Investigation of surface properties of some polymers by a thermodynamic and mechanical approach: possibility of predicting mucoadhesion and biocompatibility.

abstract：:Effects of the granularity of the raw materials on the hydration and hardening process of calcium phosphate cement (CPC) composed of equimolar tetracalcium phosphate (TECP) and dicalcium phosphate anhydrous (DCPA) were investigated systematically. The variation of pH value in CPC slurry indicated that the control step...

journal_title：Biomaterials

authors： Liu C,Shao H,Chen F,Zheng H

更新日期：2003-10-01 00:00:00

abstract：:Temperature-responsive polymers are attractive candidates for applications related to injectable delivery of biologically active therapeutics, such as stem cells. In this study, we evaluate the potential of thermosensitive hydroxybutyl chitosan (HBC) as a biomaterial for the culture of human mesenchymal stem cells (hM...

journal_title：Biomaterials

authors： Dang JM,Sun DD,Shin-Ya Y,Sieber AN,Kostuik JP,Leong KW

更新日期：2006-01-01 00:00:00

abstract：:Though reduced serum or myoblast co-culture alone can differentiate adipose-derived stem cells (ASCs) into mesenchymal lineages, efficiency is usually not sufficient to restore function in vivo. Often when injected into fibrotic muscle, their differentiation may be misdirected by the now stiffened tissue. Here ASCs ar...

journal_title：Biomaterials

authors： Choi YS,Vincent LG,Lee AR,Dobke MK,Engler AJ

更新日期：2012-03-01 00:00:00

abstract：:Parkinson's disease (PD) is one of the most common neurodegenerative diseases. Activins are members of the superfamily of transforming growth factors and have many potential neuroprotective effects. Herein, at the first place, we verified activin B's neuroprotective role in a PD model, and revealed that activin B's fa...

journal_title：Biomaterials

authors： Li J,Darabi M,Gu J,Shi J,Xue J,Huang L,Liu Y,Zhang L,Liu N,Zhong W,Zhang L,Xing M,Zhang L

更新日期：2016-09-01 00:00:00

abstract：:Because of the ability to induce cell death in certain conditions, the fullerenes (C(60)) are potential anticancer and toxic agents. The colloidal suspension of crystalline C(60) (nano-C(60), nC(60)) is extremely toxic, but the mechanisms of its cytotoxicity are not completely understood. By combining experimental ana...

journal_title：Biomaterials

authors： Markovic Z,Todorovic-Markovic B,Kleut D,Nikolic N,Vranjes-Djuric S,Misirkic M,Vucicevic L,Janjetovic K,Isakovic A,Harhaji L,Babic-Stojic B,Dramicanin M,Trajkovic V

更新日期：2007-12-01 00:00:00

abstract：:Poly(N-isopropylacrylamide) (PNIPAAm) is known to be thermally responsive material and has a lower critical solution temperature (LCST, 32 degrees C) at which a macromolecular transition from a hydrophilic to a hydrophobic structure occurs. Chitosan is a useful natural polymeric biomaterial due to its biocompatibility...

journal_title：Biomaterials

authors： Cho JH,Kim SH,Park KD,Jung MC,Yang WI,Han SW,Noh JY,Lee JW

更新日期：2004-11-01 00:00:00

abstract：:Besides as an inert carrier for hydrophobic anticancer agents, polymeric micelles composed of di-block copolymer poly(ethylene glycol)-poly(lactic acid) (PEG-b-PLA) function as biological response modifiers including reversal of multidrug resistance in cancer. However, the uptake mechanisms and the subsequent intracel...

journal_title：Biomaterials

authors： Zhang Z,Xiong X,Wan J,Xiao L,Gan L,Feng Y,Xu H,Yang X

更新日期：2012-10-01 00:00:00

abstract：:In contractile tissues such as myocardium, functional properties are directly related to the cellular orientation and elongation. Thus, tissue engineering of functional cardiac patches critically depends on our understanding of the interaction between multiple guidance cues such as topographical, adhesive or electrica...

journal_title：Biomaterials

authors： Au HT,Cheng I,Chowdhury MF,Radisic M

更新日期：2007-10-01 00:00:00

abstract：:A synthetic process for obtaining high-molecular-weight block copolymers containing poly(lactic-glycolic acid) and poly(ethylene glycol) segments has been established. This process involves the reaction of poly(ethylene glycols) with phosgene, followed by polycondensation of the resulting alpha, omega-bis(chloroformat...

journal_title：Biomaterials

authors： Ferruti P,Penco M,D'Addato P,Ranucci E,Deghenghi R

更新日期：1995-12-01 00:00:00

abstract：:We have investigated the interface between bone and hydroxyapatite (HA) chronically implanted in man. By light microscopy, HA appeared to bind directly to bone without intervening fibrous tissue. By transmission electron microscopy, two patterns were noted: (1) HA either bound directly to bone; or (2) electron-dense m...

