functions such as fighting against infection, influencing progression of pathologies, maintaining homeostasis, and regenerating tissues. Macrophages can be induced to adopt distinct polarized phenotypes, such as classically activated pro-inflammat...

journal_title：Biomaterials

authors： Kang H,Zhang K,Wong DSH,Han F,Li B,Bian L

更新日期：2018-09-01 00:00:00

abstract：:Biological processes are of great significance for the normal physiological functions of living organisms and closely related to the health. Monitoring of biological processes and diagnosis of diseases based on fluorescent techniques would provide comprehensive insight into mechanism of life and pathogenesis of diseas...

journal_title：Biomaterials

authors： Gu X,Kwok RTK,Lam JWY,Tang BZ

更新日期：2017-11-01 00:00:00

abstract：:Artemisinin (ART) is an iron-dependent anti-cancer drug. However, simultaneous delivery of hydrophobic ART and Fe(2+) ions into cancer cells remains a major challenge. Herein, we reported Fe3O4@C/Ag@mSiO2 (FCA@mSiO2) multifunctional nanocarriers which can load ART as high as 484 mg/g. Moreover, FCA@mSiO2 nanoparticles...

journal_title：Biomaterials

authors： Chen J,Guo Z,Wang HB,Zhou JJ,Zhang WJ,Chen QW

更新日期：2014-08-01 00:00:00

abstract：:The surface and bulk properties of novel methacrylate polymers prepared by gelling poly(ethyl methacrylate) (PEMA) powder with different ratios of tetrahydrofurfuryl methacrylate (THFMA) and hydroxyethyl methacrylate (HEMA) monomers were investigated. The water adsorption and desorption characteristics of these polyme...

journal_title：Biomaterials

authors： Hutcheon GA,Messiou C,Wyre RM,Davies MC,Downes S

更新日期：2001-04-01 00:00:00

abstract：:A micro-X-ray diffraction (micro-XRD) technique has been employed to determine the phases in two superelastic nickel-titanium orthodontic wires that exhibit shape memory in the oral environment and one superelastic nickel-titanium wire that does not exhibit shape memory in vivo. The micro-XRD analyses were performed o...

journal_title：Biomaterials

authors： Iijima M,Brantley WA,Kawashima I,Ohno H,Guo W,Yonekura Y,Mizoguchi I

更新日期：2004-01-01 00:00:00

abstract：:Bioabsorbable internal fixation devices were introduced clinically in the treatment of fractures and osteotomies of the extremities at the Department of Orthopaedics and Traumatology, Helsinki University, in 1984. Since November 5, 1984, a total of 3200 patients were managed using bone or ligament fixation devices mad...

journal_title：Biomaterials

authors： Rokkanen PU,Böstman O,Hirvensalo E,Mäkelä EA,Partio EK,Pätiälä H,Vainionpää SI,Vihtonen K,Törmälä P

更新日期：2000-12-01 00:00:00

abstract：:Protein therapeutics targeting inflammatory mediators have shown great promise for the treatment of autoimmunities such as rheumatoid arthritis (RA). However, a significant challenge in this area has been their low in vivo stability and consequently their severely compromised therapeutic efficacy. One such therapeutic...

journal_title：Biomaterials

authors： Pasi S,Kant R,Gupta S,Surolia A

更新日期：2015-02-01 00:00:00

abstract：:Sintering reactions and fine structures of the biocomposites prepared from powder mixtures of titanium ( alpha -Ti), hydroxyapatite (HA) and bioactive glass (BG) (SiO2-CaO-P2O5-B2O3-MgO-TiO2-CaF2) were investigated by X-ray diffraction and transmission electron microscopy. The results showed that complex reactions amo...

journal_title：Biomaterials

authors： Ning CQ,Zhou Y

更新日期：2004-08-01 00:00:00

abstract：:Chondrocytes isolated from human foetal epiphyseal cartilage were seeded dynamically into polyglycolic acid (PGA) scaffolds and cultured in recirculation column bioreactors to produce tissue-engineered cartilage. Several culture techniques with the potential to provide endogenous growth factors and other conditions be...

journal_title：Biomaterials

authors： Mahmoudifar N,Doran PM

更新日期：2005-12-01 00:00:00

abstract：:In ophthalmology, there is a need for novel degradable biomaterials for e.g. controlled drug release in the vitreous body. These degradable materials should feature both excellent biocompatibility, and well-defined kinetics of degradation. In most cases, poly(D,L-lactic acid), or poly(lactic-co-glycolic acid) are used...

