Synthesis and properties of novel block copolymers containing poly(lactic-glycolic acid) and poly(ethyleneglycol) segments.

Abstract:

:A synthetic process for obtaining high-molecular-weight block copolymers containing poly(lactic-glycolic acid) and poly(ethylene glycol) segments has been established. This process involves the reaction of poly(ethylene glycols) with phosgene, followed by polycondensation of the resulting alpha, omega-bis(chloroformates) with poly(lactic-glycolic acid) oligomers. The copolymers have been characterized for their molecular weight, solubility properties, water absorption and preliminarily thermal behaviour. All evidence points to the conclusion that the process described is a general one, enabling biodegradable polymers to be obtained tailor-made according to specific requirements.

journal_name

Biomaterials

journal_title

Biomaterials

authors

Ferruti P,Penco M,D'Addato P,Ranucci E,Deghenghi R

doi

10.1016/0142-9612(95)96879-5

subject

Has Abstract

pub_date

1995-12-01 00:00:00

pages

1423-8

issue

18

eissn

0142-9612

issn

1878-5905

pii

0142-9612(95)96879-5

journal_volume

16

pub_type

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