Synthesis and properties of novel block copolymers containing poly(lactic-glycolic acid) and poly(ethyleneglycol) segments.


:A synthetic process for obtaining high-molecular-weight block copolymers containing poly(lactic-glycolic acid) and poly(ethylene glycol) segments has been established. This process involves the reaction of poly(ethylene glycols) with phosgene, followed by polycondensation of the resulting alpha, omega-bis(chloroformates) with poly(lactic-glycolic acid) oligomers. The copolymers have been characterized for their molecular weight, solubility properties, water absorption and preliminarily thermal behaviour. All evidence points to the conclusion that the process described is a general one, enabling biodegradable polymers to be obtained tailor-made according to specific requirements.






Ferruti P,Penco M,D'Addato P,Ranucci E,Deghenghi R




Has Abstract


1995-12-01 00:00:00














  • Effect of construct properties on encapsulated chondrocyte expression of insulin-like growth factor-1.

    abstract::Hydrogels are a promising type of biomaterial for articular cartilage constructs since they have been shown to enable encapsulated chondrocytes to express their predominant phenotypic marker, type II collagen. Endogenously expressed signaling molecules, such as insulin-like growth factor-1 (IGF-1), are also known to f...


    pub_type: 杂志文章


    authors: Yoon DM,Hawkins EC,Francke-Carroll S,Fisher JP

    更新日期:2007-01-01 00:00:00

  • Cartilage repair in transplanted scaffold-free chondrocyte sheets using a minipig model.

    abstract::Lacking a blood supply and having a low cellular density, articular cartilage has a minimal ability for self-repair. Therefore, wide-ranging cartilage damage rarely resolves spontaneously. Cartilage damage is typically treated by chondrocyte transplantation, mosaicplasty or microfracture. Recent advances in tissue eng...


    pub_type: 杂志文章


    authors: Ebihara G,Sato M,Yamato M,Mitani G,Kutsuna T,Nagai T,Ito S,Ukai T,Kobayashi M,Kokubo M,Okano T,Mochida J

    更新日期:2012-05-01 00:00:00

  • Pentacyclic triterpenes grafted on CD cores to interfere with influenza virus entry: A dramatic multivalent effect.

    abstract::Multivalent effect plays an important role in biological processes, particularly in the specific recognition of virus with its host cell during the first step of infection. Here we report the synthesis of multivalent pentacyclic triterpene grafted on cyclodextrin core and potency of against influenza entry activity. N...


    pub_type: 杂志文章


    authors: Xiao S,Si L,Tian Z,Jiao P,Fan Z,Meng K,Zhou X,Wang H,Xu R,Han X,Fu G,Zhang Y,Zhang L,Zhou D

    更新日期:2016-02-01 00:00:00

  • Scanning electron microscopy of the metal-tissue interface. I. Fixation methods and interpretation of results.

    abstract::Scanning electron microscopy has been used to study the interface between implants of pure metals and the muscular tissue of rats. Several problems arise in the interpretation of the observations made, due to the potential for disruption to the tissue and the exacerbation of any corrosion that may have occurred in viv...


    pub_type: 杂志文章


    authors: McNamara A,Williams DF

    更新日期:1982-07-01 00:00:00

  • The creation of an in vitro adipose tissue that contains a vascular-adipocyte complex.

    abstract::An increased demand for soft-tissue substitutes has impelled the development of an in vitro adipose tissue. Ideally, such a tissue should contain a vascular network that can deliver blood throughout the construct following its engraftment. This study describes the in vitro fabrication of a pre-vascularized adipose tis...


    pub_type: 杂志文章


    authors: Sorrell JM,Baber MA,Traktuev DO,March KL,Caplan AI

    更新日期:2011-12-01 00:00:00

  • Characterization of interfaces in human calcified tissue.

    abstract::Thermostimulated current spectroscopy has been applied to the investigation of molecular mobility in human calcified tissue. A comparative study of extracts at various stages of demineralization is presented. The response of an organic-mineral complex interphase has been identified. ...


    pub_type: 杂志文章


    authors: Martin M,Lamure A,Lacabanne C,Betin C,Harmand MF

    更新日期:1990-07-01 00:00:00

  • Generation of an in vitro 3D PDAC stroma rich spheroid model.

