当前位置： SCI文献检索 > BIOMATERIALS期刊下所有文献 > A computational modeling approach for enhancing self-assembly and biofunctionalisation of collagen biomimetic peptides.

A computational modeling approach for enhancing self-assembly and biofunctionalisation of collagen biomimetic peptides.

Abstract：

:Collagen fibers are essential components of tissues, which are highly conserved across the animal kingdom and could be extremely useful in tissue engineering. The formation of these macromolecular fibers depends on molecular interactions-based self-assembly of the basic building blocks of collagen called tropocollagens. Several attempts to produce biomimetic collagen have been described, however the best method to achieve the optimal material for tissue engineering has not been established. Here, we describe a bottom-up approach to design two computationally mutated molecular models that use non-covalent interactions to cross-link triple helices of tropocollagen molecules and thus promote self-association. Implementing a graph theory approach in the software FIRST reveals the hotspots that are crucial for the overall rigidity of the supramolecular helical structures and the remaining non-hotspots available for mutations. The mutated models were further decorated with GFOGER, a known collagen cell binding motif, to depict a biofunctional model. In addition to their recognized role of cell binding, the charged residues of the binding motif appeared to enhance further the supramolecular helical association. These findings could help to produce biomimetic collagen for biomedical applications.

journal_name

Biomaterials

journal_title

Biomaterials

authors

Krishnamoorthy N,Yacoub MH,Yaliraki SN

doi

10.1016/j.biomaterials.2011.06.074

subject

Has Abstract

pub_date

2011-10-01 00:00:00

pages

7275-85

issue

30

eissn

0142-9612

issn

1878-5905

pii

S0142-9612(11)00754-X

journal_volume

32

pub_type

杂志文章

相关文献

BIOMATERIALS文献大全
  • The promotion of osteoblastic differentiation of rat bone marrow stromal cells by a polyvalent plant mosaic virus.

    abstract：:To investigate the role that the micro/nano-environment plays on the differentiation pathway of bone marrow stromal cells (BMSCs) into osteoblasts, we employed a 2D substrate coated with turnip yellow mosaic virus (TYMV) particles. TYMV is a non-enveloped icosahedral plant virus which has an average diameter 28 nm and...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2008.06.029

    authors： Kaur G,Valarmathi MT,Potts JD,Wang Q

    更新日期：2008-10-01 00:00:00

  • The effect of photopolymerization on stem cells embedded in hydrogels.

    abstract：:Photopolymerizable hydrogels, formed by UV-exposure of photosensitive polymers in the presence of photoinitiators, are widely used materials in tissue engineering research employed for cellular entrapment and patterning. During photopolymerization, the entrapped cells are directly exposed to polymer and photoinitiator...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2008.09.037

    authors： Fedorovich NE,Oudshoorn MH,van Geemen D,Hennink WE,Alblas J,Dhert WJ

    更新日期：2009-01-01 00:00:00

  • High throughput atmospheric pressure plasma-induced graft polymerization for identifying protein-resistant surfaces.

    abstract：:Three critical aspects of searching for and understanding how to find highly resistant surfaces to protein adhesion are addressed here with specific application to synthetic membrane filtration. They include the (i) discovery of a series of previously unreported monomers from a large library of monomers with high prot...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2011.11.001

    authors： Gu M,Kilduff JE,Belfort G

    更新日期：2012-02-01 00:00:00

  • Post-nuclear gene delivery events for transgene expression by biocleavable polyrotaxanes.

    abstract：:A quantitative comparison between nuclear DNA release from carriers and their transfection activity would be highly useful for improving the effectiveness of non-viral gene vectors. We previously reported that, for condensed DNA particles, a close relationship exists between the efficiency of DNA release and transfect...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2012.01.049

    authors： Yamada Y,Nomura T,Harashima H,Yamashita A,Yui N

    更新日期：2012-05-01 00:00:00

  • Biocompatible polymeric nanocomplexes as an intracellular stimuli-sensitive prodrug for type-2 diabetes combination therapy.

    abstract：:Combination therapy is usually considered as a promising strategy owing to its advantages such as reduced doses, minimized side effects and improved therapeutic efficiency in a variety of diseases including diabetes. Here we synthesized a new highly intracellular stimuli-sensitive chitosan-graft-metformin (CS-MET) pro...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2015.09.013

    authors： Wang FZ,Xie ZS,Xing L,Zhang BF,Zhang JL,Cui PF,Qiao JB,Shi K,Cho CS,Cho MH,Xu X,Li P,Jiang HL

    更新日期：2015-12-01 00:00:00

  • Effect of PVA-AA on dentine bonding of HEMA.

