Abstract：
:Designing biomaterial scaffolds remains a major challenge in tissue engineering. Key to this challenge is improved understanding of the relationships between the scaffold properties and its degradation kinetics, as well as the cell interactions and the promotion of new matrix deposition. Here we present the use of non-linear spectroscopic imaging as a non-invasive method to characterize not only morphological, but also structural aspects of silkworm silk fibroin-based biomaterials, relying entirely on endogenous optical contrast. We demonstrate that two photon excited fluorescence and second harmonic generation are sensitive to the hydration, overall beta sheet content and molecular orientation of the sample. Thus, the functional content and high resolution afforded by these non-invasive approaches offer promise for identifying important connections between biomaterial design and functional engineered tissue development. The strategies described also have broader implications for understanding and tracking the remodeling of degradable biomaterials under dynamic conditions both in vitro and in vivo.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Rice WL,Firdous S,Gupta S,Hunter M,Foo CW,Wang Y,Kim HJ,Kaplan DL,Georgakoudi Idoi
10.1016/j.biomaterials.2007.12.049subject
Has Abstractpub_date
2008-05-01 00:00:00pages
2015-24issue
13eissn
0142-9612issn
1878-5905pii
S0142-9612(07)01063-0journal_volume
29pub_type
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