Synthesis and properties of novel block copolymers containing poly(lactic-glycolic acid) and poly(ethyleneglycol) segments.


:A synthetic process for obtaining high-molecular-weight block copolymers containing poly(lactic-glycolic acid) and poly(ethylene glycol) segments has been established. This process involves the reaction of poly(ethylene glycols) with phosgene, followed by polycondensation of the resulting alpha, omega-bis(chloroformates) with poly(lactic-glycolic acid) oligomers. The copolymers have been characterized for their molecular weight, solubility properties, water absorption and preliminarily thermal behaviour. All evidence points to the conclusion that the process described is a general one, enabling biodegradable polymers to be obtained tailor-made according to specific requirements.






Ferruti P,Penco M,D'Addato P,Ranucci E,Deghenghi R




Has Abstract


1995-12-01 00:00:00














  • Synthetic high-density lipoprotein-like nanoparticles potently inhibit cell signaling and production of inflammatory mediators induced by lipopolysaccharide binding Toll-like receptor 4.

    abstract::Toll-like receptor 4 (TLR4) plays a critical role in the innate immune system. Stimulation of TLR4 occurs upon binding lipopolysaccharide (LPS), a component of Gram-negative bacterial cell walls. Due to the potency of the induced inflammatory response, there is a growing interest in agents that can most proximally mod...


    pub_type: 杂志文章


    authors: Foit L,Thaxton CS

    更新日期:2016-09-01 00:00:00

  • Effect of oligonucleotide mediated immobilization of bone morphogenic proteins on titanium surfaces.

    abstract::The aim of the present study was to test the hypothesis that oligonucleotides can be used for anchorage and slow release of osteogenic growth factors such as BMP to enhance the osteogenic activity of a titanium implant surface. Strands of 60-mer non-coding DNA oligonucleotides (ODN) were bound to an acid-etched sandbl...


    pub_type: 杂志文章


    authors: Schliephake H,Bötel C,Förster A,Schwenzer B,Reichert J,Scharnweber D

    更新日期:2012-02-01 00:00:00

  • The rate of change of pH of lactic acid exposed to glass-ionomer dental cements.

    abstract::The rate of change of pH of aqueous lactic acid at pH 4.2-4.5 (i.e. a little below that of active caries in vivo) in contact with disks of various commercial glass-ionomer cements has been determined in two configurations. In the first of them, a thin film set-up, 20 microl of solution was spread across the surface of...


    pub_type: 杂志文章


    authors: Nicholson JW,Aggarwal A,Czarnecka B,Limanowska-Shaw H

    更新日期:2000-10-01 00:00:00

  • Long-term culture of embryonic rat cardiomyocytes on an organosilane surface in a serum-free medium.

    abstract::Potential applications of engineered, functional, cardiac muscle extends from basic research through drug discovery to engineering heart tissue for transplantation. One of the central questions in cardiac tissue engineering is to understand and control the complex interactions between the cardiac muscle cells and thei...


    pub_type: 杂志文章


    authors: Das M,Molnar P,Gregory C,Riedel L,Jamshidi A,Hickman JJ

    更新日期:2004-11-01 00:00:00

  • Transmucosal delivery systems for calcitonin: a review.

    abstract::The commercial availability of peptides and proteins and their advantages as therapeutic agents have been the basis for tremendous efforts in designing delivery systems for such agents. The protection of these agents from biological fluids and physiological interactions is crucial for the treatment efficacy. One such ...


    pub_type: 杂志文章,评审


    authors: Torres-Lugo M,Peppas NA

    更新日期:2000-06-01 00:00:00

  • Cell growth on cordierite: an approach to the identification of reliable supports for continuous-flow solid-bed reactors.

    abstract::This study aimed to assess the biocompatibility of two cordierite ceramics (DF and Cord 1014), with similar chemical composition and different porosity, as a potential support for cell growth in a continuous-flow, solid-bed reactor. The Chinese hamster ovary (CHO) cell line transfected with HBV-DHFR recombinant plasmi...


    pub_type: 杂志文章


    authors: Orlandi L,Solmi R,Krajewski A,Bearzatto A,Biagini G,Ciccopiedi E,Ravaglioli A

    更新日期:1997-07-01 00:00:00

  • Targeting dendritic cells in lymph node with an antigen peptide-based nanovaccine for cancer immunotherapy.

    abstract::The design of peptide-based subunit vaccine formulations for the direct delivery of tumor antigen peptides (Aps) to dendritic cells (DCs) localized within draining lymph nodes (DLNs) is challenging. Mature DCs (mDCs) are abundantly distributed within DLNs but have dramatically reduced endocytic uptake and antigen-proc...