journal_title：Biomaterials

authors： Oguchi H,Ishikawa K,Mizoue K,Seto K,Eguchi G

更新日期：1995-01-01 00:00:00

abstract：:Induced pluripotent stem cells (iPSCs) with four reprogramming factors (Oct-4/Sox2/Klf-4/c-Myc) have been shown to differentiate into hepatic lineages. However, it was unclear whether obviation of the c-Myc oncogene in iPSCs affected hepatic differentiation or inhibited in vivo tumor formation. In this study, we demon...

journal_title：Biomaterials

authors： Li HY,Chien Y,Chen YJ,Chen SF,Chang YL,Chiang CH,Jeng SY,Chang CM,Wang ML,Chen LK,Hung SI,Huo TI,Lee SD,Chiou SH

更新日期：2011-09-01 00:00:00

abstract：:Ex-vivo blood-brain barrier (BBB) model is of great value for studying brain function and drug development, but it is still challenging to engineer macroscale three-dimensional (3D) tissue constructs to recapitulate physiological and functional aspects of BBB. Here, we describe a delicate 3D vascularized neural constr...

journal_title：Biomaterials

authors： Yue H,Xie K,Ji X,Xu B,Wang C,Shi P

更新日期：2020-07-01 00:00:00

abstract：:The recreation of an in vitro microenvironment to understand and manipulate the proliferation and migration of invasive breast cancer cells may allow one to put a halt to their metastasis capacity. Invasive cancer cells have been linked to embryonic stem (ES) cells as they possess certain similar characteristics and g...

journal_title：Biomaterials

authors： Raof NA,Raja WK,Castracane J,Xie Y

更新日期：2011-06-01 00:00:00

abstract：:Multiblock, high molecular weight, linear, backbone degradable HPMA copolymer-prostaglandin E1 (PGE1) conjugate has been synthesized by RAFT polymerization mediated by a new bifunctional chain transfer agent (CTA), which contains an enzymatically degradable oligopeptide sequence flanked by two dithiobenzoate groups, f...

journal_title：Biomaterials

authors： Pan H,Sima M,Miller SC,Kopečková P,Yang J,Kopeček J

更新日期：2013-09-01 00:00:00

abstract：:Graphene oxide (GO) immunotoxicity is not clarified well up to date. Herein we reported the effects of GOs with and without polyvinylpyrrolidone (PVP) coating on human immune cells such as dendritic cells (DCs), T lymphocytes and macrophages. Human immune cells such as dendritic cells (DCs), T lymphocytes and macropha...

journal_title：Biomaterials

authors： Zhi X,Fang H,Bao C,Shen G,Zhang J,Wang K,Guo S,Wan T,Cui D

更新日期：2013-07-01 00:00:00

abstract：:One of the potential factors that may affect the results of mesenchymal stem cell (MSC)-based therapy is the age of donors and recipients. However, there have been no controlled studies to investigate the influence of skeletal maturity on the MSC-based repair of cartilage. The purpose of this study was to compare the ...

journal_title：Biomaterials

authors： Shimomura K,Ando W,Tateishi K,Nansai R,Fujie H,Hart DA,Kohda H,Kita K,Kanamoto T,Mae T,Nakata K,Shino K,Yoshikawa H,Nakamura N

更新日期：2010-11-01 00:00:00

abstract：:Impurity centers associated with silicon have been observed in the phase mixture of silicon substituted apatite (Si-Ap) and silicon stabilized tricalcium phosphate (Si-TCP) using electron spin resonance (ESR). Two unique centers occur upon addition of SiO2 to the calcium phosphate system: an orthorhombic center with g...

journal_title：Biomaterials

authors： Pietak AM,Reid JW,Sayer M

更新日期：2005-06-01 00:00:00

abstract：:Brushite (dicalcium phosphate dihydrate, DCPD, CaHPO4 x 2H2O) was deposited electrolytically from calcium dihydrogen phosphate solution with and without potassium chloride (KCl) as a supporting electrolyte. The kinetics of brushite transformation to hydroxyapatite (HA, Ca5(PO4)3OH) in the presence of calcium and prote...

journal_title：Biomaterials

authors： Kumar M,Xie J,Chittur K,Riley C

更新日期：1999-08-01 00:00:00

abstract：:The present study investigated the ectopic osteoinduction and early degradation of recombinant human bone morphogenetic protein-2 (rhBMP-2)-loaded porous beta-tricalcium phosphate (beta-TCP) in mice. The porous beta-TCP with 50 microg of rhBMP-2 (n = 25) and porous beta-TCP (control group, n = 25) were implanted into ...

journal_title：Biomaterials

authors： Liang G,Yang Y,Oh S,Ong JL,Zheng C,Ran J,Yin G,Zhou D

更新日期：2005-07-01 00:00:00

abstract：:Tissue engineering therapies require biomaterials capable of encouraging an angiogenic response. To dissect the influence of different pro-angiogenic stimuli a set of starPEG-heparin hydrogels with varied physicochemical properties was used as a highly efficient reservoir and tunable delivery system for basic fibrobla...