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    pub_type: 杂志文章


    authors: Ware MJ,Keshishian V,Law JJ,Ho JC,Favela CA,Rees P,Smith B,Mohammad S,Hwang RF,Rajapakshe K,Coarfa C,Huang S,Edwards DP,Corr SJ,Godin B,Curley SA

    更新日期:2016-11-01 00:00:00

  • Adjuvant-pulsed mRNA vaccine nanoparticle for immunoprophylactic and therapeutic tumor suppression in mice.

    abstract::Synthetic mRNA represents an exciting cancer vaccine technology for the implementation of effective cancer immunotherapy. However, inefficient in vivo mRNA delivery along with a requirement for immune co-stimulation present major hurdles to achieving anti-tumor therapeutic efficacy. Here, we demonstrate a proof-of-con...


    pub_type: 杂志文章


    authors: Islam MA,Rice J,Reesor E,Zope H,Tao W,Lim M,Ding J,Chen Y,Aduluso D,Zetter BR,Farokhzad OC,Shi J

    更新日期:2021-01-01 00:00:00

  • Micro-X-ray diffraction observation of nickel-titanium orthodontic wires in simulated oral environment.

    abstract::A micro-X-ray diffraction (micro-XRD) technique has been employed to determine the phases in two superelastic nickel-titanium orthodontic wires that exhibit shape memory in the oral environment and one superelastic nickel-titanium wire that does not exhibit shape memory in vivo. The micro-XRD analyses were performed o...


    pub_type: 杂志文章


    authors: Iijima M,Brantley WA,Kawashima I,Ohno H,Guo W,Yonekura Y,Mizoguchi I

    更新日期:2004-01-01 00:00:00

  • Chemical and physical properties of a hydrogel wound dressing.

    abstract::Geliperm hydrogel provides optimal physiological conditions for wound healing. The material is composed of two interlaced networks, one of polyacrylamide and one of agar, and contains about 96% firmly bound water. It is supplied in smooth, elastic, transparent sheets which are impermeable to bacteria but permeable to ...


    pub_type: 杂志文章


    authors: Kickhöfen B,Wokalek H,Scheel D,Ruh H

    更新日期:1986-01-01 00:00:00

  • Modulation of Wnt/β-catenin signaling in human embryonic stem cells using a 3-D microwell array.

    abstract::Intercellular interactions in the cell microenvironment play a critical role in determining cell fate, but the effects of these interactions on pathways governing human embryonic stem cell (hESC) behavior have not been fully elucidated. We and others have previously reported that 3-D culture of hESCs affects cell fate...


    pub_type: 杂志文章


    authors: Azarin SM,Lian X,Larson EA,Popelka HM,de Pablo JJ,Palecek SP

    更新日期:2012-03-01 00:00:00

  • Effects of transforming growth factor-beta 1 (TGF-beta1) on in vitro mineralization of human osteoblasts on implant materials.

    abstract::An in vitro cell-implant mineralization model system was used to study the effect of transforming growth factor-beta 1(TGF-beta1) on mineralization in human osteoblast cultures. SaOs-2 and primary human osteoblast (HOB) cells were cultured on Tivanium (Ti-6Al-4V) disks. Administration of different concentrations of TG...


    pub_type: 杂志文章


    authors: Zhang H,Ahmad M,Gronowicz G

    更新日期:2003-05-01 00:00:00

  • Tissue engineering of human cartilage and osteochondral composites using recirculation bioreactors.

    abstract::Chondrocytes isolated from human foetal epiphyseal cartilage were seeded dynamically into polyglycolic acid (PGA) scaffolds and cultured in recirculation column bioreactors to produce tissue-engineered cartilage. Several culture techniques with the potential to provide endogenous growth factors and other conditions be...


    pub_type: 杂志文章


    authors: Mahmoudifar N,Doran PM

    更新日期:2005-12-01 00:00:00

  • A self-setting single-component calcium phosphate cement.

    abstract::Following an original synthesis route, we have prepared a single-component calcium phosphate apatite-like powder which settles and hardens when mixed with deionized water in an approximative 1.2 g:1 ml ratio. This paper describes the first physico-chemical studies and characterizations of the material. Observations of...


    pub_type: 杂志文章


    authors: Zoulgami M,Lucas A,Briard P,Gaudé J

    更新日期:2001-07-01 00:00:00

  • Quasi-living surface graft polymerization with phosphorylcholine group(s) at the terminal end.