    abstract：:PVA-AA, an esterification product of poly(vinyl alcohol) and acryloyl chloride, was synthesized and tested for its dentine bonding ability as an additive to 2-hydroxyethyl methacrylate (HEMA). The dentine bonding strength increased significantly by increasing the concentration of PVA-AA in HEMA. The dentine tensile bo...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/s0142-9612(96)00142-1

    authors： Gung YW,Kuo SM,Wang YJ

    更新日期：1997-02-01 00:00:00

  • Electropolymerization of pyrrole on titanium substrates for the future development of new biocompatible surfaces.

    abstract：:Titanium and its alloys are widely used in load-bearing implants as a result of their excellent mechanical properties and corrosion resistance. In order to improve their performances with respect to osseointegration, the use of bioactive coatings has been suggested. Polypyrrole (PPy) has been chosen as coating polymer...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/s0142-9612(00)00449-x

    authors： De Giglio E,Guascito MR,Sabbatin L,Zambonin G

    更新日期：2001-10-01 00:00:00

  • Non-viral gene delivery of DNA polyplexed with nanoparticles transfected into human mesenchymal stem cells.

    abstract：:Human mesenchymal stem cells (hMSCs) represent a potent target for gene delivery for both stem cell differentiation applications and clinical therapies. However, it has, thus far, proven difficult to develop delivery vehicles that increase the efficiency of gene delivery to hMSCs, due to several problematic issues. We...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2009.09.023

    authors： Park JS,Na K,Woo DG,Yang HN,Kim JM,Kim JH,Chung HM,Park KH

    更新日期：2010-01-01 00:00:00

  • Enhanced immunostimulatory effects of DNA-encapsulated peptide hydrogels.

    abstract：:DNA that encodes tumor-specific antigens represents potential immunostimulatory agents. However, rapid enzymatic degradation and fragmentation of DNA during administration can result in limited vector expression and, consequently, poor efficacy. These challenges have necessitated the use of novel strategies for DNA de...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2015.02.125

    authors： Medina SH,Li S,Howard OM,Dunlap M,Trivett A,Schneider JP,Oppenheim JJ

    更新日期：2015-01-01 00:00:00

  • Bio-orthogonal click reaction-enabled highly specific in situ cellularization of tissue engineering scaffolds.

    abstract：:Tissue engineering generally utilizes natural or synthetic scaffolds to repair or replace damaged tissues. However, due to the lack of guidance of biological signals, most of the implanted scaffolds have always suffered from poor in vivo cellularization. Herein, we demonstrate a bio-orthogonal reaction-based strategy ...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2019.119615

    authors： Mao D,Zhang C,Kenry,Liu J,Wang X,Li B,Yan H,Hu F,Kong D,Wang Z,Liu B

    更新日期：2020-02-01 00:00:00

  • The effects of heparin releasing hydrogels on vascular smooth muscle cell phenotype.

    abstract：:Poly(ethylene glycol) diacrylate (PEGDA) hydrogel scaffolds were engineered to promote contractile smooth muscle cell (SMC) phenotype via controlled release of heparin. The scaffold design was evaluated by quantifying the effects of free heparin on SMC phenotype, engineering hydrogels to provide controlled release of ...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2009.08.004

    authors： Beamish JA,Geyer LC,Haq-Siddiqi NA,Kottke-Marchant K,Marchant RE

    更新日期：2009-10-01 00:00:00

  • Combining poly-arginine with the hydrophobic counter-anion 4-(1-pyrenyl)-butyric acid for protein transduction in transdermal delivery.

    abstract：:Topical therapy is the most favored form of treatment for whitening against hyperpigmentation and sunburn because it lends itself to self-administration, patient compliance, and absence of systemic adverse effects. However, transdermal delivery of hydrophilic chemicals is difficult. The main purpose of this study is t...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2012.04.056

    authors： Candan G,Michiue H,Ishikawa S,Fujimura A,Hayashi K,Uneda A,Mori A,Ohmori I,Nishiki T,Matsui H,Tomizawa K

    更新日期：2012-09-01 00:00:00

  • Non-invasive monitoring of cell metabolism and lipid production in 3D engineered human adipose tissues using label-free multiphoton microscopy.

    abstract：:Non-linear optical microscopy methods can characterize over time multiple functional properties of engineered tissues during development. Here, we demonstrate how the combined use of third-harmonic generation (THG) and two-photon excited fluorescence (2PEF) imaging can provide direct quantitative biomarkers of adipoge...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2013.07.066

    authors： Chang T,Zimmerley MS,Quinn KP,Lamarre-Jouenne I,Kaplan DL,Beaurepaire E,Georgakoudi I

    更新日期：2013-11-01 00:00:00

  • Resorption of sintered synthetic hydroxyapatite by osteoclasts in vitro.