    pub_type: 杂志文章


    authors: Qian Y,Jin H,Qiao S,Dai Y,Huang C,Lu L,Luo Q,Zhang Z

    更新日期:2016-08-01 00:00:00

  • Prodrug-embedded angiogenic vessel-targeting nanoparticle: A positive feedback amplifier in hypoxia-induced chemo-photo therapy.

    abstract::Photodynamic therapy (PDT) induced hypoxia can significantly upregulate the expression of vascular endothelial growth factor (VEGF) at the tumor-stromal interface, resulting in a promoted angiogenesis. Thus, an angiogenesis vessel-targeting nanoparticle (AVT-NP) consisting of photosensitizer, angiogenic vessel-targeti...


    pub_type: 杂志文章


    authors: Guo D,Xu S,Wang N,Jiang H,Huang Y,Jin X,Xue B,Zhang C,Zhu X

    更新日期:2017-11-01 00:00:00

  • Upregulation of bone cell differentiation through immobilization within a synthetic extracellular matrix.

    abstract::There is a need for new therapeutic strategies to treat bone defects caused by trauma, disease or tissue loss. Injectable systems for cell transplantation have the advantage of allowing the use of minimally invasive surgical procedures, and thus for less discomfort to patients. In the present study, it is hypothesized...


    pub_type: 杂志文章


    authors: Evangelista MB,Hsiong SX,Fernandes R,Sampaio P,Kong HJ,Barrias CC,Salema R,Barbosa MA,Mooney DJ,Granja PL

    更新日期:2007-09-01 00:00:00

  • Biocompatibility of the Vascugraft: evaluation of a novel polyester urethane vascular substitute by an organotypic culture technique.

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    pub_type: 杂志文章


    authors: Guidoin R,Sigot M,King M,Sigot-Luizard MF

    更新日期:1992-01-01 00:00:00

  • Predicting the therapeutic efficacy of MSC in bone tissue engineering using the molecular marker CADM1.

    abstract::Mesenchymal stromal cells (hMSCs) are advancing into the clinic but the therapeutic efficacy of hMSCs faces the problem of donor variability. In bone tissue engineering, no reliable markers have been identified which are able to predict the bone-forming capacity of hMSCs prior to implantation. To this end, we isolated...


    pub_type: 杂志文章


    authors: Mentink A,Hulsman M,Groen N,Licht R,Dechering KJ,van der Stok J,Alves HA,Dhert WJ,van Someren EP,Reinders MJ,van Blitterswijk CA,de Boer J

    更新日期:2013-06-01 00:00:00

  • Effect of resin hydrophilicity and temperature on water sorption of dental adhesive resins.

    abstract::This study examined the effects of copolymer hydrophilicity and temperature on water sorption and solubility characteristics of five copolymer blends of increasing degree of hydrophilicity using gravimetric measurements. Six resin disks (15 mm in diameter x 1 mm in thickness) were prepared from each copolymer blend an...


    pub_type: 杂志文章


    authors: Yiu CK,King NM,Carrilho MR,Sauro S,Rueggeberg FA,Prati C,Carvalho RM,Pashley DH,Tay FR

    更新日期:2006-03-01 00:00:00

  • Antibacterial activity of bactericide-immobilized filler for resin-based restoratives.

    abstract::This study examined the antibacterial activity of prepolymerized resin filler, in which the bactericide quaternary ammonium was immobilized. The experimental filler was prepared by grinding prepolymerized resin blocks of methacrylate monomers, silica particles, and the antibacterial monomer methacryloyloxydodecylpyrid...


    pub_type: 杂志文章


    authors: Imazato S,Ebi N,Takahashi Y,Kaneko T,Ebisu S,Russell RR

    更新日期:2003-09-01 00:00:00

  • Biomechanical and histomorphometric study on the bone-screw interface of bioactive ceramic-coated titanium screws.

    abstract::The purpose of this study was to compare the osseointegration of 4 different kinds of bioactive ceramic-coated screws with uncoated screws by biomechanical and histomorphometric analysis. Calcium pyrophosphate (CPP), apatite-wollastonite 1:3 glass ceramic (W3G), apatite-wollastonite 1:1 glass ceramic (WAG) and bioacti...


    pub_type: 杂志文章


    authors: Lee JH,Ryu HS,Lee DS,Hong KS,Chang BS,Lee CK

    更新日期:2005-06-01 00:00:00

  • Electroporation-mediated transfer of Runx2 and Osterix genes to enhance osteogenesis of adipose stem cells.

