Abstract:
:Recent developments in cell culture techniques have made it possible to study the cellular mechanisms involved in carcinogenesis and to apply these methods as screening tools in vitro. This study investigated and compared the ability of the metals most commonly used in orthopedic implants to induce toxicity and neoplastic transformation in the C3H10T1/2 mouse fibroblast cell line. Eight metals (cobalt, chromium, nickel, iron, molybdenum, aluminium, vanadium and titanium) and their alloys (stainless steel, cobalt-chrome alloy and titanium alloy) were tested, both as soluble salts and as solid particles. There were marked differences between the various metals in terms of both toxicity and transforming ability. Significant increases in the incidence of cell transformation were seen with soluble forms of cobalt, chromium, nickel and molybdenum but not with iron, aluminium, vanadium or titanium. For most of the metals. transforming ability was directly related to toxicity, although this correlation did not hold for either molybdenum or vanadium. The physical form of the metal was critically important in determining its effects, and transformation occurred only with soluble metal salts.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Doran A,Law FC,Allen MJ,Rushton Ndoi
10.1016/s0142-9612(97)00209-3subject
Has Abstractpub_date
1998-04-01 00:00:00pages
751-9issue
7-9eissn
0142-9612issn
1878-5905pii
S0142-9612(97)00209-3journal_volume
19pub_type
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