    abstract：:Primary rat bone marrow cells were cultured for periods of 8 d on hydroxyapatite discs produced by sintering compressed powder at 1130 degrees C. The disc surfaces were roughened using silicon carbide paper to create three groups of samples (n = 10) of differing surface topography. The culture conditions permitted bot...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/0142-9612(93)90216-o

    authors： Gomi K,Lowenberg B,Shapiro G,Davies JE

    更新日期：1993-01-01 00:00:00

  • 3D surface topology guides stem cell adhesion and differentiation.

    abstract：:Polymerized high internal phase emulsion (polyHIPE) foams are extremely versatile materials for investigating cell-substrate interactions in vitro. Foam morphologies can be controlled by polymerization conditions to result in either open or closed pore structures with different levels of connectivity, consequently ena...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2015.01.034

    authors： Viswanathan P,Ondeck MG,Chirasatitsin S,Ngamkham K,Reilly GC,Engler AJ,Battaglia G

    更新日期：2015-06-01 00:00:00

  • Biodegradable microspheres of novel segmented poly(ether-ester-amide)s based on poly(epsilon-caprolactone) for the delivery of bioactive compounds.

    abstract：:A novel class of multiblock poly(epsilon-caprolactone)-based polymers containing hydrophilic trioxyethylene segments and potentially relevant to the delivery of drugs is described in this work. L-phenylalanine residues may also be inserted into the hydrophilic blocks to generate peptide bonds susceptible to enzymatic ...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/s0142-9612(00)00291-x

    authors： Barbato F,La Rotonda MI,Maglio G,Palumbo R,Quaglia F

    更新日期：2001-06-01 00:00:00

  • Inorganic phase composition of remineralisation in porous CaP ceramics.

    abstract：:The formation of bone tissue in pores, and around, a block made of partially dehydroxylated porous hydroxyapatite ceramic and implanted into a rat's femur using X-ray diffraction (XRD), infrared spectroscopy (IRS) and histological methods were investigated. Structural characteristics and composition of new bone tissue...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/s0142-9612(98)00024-6

    authors： Zyman Z,Ivanov I,Glushko V,Dedukh N,Malyshkina S

    更新日期：1998-07-01 00:00:00

  • Tissue-specific extracellular matrix coatings for the promotion of cell proliferation and maintenance of cell phenotype.

    abstract：:Recent studies have shown that extracellular matrix (ECM) substitutes can have a dramatic impact on cell growth, differentiation and function. However, these ECMs are often applied generically and have yet to be developed for specific cell types. In this study, we developed tissue-specific ECM-based coating substrates...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2009.04.005

    authors： Zhang Y,He Y,Bharadwaj S,Hammam N,Carnagey K,Myers R,Atala A,Van Dyke M

    更新日期：2009-08-01 00:00:00

  • Surface roughening of glass ionomer cements by neutral NaF solutions.

    abstract：:The objective of this study was to investigate the effect of repeated applications of a neutral NaF solution on the surface roughness of four conventional glass ionomer cements (GIC) (ChemFil Superior encapsulated, Fuji Cap II, Ketac-Fil and Hi Dense), three resin-modified (RM-) GIC (Fuji II LC encapsulated, Photac-Fi...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/s0142-9612(02)00617-8

    authors： De Witte AM,De Maeyer EA,Verbeeck RM

    更新日期：2003-05-01 00:00:00

  • Cell behavior on extracellular matrix mimic materials based on mussel adhesive protein fused with functional peptides.

    abstract：:Adhesion of cells to surfaces is a basic and important requirement in cell culture and tissue engineering. Here, we designed artificial extracellular matrix (ECM) mimics for efficient cellular attachment, based on mussel adhesive protein (MAP) fusion with biofunctional peptides originating from ECM materials, includin...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2010.08.027

    authors： Choi BH,Choi YS,Kang DG,Kim BJ,Song YH,Cha HJ

    更新日期：2010-12-01 00:00:00

  • (Poly)acrylonitrile-based hydrogel as a therapeutic bulking agent in urology.

    abstract：:Vesicoureteral reflux and urinary incontinence can be treated by endoscopic injection. Injectables such as collagen and hyaluronic acid-dextranomer are commonly used, however are not offering optimal therapeutic effect yet. In the present study a novel application for poly(acrylonitrile)-based hydrogel (Hypan), alread...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2006.09.019

    authors： Ramseyer P,Meagher-Villemure K,Burki M,Frey P

    更新日期：2007-02-01 00:00:00

  • Hierarchically constructed selenium-doped bone-mimetic nanoparticles promote ROS-mediated autophagy and apoptosis for bone tumor inhibition.