    abstract::In the present study, we tested the hypothesis that electroporation-mediated transfer of Runx2, Osterix, or both genes enhances the in vitro and in vivo osteogenesis from adipose stem cells (ASCs). ASCs were transfected with Runx2, Osterix, or both genes using electroporation, and further cultured in monolayer or in P...


    pub_type: 杂志文章


    authors: Lee JS,Lee JM,Im GI

    更新日期:2011-01-01 00:00:00

  • Biocompatibility and healing process of polyester meshes in the brain: in vivo examination in rats.

    abstract:OBJECTIVES:To analyze the biocompatibility of multifilament polyester (PET) meshes used for the implantation of auditory brainstem implants in a standardized Wistar rat model (n=29). METHODS:The physical properties of the meshes were examined during surgery. Using a modified plastic embedding, the local tissue reactio...


    pub_type: 杂志文章


    authors: Quester R,Hermanns B,Klosterhalfen B,Schröder R,Klug N

    更新日期:2003-02-01 00:00:00

  • A biomimetic cascade nanoreactor for tumor targeted starvation therapy-amplified chemotherapy.

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    pub_type: 杂志文章


    authors: Cheng H,Jiang XY,Zheng RR,Zuo SJ,Zhao LP,Fan GL,Xie BR,Yu XY,Li SY,Zhang XZ

    更新日期:2019-03-01 00:00:00

  • A novel soft tissue model for biomaterial-associated infection and inflammation - bacteriological, morphological and molecular observations.

    abstract::Infection constitutes a major risk for implant failure, but the reasons why biomaterial sites are more vulnerable than normal tissue are not fully elucidated. In this study, a soft tissue infection model was developed, allowing the analysis of cellular and molecular responses in each of the sub-compartments of the imp...


    pub_type: 杂志文章


    authors: Svensson S,Trobos M,Hoffman M,Norlindh B,Petronis S,Lausmaa J,Suska F,Thomsen P

    更新日期:2015-02-01 00:00:00

  • Surface properties and biocompatibility of solvent-cast poly[-caprolactone] films.

    abstract::Poly(epsilon-caprolactone) (PCL) was dissolved in four solvent systems, chloroform, tetrahydrofuran, acetone and ethyl acetate, and cast onto glass Petri dishes. The surface properties of the resulting films were investigated. The extent to which their properties were determined by the solvent used in each case was qu...


    pub_type: 杂志文章


    authors: Tang ZG,Black RA,Curran JM,Hunt JA,Rhodes NP,Williams DF

    更新日期:2004-08-01 00:00:00

  • Modulation of biological processes in the nucleus by delivery of DNA oligonucleotides conjugated with gold nanoparticles.

    abstract::The development of a method that can efficiently deliver nucleic acids into the nucleus of living systems remains one of the key challenges for experimental and therapeutic use of nonbiological gene delivery agents. In the current study, we demonstrate a functionalized gold nanoparticle (AuNP) that can serve as a univ...


    pub_type: 杂志文章


    authors: Kim DW,Kim JH,Park M,Yeom JH,Go H,Kim S,Han MS,Lee K,Bae J

    更新日期:2011-04-01 00:00:00

  • Development and applications of injectable poly(ortho esters) for pain control and periodontal treatment.

    abstract::Poly(ortho esters) with a low glass transition temperature are semi-solid materials so that therapeutic agents can be incorporated at room temperature, without the use of solvents, by a simple mixing procedure. When molecular weights are limited to < 5 kDa, such materials are directly injectable using a needle size no...


    pub_type: 杂志文章


    authors: Helle J,Barr J,Ng SY,Shen HR,Schwach-Abdellaoui K,Gurny R,Vivien-Castioni N,Loup PJ,Baehni P,Mombelli A

    更新日期:2002-11-01 00:00:00

  • Water-soluble superparamagnetic manganese ferrite nanoparticles for magnetic resonance imaging.

    abstract::We report here a thermal decomposition approach to the synthesis of water-soluble superparamagnetic manganese ferrite (MnFe(2)O(4)) nanoparticles (NPs) for magnetic resonance (MR) imaging applications. In this approach, tetraethylene glycol was utilized as a coordination and stabilization agent, rendering the NPs wate...


    pub_type: 杂志文章


    authors: Yang H,Zhang C,Shi X,Hu H,Du X,Fang Y,Ma Y,Wu H,Yang S

    更新日期:2010-05-01 00:00:00

  • Engineered magnetic hybrid nanoparticles with enhanced relaxivity for tumor imaging.