    abstract::A surface graft polymer with one or two phosphorylcholine (PC) polarheads at the terminus of the growing chain end was prepared by sequential reactions on a glass substrate. The dithiocarbamate group covalently bound to glass surfaces was derivatized with one or two PC groups and then irradiated with ultraviolet light...


    pub_type: 杂志文章


    authors: Matsuda T,Kaneko M,Ge S

    更新日期:2003-11-01 00:00:00

  • Evaluation of tetrafunctional block copolymers as synthetic vectors for lung gene transfer.

    abstract::In the present study, we evaluated, in mice, the efficacy of the tetrafunctional block copolymer 704 as a nonviral gene delivery vector to the lungs. SPECT/CT molecular imaging of gene expression, biochemical assays, and immunohistochemistry were used. Our dataset shows that the formulation 704 resulted in higher leve...


    pub_type: 杂志文章


    authors: Richard-Fiardo P,Hervouet C,Marsault R,Franken PR,Cambien B,Guglielmi J,Warnez-Soulie J,Darcourt J,Pourcher T,Colombani T,Haudebourg T,Peuziat P,Pitard B,Vassaux G

    更新日期:2015-03-01 00:00:00

  • Tracking and protection of transplanted stem cells using a ferrocenecarboxylic acid-conjugated peptide that mimics hTERT.

    abstract::In vivo tracking of transplanted stem cells has been a central aim of stem cell therapy. Although many tracking systems have been introduced, no method has yet been validated for clinical applications. We developed a novel sophisticated peptide (GV1001) that mimics hTERT (human telomerase reverse transcriptase) and an...


    pub_type: 杂志文章


    authors: Park HH,Lee KY,Park DW,Choi NY,Lee YJ,Son JW,Kim S,Moon C,Kim HW,Rhyu IJ,Koh SH

    更新日期:2018-02-01 00:00:00

  • Biointeractive polymers and tissue engineered blood vessels.

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    pub_type: 杂志文章,评审


    authors: Greisler HP,Gosselin C,Ren D,Kang SS,Kim DU

    更新日期:1996-02-01 00:00:00

  • Convection-driven generation of long-range material gradients.

    abstract::Natural materials exhibit anisotropy with variations in soluble factors, cell distribution, and matrix properties. The ability to recreate the heterogeneity of the natural materials is a major challenge for investigating cell-material interactions and for developing biomimetic materials. Here we present a generic flui...


    pub_type: 杂志文章


    authors: Du Y,Hancock MJ,He J,Villa-Uribe JL,Wang B,Cropek DM,Khademhosseini A

    更新日期:2010-03-01 00:00:00

  • pH-responsive complexes using prefunctionalized polymers for synchronous delivery of doxorubicin and siRNA to cancer cells.

    abstract::A nanocarrier delivery system that can simultaneously deliver a chemotherapeutic drug and siRNA to the tumor is emerging as a promising treatment strategy for cancer treatment. In this study, a multifunctional PHD/PPF/siRNA complexes was developed by one-step assembly of prefunctionalized polymers: PEI-HZ-DOX (PHD) an...


    pub_type: 杂志文章


    authors: Dong DW,Xiang B,Gao W,Yang ZZ,Li JQ,Qi XR

    更新日期:2013-07-01 00:00:00

  • Dermal matrix as a carrier for in vivo delivery of human adipose-derived stem cells.

    abstract::The aim of the present study was to evaluate the potential of acellular dermal matrix as a carrier for delivery of stem cells to the site of soft tissue defect in a murine skin injury model and to determine the potential of stem cells delivered via such an approach to successfully engraft, survive and differentiate lo...


    pub_type: 杂志文章


    authors: Altman AM,Matthias N,Yan Y,Song YH,Bai X,Chiu ES,Slakey DP,Alt EU

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  • Antiviral peptide nanocomplexes as a potential therapeutic modality for HIV/HCV co-infection.

    abstract::It is estimated that 4 to 5 million people are currently co-infected with Human Immunodeficiency Virus (HIV) and Hepatitis C Virus (HCV). HIV/HCV co-infection is associated with unique health risks including increased hepatotoxicity of antiretrovirals, accelerated progression of HCV and liver diseases. The standard in...


    pub_type: 杂志文章


    authors: Zhang J,Mulvenon A,Makarov E,Wagoner J,Knibbe J,Kim JO,Osna N,Bronich TK,Poluektova LY