    abstract：:Biomimetic materials are often capable of subtly affecting tissue development, regeneration and carcinogenesis due to their high similarity to natural tissues. Despite the benefit of using such materials in tissue engineering, their prospective use in cancer therapy has been neglected, particularly the functions and m...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2020.120253

    authors： Li X,Wang Y,Chen Y,Zhou P,Wei K,Wang H,Wang J,Fang H,Zhang S

    更新日期：2020-10-01 00:00:00

  • Limiting the protein corona: A successful strategy for in vivo active targeting of anti-HER2 nanobody-functionalized nanostars.

    abstract：:Gold nanoparticles hold great promise as anti-cancer theranostic agents against cancer by actively targeting the tumor cells. As this potential has been supported numerously during in vitro experiments, the effective application is hampered by our limited understanding and control of the interactions within complex in...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2017.01.007

    authors： D'Hollander A,Jans H,Velde GV,Verstraete C,Massa S,Devoogdt N,Stakenborg T,Muyldermans S,Lagae L,Himmelreich U

    更新日期：2017-04-01 00:00:00

  • Dragon fruit-like biocage as an iron trapping nanoplatform for high efficiency targeted cancer multimodality imaging.

    abstract：:Natural biopolymer based multifunctional nanomaterials are perfect candidates for multimodality imaging and therapeutic applications. Conventional methods of building multimodal imaging probe require either cross-linking manners to increase its in vivo stability or attach a target module to realize targeted imaging. I...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2015.08.001

    authors： Yang M,Fan Q,Zhang R,Cheng K,Yan J,Pan D,Ma X,Lu A,Cheng Z

    更新日期：2015-11-01 00:00:00

  • Light-induced cell detachment for cell sheet technology.

    abstract：:The phenomenon of light-induced cell detachment is reported. Mouse calvaria-derived, pre-osteoblastic (MC3T3-E1) cells were cultured on a TiO(2) nanodot-coated quartz substrate. After 20 min of UV365 illumination, over 90% of the cells would detach from the surface. Moreover, intact cell sheets could be obtained in th...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2012.09.043

    authors： Hong Y,Yu M,Weng W,Cheng K,Wang H,Lin J

    更新日期：2013-01-01 00:00:00

  • Adhesion contact dynamics of primary hepatocytes on poly(ethylene terephthalate) surface.

    abstract：:The design of bioartificial liver assist device requires an effective attachment of primary hepatocytes on polymeric biomaterials. A better understanding of this cell-surface interaction would aid the optimal choice of biomaterials. In this study, the adhesion contact dynamics of primary hepatocytes on poly(ethylene t...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2004.03.041

    authors： Tan WJ,Teo GP,Liao K,Leong KW,Mao HQ,Chan V

    更新日期：2005-03-01 00:00:00

  • Multilayer polypeptide nanoscale coatings incorporating IL-12 for the prevention of biomedical device-associated infections.

    abstract：:Biomedical device-associated infection is one of the most common and problematic complications faced by millions of patients worldwide. The current antibiotic therapy strategies face challenges, the most serious of which is antibiotic resistance. Studies have shown that the systemic level of interleukin 12 (IL-12) dec...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2009.01.042

    authors： Li B,Jiang B,Boyce BM,Lindsey BA

    更新日期：2009-05-01 00:00:00

  • Neurite outgrowth on well-characterized surfaces: preparation and characterization of chemically and spatially controlled fibronectin and RGD substrates with good bioactivity.

    abstract：:Study of axonal growth and ligand-receptor interactions requires specificity and careful characterization of the biomaterial substrates to which the neurons bind. It would be impossible to predict the effects of important variables such as composition, surface density, spatial distribution, and conformation of the lig...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2004.02.004

    authors： Zhang Z,Yoo R,Wells M,Beebe TP Jr,Biran R,Tresco P

    更新日期：2005-01-01 00:00:00

  • Redox-responsive nanocapsules for intracellular protein delivery.

    abstract：:Direct delivery of proteins to the cytosol of cells holds tremendous potential in biological and medical applications. Engineering vehicles for escorting proteins to the cytosol in a controlled release fashion has thus generated considerable interest. We report here the preparation of redox-responsive single-protein n...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2011.03.060

    authors： Zhao M,Biswas A,Hu B,Joo KI,Wang P,Gu Z,Tang Y

    更新日期：2011-08-01 00:00:00

  • Peptide targeted tripod macrocyclic Gd(III) chelates for cancer molecular MRI.

    abstract：:Rational design and develop of targeted contrast agents binding to cancer-related proteins will achieve more accurate cancer diagnosis and prognosis by magnetic resonance (MR) imaging. CREKA is a tumor-homing pentapeptide (Cys-Arg-Glu-Lys-Ala) specifically homes to fibrin-fibronectin complexes abundantly expressed in ...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2013.06.057

    authors： Zhou Z,Wu X,Kresak A,Griswold M,Lu ZR

    更新日期：2013-10-01 00:00:00