    abstract::Clinically used contrast agents for magnetic resonance imaging (MRI) suffer by the lack of specificity; short circulation time; and insufficient relaxivity. Here, a one-step combinatorial approach is described for the synthesis of magnetic lipid-polymer (hybrid) nanoparticles (MHNPs) encapsulating 5 nm ultra-small sup...


    pub_type: 杂志文章


    authors: Aryal S,Key J,Stigliano C,Ananta JS,Zhong M,Decuzzi P

    更新日期:2013-10-01 00:00:00

  • Stability of some soluble alginate solutions.

    abstract::The stability of some water alginates against bacterial degradation was studied. The study was based on viscosity and pH measurements of some typical alginate solutions, containing suitable additives during an extended time period (222 days). ...


    pub_type: 杂志文章


    authors: Polyzois GL,Andreopoulos AG

    更新日期:1985-01-01 00:00:00

  • DNA image cytometry and Ag-NORs-staining application in biocompatibility studies on human osteoblast cells in vitro.

    abstract::We report here the study of the biocompatibility of a bone graft material, the Pyrost, using a previously established in vitro model of human osteoblasts. The effect of this material on cell proliferation was evaluated by the MTS assay. Results indicated the absolute absence of cytotoxic or cytostatic effect of Pyrost...


    pub_type: 杂志文章


    authors: Josset Y,Oum'hamed Z,Zarrinpour A,Lorenzato M,Adnet JJ,Laurent-Maquin D

    更新日期:1998-10-01 00:00:00

  • Biodegradable poly(ethylene glycol) hydrogels based on a self-elimination degradation mechanism.

    abstract::Two vinyl sulfone functionalized crosslinkers were developed for the purpose of preparing degradable poly(ethylene glycol) (PEG) hydrogels (EMXL and GABA-EMXL hydrogels). A self-elimination degradation mechanism in which an N-terminal residue of a glutamine is converted to pyroglutamic acid with subsequent release of ...


    pub_type: 杂志文章


    authors: Deshmukh M,Singh Y,Gunaseelan S,Gao D,Stein S,Sinko PJ

    更新日期:2010-09-01 00:00:00

  • Simultaneous in vivo tracking of dendritic cells and priming of an antigen-specific immune response.

    abstract::We report the fabrication of a one-pot antigen system that delivers antigen to dendritic cells (DCs) and tracks their in vivo migration after injection. Multifunctional polymer nanoparticles containing ovalbumin protein, magnetic resonance imaging contrast agents (iron oxide nanoparticles), and near-infrared fluoropho...


    pub_type: 杂志文章


    authors: Noh YW,Jang YS,Ahn KJ,Lim YT,Chung BH

    更新日期:2011-09-01 00:00:00

  • Tolerance induction by surface immobilization of Jagged-1 for immunoprotection of pancreatic islets.

    abstract::Although transplantation of pancreatic islets is a promising approach for treatment of type 1 diabetes mellitus, the engraftment efficiency of these islets is limited by host immune responses. Extensive efforts have been made to immunoisolate these islets by introducing barriers on the islet surface. To date, these ba...


    pub_type: 杂志文章


    authors: Izadi Z,Hajizadeh-Saffar E,Hadjati J,Habibi-Anbouhi M,Ghanian MH,Sadeghi-Abandansari H,Ashtiani MK,Samsonchi Z,Raoufi M,Moazenchi M,Izadi M,Nejad ASSH,Namdari H,Tahamtani Y,Ostad SN,Akbari-Javar H,Baharvand H

    更新日期:2018-11-01 00:00:00

  • Antibody and cytokine-associated immune responses to S. equi antigens entrapped in PLA nanospheres.

    abstract::Strangles is an infectious disease caused by Streptococcus equi subspecies equi that affects the upper respiratory tract of the Equidae. The control of this disease seems to be dependent on its earlier detection and prevention, but prolonged animal protection without development of strong and severe side effects has n...


    pub_type: 杂志文章


    authors: Florindo HF,Pandit S,Gonçalves LM,Videira M,Alpar O,Almeida AJ

    更新日期:2009-10-01 00:00:00

  • Wound treatment with Sorbsan--an alginate fibre dressing.

    abstract::This highly absorbent, biodegradable dressing derived from seaweed can be successfully applied to cleanse a wide variety of secreting lesions. The high absorption of exudate is achieved via strong hydrophilic gel formation and this serves to control wound secretion levels and to minimize bacterial contamination. Algin...


    pub_type: 杂志文章


    authors: Gilchrist T,Martin AM

    更新日期:1983-10-01 00:00:00