journal_title：Biomaterials

authors： Zieris A,Prokoph S,Levental KR,Welzel PB,Grimmer M,Freudenberg U,Werner C

更新日期：2010-11-01 00:00:00

abstract：:Ischemic stroke is the leading cause of disability and death worldwide. An effective therapeutic approach is urgently needed. Stroke-induced angiogenesis and neurogenesis are essential mechanisms in the long-term repair. Extracellular matrix proteins are also involved in tissue self-repair. Recently, a PHSRN (Pro-His-...

journal_title：Biomaterials

authors： Wu CC,Wang LC,Su YT,Wei WY,Tsai KJ

更新日期：2018-12-01 00:00:00

abstract：:A comparative in vitro assessment of 4 types of tubing representative of the materials currently used in cardiopulmonary bypass (CPB) procedures was conducted under static conditions using liquid extracts of the materials or direct contact with fresh human blood or serum. The parameters monitored were biomarkers of co...

journal_title：Biomaterials

authors： Harmand MF,Briquet F

更新日期：1999-09-01 00:00:00

abstract：:The aim of this study was to evaluate the bacterial adherence to biodegradable self-reinforced polyglycolic acid (SR-PGA) and self-reinforced poly-DL-lactic acid (SR-PLA 96) spiral stents in vitro. They are used as temporary urethral stents in urology. Gold-plated metal wire, polyurethane and latex were used as contro...

journal_title：Biomaterials

authors： Pétas A,Vuopio-Varkila J,Siitonen A,Välimaa T,Talja M,Taari K

更新日期：1998-04-01 00:00:00

abstract：:Microspheres of a hydrophobic and a hydrophilic poly(ether-ester) copolymer were evaluated for their in vitro and in vivo biocompatibility and degradation. The microspheres prior to and after sterilization were tested for in vitro cytotoxicity. The in vivo biocompatibility of the poly(ethylene glycol) terephthalate an...

journal_title：Biomaterials

authors： van Dijkhuizen-Radersma R,Hesseling SC,Kaim PE,de Groot K,Bezemer JM

更新日期：2002-12-01 00:00:00

abstract：:Current synthetic vascular grafts possess a significant mechanical mismatch compared to the native vasculature and do not permit endothelialization; both of these deficiencies contribute to the relatively high rate of failure of many synthetic grafts. In this communication, we report the modification of polyurethane (...

journal_title：Biomaterials

authors： Chuang TW,Masters KS

更新日期：2009-10-01 00:00:00

abstract：:The clustered regularly interspaced short palindromic repeat (CRISPR) systems have a wide variety of applications besides precise genome editing. In particular, the CRISPR/dCas9 system can be used to control specific gene expression by CRISPR activation (CRISPRa) or interference (CRISPRi). However, the safety concerns...

journal_title：Biomaterials

authors： Zhang K,Chooi WH,Liu S,Chin JS,Murray A,Nizetic D,Cheng D,Chew SY

更新日期：2020-10-01 00:00:00

abstract：:We investigated the bioactivity of new chitosan-based multi-membrane hydrogel (MMH) architectures towards chondrocyte-like cells. The microstructure of the hydrogels constituting the membranes precludes any living cell penetration, whereas their lower scale architecture allows the protein diffusion. The biological beh...

journal_title：Biomaterials

authors： Ladet SG,Tahiri K,Montembault AS,Domard AJ,Corvol MT

更新日期：2011-08-01 00:00:00

abstract：:The effect of surface characteristics on the interaction of sterically stabilized polystyrene particles with mouse peritoneal macrophages was studied using a range of poloxamers and poloxamine as coating agents. The coated particles were characterized in terms of thickness of coating layer, surface charge and critical...

journal_title：Biomaterials

authors： Illum L,Jacobsen LO,Müller RH,Mak E,Davis SS

更新日期：1987-03-01 00:00:00

abstract：:Plaque-induced lesions can produce peri-implant bone loss with ultimate implant loss. Although the peri-implant tissues seem to be more resistant than the periodontal ones to plaque and calculus, they can produce a more extensive spread of the infection to the deeper tissues around implants. The case of a 45-year-old ...

journal_title：Biomaterials

authors： Piattelli A,Cosci F,Scarano A,Trisi P

更新日期：1995-08-01 00:00:00

abstract：:Biodegradable polylactide implants allow secure fixation of osteochondral fractures with minimal adverse effects. The goal of this prospective, randomized animal study was to show whether osteoconductive effects can be achieved through the development of poly-L/DL(70/30)lactide composite implants with 10% beta-tricalc...

journal_title：Biomaterials

authors： Prokop A,Jubel A,Hahn U,Dietershagen M,Bleidistel M,Peters C,Höfl A,Rehm KE

更新日期：2005-07-01 00:00:00