journal_title：Biomaterials

authors： Bruining MJ,Blaauwgeers HG,Kuijer R,Pels E,Nuijts RM,Koole LH

更新日期：2000-03-01 00:00:00

abstract：:Mucoadhesive properties of several polymers, such as sodium alginate, hydroxypropylmethyl cellulose, scleroglucan, xanthan gum, polyacrylic acid (Carbopol), and poly co-(methyl vinyl ether-maleic anhydride) (Gantrez), have been investigated by comparing a thermodynamical and a mechanical approach. Surface properties o...

journal_title：Biomaterials

authors： Esposito P,Colombo I,Lovrecich M

更新日期：1994-02-01 00:00:00

abstract：:We report here the development of a chitosan/beta-glycerophosphate(Ch/beta-GP) thermo-sensitive gel to deliver ellagic acid (EA) for cancer treatment. The properties of the Ch/beta-GP gels were characterized regarding chemical structure, surface morphology, and viscoelasticity. In vitro EA release rate from the EA loa...

journal_title：Biomaterials

authors： Kim S,Nishimoto SK,Bumgardner JD,Haggard WO,Gaber MW,Yang Y

更新日期：2010-05-01 00:00:00

abstract：:A number of phase separation pHEMA sponge hydrogels have been prepared based on variations in monomer contents, concentration of cross-linking agent, solvent mixture and temperature of polymerization. The loading levels and release profiles of the anti-inflammatory drug prednisolone were examined for each of the pHEMA...

journal_title：Biomaterials

authors： Lou X,Munro S,Wang S

更新日期：2004-09-01 00:00:00

abstract：:Novel acid-base reaction cements have been developed for use as controlled release formulations. Many new ones have been discovered and assessed; these include those which are capable of releasing copper, cobalt or selenium singly or in combination. A selection was made of the most suitable formulations for this purpo...

journal_title：Biomaterials

authors： Prosser HJ,Wilson AD,Groffman DM,Brookman PJ,Allen WM,Gleed PT,Manston R,Sansom BF

更新日期：1986-03-01 00:00:00

abstract：:Development of highly efficient nonviral gene delivery vectors still remains a great challenge. In this study, we report a new gene delivery vector based on dendrimer-entrapped gold nanoparticles (Au DENPs) with significantly higher gene transfection efficiency than that of dendrimers without AuNPs entrapped. Amine-te...

journal_title：Biomaterials

authors： Shan Y,Luo T,Peng C,Sheng R,Cao A,Cao X,Shen M,Guo R,Tomás H,Shi X

更新日期：2012-04-01 00:00:00

abstract：:Collagen in vertebrate animals is often arranged in alternating lamellae or in bundles of aligned fibrils which are designed to withstand in vivo mechanical loads. The formation of these organized structures is thought to result from a complex, large-area integration of individual cell motion and locally-controlled sy...

journal_title：Biomaterials

authors： Saeidi N,Karmelek KP,Paten JA,Zareian R,DiMasi E,Ruberti JW

更新日期：2012-10-01 00:00:00

abstract：:To avoid the overheating effect of excitation light and improve the efficacy of photodynamic therapy (PDT) of upconversion nanoplatform, a novel nanoprobe based on 808 nm-excited upconversion nanocomposites (T-UCNPs@Ce6@mSiO2) with low heating effect and deep penetration has been successfully constructed for targeted ...

journal_title：Biomaterials

authors： Zeng L,Pan Y,Zou R,Zhang J,Tian Y,Teng Z,Wang S,Ren W,Xiao X,Zhang J,Zhang L,Li A,Lu G,Wu A

更新日期：2016-10-01 00:00:00

abstract：:Human adipose tissue extracellular matrix, derived through decellularization processing, has been shown to provide a biomimetic microenvironment for adipose tissue regeneration. This study reports the use of human adipose tissue-derived extracellular matrix (hDAM) scaffolds as a three-dimensional cell culturing system...

journal_title：Biomaterials

authors： Dunne LW,Huang Z,Meng W,Fan X,Zhang N,Zhang Q,An Z

更新日期：2014-06-01 00:00:00

abstract：:Dense, reconstituted collagen membranes, using an optimized cross-linking protocol, were implanted subcutaneously into rats. After implantation, only a mild inflammatory response in the surrounding tissues was observed. The morphology of the fibroblasts around the membranes was seen to go through characteristic stages...

journal_title：Biomaterials

authors： Boon ME,Ruijgrok JM,Vardaxis MJ

更新日期：1995-09-01 00:00:00