    更新日期:2013-05-01 00:00:00

  • Non-viral gene delivery of DNA polyplexed with nanoparticles transfected into human mesenchymal stem cells.

    abstract::Human mesenchymal stem cells (hMSCs) represent a potent target for gene delivery for both stem cell differentiation applications and clinical therapies. However, it has, thus far, proven difficult to develop delivery vehicles that increase the efficiency of gene delivery to hMSCs, due to several problematic issues. We...


    pub_type: 杂志文章


    authors: Park JS,Na K,Woo DG,Yang HN,Kim JM,Kim JH,Chung HM,Park KH

    更新日期:2010-01-01 00:00:00

  • An 'in vitro' study of mechanical fatigue in glutaraldehyde-treated porcine aortic valve tissue.

    abstract::Leaflet tissue specimens prepared from porcine aortic valves treated with glutaraldehyde at low and high pressures have been subjected to 0.45 x 10(9) accelerated fatigue cycles in Ringer's solution. The waveform or crimped property of the collagen fibres in the leaflet tissue is an essential requirement for its abili...


    pub_type: 杂志文章


    authors: Broom ND

    更新日期:1980-01-01 00:00:00

  • Immunomodulatory injectable silk hydrogels maintaining functional islets and promoting anti-inflammatory M2 macrophage polarization.

    abstract::Islet transplantation is considered the most promising treatment for type 1 diabetes. However, the clinical success is limited by islet dysfunction in long-term culture. In this study, we have utilized the rapid self-gelation and injectability offered by blending of mulberry silk (Bombyx mori) with non-mulberry (Anthe...


    pub_type: 杂志文章


    authors: Kumar M,Gupta P,Bhattacharjee S,Nandi SK,Mandal BB

    更新日期:2018-12-01 00:00:00

  • VEGFR targeting leads to significantly enhanced tumor uptake of nanographene oxide in vivo.

    abstract::Although graphene oxide (GO) has recently been considered as a highly attractive nanomaterial for future cancer imaging and therapy, it is still a major challenge to improve its in vivo tumor active targeting efficiency. Here in this full article, we demonstrated the successful and significantly enhanced in vivo tumor...


    pub_type: 杂志文章


    authors: Shi S,Yang K,Hong H,Chen F,Valdovinos HF,Goel S,Barnhart TE,Liu Z,Cai W

    更新日期:2015-01-01 00:00:00

  • Fibre reinforced composite dental bridge. Part I: Experimental investigation.

    abstract::This experimental investigation aims at revealing the mechanical behaviour and failure pattern of direct fibre-reinforced resin-bonded dental bridge with various designs. To evaluate the overall effects of some newly developed dental materials, in the experiment, genuine composite dental bridge specimens are prepared ...


    pub_type: 杂志文章


    authors: Li W,Swain MV,Li Q,Ironside J,Steven GP

    更新日期:2004-09-01 00:00:00

  • High throughput atmospheric pressure plasma-induced graft polymerization for identifying protein-resistant surfaces.

    abstract::Three critical aspects of searching for and understanding how to find highly resistant surfaces to protein adhesion are addressed here with specific application to synthetic membrane filtration. They include the (i) discovery of a series of previously unreported monomers from a large library of monomers with high prot...


    pub_type: 杂志文章


    authors: Gu M,Kilduff JE,Belfort G

    更新日期:2012-02-01 00:00:00

  • Polyesterurethane foam scaffold for smooth muscle cell tissue engineering.

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    pub_type: 杂志文章


    authors: Danielsson C,Ruault S,Simonet M,Neuenschwander P,Frey P

    更新日期:2006-03-01 00:00:00

  • Anterior cruciate ligament regeneration using braided biodegradable scaffolds: in vitro optimization studies.

    abstract::The anterior cruciate ligament (ACL) is the most commonly injured intra-articular ligament of the knee, and limitations in existing reconstruction grafts have prompted an interest in tissue engineered solutions. Previously, we reported on a tissue-engineered ACL scaffold fabricated using a novel, three-dimensional bra...


    pub_type: 杂志文章


    authors: Lu HH,Cooper JA Jr,Manuel S,Freeman JW,Attawia MA,Ko FK,Laurencin CT

    更新日期:2005-08-01 00:00:00